AUSTRALIAN CENTRE OF EXCELLENCE IN TWIN RESEARCH

Epigenome-wide association study of short-term temperature fluctuations based on within-sibship analyses in Australian females

Yao Wu, Rongbin Xu, Shanshan Li, Ee Ming Wong, Melissa C Southey, John L Hopper, Michael J Abramson, Shuai Li, Yuming Guo

2023-01-01

BACKGROUND: Temperature fluctuations can affect human health independent of the effect of mean temperature. However, no study has ..

Wildfire-related PM2.5 and DNA methylation: An Australian twin and family study.

Rongbin Xu, Shanshan Li, Yao Wu, Xu Yue, Ee Ming Wong, Melissa C Southey, John L Hopper, Michael J Abramson, Shuai Li, Yuming Guo

2023-01-01

BACKGROUND: Wildfire-related fine particulate matter (PM2.5) has many adverse health impacts, but its impacts on human epigenome a..

High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile

Mary Revelas, Anbupalam Thalamuthu, Anna Zettergren, Christopher Oldmeadow, Jenna Najar, Nazib M Seidu, Nicola J Armstrong, Carlos Riveros, John B Kwok, Peter R Schofield, Julian N Trollor, Margda Waern, Margaret J Wright, Henrik Zetterberg, David Ames, Kaj Belnnow, Henry Brodaty, Rodney J Scott, Ingmar Skoog, John R Attia

2022-08-16

Healthy metabolic measures in humans are associated with longevity. Dysregulation leads to metabolic syndrome (MetS) and negative ..

Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts.

Karri Silventoinen, Maarit Piirtola, Aline Jelenkovic, Reijo Sund, Adam D Tarnoki, David L Tarnoki, Emanuela Medda, Lorenza Nisticò, Virgilia Toccaceli, Chika Honda, Fujio Inui, Rie Tomizawa, Mikio Watanabe, Norio Sakai, Margaret Gatz, David A Butler, Jooyeon Lee, Soo Ji Lee, Joohon Sung, Carol E Franz

2022-07-31

We tested the causality between education and smoking using the natural experiment of discordant twin pairs allowing to optimally ..

Left Ventricular Adaptation to Exercise Training via Magnetic Resonance Imaging: Studies of Twin Responses to Understand Exercise THerapy.

Channa E Marsh, Hannah J Thomas, Louise H Naylor, Lawrence G Dembo, Katrina J Scurrah, Daniel J Green

2022-07-01

PURPOSE: Changes in left ventricular mass (LVM) and end-diastolic volume (EDV) in response to exercise training are important dete..

The impact of different intensities and domains of physical activity on analgesic use and activity limitation in people with low back pain: A prospective cohort study with a one-year followup

Thomas G Patterson, Paula R Beckenkamp, Manuela Ferreira, Adrian Bauman, Ana Paula Carvalho-e-Silva, Lucas Calais Ferreira, Paulo H Ferreira

2022-06-16

BACKGROUND: Analgesics are the most common form of managing low back pain (LBP). No previous study has examined which domains and ..

Genetic Aspects of Mammographic Density Measures Associated with Breast Cancer Risk

Shuai Li, Tuong L Nguyen, Nguyen-Dumont Tu, James G Dowty, Gillian S Dite, Zhoufeng Ye, Ho N Trinh, Christopher F Evans, Maxine Tan, Joohon Sung, Mark A Jenkins, Graham G Giles, John L Hopper, Melissa C Southey

2022-06-01

Cumulus, Altocumulus, and Cirrocumulus are measures of mammographic density defined at increasing pixel brightness thresholds, whi..

Studies of Twin Responses to Understand Exercise THerapy (STRUETH): cerebrovascular function.

Hannah J Thomas, Channa E Marsh, Katrina J Scurrah, Louise H Naylor, Kurt J Smith, Daniel J Green

2022-06-01

We studied monozygotic (MZ) and dizygotic (DZ) twin pairs following resistance (RES) and endurance (END) training to assess geneti..

