PROMOTING UPPER LIMB RECOVERY AFTER STROKE IN PEOPLE WITH SEVERE PARESIS

Examining Dose Frameworks to Improve Aphasia Rehabilitation Research.

Sam Harvey, Miranda L Rose, Emily Brogan, John E Pierce, Erin Godecke, Sonia LE Brownsett, Leonid Churilov, David Copland, Michael Walsh Dickey, Jade Dignam, Natasha A Lannin, Lyndsey Nickels, Julie Bernhardt, Kathryn S Hayward

2022-12-24

The effect of treatment dose on recovery of post-stroke aphasia is not well understood. Inconsistent conceptualization, measuremen..

Upper-Limb Motor Intervention Elements That Drive Improvement in Biomarkers and Clinical Measures Post-Stroke: A Systematic Review in a Systems Paradigm

Matthew Wingfield, Natalie A Fini, Amy Brodtmann, Gavin Williams, Leonid Churilov, Kathryn S Hayward

2022-10-08

OBJECTIVE: To use a systems paradigm to examine upper limb (UL) motor intervention elements driving biomarker and clinical measure..

Observational Study of Neuroimaging Biomarkers of Severe Upper Limb Impairment After Stroke

Kathryn S Hayward, Jennifer K Ferris, Keith R Lohse, Michael R Borich, Alexandra Borstad, Jessica M Cassidy, Steven C Cramer, Sean P Dukelow, Sonja E Findlater, Rachel L Hawe, Sook-Lei Liew, Jason L Neva, Jill C Stewart, Lara A Boyd

2022-07-26

BACKGROUND AND OBJECTIVES: It is difficult to predict post-stroke outcome for people with severe motor impairment, as both clinica..

Acute High-Intensity Interval Exercise Modulates Corticospinal Excitability in Older Adults

Jason L Neva, Brian Greeley, Briana Chau, Jennifer K Ferris, Christina B Jones, Ronan Denyer, Kathryn S Hayward, Kristin L Campbell, Lara A Boyd

2022-04-01

INTRODUCTION: Acute exercise can modulate the excitability of the nonexercised upper limb representation in the primary motor cort..

Early-phase dose articulation trials are underutilized for post-stroke motor recovery: A systematic scoping review

Emily J Dalton, Leonid Churilov, Natasha A Lannin, Dale Corbett, Bruce C Campbell, Kathryn S Hayward

2021-11-23

BACKGROUND: To enable development of effective interventions, there is a need to complete systematic early-phase dose articulation..

Timing and Dose of Upper Limb Motor Intervention After Stroke A Systematic Review

Kathryn S Hayward, Sharon F Kramer, Emily J Dalton, Gemma R Hughes, Amy Brodtmann, Leonid Churilov, Geoffrey Cloud, Dale Corbett, Laura Jolliffe, Tina Kaffenberger, Venesha Rethnam, Vincent Thijs, Nick Ward, Natasha Lannin, Julie Bernhardt

2021-11-01

This systematic review aimed to investigate timing, dose, and efficacy of upper limb intervention during the first 6 months postst..

Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide

Sook-Lei Liew, Artemis Zavaliangos-Petropulu, Nicolas Schweighofer, Neda Jahanshad, Catherine E Lang, Keith R Lohse, Nerisa Banaj, Giuseppe Barisano, Lee A Baugh, Anup K Bhattacharya, Bavrina Bigjahan, Michael R Borich, Lara A Boyd, Amy Brodtmann, Cathrin M Buetefisch, Winston D Byblow, Jessica M Cassidy, Charalambos C Charalambous, Valentina Ciullo, Adriana B Conforto

2021-10-01

Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared br..

Challenges of Estimating Accurate Prevalence of Arm Weakness Early After Stroke

Lisa A Simpson, Kathryn S Hayward, Moira McPeake, Thalia S Field, Janice J Eng

2021-07-28

Background. Recent studies have reported lower statistics of upper limb (UL) weakness (48-57%) compared to widely cited values col..

