CHARACTERISING FACIAL EMOTION PROCESSING NETWORKS IN BIPOLAR DISORDER
Grant number: 1088785 | Funding period: 2015 - 2022
This research will use cutting edge imaging methodologies to investigate brain connectivity in neural circuits involved in emotion processing in people with bipolar disorder compared to their relatives and controls. It will provide insight into the factors associated with disease expression and genetic risk and will directly inform novel cognitive remediation treatments focused on directly addressing emotional processing difficulties in bipolar disorder at their source.
Related publications (53)
An overview of current mental health in the general population of Australia during the COVID-19 pandemic: Results from the COLLATE project
Susan L Rossell, Erica Neill, Andrea Phillipou, Eric J Tan, Wei Lin Toh, Tamsyn E Van Rheenen, Denny Meyer
<jats:title>Abstract</jats:title><jats:p>The novel coronavirus disease (COVID-19) poses significant mental health challenges globa..
Mental health of individuals with and without eating disorders across six months and two waves of COVID-19
Andrea Phillipou, Eric J Tan, Wei Lin Toh, Tamsyn E Van Rheenen, Denny Meyer, Erica Neill, Philip Sumner, Susan L Rossell
PURPOSE: The COVID-19 global pandemic has resulted in a significant mental health toll, and recent findings suggest that individua..
Characterization of facial emotion recognition in bipolar disorder: Focus on emotion mislabelling and neutral expressions
Lisa S Furlong, Susan L Rossell, James A Karantonis, Vanessa L Cropley, Matthew Hughes, Tamsyn E Van Rheenen
Increasing evidence suggests that facial emotion recognition is impaired in bipolar disorder (BD). However, patient-control differ..
A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum
James A Karantonis, Sean P Carruthers, Susan L Rossell, Christos Pantelis, Matthew Hughes, Cassandra Wannan, Vanessa Cropley, Tamsyn E Van Rheenen
The nature of the relationship between cognition and brain morphology in schizophrenia-spectrum disorders (SSD) and bipolar disord..
Characterising Demographic, Clinical and Functional Features of Cognitive Subgroups in Schizophrenia Spectrum Disorders: A Systematic Review
Sean P Carruthers, Tamsyn E Van Rheenen, James A Karantonis, Susan L Rossell
Considerable cognitive heterogeneity is present within the schizophrenia spectrum disorder (SSD) population. Several subgroups cha..
Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis
Ya Wang, Esmee E Braam, Cassandra MJ Wannan, Tamsyn E Van Rheenen, Raymond CK Chan, Barnaby Nelson, Patrick D McGorry, Alison R Yung, Ashleigh Lin, Warrick J Brewer, John Koutsogiannis, Stephen J Wood, Dennis Velakoulis, Christos Pantelis, Vanessa L Cropley
Increased severity of neurological soft signs (NSS) in schizophrenia have been associated with abnormal brain morphology in cerebe..
Psychosis and Hopelessness Mediate the Relationship Between Reduced Sleep and Suicidal Ideation in Schizophrenia Spectrum Disorders
Sean P Carruthers, Stuart J Lee, Anoop Sankaranarayanan, Philip J Sumner, Wei Lin Toh, Eric J Tan, Erica Neill, Tamsyn E Van Rheenen, Caroline Gurvich, Susan L Rossell
OBJECTIVE: Suicide is a major cause of death amongst individuals with schizophrenia spectrum disorders (SSD). Despite numerous ris..
Cognitive impairment and consumption of mental healthcare resources in outpatients with bipolar disorder
Carlos Ribera, Sonia LL Vidal-Rubio, Jose E Romeu-Climent, Joan Vila-Frances, Tamsyn E Van Rheenen, Vicent Balanza-Martinez
Cognitive dysfunction is a major predictor of functional outcomes, and loss of occupational functioning is usually linked with a h..
Mental health status of healthcare versus other essential workers in Australia amidst the COVID-19 pandemic: Initial results from the collate project
Wei Lin Toh, Denny Meyer, Andrea Phillipou, Eric J Tan, Tamsyn E Van Rheenen, Erica Neill, Susan L Rossell
The novel coronavirus (COVID-19) has necessitated many healthcare workers operating on the frontlines. Another segment of the popu..
An overview of current mental health in the general population of Australia during the COVID-19 pandemic: Results from the COLLATE project.