Genetic factors and shared environment contribute equally to objective singing ability

Daniel Yeom, Yi Ting Tan, Nick Haslam, Miriam A Mosing, Valerie MZ Yap, Trisnasari Fraser, Michael S Hildebrand, Sam F Berkovic, Gary E McPherson, Isabelle Peretz, Sarah J Wilson

2022-05-23

Singing ability is a complex human skill influenced by genetic and environmental factors, the relative contributions of which rema..

Early life affects late-life health through determining DNA methylation across the lifespan: A twin study

Shuai Li, Zhoufeng Ye, Karen A Mather, Tuong L Nguyen, Gillian S Dite, Nicola J Armstrong, Ee Ming Wong, Anbupalam Thalamuthu, Graham G Giles, Jeffrey M Craig, Richard Saffery, Melissa C Southey, Qihua Tan, Perminder S Sachdev, John L Hopper

2022-03-14

BACKGROUND: Previous findings for the genetic and environmental contributions to DNA methylation variation were for limited age ra..

Familial Aspects of Mammographic Density Measures Associated with Breast Cancer Risk

Tuong L Nguyen, Shuai Li, James G Dowty, Gillian S Dite, Zhoufeng Ye, Tu Nguyen-Dumont, Ho N Trinh, Christopher F Evans, Maxine Tan, Joohon Sung, Mark A Jenkins, Graham G Giles, Melissa C Southey, John L Hopper

2022-03-01

Cumulus, Cumulus-percent, Altocumulus, Cirrocumulus, and Cumulus-white are mammogram risk scores (MRSs) for breast cancer based on..

The heritability of amyloid burden in older adults: the Older Australian Twins Study

Rebecca Koncz, Anbupalam Thalamuthu, Wei Wen, Vibeke S Catts, Vincent Dore, Teresa Lee, Karen A Mather, Melissa J Slavin, Eva A Wegner, Jiyang Jiang, Julian N Trollor, David Ames, Victor L Villemagne, Christopher C Rowe, Perminder S Sachdev

2022-03-01

OBJECTIVE: To determine the proportional genetic contribution to the variability of cerebral β-amyloid load in older adults using ..

Financial strain moderates genetic influences on self-rated health: support for diathesis-stress model of gene-environment interplay

Deborah Finkel, Catalina Zavala, Carol E Franz, Shandell Pahlen, Margaret Gatz, Nancy L Pedersen, Brian K Finch, Anna Dahl Aslan, Vibeke S Catts, Malin Ericsson, Robert F Krueger, Nicholas G Martin, Adith Mohan, Miriam A Mosing, Carol A Prescott, Keith E Whitfield

2022-02-16

Data from the Interplay of Genes and Environment across Multiple Studies (IGEMS) consortium were used to examine predictions of di..

Birthweight, gestational age and familial confounding in sex differences in infant mortality: a matched co-twin control study of Brazilian male-female twin pairs identified by population data linkage

Lucas Calais-Ferreira, Marcos E Barreto, Everton Mendonca, Gillian S Dite, Martha Hickey, Paulo H Ferreira, Katrina J Scurrah, John L Hopper

2021-11-29

BACKGROUND: In infancy, males are at higher risk of dying than females. Birthweight and gestational age are potential confounders ..

Diet and depression: future needs to unlock the potential

Wolfgang Marx, Melissa M Lane, Meghan Hockey, Hajara Aslam, Ken Walder, Alessandra Borsini, Joseph Firth, Carmine M Pariante, Kirsten Berding, John F Cryan, Gerard Clarke, Jeffrey M Craig, Kuan-Pin Su, David Mischoulon, Fernando Gomez-Pinilla, Jane A Foster, Patrice D Cani, Sandrine Thuret, Heidi M Staudacher, Almudena Sanchez-Villegas

2021-11-09

Educational attainment of same-sex and opposite-sex dizygotic twins: An individual-level pooled study of 19 twin cohorts.

Karri Silventoinen, Leonie H Bogl, Aline Jelenkovic, Eero Vuoksimaa, Antti Latvala, Weilong Li, Qihua Tan, Dongfeng Zhang, Zengchang Pang, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Gonneke Willemsen, Meike Bartels, Catharina EM van Beijsterveldt, Esther Rebato, Robin P Corley, Brooke M Huibregtse, John L Hopper, Jessica Tyler

2021-11-01

Comparing twins from same- and opposite-sex pairs can provide information on potential sex differences in a variety of outcomes, i..

