A NEW THERAPEUTIC TARGET FOR STRESS-RELATED RELAPSE
Grant number: 1079893 | Funding period: 2015 - 2018
Relapse and hazardous drinking represent the most difficult clinical problems in treating patients with alcohol use disorders. We have identified a novel system in the brain for the regulation of stress-induced relapse. Successful completion of this project will indicate improved pharmacotherapeutic strategies for the treatment of alcoholism and drug abuse. Given the scale and costs of substance abuse disorders, improved therapeutic approaches will have immediate and sustained impact.
Related publications (11)
Cocaine and amphetamine regulated transcript (CART) signalling in the central nucleus of the amygdala modulates stress-induced alcohol seeking
Leigh C Walker, Lexi J Hand, Bethany Letherby, Kate L Huckstep, Erin J Campbell, Andrew J Lawrence
The central nucleus of the amygdala (CeA) is a key hub of the neural circuitry regulating alcohol and stress interactions. However..
Characterization of the relaxin family peptide receptor 3 system in the mouse bed nucleus of the stria terminalis
Sarah S Ch'ng, Jingjing Fu, Robyn M Brown, Craig M Smith, Mohammed Akhter Hossain, Stuart J McDougall, Andrew J Lawrence
The bed nucleus of the stria terminalis (BNST) is a critical node involved in stress and reward-related behaviors. Relaxin family ..
The effect of acute or repeated stress on the corticotropin releasing factor system in the CRH-IRES-Cre mouse: A validation study
Leigh C Walker, Lara C Cornish, Andrew J Lawrence, Erin J Campbell
Corticotropin releasing factor (CRF) is a key component of stress responsivity, modulating related behaviors including anxiety and..
Novel approaches to alcohol rehabilitation: Modification of stress-responsive brain regions through environmental enrichment
Terence Y Pang, Anthony J Hannan, Andrew J Lawrence
Relapse remains the most prominent hurdle to successful rehabilitation from alcoholism. The neural mechanisms underlying relapse a..
The intersection of stress and reward: BNST modulation of aversive and appetitive states
Sarah Ch'ng, Jingjing Fu, Robyn M Brown, Stuart J McDougall, Andrew J Lawrence
The bed nucleus of the stria terminalis (BNST) is widely acknowledged as a brain structure that regulates stress and anxiety state..
Nucleus incertus corticotrophin-releasing factor 1 receptor signalling regulates alcohol seeking in rats
Leigh C Walker, Hanna E Kastman, Jan A Koeleman, Craig M Smith, Christina J Perry, Elena V Krstew, Andrew L Gundlach, Andrew J Lawrence
Alcoholism is a chronic relapsing disorder, and stress is a key precipitant of relapse. The nucleus incertus (NI) is highly respon..
Central amygdala relaxin-3/relaxin family peptide receptor 3 signalling modulates alcohol seeking in rats
Leigh C Walker, Hanna E Kastman, Elena V Krstew, Andrew L Gundlach, Andrew J Lawrence
BACKGROUND AND PURPOSE: Alcohol use disorders are a leading cause of preventable deaths worldwide, and stress is a major trigger o..
Nucleus incertus Orexin(2) receptors mediate alcohol seeking in rats
Hanna E Kastman, Anna Blasiak, Leigh Walker, Marcin Siwiec, Elena V Krstew, Andrew L Gundlach, Andrew J Lawrence
Alcoholism is a chronic relapsing disorder and a major global health problem. Stress is a key precipitant of relapse in human alco..