CELL THERAPY FOR ENTERIC NEUROPATHIES - THE ESSENTIAL NEXT STEPS

Grant number: 1079234 | Funding period: 2015 - 2018

Completed

Abstract

Gastrointestinal motility disorders caused by damage or diseased neurons in the gut wall ('enteric neuropathies) are some of the most clinically challenging conditions to manage because of a lack of effective treatments. Our recent animal studies suggest that cell-based therapies are a real possibility to treat enteric neuropathies. In this project, we will methodically address the outstanding steps that need to be addressed with the aim of moving enteric cell therapies to the clinic.

Related publications (9)

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Fine scale differences within the vagal neural crest for enteric nervous system formation

Johanna E Simkin, Dongcheng Zhang, Lincon A Stamp, Donald F Newgreen

2019-02-01

The enteric nervous system is mostly derived from vagal neural crest (NC) cells adjacent to somites (s)1-7. We used in ovo focal f..

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The enteric neural crest progressively loses capacity to form enteric nervous system

Dongcheng Zhang, Benjamin N Rollo, Nandor Nagy, Lincon Stamp, Donald F Newgreen

2019-02-01

Cells of the vagal neural crest (NC) form most of the enteric nervous system (ENS) by a colonising wave in the embryonic gut, with..

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Development of the Enteric Nervous System

HM Young, LA Stamp, T Uesaka, MM Hao, DF Newgreen, H Enomoto

2018-01-01

Enteric neurons and glial cells arise from neural crest cells, most of which emigrate from the caudal hindbrain (“vagal” level) an..

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Optogenetic Demonstration of Functional Innervation of Mouse Colon by Neurons Derived From Transplanted Neural Cells

Lincon A Stamp, Rachel M Gwynne, Jaime PP Foong, Alan E Lomax, Marlene M Hao, David I Kaplan, Christopher A Reid, Steven Petrou, Andrew M Allen, Joel C Bornstein, Heather M Young

2017-05-01

BACKGROUND & AIMS: Cell therapy offers the potential to treat gastrointestinal motility disorders caused by diseased or absent ent..

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Cell therapy for GI motility disorders: comparison of cell sources and proposed steps for treating Hirschsprung disease

Lincon A Stamp

2017-04-01

Cell therapeutic approaches to treat a range of congenital and degenerative neuropathies are under intense investigation. There ha..

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Exposure to GDNF Enhances the Ability of Enteric Neural Progenitors to Generate an Enteric Nervous System

Sonja J McKeown, Mitra Mohsenipour, Annette J Bergner, Heather M Young, Lincon A Stamp

2017-02-14

Cell therapy is a promising approach to generate an enteric nervous system (ENS) and treat enteric neuropathies. However, for tran..

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Recent advances in regenerative medicine to treat enteric neuropathies: use of human cells

LA Stamp, HM Young

2017-01-01

As current options for treating most enteric neuropathies are either non-effective or associated with significant ongoing problems..

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A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy

Ian A Parish, Lincon A Stamp, Ayla May D Lorenzo, Suzanne M Fowler, Yovina Sontani, Lisa A Miosge, Debbie R Howard, Christopher C Goodnow, Heather M Young, John B Furness

2016-09-01

Chronic intestinal pseudo-obstruction (CIPO) is a rare but life-threatening disease characterized by severe intestinal dysmotility..

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Surgical Intervention to Rescue Hirschsprung Disease in a Rat Model

Lincon A Stamp, Florian Obermayr, Louise Pontell, Heather M Young, Dan Xie, David H Croaker, Zan-Min Song, John B Furness

2015-10-01

BACKGROUND/AIMS: Rats with a spontaneous null mutation in endothelin receptor type B or Ednrb (sl/sl; spotting lethal) lack enteri..