CELL THERAPY FOR ENTERIC NEUROPATHIES - THE ESSENTIAL NEXT STEPS
Grant number: 1079234 | Funding period: 2015 - 2018
Gastrointestinal motility disorders caused by damage or diseased neurons in the gut wall ("enteric neuropathies) are some of the most clinically challenging conditions to manage because of a lack of effective treatments. Our recent animal studies suggest that cell-based therapies are a real possibility to treat enteric neuropathies. In this project, we will methodically address the outstanding steps that need to be addressed with the aim of moving enteric cell therapies to the clinic.
Related publications (9)
Fine scale differences within the vagal neural crest for enteric nervous system formation
Johanna E Simkin, Dongcheng Zhang, Lincon A Stamp, Donald F Newgreen
The enteric nervous system is mostly derived from vagal neural crest (NC) cells adjacent to somites (s)1-7. We used in ovo focal f..
The enteric neural crest progressively loses capacity to form enteric nervous system
Dongcheng Zhang, Benjamin N Rollo, Nandor Nagy, Lincon Stamp, Donald F Newgreen
Cells of the vagal neural crest (NC) form most of the enteric nervous system (ENS) by a colonising wave in the embryonic gut, with..
Optogenetic Demonstration of Functional Innervation of Mouse Colon by Neurons Derived From Transplanted Neural Cells
Lincon A Stamp, Rachel M Gwynne, Jaime PP Foong, Alan E Lomax, Marlene M Hao, David I Kaplan, Christopher A Reid, Steven Petrou, Andrew M Allen, Joel C Bornstein, Heather M Young
BACKGROUND & AIMS: Cell therapy offers the potential to treat gastrointestinal motility disorders caused by diseased or absent ent..
Exposure to GDNF Enhances the Ability of Enteric Neural Progenitors to Generate an Enteric Nervous System
Sonja J McKeown, Mitra Mohsenipour, Annette J Bergner, Heather M Young, Lincon A Stamp
Cell therapy is a promising approach to generate an enteric nervous system (ENS) and treat enteric neuropathies. However, for tran..
A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy
Ian A Parish, Lincon A Stamp, Ayla May D Lorenzo, Suzanne M Fowler, Yovina Sontani, Lisa A Miosge, Debbie R Howard, Christopher C Goodnow, Heather M Young, John B Furness
Chronic intestinal pseudo-obstruction (CIPO) is a rare but life-threatening disease characterized by severe intestinal dysmotility..
Surgical Intervention to Rescue Hirschsprung Disease in a Rat Model
Lincon A Stamp, Florian Obermayr, Louise Pontell, Heather M Young, Dan Xie, David H Croaker, Zan-Min Song, John B Furness
BACKGROUND/AIMS: Rats with a spontaneous null mutation in endothelin receptor type B or Ednrb (sl/sl; spotting lethal) lack enteri..