IDENTIFICATION OF HOST FACTORS THAT RESTRICT INFLUENZA VIRUS REPLICATION IN MACROPHAGES

Grant number: 1083307 | Funding period: 2015 - 2017

Completed

Abstract

Influenza virus infects different cells in the airways, including immune cells (macrophages) and non-immune cells (epithelial cells). Epithelial cell infection results in virus amplification and release whereas macrophage infection leads to virus destruction. This project will identify cellular factors expressed by macrophages that block virus amplification and release. Identification of novel antiviral factors is an important step towards developing strategies to reduce influenza disease.

Related publications (2)

DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans

Leah Gillespie, Kathleen Gerstenberg, Fernanda Ana-Sosa-Batiz, Matthew S Parsons, Rubaiyea Farrukee, Mark Krabbe, Kirsten Spann, Andrew G Brooks, Sarah L Londrigan, Patrick C Reading

2016-09-01

Infection of Mouse Macrophages by Seasonal Influenza Viruses Can Be Restricted at the Level of Virus Entry and at a Late Stage in the Virus Life Cycle

Sarah L Londrigan, Kirsty R Short, Joel Ma, Leah Gillespie, Steven P Rockman, Andrew G Brooks, Patrick C Reading

2015-12-01

Researchers

Patrick Reading

Sarah Londrigan

IDENTIFICATION OF HOST FACTORS THAT RESTRICT INFLUENZA VIRUS REPLICATION IN MACROPHAGES

Abstract

Related publications (2)

DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans

Infection of Mouse Macrophages by Seasonal Influenza Viruses Can Be Restricted at the Level of Virus Entry and at a Late Stage in the Virus Life Cycle

Researchers

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