CELL THERAPY FOR ENTERIC NEUROPATHIES - THE ESSENTIAL NEXT STEPS

Grant number: 1079234 | Funding period: 2015 - 2018

Completed

Abstract

Gastrointestinal motility disorders caused by damage or diseased neurons in the gut wall ("enteric neuropathies) are some of the most clinically challenging conditions to manage because of a lack of effective treatments. Our recent animal studies suggest that cell-based therapies are a real possibility to treat enteric neuropathies. In this project, we will methodically address the outstanding steps that need to be addressed with the aim of moving enteric cell therapies to the clinic.

Related publications (9)

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Fine scale differences within the vagal neural crest for enteric nervous system formation

Johanna E Simkin, Dongcheng Zhang, Lincon A Stamp, Donald F Newgreen

2019-02-01

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The enteric neural crest progressively loses capacity to form enteric nervous system

Dongcheng Zhang, Benjamin N Rollo, Nandor Nagy, Lincon Stamp, Donald F Newgreen

2019-02-01

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Development of the Enteric Nervous System

HM Young, LA Stamp, T Uesaka, MM Hao, DF Newgreen, H Enomoto

2018-03-28

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Optogenetic Demonstration of Functional Innervation of Mouse Colon by Neurons Derived From Transplanted Neural Cells

Lincon A Stamp, Rachel M Gwynne, Jaime PP Foong, Alan E Lomax, Marlene M Hao, David I Kaplan, Christopher A Reid, Steven Petrou, Andrew M Allen, Joel C Bornstein, Heather M Young

2017-05-01

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Cell therapy for GI motility disorders: comparison of cell sources and proposed steps for treating Hirschsprung disease

Lincon A Stamp

2017-04-01

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Exposure to GDNF Enhances the Ability of Enteric Neural Progenitors to Generate an Enteric Nervous System

Sonja J McKeown, Mitra Mohsenipour, Annette J Bergner, Heather M Young, Lincon A Stamp

2017-02-14

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Recent advances in regenerative medicine to treat enteric neuropathies: use of human cells

LA Stamp, HM Young

2017-01-01

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A Novel Mutation in Nucleoporin 35 Causes Murine Degenerative Colonic Smooth Muscle Myopathy

Ian A Parish, Lincon A Stamp, Ayla May D Lorenzo, Suzanne M Fowler, Yovina Sontani, Lisa A Miosge, Debbie R Howard, Christopher C Goodnow, Heather M Young, John B Furness

2016-09-01

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Surgical Intervention to Rescue Hirschsprung Disease in a Rat Model

Lincon A Stamp, Florian Obermayr, Louise Pontell, Heather M Young, Dan Xie, David H Croaker, Zan-Min Song, John B Furness

2015-10-01