IDENTIFICATION OF HOST FACTORS THAT RESTRICT INFLUENZA VIRUS REPLICATION IN MACROPHAGES

Grant number: 1083307 | Funding period: 2015 - 2017

Completed

Abstract

Influenza virus infects different cells in the airways, including immune cells (macrophages) and non-immune cells (epithelial cells). Epithelial cell infection results in virus amplification and release whereas macrophage infection leads to virus destruction. This project will identify cellular factors expressed by macrophages that block virus amplification and release. Identification of novel antiviral factors is an important step towards developing strategies to reduce influenza disease.