DEVELOPMENT OF SPECIFIC INHIBITORS OF PORPHYROMONAS GINGIVALIS GINGIPAINS BASED ON THEIR COGNATE PROPEPTIDES
Grant number: 1081252 | Funding period: 2015 - 2017
Gum disease (periodontitis) is an inflammatory disease caused by bacterial pathogens that is the major cause of tooth loss in adults. It is also associated with systemic diseases such as cardiovascular disease. In this study we will develop novel peptide-based therapeutics to inhibit the proteases that enable these bacteria to cause disease.