NEW INSIGHT INTO GLYCAN REQUIREMENTS FOR ROTAVIRUS-CELL ATTACHMENT AND ENTRY
Grant number: 1085596 | Funding period: 2015 - 2018
Rotavirus causes significant infection and loss of life in children, particularly in underdeveloped countries. This project will investigate the role of carbohydrates as contact points for this deadly virus towards the goal of developing novel vaccines and drug therapies.
Related publications (4)
Specificity and affinity of neuraminic acid exhibited by canine rotavirus strain K9 carbohydrate-binding domain (VP8*)
Rahul Mishra, Xing Yu, Chandan Kishor, Gavan Holloway, Kam Lau, Mark von Itzstein, Barbara S Coulson, Helen Blanchard
The outer capsid spike protein VP4 of rotaviruses is a major determinant of infectivity and serotype specificity. Proteolytic clea..
Substantial Receptor-induced Structural Rearrangement of Rotavirus VP8*: Potential Implications for Cross-Species Infection
Xing Yu, Rahul Mishra, Gavan Holloway, Mark von Itzstein, Barbara S Coulson, Helen Blanchard
Rotavirus-cell binding is the essential first step in rotavirus infection. This binding is a major determinant of rotavirus tropis..