CENTRE OF RESEARCH EXCELLENCE IN INFECTIOUS DISEASES MODELLING TO INFORM PUBLIC HEALTH POLICY
Grant number: 1078068 | Funding period: 2014 - 2020
Infectious diseases pose a global challenge, with substantial human and economic costs. Mathematical models provide valuable frameworks to assess likely benefits of interventions to control infection spread and burden. Leveraging existing NHMRC support, we will expand modeling capability to inform infectious disease control policy in Australia and our region. Focus areas include vaccine preventable disease, respiratory viruses and emerging pathogens, supported by innovative methods development.
Related publications (23)
Enhanced viral infectivity and reduced interferon production are associated with high pathogenicity for influenza viruses.
Ke Li, James M McCaw, Pengxing Cao
Epidemiological and clinical evidence indicates that humans infected with the 1918 pandemic H1N1 influenza virus and highly pathog..
Development of an influenza pandemic decision support tool linking situational analytics to national response policy.
Freya M Shearer, Robert Moss, David J Price, Alexander E Zarebski, Peter G Ballard, Jodie McVernon, Joshua V Ross, James M McCaw
National influenza pandemic plans have evolved substantially over recent decades, as has the scientific research that underpins th..
Estimation of the force of infection and infectious period of skin sores in remote Australian communities using interval-censored data
Michael J Lydeamore, Patricia T Campbell, David J Price, Yue Wu, Adrian J Marcato, Will Cuningham, Jonathan R Carapetis, Ross M Andrews, Malcolm McDonald, Jodie McVernon, Steven YC Tong, James M McCaw
Prevalence of impetigo (skin sores) remains high in remote Australian Aboriginal communities, Fiji, and other areas of socio-econo..
A biological model of scabies infection dynamics and treatment informs mass drug administration strategies to increase the likelihood of elimination
MJ Lydeamore, PT Campbell, DG Regan, SYC Tong, RM Andrews, AC Steer, L Romani, JM Kaldor, J McVernon, JM McCaw
Infections with Sarcoptes scabiei, or scabies, remain common in many disadvantaged populations. Mass drug administration (MDA) has..
Accounting for Healthcare-Seeking Behaviours and Testing Practices in Real-Time Influenza Forecasts
R Moss, Alexander E Zarebski, Sandra J Carlson, James M McCaw
For diseases such as influenza, where the majority of infected persons experience mild (if any) symptoms, surveillance systems are..
Investigating the Efficacy of Triple Artemisinin-Based Combination Therapies for Treating Plasmodium falciparum Malaria Patients Using Mathematical Modeling
Saber Dini, Sophie Zaloumis, Pengxing Cao, Ric N Price, Freya J Fowkes, E Rob W van der Pluijm, James M McCaw, Julie A Simpson
The first line treatment for uncomplicated falciparum malaria is artemisinin-based combination therapy (ACT), which consists of an..
The distribution of the time taken for an epidemic to spread between two communities
Ada WC Yan, Andrew J Black, James M McCaw, Nicolas Rebuli, Joshua Ross, Annalisa J Swan, Roslyn Hickson
Assessing the risk of disease spread between communities is important in our highly connected modern world. However, the impact of..
Calculation of the age of the first infection for skin sores and scabies in five remote communities in northern Australia
MJ Lydeamore, PT Campbell, W Cuningham, RM Andrews, T Kearns, D Clucas, R Gundjirryirr Dhurrkay, J Carapetis, SYC Tong, JM McCaw, J McVernon
Prevalence of skin sores and scabies in remote Australian Aboriginal communities remains unacceptably high, with Group A Streptoco..
A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum
Pengxing Cao, Nectarios Klonis, Sophie Zaloumis, Con Dogovski, Stanley C Xie, Sompob Saralamba, Lisa J White, Freya JI Fowkes, Leann Tilley, Julie A Simpson, James M McCaw
Artemisinin resistance constitutes a major threat to the continued success of control programs for malaria, particularly in light ..
A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection
Pengxing Cao, Nectarios Klonis, Sophie Zaloumis, David S Khoury, Deborah Cromer, Miles P Davenport, Leann Tilley, Julie A Simpson, James M McCaw
Falciparum malaria is a major parasitic disease causing widespread morbidity and mortality globally. Artemisinin derivatives-the m..
Vaccine efficacy against Indonesian Highly Pathogenic Avian Influenza H5N1: systematic review and meta-analysis
Juan P Villanueva-Cabezas, Mauricio JC Coppo, Peter A Durr, Jodie McVernon
Indonesia has implemented multiple strategies to control Highly Pathogenic Avian Influenza H5N1 (HPAI/H5N1), including the licensu..
Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host
Ada WC Yan, Pengxing Cao, Jane M Heffernan, Jodie McVernon, Kylie M Quinn, Nicole L La Gruta, Karen L Laurie, James M McCaw
The cellular adaptive immune response plays a key role in resolving influenza infection. Experiments where individuals are success..
On the Role of CD8( ) T Cells in Determining Recovery Time from Influenza Virus Infection
Pengxing Cao, Zhongfang Wang, Ada WC Yan, Jodie McVernon, Jianqing Xu, Jane M Heffernan, Katherine Kedzierska, James M McCaw
Myriad experiments have identified an important role for CD8+ T cell response mechanisms in determining recovery from influenza A ..
Influence of Population Demography and Immunization History on the Impact of an Antenatal Pertussis Program
Patricia Therese Campbell, Jodie McVernon, Peter McIntyre, Nicholas Geard
BACKGROUND: Antenatal pertussis vaccination is being considered as a means to reduce the burden of infant pertussis in low- and m..
High Conservation Level of CD8( ) T Cell Immunogenic Regions Within an Unusual H1N2 Human Influenza Variant
Naomi Komadina, Sergio M Quinones-Parra, Katherine Kedzierska, James M McCaw, Anne Kelso, Karin Leder, Jodie McVernon
Current seasonal influenza vaccines require regular updates due to antigenic drift causing loss of effectiveness and therefore pro..
On the efficient determination of optimal Bayesian experimental designs using ABC: A case study in optimal observation of epidemics
David J Price, Nigel G Bean, Joshua V Ross, Jonathan Tuke
We present a new method for determining optimal Bayesian experimental designs, which we refer to as ABCdE. ABCdE uses Approximate ..