Surrounding Greenness and Biological Aging Based on DNA Methylation: A Twin and Family Study in Australia

Rongbin Xu, Shuai Li, Shanshan Li, Ee Ming Wong, Melissa C Southey, John L Hopper, Michael J Abramson, Yuming Guo

2021-08-01

BACKGROUND: High surrounding greenness has many health benefits and might contribute to slower biological aging. However, very few..

Ambient temperature and genome-wide DNA methylation: A twin and family study in Australia

Rongbin Xu, Shuai Li, Shanshan Li, Ee Ming Wong, Melissa C Southey, John L Hopper, Michael J Abramson, Yuming Guo

2021-07-03

Little is known about the association between ambient temperature and DNA methylation, which is a potential biological process thr..

Pregnancy and birth characteristics of Aboriginal twins in two Australian states: a data linkage study

Alison J Gibberd, Jessica Tyler, Kathleen Falster, David B Preen, Mark Hanly, Marilyn J Clarke, Bridgette J McNamara, Sandra J Eades, Katrina J Scurrah

2021-06-28

INTRODUCTION: Perinatal outcomes for singleton pregnancies are poorer, on average, for Aboriginal people than non-Aboriginal peopl..

Investigating Olfactory Gene Variation and Odour Identification in Older Adults

Siddharth Raj, Anbupalam Thalamuthu, Nicola J Armstrong, Margaret J Wright, John B Kwok, Julian N Trollor, David Ames, Peter R Schofield, Henry Brodaty, Perminder S Sachdev, Karen A Mather

2021-05-01

Ageing is associated with a decrease in odour identification. Additionally, deficits in olfaction have been linked to age-related ..

Residential surrounding greenness and DNA methylation: An epigenome-wide association study

Rongbin Xu, Shuai Li, Shanshan Li, Ee Ming Wong, Melissa C Southey, John L Hopper, Michael J Abramson, Yuming Guo

2021-04-13

BACKGROUND: DNA methylation is a potential biological mechanism through which residential greenness affects health, but little is ..

Association of Adult Socioeconomic Status with Body Mass Index: A Within- and Between-Twin Study

Samuel JC Crofts, Janine Lam, Katrina J Scurrah, Gillian S Dite

2021-04-01

Adult socioeconomic status (SES) has been consistently associated with body mass index (BMI), but it is unclear whether it is link..

ESTABLISHING THE RELIABILITY AND VALIDITY OF WEB-BASED SINGING RESEARCH

Yi Ting Tan, Isabelle Peretz, Gary E McPherson, Sarah J Wilson

2021-04-01

IN THIS STUDY, THE ROBUSTNESS OF AN ONLINE tool for objectively assessing singing ability was examined by: (1) determining the int..

1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

Ida E Sonderby, Dennis van der Meer, Clara Moreau, Tobias Kaufmann, G Bragi Walters, Maria Ellegaard, Abdel Abdellaoui, David Ames, Katrin Amunts, Micael Andersson, Nicola J Armstrong, Manon Bernard, Nicholas B Blackburn, John Blangero, Dorret I Boomsma, Henry Brodaty, Rachel M Brouwer, Robin Buelow, Rune Boen, Wiepke Cahn

2021-03-22

Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopme..

The Association Between Chronic Disease and Psychological Distress: An Australian Twin Study

Jessica Tyler, Janine Lam, Katrina Scurrah, Gillian Dite

2020-12-01

There is a commonly observed association between chronic disease and psychological distress, but many potential factors could conf..

Diverse phenotypic measurements of wellbeing: Heritability, temporal stability and the variance explained by polygenic scores.

Javad Jamshidi, Leanne M Williams, Peter R Schofield, Haeme RP Park, Arthur Montalto, Miranda R Chilver, Richard A Bryant, Claudio Toma, Janice M Fullerton, Justine M Gatt

2020-11-01

Wellbeing, a key aspect of mental health, is moderately heritable with varying estimates reported from independent studies employi..

