UNDERSTANDING THE ORIGINS OF NEUROGENIC HYPERTENSION
Grant number: 1079680 | Funding period: 2015 - 2017
Brain cells that control the cardiovascular system are thought to have stopped dividing by adulthood. We recently discovered that this is not the case. Our initial findings suggest that these nascent cells might be important for maintaining normal blood pressure. This work will allow us to elucidate the function of these nascent cells and how they integrate into the circuit that controls the cardiovascular system. Our findings will be fundamental for understanding diseases such as hypertension.
Related publications (12)
Systemic administration of pentoxifylline attenuates the development of hypertension in renovascular hypertensive rats
Anthony Setiadi, Willian S Korim, Clive N May, Song T Yao
There is evidence to suggest that hypertension involves a chronic low-grade systemic inflammatory response; however, the underlyin..
Chemoattraction and Recruitment of Activated Immune Cells, Central Autonomic Control, and Blood Pressure Regulation
Khalid Elsaafien, Willian S Korim, Anthony Setiadi, Clive N May, Song T Yao
Inflammatory mediators play a critical role in the regulation of sympathetic outflow to cardiovascular organs in hypertension. Eme..
In renovascular hypertension, TNF- type-1 receptors in the area postrema mediate increases in cardiac and renal sympathetic nerve activity and blood pressure
Willian S Korim, Khalid Elsaafien, Jeremy R Basser, Anthony Setiadi, Clive N May, Song T Yao
AIMS: Neuroinflammation is a common feature in renovascular, obesity-related, and angiotensin II mediated hypertension. There is e..
Glycinergic neurotransmission in the rostral ventrolateral medulla controls the time course of baroreflex-mediated sympathoinhibition
Hong Gao, Willian S Korim, Song T Yao, Cheryl M Heesch, Andrei V Derbenev
KEY POINTS: To maintain appropriate blood flow to various tissues of the body under a variety of physiological states, autonomic n..
PURINERGIC P2 RECEPTORS IN THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS ARE INVOLVED IN HYPEROSMOTIC-INDUCED SYMPATHOEXCITATION
HC Ferreira-Neto, IMR Ribeiro, TS Moreira, ST Yao, VR Antunes
Increases in plasma osmolality activates the paraventricular nucleus of the hypothalamus (PVN) which in turn mounts a physiologica..
A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1
Mohammed Akhter Hossain, Martina Kocan, Song T Yao, Simon G Royce, Vinojini B Nair, Christopher Siwek, Nitin A Patil, Ian P Harrison, K Johan Rosengren, Stavros Selemidis, Roger J Summers, John D Wade, Ross AD Bathgate, Chrishan S Samuel
Human gene-2 relaxin (H2 relaxin) is a pleiotropic hormone with powerful vasodilatory and anti-fibrotic properties which has led t..