A Self-Empowered Upper Limb Repetitive Engagement Program to Improve Upper Limb Recovery Early Post-Stroke: Phase II Pilot Randomized Controlled Trial

Lay Fong Chin, Kathryn S Hayward, Audrey Lik Ming Chai, Sandra G Brauer

2021-07-19

Background. Time outside therapy provides an opportunity to increase upper limb (UL) use during post-stroke hospitalization. Objec..

Factors associated with time to independent walking recovery post-stroke

Caitlin Kennedy, Julie Bernhardt, Leonid Churilov, Janice M Collier, Fiona Ellery, Venesha Rethnam, Lilian B Carvalho, Geoffrey A Donnan, Kathryn S Hayward

2021-07-01

BACKGROUND: Past studies have inconsistently identified factors associated with independent walking post-stroke. We investigated t..

Multidimensional Phase I Dose Ranging Trials for Stroke Recovery Interventions: Key Challenges and How to Address Them

Emily J Dalton, Leonid Churilov, Natasha A Lannin, Dale Corbett, Bruce C Campbell, Kathryn S Hayward

2021-06-04

Despite an increase in the amount of published stroke recovery research, interventions have failed to markedly affect the trajecto..

What Is Next After This Well-Conducted, but Neutral, Multisite Trial Testing Self-Rehabilitation Approaches?

Julie Bernhardt, Kathryn S Hayward

2021-06-01

Cortical N-acetylaspartate concentrations are impacted in chronic stroke but do not relate to motor impairment: A magnetic resonance spectroscopy study

Jennifer K Ferris, Jason L Neva, Irene M Vavasour, Kaitlin J Attard, Brian Greeley, Kathryn S Hayward, Katie P Wadden, Alex L MacKay, Lara A Boyd

2021-05-03

Magnetic resonance spectroscopy (MRS) measures cerebral metabolite concentrations, which can inform our understanding of the neuro..

Perseverance with technology-facilitated home-based upper limb practice after stroke: a systematic mixed studies review

Bridee A Neibling, Sarah M Jackson, Kathryn S Hayward, Ruth N Barker

2021-02-24

BACKGROUND: Technology is being increasingly investigated as an option to allow stroke survivors to exploit their full potential f..

Early Mobilization After Stroke: Do Clinical Practice Guidelines Support Clinicians' Decision-Making?

Venesha Rethnam, Kathryn S Hayward, Julie Bernhardt, Leonid Churilov

2021-02-05

Importance: Early mobilization, out-of-bed activity, is a component of acute stroke unit care; however, stroke patient heterogenei..

Advancing Stroke Recovery Through Improved Articulation of Nonpharmacological Intervention Dose

Kathryn S Hayward, Leonid Churilov, Emily J Dalton, Amy Brodtmann, Bruce CV Campbell, David Copland, Numa Dancause, Erin Godecke, Tammy C Hoffmann, Natasha A Lannin, Matthew W McDonald, Dale Corbett, Julie Bernhardt

2021-02-01

Dose articulation is a universal issue of intervention development and testing. In stroke recovery, dose of a nonpharmaceutical in..

Factors Influencing Paretic Upper Limb Use During First 4 Weeks After Stroke A Cross-Sectional Accelerometry Study

Lay Fong Chin, Kathryn S Hayward, Sandra G Brauer

2021-02-01

OBJECTIVE: This study aimed to investigate factors related to paretic upper limb use within the first 4 wks after stroke. DESIGN: ..

In search of Kipling's six honest serving men in upper limb rehabilitation: within participant case-crossover experiment nested within a web-based questionnaire

KS Hayward, L Jolliffe, L Churilov, A Herrmann, GC Cloud, NA Lannin

2020-09-11

PURPOSE: In search of Kipling's six honest serving men in upper limb rehabilitation after stroke, we sought to investigate clinici..

Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) in Stroke

Jason L Neva, Kathryn S Hayward, Lara A Boyd

2020-09-02

Look closer: The multidimensional patterns of post-stroke burden behind the modified Rankin Scale

Venesha Rethnam, Julie Bernhardt, Hannah Johns, Kathryn S Hayward, Janice M Collier, Fiona Ellery, Lan Gao, Marj Moodie, Helen Dewey, Geoffrey A Donnan, Leonid Churilov

2020-08-27

BACKGROUND: The utility-weighted modified Rankin Scale, representing patient perspectives of quality of life, is a newly proposed ..