Genetic and environmental causes of variation in epigenetic aging across the lifespan

Shuai Li, Tuong L Nguyen, Ee Ming Wong, Pierre-Antoine Dugue, Gillian S Dite, Nicola J Armstrong, Jeffrey M Craig, Karen A Mather, Perminder S Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L Milne, Graham G Giles, Melissa C Southey, John L Hopper

2020-10-22

BACKGROUND: DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ra..

Exploring human trainability: Design and rationale of Studies of Twin Responses to Understand Exercise as a Therapy (STRUETH) study

Channa E Marsh, Hannah J Thomas, Louise H Naylor, Katrina J Scurrah, Daniel J Green

2020-09-01

BACKGROUND: Exercise confers myriad health benefits and physical inactivity is a modifiable risk factor for many non-communicable ..

Heritability of overlapping impulsivity and compulsivity dimensional phenotypes

Jeggan Tiego, Samuel R Chamberlain, Ben J Harrison, Andrew Dawson, Lucy Albertella, George J Youssef, Leonardo F Fontenelle, Murat Yucel

2020-09-01

Impulsivity and compulsivity are traits relevant to a range of mental health problems and have traditionally been conceptualised a..

Inference about causation from examination of familial confounding (ICE FALCON): a model for assessing causation analogous to Mendelian randomization

Shuai Li, Minh Bui, John L Hopper

2020-08-01

BACKGROUND: We developed a method to make Inference about Causation from Examination of FAmiliaL CONfounding (ICE FALCON) using ob..

Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts

Karri Silventoinen, Aline Jelenkovic, Reijo Sund, Antti Latvala, Chika Honda, Fujio Inui, Rie Tomizawa, Mikio Watanabe, Norio Sakai, Esther Rebato, Andreas Busjahn, Jessica Tyler, John L Hopper, Juan R Ordonana, Juan F Sanchez-Romera, Lucia Colodro-Conde, Lucas Calais-Ferreira, Vinicius C Oliveira, Paulo H Ferreira, Emanuela Medda

2020-07-29

We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural-geographic regio..

Genetic and environmental determinants of variation in the plasma lipidome of older Australian twins

Matthew WK Wong, Anbupalam Thalamuthu, Nady Braidy, Karen A Mather, Yue Liu, Liliana Ciobanu, Bernhardt T Baune, Nicola J Armstrong, John Kwok, Peter Schofield, Margaret J Wright, David Ames, Russell Pickford, Teresa Lee, Anne Poljak, Perminder S Sachdev

2020-07-22

The critical role of blood lipids in a broad range of health and disease states is well recognised but less explored is the interp..

Fitness and strength responses to distinct exercise modes in twins:Studies ofTwinResponses toUnderstandExercise as aTHerapy (STRUETH) study

Channa E Marsh, Hannah J Thomas, Louise H Naylor, Katrina J Scurrah, Daniel J Green

2020-07-07

KEY POINTS: Exercise is considered medicine; however, the individual degree of responsiveness to a standardized dose of exercise i..

Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education

Aline Jelenkovic, Reijo Sund, Yoshie Yokoyama, Antti Latvala, Masumi Sugawara, Mami Tanaka, Satoko Matsumoto, Duarte L Freitas, Jose Antonio Maia, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Kimberly J Saudino, Tessa L Cutler, John L Hopper, Vilhelmina Ullemar

2020-05-14

Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between..

Individualised MRI training for paediatric neuroimaging: A child-focused approach

Emmanuel Peng Kiat Pua, Sarah Barton, Katrina Williams, Jeffrey M Craig, Marc L Seal

2020-02-01

Magnetic Resonance Imaging (MRI) in paediatric cohorts is often complicated by reluctance to enter the scanner and head motion-rel..

The Value of Twins for Health and Medical Research: A Third of a Century of Progress

Jeffrey M Craig, Lucas Calais-Ferreira, Mark P Umstad, Dedra Buchwald

2020-02-01

In 1984, Hrubec and Robinette published what was arguably the first review of the role of twins in medical research. The authors a..

IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update

Nancy L Pedersen, Margaret Gatz, Brian K Finch, Deborah Finkel, David A Butler, Anna Dahl Aslan, Carol E Franz, Jaakko Kaprio, Susan Lapham, Matt McGue, Miriam A Mosing, Jenae Neiderhiser, Marianne Nygaard, Matthew Panizzon, Carol A Prescott, Chandra A Reynolds, Perminder Sachdev, Keith E Whitfield

2019-12-01

The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 18 twin studies from 5 different countri..

The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

K Silventoinen, A Jelenkovic, Y Yokoyama, R Sund, M Sugawara, M Tanaka, S Matsumoto, LH Bogl, DL Freitas, JA Maia, JVB Hjelmborg, S Aaltonen, M Piirtola, A Latvala, L Calais-Ferreira, VC Oliveira, PH Ferreira, F Ji, F Ning, Z Pang

2019-12-01

The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collab..

Twins Research Australia: A New Paradigm for Driving Twin Research

Kate Murphy, Janine Lam, Tessa Cutler, Jess Tyler, Lucas Calais-Ferreira, Shuai Li, Callie Little, Paulo Ferreira, Jeffrey M Craig, Katrina J Scurrah, John L Hopper

2019-12-01

Twins Research Australia (TRA) is a community of twins and researchers working on health research to benefit everyone, including t..

DNA methylation-based biological age, genome-wide average DNA methylation, and conventional breast cancer risk factors

Minyuan Chen, Ee Ming Wong, Tuong L Nguyen, Gillian S Dite, Jennifer Stone, Pierre-Antoine Dugue, Graham G Giles, Melissa C Southey, Roger L Milne, John L Hopper, Shuai Li

2019-10-21

DNA methylation-based biological age (DNAm age), as well as genome-wide average DNA methylation, have been reported to predict bre..

Research priorities for the future health of multiples and their families: The Global Twins and Multiples Priority Setting Partnership

JR Lam, B Liu, R Bhate, N Fenwick, K Reed, JMN Duffy, A Khalil, H Bartley, A Baschat, M Bennasar Sans, R Bhate, C Bolch, J Craig, J Denton, JMN Duffy, S Ernst-Milner, N Fenwick, M Gevers, S Griffith, J Harris

2019-10-10

Genome-wide association study of peripheral blood DNA methylation and conventional mammographic density measures

Shuai Li, Pierre-Antoine Dugue, Laura Baglietto, Gianluca Severi, Ee Ming Wong, Tuong L Nguyen, Jennifer Stone, Dallas R English, Melissa C Southey, Graham G Giles, John L Hopper, Roger L Milne

2019-10-01

Age- and body mass index (BMI)-adjusted mammographic density is one of the strongest breast cancer risk factors. DNA methylation i..

The Association between Socioeconomic Status and Psychological Distress: A Within and Between Twin Study

Janine R Lam, Jessica Tyler, Katrina J Scurrah, Nicola J Reavley, Gillian S Dite

2019-10-01

Low socioeconomic status (SES) has been established as a risk factor for poor mental health; however, the relationship between SES..

Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts

Karri Silventoinen, Aline Jelenkovic, Antti Latvala, Yoshie Yokoyama, Reijo Sund, Masumi Sugawara, Mami Tanaka, Satoko Matsumoto, Sari Aaltonen, Maarit Piirtola, Duarte L Freitas, Jose A Maia, Sevgi Y Oncel, Fazil Aliev, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Kimberly J Saudino, Tessa L Cutler

2019-05-01

OBJECTIVE: The objective of this study was to analyze how parental education modifies the genetic and environmental variances of B..

Contributions of birthweight, annualised weight gain and BMI to back pain in adults: a population-based co-twin control study of 2754 Australian twins

Hercules R Leite, Amabile B Dario, Alison R Harmer, Vinicius C Oliveira, Manuela L Ferreira, Lucas Calais-Ferreira, Paulo H Ferreira

2019-02-01

PURPOSE: To investigate associations between anthropometric measures (birthweight, weight gain and current BMI) and back pain; and..

Inference about causation between body mass index and DNA methylation in blood from a twin family study

Shuai Li, Ee Ming Wong, Minh Bui, Tuong L Nguyen, Ji-Hoon Eric Joo, Jennifer Stone, Gillian S Dite, Pierre-Antoine Dugue, Roger L Milne, Graham G Giles, Richard Saffery, Melissa C Southey, John L Hopper

2019-02-01

BACKGROUND: Several studies have reported DNA methylation in blood to be associated with body mass index (BMI), but few have inves..

