DEVELOPMENT OF SPECIFIC INHIBITORS OF PORPHYROMONAS GINGIVALIS GINGIPAINS BASED ON THEIR COGNATE PROPEPTIDES

Grant number: 1081252 | Funding period: 2015 - 2017

Completed

Abstract

Gum disease (periodontitis) is an inflammatory disease caused by bacterial pathogens that is the major cause of tooth loss in adults. It is also associated with systemic diseases such as cardiovascular disease. In this study we will develop novel peptide-based therapeutics to inhibit the proteases that enable these bacteria to cause disease.

Related publications (5)

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Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains

Christine A Seers, A Sayeed M Mahmud, N Laila Huq, Keith J Cross, Eric C Reynolds

2021-01-01

Background: The cell-surface cysteine proteinases RgpA, RgpB (Arg-gingipain), and Kgp (Lys-gingipain) are major virulence factors ..

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Porphyromonas gingivalis Uses Specific Domain Rearrangements and Allelic Exchange to Generate Diversity in Surface Virulence Factors

Stuart G Dashper, Helen L Mitchell, Christine A Seers, Simon L Gladman, Torsten Seemann, Dieter M Bulach, P Scott Chandry, Keith J Cross, Steven M Cleal, Ericc Reynolds

2017-01-26

Porphyromonas gingivalis is a keystone pathogen of chronic periodontitis. The virulence of P. gingivalis is reported to be strain ..

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Bioinformatic investigation of the cost management strategies of five oral microbes

KJ Cross, NL Huq, SH Park, JS Park, P Pham, M Quah, M Ranjan, EC Reynolds

2015-04-01

Some amino acids are more energetically costly to synthesize de novo, therefore many microbes have evolved to regulate the metabol..

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Development and evaluation of a saliva-based chair-side diagnostic for the detection of Porphyromonas gingivalis

Neil M O'Brien-Simpson, Kate Burgess, Gail C Brammar, Ivan B Darby, Eric C Reynolds

2015-01-01

Porphyromonas gingivalis is a key pathogen in the polymicrobial biofilm that is associated with the oral disease chronic periodont..

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Prospects for treatment of Porphyromonas gingivalis-mediated disease – immune-based therapy

Eric C Reynolds, Neil O'Brien-Simpson, Tony Rowe, Andrew Nash, Jackie McCluskey, Didier Vingadassalom, Harold Kleanthous

2015-01-01