Early mobilisation post-stroke: a systematic review and meta-analysis of individual participant data

Venesha Rethnam, Peter Langhorne, Leonid Churilov, Kathryn S Hayward, Fanny Herisson, Simone R Poletto, Yanna Tong, Julie Bernhardt

2020-07-15

PURPOSE: To investigate the safety and efficacy of early mobilisation (EM) compared to usual care by meta-analysing individual par..

The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain-behavior relationships after stroke

Sook-Lei Liew, Artemis Zavaliangos-Petropulu, Neda Jahanshad, Catherine E Lang, Kathryn S Hayward, Keith R Lohse, Julia M Juliano, Francesca Assogna, Lee A Baugh, Anup K Bhattacharya, Bavrina Bigjahan, Michael R Borich, Lara A Boyd, Amy Brodtmann, Cathrin M Buetefisch, Winston D Byblow, Jessica M Cassidy, Adriana B Conforto, R Cameron Craddock, Michael A Dimyan

2020-04-20

The goal of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Stroke Recovery working group is to understand brai..

Emerging Stroke Clinicians and Scientists An Australasian Experience

Kathryn S Hayward, Liam Johnson, Nawaf Yassi

2020-02-01

Pushing the limits of recovery in chronic stroke survivors: a descriptive qualitative study of users perceptions of the Queen Square Upper Limb Neurorehabilitation Programme

Kate Kelly, Fran Brander, Amanda Strawson, Nick Ward, Kathryn Hayward

2020-01-01

INTRODUCTION: The Queen Square Upper Limb (QSUL) Neurorehabilitation Programme is a clinical service within the National Health Se..

Upper limb use differs among people with varied upper limb impairment levels early post-stroke: a single-site, cross-sectional, observational study

Lay Fong Chin, Kathryn S Hayward, Sandra Brauer

2019-11-17

Background: There is limited knowledge on the upper limb (UL) use early post-stroke by impairment levels.Objectives: To 1) To char..

Dose Articulation in Preclinical and Clinical Stroke Recovery: Refining a Discovery Research Pipeline and Presenting a Scoping Review Protocol

Emily Dalton, Leonid Churilov, Natasha A Lennin, Dale Corbett, Kathryn S Hayward

2019-11-06

Introduction: Despite an increase in the quality of clinical trials in stroke recovery, interventions have failed to markedly impa..

An accelerometry and observational study to quantify upper limb use after stroke during inpatient rehabilitation

Lay Fong Chin, Kathryn S Hayward, Aloysius Jun An Soh, Chin Mei Tan, Cheryl Jing Ru Wong, Jia Wei Loh, Genevieve Jia Hui Loke, Sandra Brauer

2019-10-01

OBJECTIVES: The objectives of the study are to characterize paretic upper limb (UL) use in people with different levels of impairm..

A systematic review protocol of timing, efficacy and cost effectiveness of upper limb therapy for motor recovery post-stroke

Kathryn S Hayward, Sharon F Kramer, Vincent Thijs, Julie Ratcliffe, Nick S Ward, Leonid Churilov, Laura Jolliffe, Dale Corbett, Geoffrey Cloud, Tina Kaffenberger, Amy Brodtmann, Julie Bernhardt, Natasha A Lannin

2019-07-25

BACKGROUND: Improving upper limb (UL) motor recovery after stroke represents a major clinical and scientific goal. We aim to compl..

Validity and reliability of a smartphone inclinometer app for measuring passive upper limb range of motion in a stroke population*

Natalie Chew Jin Lin, Kathryn S Hayward, Kate D'Cruz, Eloise Thompson, Xia Li, Natasha A Lannin

2019-04-22

Purpose: To demonstrate the validity and reliability of a smartphone app to measure ROM after stroke.Materials and methods: Twenty..

Additional early active repetitive motor training did not prevent contracture in adults receiving task-specific upper limb training after stroke: a randomised trial

Sally Horsley, Natasha A Lannin, Kathryn S Hayward, Robert D Herbert

2019-04-01

QUESTION: In adults undergoing rehabilitation after stroke, does 1 hour of additional active repetitive reaching per day prevent o..