Association between birth weight and educational attainment: an individual-based pooled analysis of nine twin cohorts

Aline Jelenkovic, Janne Mikkonen, Pekka Martikainen, Antti Latvala, Yoshie Yokoyama, Reijo Sund, Eero Vuoksimaa, Esther Rebato, Joohon Sung, Jina Kim, Jooyeon Lee, Sooji Lee, Maria A Stazi, Corrado Fagnani, Sonia Brescianini, Catherine A Derom, Robert F Vlietinck, Ruth JF Loos, Robert F Krueger, Matt Mcgue

2018-09-01

BACKGROUND: There is evidence that birth weight is positively associated with education, but it remains unclear whether this assoc..

An open-source, integrated pedigree data management and visualization tool for genetic epidemiology

Thilina Ranaweera, Enes Makalic, John L Hopper, Adrian Bickerstaffe

2018-08-01

With advances in genetic epidemiology, increasingly large amounts of pedigree-related information are being collected by family st..

Genetic and environmental factors affecting birth size variation: a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts

Yoshie Yokoyama, Aline Jelenkovic, Yoon-Mi Hur, Reijo Sund, Corrado Fagnani, Maria A Stazi, Sonia Brescianini, Fuling Ji, Feng Ning, Zengchang Pang, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Esther Rebato, John L Hopper, Tessa L Cutler, Kimberly J Saudino, Tracy L Nelson, Keith E Whitfield, Robin P Corley

2018-08-01

BACKGROUND: The genetic architecture of birth size may differ geographically and over time. We examined differences in the genetic..

Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts

Maarit Piirtola, Aline Jelenkovic, Antti Latvala, Reijo Sund, Chika Honda, Fujio Inui, Mikio Watanabe, Rie Tomizawa, Yoshinori Iwatani, Juan R Ordonana, Juan F Sanchez-Romera, Lucia Colodro-Conde, Adam D Tarnoki, David L Tarnoki, Nicholas G Martin, Grant W Montgomery, Sarah E Medland, Finn Rasmussen, Per Tynelius, Qihua Tan

2018-07-12

BACKGROUND: Smokers tend to weigh less than never smokers, while successful quitting leads to an increase in body weight. Because ..

Genome-wide average DNA methylation is determined in utero

Shuai Li, Ee Ming Wong, Pierre-Antoine Dugue, Allan F McRae, Eunae Kim, Ji-Hoon Eric Joo, Tuong L Nguyen, Jennifer Stone, Gillian S Dite, Nicola J Armstrong, Karen A Mather, Anbupalam Thalamuthu, Margaret J Wright, David Ames, Roger L Milne, Jeffrey M Craig, Richard Saffery, Grant W Montgomery, Yun-Mi Song, Joohon Sung

2018-06-01

BACKGROUND: Investigating the genetic and environmental causes of variation in genome-wide average DNA methylation (GWAM), a globa..

Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project

Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Yoon-Mi Hur, Jennifer R Harris, Ingunn Brandt, Thomas Sevenius Nilsen, Syuichi Ooki, Vilhelmina Ullemar, Catarina Almqvist, Patrik KE Magnusson, Kimberly J Saudino, Maria A Stazi, Corrado Fagnani, Sonia Brescianini, Tracy L Nelson, Keith E Whitfield, Ariel Knafo-Noam, David Mankuta, Lior Abramson

2018-05-01

BACKGROUND: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether t..

Twin studies for the prognosis, prevention and treatment of musculoskeletal conditions

Lucas Calais-Ferreira, Vinicius C Oliveira, Jeffrey M Craig, Louisa B Flander, John L Hopper, Luci F Teixeira-Salmela, Paulo H Ferreira

2018-05-01

BACKGROUND: Musculoskeletal conditions are highly prevalent in our ageing society and are therefore incurring substantial increase..

