PROMOTING UPPER LIMB RECOVERY AFTER STROKE IN PEOPLE WITH SEVERE PARESIS
Grant number: 1088449 | Funding period: 2016 - 2020
Stroke survivors with severe arm disability have poor potential for functional recovery. Yet, an incomplete understanding of indicators of good potential currently dictate clinical decisions concerning referral to rehabilitation and therapy provision. The proposed research aims to characterise the dynamic capacity of the severely damaged brain to recover. This research will provide the foundations for more personalized health care options and extend our understanding of this growing cohort.
Related publications (37)
Factors associated with time to independent walking recovery post-stroke
Caitlin Kennedy, Julie Bernhardt, Leonid Churilov, Janice M Collier, Fiona Ellery, Venesha Rethnam, Lilian B Carvalho, Geoffrey A Donnan, Kathryn S Hayward
BACKGROUND: Past studies have inconsistently identified factors associated with independent walking post-stroke. We investigated t..
Multidimensional Phase I Dose Ranging Trials for Stroke Recovery Interventions: Key Challenges and How to Address Them
Emily J Dalton, Leonid Churilov, Natasha A Lannin, Dale Corbett, Bruce C Campbell, Kathryn S Hayward
Despite an increase in the amount of published stroke recovery research, interventions have failed to markedly affect the trajecto..
Cortical N-acetylaspartate concentrations are impacted in chronic stroke but do not relate to motor impairment: A magnetic resonance spectroscopy study
Jennifer K Ferris, Jason L Neva, Irene M Vavasour, Kaitlin J Attard, Brian Greeley, Kathryn S Hayward, Katie P Wadden, Alex L MacKay, Lara A Boyd
Magnetic resonance spectroscopy (MRS) measures cerebral metabolite concentrations, which can inform our understanding of the neuro..
Perseverance with technology-facilitated home-based upper limb practice after stroke: a systematic mixed studies review
Bridee A Neibling, Sarah M Jackson, Kathryn S Hayward, Ruth N Barker
BACKGROUND: Technology is being increasingly investigated as an option to allow stroke survivors to exploit their full potential f..
Early Mobilization After Stroke: Do Clinical Practice Guidelines Support Clinicians' Decision-Making?
Venesha Rethnam, Kathryn S Hayward, Julie Bernhardt, Leonid Churilov
Importance: Early mobilization, out-of-bed activity, is a component of acute stroke unit care; however, stroke patient heterogenei..
Factors Influencing Paretic Upper Limb Use During First 4 Weeks After Stroke A Cross-Sectional Accelerometry Study
Lay Fong Chin, Kathryn S Hayward, Sandra G Brauer
OBJECTIVE: This study aimed to investigate factors related to paretic upper limb use within the first 4 wks after stroke. DESIGN: ..
Pushing the limits of recovery in chronic stroke survivors: A descriptive qualitative study of user’s perceptions of the Queen Square Upper Limb Neurorehabilitation Programme.
Kate Kelly, Fran Brander, Amanda Strawson, Nick Ward, Kathryn Hayward
INTRODUCTION: The Queen Square Upper Limb (QSUL) Neurorehabilitation Programme is a clinical service within the National Health Se..
In search of Kipling's six honest serving men in upper limb rehabilitation: within participant case-crossover experiment nested within a web-based questionnaire
KS Hayward, L Jolliffe, L Churilov, A Herrmann, GC Cloud, NA Lannin
PURPOSE: In search of Kipling's six honest serving men in upper limb rehabilitation after stroke, we sought to investigate clinici..
The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain-behavior relationships after stroke
Sook-Lei Liew, Artemis Zavaliangos-Petropulu, Neda Jahanshad, Catherine E Lang, Kathryn S Hayward, Keith R Lohse, Julia M Juliano, Francesca Assogna, Lee A Baugh, Anup K Bhattacharya, Bavrina Bigjahan, Michael R Borich, Lara A Boyd, Amy Brodtmann, Cathrin M Buetefisch, Winston D Byblow, Jessica M Cassidy, Adriana B Conforto, R Cameron Craddock, Michael A Dimyan
The goal of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Stroke Recovery working group is to understand brai..
Upper limb use differs among people with varied upper limb impairment levels early post-stroke: a single-site, cross-sectional, observational study
Lay Fong Chin, Kathryn S Hayward, Sandra Brauer
Background: There is limited knowledge on the upper limb (UL) use early post-stroke by impairment levels.Objectives: To 1) To char..