The impact of environmental enrichment in an acute stroke unit on how and when patients undertake activities

Ingrid CM Rosbergen, Rohan S Grimley, Kathryn S Hayward, Sandra G Brauer

2019-04-01

OBJECTIVES:: To explore the effect of environmental enrichment within an acute stroke unit on how and when patients undertake acti..

Clinical perspective of stroke rehabilitation and recovery.

kathryn Hayward

2019-01-01

Designing the next generation stroke recovery trials: Stroke Rehabilitation and Recovery Roundtable Trials Development Framework.

kathryn Hayward

2019-01-01

Stroke recovery: How much of what for who and when post stroke?

kathryn Hayward

2019-01-01

What we have yet to learn about precision stroke rehabilitation ...

kathryn Hayward

2019-01-01

White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study

KP Wadden, S Peters, MR Borich, JL Neva, KS Hayward, CS Mang, NJ Snow, KE Brown, TS Woodward, SK Meehan, LA Boyd

2019-01-01

Continuous theta burst stimulation (cTBS) is a form of noninvasive repetitive brain stimulation that, when delivered over the cont..

Characterising Arm Recovery in People with Severe Stroke (CARPSS): protocol for a 12-month observational study of clinical, neuroimaging and neurophysiological biomarkers

Kathryn S Hayward, Keith R Lohse, Julie Bernhardt, Catherine E Lang, Lara A Boyd

2018-11-01

INTRODUCTION: In individuals with early (indexed ≤7 days poststroke) and severe upper limb paresis (shoulder abduction and finger ..

PROGRESSING STROKE RECOVERY RESEARCH: RECOMMENDATIONS FROM 1ST STROKE RECOVERY AND REHABILITATION ROUNDTABLE

K Borschmann, K Hayward, J Bernhardt

2018-10-01

Is Environmental Enrichment Ready for Clinical Application in Human Post-stroke Rehabilitation?

Matthew W McDonald, Kathryn S Hayward, Ingrid CM Rosbergen, Matthew S Jeffers, Dale Corbett

2018-07-11

Environmental enrichment (EE) has been widely used as a means to enhance brain plasticity mechanisms (e.g., increased dendritic br..

Extraction of corticospinal tract microstructural properties in chronic stroke

SJ Feldman, LA Boyd, JL Neva, S Peters, KS Hayward

2018-05-01

BACKGROUND: Information about the structural integrity of the corticospinal tract (CST) from diffusion-weighted imaging can improv..

Imaging in Pediatric Concussion: A Systematic Review

Julia Schmidt, Kathryn S Hayward, Katlyn E Brown, Jill G Zwicker, Jennie Ponsford, Paul van Donkelaar, Shelina Babul, Lara A Boyd

2018-05-01

CONTEXT: Pediatric mild traumatic brain injury (mTBI) is a common and poorly understood injury. Neuroimaging indexes brain injury ..

Neuroimaging for physical therapists

kathryn Hayward

2018-01-01

Precision Stroke Rehabilitation.

Kathryn Hayward

2018-01-01

Upper limb motor recovery after stroke: What’s next?

kathryn Hayward

2018-01-01

Upper limb recovery trials are failing: what is the way forward?

Kathryn Hayward

2018-01-01

Qualitative investigation of the perceptions and experiences of nursing and allied health professionals involved in the implementation of an enriched environment in an Australian acute stroke unit

Ingrid CM Rosbergen, Sandra G Brauer, Sarah Fitzhenry, Rohan S Grimley, Kathryn S Hayward

2017-12-01

OBJECTIVE: An enriched environment embedded in an acute stroke unit can increase activity levels of patients who had stroke, with ..

Embedding an enriched environment in an acute stroke unit increases activity in people with stroke: a controlled before-after pilot study

Ingrid CM Rosbergen, Rohan S Grimley, Kathryn S Hayward, Katrina C Walker, Donna Rowley, Alana M Campbell, Suzanne McGufficke, Samantha T Robertson, Janelle Trinder, Heidi Janssen, Sandra G Brauer

2017-11-01

OBJECTIVES: To determine whether an enriched environment embedded in an acute stroke unit could increase activity levels in acute ..