Birth size and gestational age in opposite-sex twins as compared to same-sex twins: An individual-based pooled analysis of 21 cohorts

Aline Jelenkovic, Reijo Sund, Yoshie Yokoyama, Yoon-Mi Hur, Vilhelmina Ullemar, Catarina Almqvist, Patrik KE Magnusson, Gonneke Willemsen, Meike Bartels, Catharina EM van Beijsterveldt, Leonie H Bogl, Kirsi H Pietilainen, Eero Vuoksimaa, Fuling Ji, Feng Ning, Zengchang Pang, Tracy L Nelson, Keith E Whitfield, Esther Rebato, Clare H Llewellyn

2018-04-19

It is well established that boys are born heavier and longer than girls, but it remains unclear whether birth size in twins is aff..

Novel associations between blood DNA methylation and body mass index in middle-aged and older adults

YM Geurts, P-A Dugue, JE Joo, E Makalic, C-H Jung, W Guan, S Nguyen, ML Grove, EM Wong, AM Hodge, JK Bassett, LM FitzGerald, H Tsimiklis, L Baglietto, G Severi, DF Schmidt, DD Buchanan, RJ MacInnis, JL Hopper, JS Pankow

2018-04-01

BACKGROUND/OBJECTIVES: There is increasing evidence of a relationship between blood DNA methylation and body mass index (BMI). We ..

Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study

Shuai Li, Ee Ming Wong, Minh Bui, Tuong L Nguyen, Ji-Hoon Eric Joo, Jennifer Stone, Gillian S Dite, Graham G Giles, Richard Saffery, Melissa C Southey, John L Hopper

2018-02-09

BACKGROUND: Smoking has been reported to be associated with peripheral blood DNA methylation, but the causal aspects of the associ..

Twins as Participants in Randomized Controlled Trials: A Review of Published Literature

Athula Sumathipala, Lisa Yelland, Debra Green, Tom Shepherd, Kaushalya Jayaweera, Paulo Ferreira, Jeffrey M Craig

2018-02-01

Monozygotic (MZ) and dizygotic (DZ) twins participate in research that partitions variance in health, disease, and behavior into g..

Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Kirsi H Pietilainen, Yoon-Mi Hur, Gonneke Willemsen, Meike Bartels, Toos CEM van Beijsterveldt, Syuichi Ooki, Kimberly J Saudino, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Tracy L Nelson, Keith E Whitfield, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Kauko Heikkila, Tessa L Cutler

2017-10-01

BACKGROUND: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains u..

Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts

Karri Silventoinen, Aline Jelenkovic, Antti Latvala, Reijo Sund, Yoshie Yokoyama, Vilhelmina Ullemar, Catarina Almqvist, Catherine A Derom, Robert F Vlietinck, Ruth JF Loos, Christian Kandler, Chika Honda, Fujio Inui, Yoshinori Iwatani, Mikio Watanabe, Esther Rebato, Maria A Stazi, Corrado Fagnani, Sonia Brescianini, Yoon-Mi Hur

2017-10-01

Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin ..

Twin birth changes DNA methylation of subsequent siblings

Shuai Li, Eunae Kim, Ee Ming Wong, Ji-Hoon Eric Joo, Tuong L Nguyen, Jennifer Stone, Yun-Mi Song, Louisa B Flander, Richard Saffery, Graham G Giles, Melissa C Southey, Joohon Sung, John L Hopper

2017-08-16

We asked if twin birth influences the DNA methylation of subsequent siblings. We measured whole blood methylation using the HumanM..

Does the sex of one's co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts

Leonie H Bogl, Aline Jelenkovic, Eero Vuoksimaa, Linda Ahrenfeldt, Kirsi H Pietilainen, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Yoon-Mi Hur, Hoe-Uk Jeong, Judy L Silberg, Lindon J Eaves, Hermine H Maes, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Tessa L Cutler, Christian Kandler, Kerry L Jang, Kaare Christensen, Axel Skytthe

2017-04-27

BACKGROUND: The comparison of traits in twins from opposite-sex (OS) and same-sex (SS) dizygotic twin pairs is considered a proxy ..

The Ark: a customizable web-based data management tool for health and medical research

Adrian Bickerstaffe, Thilina Ranaweera, Travis Endersby, Christopher Ellis, Sanjaya Maddumarachchi, George E Gooden, Paul White, Eric K Moses, Alex W Hewitt, John L Hopper

2017-02-15

SUMMARY: The Ark is an open-source web-based tool that allows researchers to manage health and medical research data for humans an..