Susan L Rossell, Erica Neill, Andrea Phillipou, Eric J Tan, Wei Lin Toh, Tamsyn E Van Rheenen, Denny Meyer
The novel coronavirus disease (COVID-19) poses mental health challenges globally; however, to date, there is limited community lev..
The activity and connectivity of the facial emotion processing neural circuitry in bipolar disorder: a systematic review
Lisa S Furlong, Susan L Rossell, Georgia F Caruana, Vanessa L Cropley, Matthew Hughes, Tamsyn E Van Rheenen
BACKGROUND: Facial emotion processing abnormalities may be a trait feature of bipolar disorder (BD). These social cognitive impair..
Cumulative Cardiovascular Disease Risk and Triglycerides Differentially Relate to Subdomains of Executive Function in Bipolar Disorder; preliminary findings
Tamsyn E Van Rheenen, Roger S McIntyre, Vicent Balanza-Martinez, Michael Berk, Susan L Rossell
OBJECTIVES: Cardiovascular disease is disproportionally prevalent in bipolar disorder (BD) and has been linked to cognition in pre..
White Matter Alterations Between Brain Network Hubs Underlie Processing Speed Impairment in Patients With Schizophrenia
Paul Klauser, Vanessa L Cropley, Philipp S Baumann, Jinglei Lv, Pascal Steullet, Daniella Dwir, Yasser Alemán-Gómez, Meritxell Bach Cuadra, Michel Cuenod, Kim Q Do, Philippe Conus, Christos Pantelis, Alex Fornito, Tamsyn E Van Rheenen, Andrew Zalesky
<jats:title>Abstract</jats:title> <jats:p>Processing speed (PS) impairment is one of the most severe and common cog..
Mental health status of individuals with a mood-disorder during the COVID-19 pandemic in Australia: Initial results from the COLLATE project
Tamsyn E Van Rheenen, Denny Meyer, Erica Neill, Andrea Phillipou, Eric J Tan, Wei Lin Toh, Susan L Rossell
BACKGROUND: Physical-distancing strategies during the coronavirus (COVID-19) pandemic may be particularly detrimental to the menta..
Considerations for assessing the impact of the COVID-19 pandemic on mental health in Australia
Eric J Tan, Denny Meyer, Erica Neill, Andrea Phillipou, Wei Lin Toh, Tamsyn E Van Rheenen, Susan L Rossell
During this unprecedented novel coronavirus (COVID-19) pandemic, there is an urgent need for empirical data to characterise its im..
Alcohol use in Australia during the early days of theCOVID-19 pandemic: Initial results from theCOLLATEproject
Erica Neill, Denny Meyer, Wei Lin Toh, Tamsyn Elizabeth van Rheenen, Andrea Phillipou, Eric Josiah Tan, Susan Lee Rossell
AIM: The effects of social isolation measures used to control the spread of COVID-19 are negatively impacting the mental health of..
Eating and exercise behaviors in eating disorders and the general population during the COVID-19 pandemic in Australia: Initial results from the COLLATE project
Andrea Phillipou, Denny Meyer, Erica Neill, Eric J Tan, Wei Lin Toh, Tamsyn E Van Rheenen, Susan L Rossell
OBJECTIVE: Emerging evidence suggests that the coronavirus (COVID-19) pandemic may be negatively impacting mental health. The impa..
Identifying the cognitive underpinnings of voice-hearing by comparing never, past and current voice-hearers
WL Toh, EJ Tan, E Neill, TE Van Rheenen, C Gurvich, PJ Sumner, SP Carruthers, EHX Thomas, SL Rossell
OBJECTIVE: The current study aimed to compare specific cognitive profiles corresponding to auditory verbal hallucinations (AVH) st..
A sensorimotor control framework for understanding emotional communication and regulation
Justin HG Williams, Charlotte F Huggins, Barbra Zupan, Megan Willis, Tamsyn E Van Rheenen, Wataru Sato, Romina Palermo, Catherine Ortner, Martin Krippl, Mariska Kret, Joanne M Dickson, Chiang-shan R Li, Leroy Lowe
Our research team was asked to consider the relationship of the neuroscience of sensorimotor control to the language of emotions a..