Biomarkers of Stroke Recovery: Consensus-Based Core Recommendations from the Stroke Recovery and Rehabilitation Roundtable

Lara A Boyd, Kathryn S Hayward, Nick S Ward, Cathy M Stinear, Charlotte Rosso, Rebecca J Fisher, Alexandre R Carter, Alex P Leff, David A Copland, Leeanne M Carey, Leonardo G Cohen, D Michele Basso, Jane M Maguire, Steven C Cramer

2017-10-01

The most difficult clinical questions in stroke rehabilitation are "What is this patient's potential for recovery?" and "What is t..

A structural motor network correlates with motor function and not impairment post stroke

Sue Peters, Katie P Wadden, Kathryn S Hayward, Jason L Neva, Angela M Auriat, Lara A Boyd

2017-09-29

Combining structural and functional magnetic resonance imaging may provide insight into how residual motor networks contribute to ..

Agreed Definitions and a Shared Vision for New Standards in Stroke Recovery Research: The Stroke Recovery and Rehabilitation Roundtable Taskforce

Julie Bernhardt, Kathryn S Hayward, Gert Kwakkel, Nick S Ward, Steven L Wolf, Karen Borschmann, John W Krakauer, Lara A Boyd, S Thomas Carmichael, Dale Corbett, Steven C Cramer

2017-09-01

The first Stroke Recovery and Rehabilitation Roundtable established a game changing set of new standards for stroke recovery resea..

Agreed definitions and a shared vision for new standards in stroke recovery research: The Stroke Recovery and Rehabilitation Roundtable taskforce

Julie Bernhardt, Kathryn S Hayward, Gert Kwakkel, Nick S Ward, Steven L Wolf, Karen Borschmann, John W Krakauer, Lara A Boyd, S Thomas Carmichael, Dale Corbett, Steven C Cramer

2017-07-01

The first Stroke Recovery and Rehabilitation Roundtable established a game changing set of new standards for stroke recovery resea..

Biomarkers of stroke recovery: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable

Lara A Boyd, Kathryn S Hayward, Nick S Ward, Cathy M Stinear, Charlotte Rosso, Rebecca J Fisher, Alexandre R Carter, Alex P Leff, David A Copland, Leeanne M Carey, Leonardo G Cohen, D Michele Basso, Jane M Maguire, Steven C Cramer

2017-07-01

The most difficult clinical questions in stroke rehabilitation are "What is this patient's potential for recovery?" and "What is t..

Are we armed with the right data? Pooled individual data review of biomarkers in people with severe upper limb impairment after stroke

Kathryn S Hayward, Julia Schmidt, Keith R Lohse, Sue Peters, Julie Bernhardt, Natasha A Lannin, Lara A Boyd

2017-01-01

UNLABELLED: To build an understanding of the neurobiology underpinning arm recovery in people with severe arm impairment due to st..

Hemispheric asymmetry in myelin after stroke is related to motor impairment and function

Bimal Lakhani, Kathryn S Hayward, Lara A Boyd

2017-01-01

The relationships between impairment, function, arm use and underlying brain structure following stroke remain unclear. Although d..

Interhemispheric Pathways Are Important for Motor Outcome in Individuals with Chronic and Severe Upper Limb Impairment Post Stroke

Kathryn S Hayward, Jason L Neva, Cameron S Mang, Sue Peters, Katie P Wadden, Jennifer K Ferris, Lara A Boyd

2017-01-01

BACKGROUND: Severity of arm impairment alone does not explain motor outcomes in people with severe impairment post stroke. OBJECTI..

Severe upper limb impairment after stroke: Therapeutic nihilism or cautious optimism?

Kathryn Hayward

2017-01-01

Monitoring activity in the hemiplegic upper limb.

Kathryn Hayward

2016-01-01

Severe stroke: Moving from therapeutic nihilism to cautious optimism.

Kathryn Hayward

2016-01-01

Turning the accelerometer signal into a clinically meaningful output.

Kathryn Hayward

2016-01-01

Promoting arm recovery in stroke survivors with severe paresis.

Kathryn S Hayward

2015-01-01