CHARACTERISATION OF PORPHYROMONAS GINGIVALIS AND TREPONEMA DENTICOLA INTERACTIONS IN THE DEVELOPMENT OF A PATHOGENIC BIOFILM

Grant number: 1083600 | Funding period: 2015 - 2017

Completed

Abstract

Gum disease (periodontitis) is an inflammatory disease caused by bacterial pathogens that is the major cause of tooth loss in adults. It is also associated with systemic diseases such as cardiovascular disease. In this study we will determine the mechanisms by which two bacterial species work together to produce the pathogenic dental plaque that causes disease.

Related publications (9)

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Background:  Porphyromonas gingivalis and Treponema denticola are proteolytic periodontopathogens that co-localize in polymicrobia..

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The Role of Treponema denticola Motility in Synergistic Biofilm Formation With Porphyromonas gingivalis

Hong Min Ng, Nada Slakeski, Catherine A Butler, Paul D Veith, Yu-Yen Chen, Sze Wei Liu, Brigitte Hoffmann, Stuart G Dashper, Eric C Reynolds

2019-12-18

Chronic periodontitis has a polymicrobial biofilm etiology and interactions between key oral bacterial species, such as Porphyromo..

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Spheres of influence: Porphyromonas gingivalis outer membrane vesicles

MJ Gui, SG Dashper, N Slakeski, Y-Y Chen, EC Reynolds

2016-10-01

Outer membrane vesicles (OMVs) are asymmetrical single bilayer membranous nanostructures produced by Gram-negative bacteria import..

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Bacterial interactions in pathogenic subgingival plaque

Hong Min Ng, Lin Xin Kin, Stuart G Dashper, Nada Slakeski, Catherine A Butler, Eric C Reynolds

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Chronic periodontitis has a polymicrobial biofilm aetiology. Polymicrobial biofilms are complex, dynamic microbial communities for..

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Characterisation of the Porphyromonas gingivalis Manganese Transport Regulator Orthologue

Lianyi Zhang, Catherine A Butler, Hasnah SG Khan, Stuart G Dashper, Christine A Seers, Paul D Veith, Jian-Guo Zhang, Eric C Reynolds

2016-03-23

PgMntR is a predicted member of the DtxR family of transcriptional repressors responsive to manganese in the anaerobic periodontal..

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Tannerella forsythia Outer Membrane Vesicles Are Enriched with Substrates of the Type IX Secretion System and TonB-Dependent Receptors

Paul D Veith, Yu-Yen Chen, Dina Chen, Neil M O'Brien-Simpson, Jessica D Cecil, James A Holden, Jason C Lenzo, Eric C Reynolds

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Tannerella forsythia, a Gram-negative oral bacterium closely associated with chronic periodontitis, naturally produces outer membr..

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Lysine acetylation is a common post-translational modification of key metabolic pathway enzymes of the anaerobe Porphyromonas gingivalis

Catherine A Butler, Paul D Veith, Matthew F Nieto, Stuart G Dashper, Eric C Reynolds

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Porphyromonas gingivalis is a Gram-negative anaerobe considered to be a keystone pathogen in the development of the bacterial-asso..

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The interplay between iron, haem and manganese in Porphyromonas gingivalis

CA Butler, SG Dashper, HSG Khan, L Zhang, EC Reynolds

2015-05-01

Background Transition metals including iron and manganese are necessary for life because of their ability to donate and accept ele..

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Polymicrobial nature of chronic oral disease

S Dashper, H MITCHELL, G Adams, E Reynolds

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Recent microbiome studies have shown that the human oral microbiome is composed of over 260 abundant bacterial species that predom..

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