An accelerometry and observational study to quantify upper limb use after stroke during inpatient rehabilitation
Lay Fong Chin, Kathryn S Hayward, Aloysius Jun An Soh, Chin Mei Tan, Cheryl Jing Ru Wong, Jia Wei Loh, Genevieve Jia Hui Loke, Sandra Brauer
OBJECTIVES: The objectives of the study are to characterize paretic upper limb (UL) use in people with different levels of impairm..
A systematic review protocol of timing, efficacy and cost effectiveness of upper limb therapy for motor recovery post-stroke
Kathryn S Hayward, Sharon F Kramer, Vincent Thijs, Julie Ratcliffe, Nick S Ward, Leonid Churilov, Laura Jolliffe, Dale Corbett, Geoffrey Cloud, Tina Kaffenberger, Amy Brodtmann, Julie Bernhardt, Natasha A Lannin
BACKGROUND: Improving upper limb (UL) motor recovery after stroke represents a major clinical and scientific goal. We aim to compl..
Validity and reliability of a smartphone inclinometer app for measuring passive upper limb range of motion in a stroke population*
Natalie Chew Jin Lin, Kathryn S Hayward, Kate D'Cruz, Eloise Thompson, Xia Li, Natasha A Lannin
Purpose: To demonstrate the validity and reliability of a smartphone app to measure ROM after stroke.Materials and methods: Twenty..
Additional early active repetitive motor training did not prevent contracture in adults receiving task-specific upper limb training after stroke: a randomised trial
Sally Horsley, Natasha A Lannin, Kathryn S Hayward, Robert D Herbert
QUESTION: In adults undergoing rehabilitation after stroke, does 1 hour of additional active repetitive reaching per day prevent o..
The impact of environmental enrichment in an acute stroke unit on how and when patients undertake activities
Ingrid CM Rosbergen, Rohan S Grimley, Kathryn S Hayward, Sandra G Brauer
OBJECTIVES:: To explore the effect of environmental enrichment within an acute stroke unit on how and when patients undertake acti..
White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study
KP Wadden, S Peters, MR Borich, JL Neva, KS Hayward, CS Mang, NJ Snow, KE Brown, TS Woodward, SK Meehan, LA Boyd
Continuous theta burst stimulation (cTBS) is a form of noninvasive repetitive brain stimulation that, when delivered over the cont..
Characterising Arm Recovery in People with Severe Stroke (CARPSS): protocol for a 12-month observational study of clinical, neuroimaging and neurophysiological biomarkers
Kathryn S Hayward, Keith R Lohse, Julie Bernhardt, Catherine E Lang, Lara A Boyd
INTRODUCTION: In individuals with early (indexed ≤7 days poststroke) and severe upper limb paresis (shoulder abduction and finger ..
Is Environmental Enrichment Ready for Clinical Application in Human Post-stroke Rehabilitation?
Matthew W McDonald, Kathryn S Hayward, Ingrid CM Rosbergen, Matthew S Jeffers, Dale Corbett
Environmental enrichment (EE) has been widely used as a means to enhance brain plasticity mechanisms (e.g., increased dendritic br..
A structural motor network correlates with motor function and not impairment post stroke
Sue Peters, Katie P Wadden, Kathryn S Hayward, Jason L Neva, Angela M Auriat, Lara A Boyd
Combining structural and functional magnetic resonance imaging may provide insight into how residual motor networks contribute to ..
Are we armed with the right data? Pooled individual data review of biomarkers in people with severe upper limb impairment after stroke
Kathryn S Hayward, Julia Schmidt, Keith R Lohse, Sue Peters, Julie Bernhardt, Natasha A Lannin, Lara A Boyd
To build an understanding of the neurobiology underpinning arm recovery in people with severe arm impairment due to stroke, we con..
Interhemispheric Pathways Are Important for Motor Outcome in Individuals with Chronic and Severe Upper Limb Impairment Post Stroke
Kathryn S Hayward, Jason L Neva, Cameron S Mang, Sue Peters, Katie P Wadden, Jennifer K Ferris, Lara A Boyd
Background: Severity of arm impairment alone does not explain motor outcomes in people with severe impairment post stroke. Objecti..