Cognitive validation of cross-diagnostic cognitive subgroups on the schizophrenia-bipolar spectrum
James A Karantonis, Susan L Rossell, Sean P Carruthers, Philip Sumner, Matthew Hughes, Melissa J Green, Christos Pantelis, Katherine E Burdick, Vanessa Cropley, Tamsyn E Van Rheenen
BACKGROUND: Cognitive heterogeneity in schizophrenia spectrum disorders (SSD) and bipolar disorder (BD) has been explored using cl..
Sex differences in schizophrenia, bipolar disorder, and post-traumatic stress disorder: Are gonadal hormones the link?
Andrea Gogos, Luke J Ney, Natasha Seymour, Tamsyn E Van Rheenen, Kim L Felmingham
In this review, we describe the sex differences in prevalence, onset, symptom profiles, and disease outcome that are evident in sc..
Affective cognition in bipolar disorder: A systematic review by the ISBD targeting cognition task force
Kamilla W Miskowiak, Ida Seeberg, Hanne L Kjaerstad, Katherine E Burdick, Anabel Martinez-Aran, Caterina del Mar Bonnin, Christopher R Bowie, Andre F Carvalho, Peter Gallagher, Gregor Hasler, Beny Lafer, Carlos Lopez-Jaramillo, Tomiki Sumiyoshi, Roger S McIntyre, Ayal Schaffer, Richard J Porter, Scot Purdon, Ivan J Torres, Lakshmi N Yatham, Allan H Youn
BACKGROUND: Impairments in affective cognition are part of the neurocognitive profile and possible treatment targets in bipolar di..
Hippocampal subfields and visuospatial associative memory across stages of schizophrenia-spectrum disorder
Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Tamsyn E Van Rheenen, Sam Mancuso, Chad Bousman, Ian Everall, Patrick D McGorry, Christos Pantelis, Cali F Bartholomeusz
BACKGROUND: While previous studies have identified relationships between hippocampal volumes and memory performance in schizophren..
Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: An overview of evidence
Tamsyn E Van Rheenen, Kathryn E Lewandowski, Isabelle E Bauer, Flavio Kapczinski, Kamilla Miskowiak, Katherine E Burdick, Vicent Balanza-Martinez
OBJECTIVES: Cognitive dysfunction affects a significant proportion of people with bipolar disorder (BD), but the cause, trajectory..
Exploring Heterogeneity on the Wisconsin Card Sorting Test in Schizophrenia Spectrum Disorders: A Cluster Analytical Investigation
Sean P Carruthers, Caroline T Gurvich, Denny Meyer, Chad Bousman, Ian P Everall, Erica Neill, Christos Pantelis, Philip J Sumner, Eric J Tan, Elizabeth HX Thomas, Tamsyn E Van Rheenen, Susan L Rossell
OBJECTIVES: The Wisconsin Card Sorting Test (WCST) is a complex measure of executive function that is frequently employed to inves..
Do schizotypy dimensions reflect the symptoms of schizophrenia?
Elizabeth HX Thomas, Susan L Rossell, Eric J Tan, Erica Neill, Tamsyn E Van Rheenen, Sean P Carruthers, Philip J Sumner, Stephanie Louise, Kiymet Bozaoglu, Caroline Gurvich
OBJECTIVE: The personality characteristics and symptoms observed in schizophrenia are postulated to lie on a continuum, with non-c..
The effects of a muscarinic receptor 1 gene variant on executive and nonexecutive cognition in schizophrenia spectrum disorders
Sean P Carruthers, Vanessa Cropley, Chad Bousman, Ian P Everall, Erica Neill, Christos Pantelis, Philip J Sumner, Eric J Tan, Kiymet Bozaoglu, Elizabeth HX Thomas, Tamsyn E Van Rheenen, Caroline T Gurvich, Susan L Rossell
Individuals with schizophrenia who are homozygous at the c.267C > A (rs2067477) single nucleotide polymorphism within the muscarin..
The use of component-wise gradient boosting to assess the possible role of cognitive measures as markers of vulnerability to pediatric bipolar disorder.
Isabelle E Bauer, Robert Suchting, Tamsyn E Van Rheenen, Mon-Ju Wu, Benson Mwangi, Danielle Spiker, Giovana B Zunta-Soares, Jair C Soares
BACKGROUND AND AIMS: Cognitive impairments are primary hallmarks symptoms of bipolar disorder (BD). Whether these deficits are mar..
