REGULATION FROM THE OUTSIDE: CONTROL OF TRANSPORT AND ASSEMBLY OF MAJOR CELL WALL COMPONENTS IN MYCOBACTERIA
Grant number: 1064466 | Funding period: 2014 - 2016
Tuberculosis (TB) kills nearly two million people each year while the causative bacterial species, Mycobacterium tuberculosis, infects one-third of the entire human population. An alarmingly high rate of TB exists in Australia's indigenous population. This proposal aims to identify and characterise essential processes that regulate synthesis of the outer coat of the bacterium, which are potential targets for new drugs for the treatment of this devastating disease.
Related publications (3)
MtrP, a putative methyltransferase in Corynebacteria, is required for optimal membrane transport of trehalose mycolates
Arek K Rainczuk, Stephan Klatt, Yoshiki Yamaryo-Botte, Rajini Brammananth, Malcolm J McConville, Ross L Coppel, Paul K Crellin
Pathogenic bacteria of the genera Mycobacterium and Corynebacterium cause severe human diseases such as tuberculosis (Mycobacteriu..
Identification of a Membrane Protein Required for Lipomannan Maturation and Lipoarabinomannan Synthesis in Corynebacterineae
Tamaryn J Cashmore, Stephan Klatt, Yoshiki Yamaryo-Botte, Rajini Brammananth, Arek K Rainczuk, Malcolm J McConville, Paul K Crellin, Ross L Coppel
Mycobacterium tuberculosis and related Corynebacterineae synthesize a family of lipomannans (LM) and lipoarabinomannans (LAM) that..
Proteomic Characterization of a Natural Host Pathogen Interaction: Repertoire of in Vivo Expressed Bacterial and Host Surface-Associated Proteins
Megan A Rees, Oded Kleifeld, Paul K Crellin, Bosco Ho, Timothy P Stinear, A Ian Smith, Ross L Coppel
Interactions between a host and a bacterial pathogen are mediated by cross-talk between molecules present on, or secreted by, path..