IDENTIFICATION OF HOST FACTORS THAT RESTRICT INFLUENZA VIRUS REPLICATION IN MACROPHAGES
Grant number: 1083307 | Funding period: 2015 - 2017
Influenza virus infects different cells in the airways, including immune cells (macrophages) and non-immune cells (epithelial cells). Epithelial cell infection results in virus amplification and release whereas macrophage infection leads to virus destruction. This project will identify cellular factors expressed by macrophages that block virus amplification and release. Identification of novel antiviral factors is an important step towards developing strategies to reduce influenza disease.
Related publications (6)
Influenza A virus interactions with macrophages: Lessons from epithelial cells
Tina Meischel, Fernando Villalon-Letelier, Philippa M Saunders, Patrick C Reading, Sarah L Londrigan
Influenza viruses are an important cause of respiratory infection worldwide. In humans, infection with seasonal influenza A virus ..
IFITM3 and type I interferons are important for the control of influenza A virus replication in murine macrophages
Sarah L Londrigan, Linda M Wakim, Jeffrey Smith, Anne J Haverkate, Andrew G Brooks, Patrick C Reading
Abortive infection of macrophages serves as a "dead end" for most seasonal influenza A virus (IAV) strains, and it is likely to co..
Host Cell Restriction Factors that Limit Influenza A Infection
Fernando Villalon-Letelier, Andrew G Brooks, Philippa M Saunders, Sarah L Londrigan, Patrick C Reading
Viral infection of different cell types induces a unique spectrum of host defence genes, including interferon-stimulated genes (IS..
DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans
Leah Gillespie, Kathleen Gerstenberg, Fernanda Ana-Sosa-Batiz, Matthew S Parsons, Rubaiyea Farrukee, Mark Krabbe, Kirsten Spann, Andrew G Brooks, Sarah L Londrigan, Patrick C Reading
UNLABELLED: It is well established that glycosaminoglycans (GAGs) function as attachment factors for human metapneumovirus (HMPV),..
Infection of Mouse Macrophages by Seasonal Influenza Viruses Can Be Restricted at the Level of Virus Entry and at a Late Stage in the Virus Life Cycle
Sarah L Londrigan, Kirsty R Short, Joel Ma, Leah Gillespie, Steven P Rockman, Andrew G Brooks, Patrick C Reading
UNLABELLED: Airway epithelial cells are susceptible to infection with seasonal influenza A viruses (IAV), resulting in productive ..
Endogenous Murine BST-2/Tetherin Is Not a Major Restriction Factor of Influenza A Virus Infection
Sarah L Londrigan, Michelle D Tate, Emma R Job, Jessica M Moffat, Linda M Wakim, Christopher A Gonelli, Damien FJ Purcell, Andrew G Brooks, Jose A Villadangos, Patrick C Reading, Justine D Mintern
BST-2 (tetherin, CD317, HM1.24) restricts virus growth by tethering enveloped viruses to the cell surface. The role of BST-2 durin..