Characterization of social cognitive deficits on the schizophrenia-bipolar disorder spectrum: An overview of current evidence
Tamsyn E Van Rheenen, Eleni P Ganella, Isabelle E Bauer, Cali F Bartholomeusz
A significant amount of literature has highlighted that patients with schizophrenia (Sz)-spectrum disorders, and to a lesser exten..
Exploring the moderating effects of dopaminergic polymorphisms and childhood adversity on brain morphology in schizophrenia-spectrum disorders
Cassandra Hoffmann, Tamsyn E Van Rheenen, Serafino G Mancuso, Andrew Zalesky, Jason Bruggemann, Rhoshel K Lenroot, Suresh Sundram, Cynthia Shannon Weickert, Thomas W Weickert, Christos Pantelis, Vanessa Cropley, Chad A Bousman
Genetic and environmental etiologies may contribute to schizophrenia and its associated neurobiological profile. We examined the i..
Widespread Volumetric Reductions in Schizophrenia and Schizoaffective Patients Displaying Compromised Cognitive Abilities
Tamsyn E Van Rheenen, Vanessa Cropley, Andrew Zalesky, Chad Bousman, Ruth Wells, Jason Bruggemann, Suresh Sundram, Danielle Weinberg, Roshel K Lenroot, Avril Pereira, Cynthia Shannon Weickert, Thomas W Weickert, Christos Pantelis
Objective: Progress toward understanding brain mechanisms in psychosis is hampered by failures to account for within-group heterog..
An update on adjunctive treatment options for bipolar disorder
Olivia M Dean, Emma Gliddon, Tamsyn E Van Rheenen, Francesco Giorlando, Sandra K Davidson, Manreena Kaur, Trung T Ngo, Lana J Williams
OBJECTIVES: Bipolar disorder is a complex illness often requiring combinations of therapies to successfully treat symptoms. In rec..
Deterioration of visuospatial associative memory following a first psychotic episode: a long-term follow-up study
CMJ Wannan, CF Bartholomeusz, VL Cropley, TE Van Rheenen, A Panayiotou, WJ Brewer, TM Proffitt, L Henry, MG Harris, D Velakoulis, P McGorry, C Pantelis, SJ Wood
BACKGROUND: Cognitive deficits are a core feature of schizophrenia, and impairments in most domains are thought to be stable over ..
Neurocognitive subtypes in patients with bipolar disorder and their unaffected siblings
M Russo, TE Van Rheenen, M Shanahan, K Mahon, MM Perez-Rodriguez, A Cuesta-Diaz, E Larsen, AK Malhotra, KE Burdick
BACKGROUND: Our previous work revealed substantial heterogeneity in the cognitive profile of bipolar disorder (BD) due to the pres..
Characterizing cognitive heterogeneity on the schizophrenia-bipolar disorder spectrum
TE Van Rheenen, KE Lewandowski, EJ Tan, LH Ospina, D Ongur, E Neill, C Gurvich, C Pantelis, AK Malhotra, SL Rossell, KE Burdick
BACKGROUND: Current group-average analysis suggests quantitative but not qualitative cognitive differences between schizophrenia (..
Configural and Featural Face Processing Influences on Emotion Recognition in Schizophrenia and Bipolar Disorder
Tamsyn E Van Rheenen, Nicole Joshua, David J Castle, Susan L Rossell
OBJECTIVES: Emotion recognition impairments have been demonstrated in schizophrenia (Sz), but are less consistent and lesser in ma..
An Investigation of Brain Structural Abnormalities in Neurocognitive Subgroups of Schizophrenia
Tamsyn E Van Rheenen, Vanessa Cropley, Ruth Wells, Jason Bruggemannd, Vaidy Swaminathan, Suresh Sundram, Danielle Weinberg, Isabella Jacomb, Rhoshel Lenroot, Avril M Pereira, Andrew Zalesky, Chad Bousman, Cynthia Shannon Weickert, Thomas W Weickert, Christos Pantelis
Does cognitive performance map to categorical diagnoses of schizophrenia, schizoaffective disorder and bipolar disorder? A discriminant functions analysis
Tamsyn E Van Rheenen, Shayden Bryce, Eric J Tan, Erica Neill, Caroline Gurvich, Stephanie Louise, Susan L Rossell
OBJECTIVES: Despite known overlaps in the pattern of cognitive impairments in individuals with bipolar disorder (BD), schizophreni..