Causes of blood methylomic variation for middle-aged women measured by the HumanMethylation450 array

Shuai Li, Ee Ming Wong, Tuong L Nguyen, Ji-Hoon Eric Joo, Jennifer Stone, Gillian S Dite, Graham G Giles, Richard Saffery, Melissa C Southey, John L Hopper

2017-01-01

To address the limitations in current classic twin/family research on the genetic and/or environmental causes of human methylomic ..

Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

Aline Jelenkovic, Yoon-Mi Hur, Reijo Sund, Yoshie Yokoyama, Sisira H Siribaddana, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk, Qihua Tan, Dongfeng Zhang, Zengchang Pang, Sari Aaltonen, Kauko Heikkila, Sevgi Y Oncel, Fazil Aliev, Esther Rebato, Adam D Tarnoki, David L Tarnoki, Kaare Christensen, Axel Skytthe

2016-12-14

Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ ..

Distinct Genetic Influences on Cortical and Subcortical Brain Structures

Wei Wen, Anbupalam Thalamuthu, Karen A Mather, Wanlin Zhu, Jiyang Jiang, Pierre Lafaye de Micheaux, Margaret J Wright, David Ames, Perminder S Sachdev

2016-09-06

This study examined the heritability of brain grey matter structures in a subsample of older adult twins (93 MZ and 68 DZ twin pai..

The Charles Perkins Centre's Twins Research Node

Lucas C Ferreira, Jeffrey M Craig, John L Hopper, Susan E Carrick

2016-08-01

Twins can help researchers disentangle the roles of genes from those of the environment on human traits, health, and diseases. To ..

Early origins of mental disorder - risk factors in the perinatal and infant period

Louise Newman, Fiona Judd, Craig A Olsson, David Castle, Chad Bousman, Penelope Sheehan, Christos Pantelis, Jeffrey M Craig, Angela Komiti, Ian Everall

2016-07-29

BACKGROUND: There is increasing understanding of the significance of early neurodevelopment in establishing risk for the range of ..

White Matter Hyperintensities Are Under Strong Genetic Influence

Perminder S Sachdev, Anbupalam Thalamuthu, Karen A Mather, David Ames, Margaret J Wright, Wei Wen

2016-06-01

BACKGROUND AND PURPOSE: The genetic basis of white matter hyperintensities (WMH) is still unknown. This study examines the heritab..

Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project

Yoshie Yokoyama, Aline Jelenkovic, Reijo Sund, Joohon Sung, John L Hopper, Syuichi Ooki, Kauko Heikkila, Sari Aaltonen, Adam D Tarnoki, David L Tarnoki, Gonneke Willemsen, Meike Bartels, Toos CEM van Beijsterveldt, Kimberly J Saudino, Tessa L Cutler, Tracy L Nelson, Keith E Whitfield, Jane Wardle, Clare H Llewellyn, Abigail Fisher

2016-04-01

We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (..

Genetic and Environmental Causes of Variation in the Difference Between Biological Age Based on DNA Methylation and Chronological Age for Middle-Aged Women

Shuai Li, Ee Ming Wong, JiHoon E Joo, Chol-Hee Jung, Jessica Chung, Carmel Apicella, Jennifer Stone, Gillian S Dite, Graham G Giles, Melissa C Southey, John L Hopper

2015-12-01

The disease- and mortality-related difference between biological age based on DNA methylation and chronological age (Δage) has bee..

Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project

Aline Jelenkovic, Yoshie Yokoyama, Reijo Sund, Chika Honda, Leonie H Bogl, Sari Aaltonen, Fuling Ji, Feng Ning, Zengchang Pang, Juan R Ordonana, Juan F Sanchez-Romera, Lucia Colodro-Conde, S Alexandra Burt, Kelly L Klump, Sarah E Medland, Grant W Montgomery, Christian Kandler, Tom A McAdams, Thalia C Eley, Alice M Gregory

2015-10-01

A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, ..

The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits

Karri Silventoinen, Aline Jelenkovic, Reijo Sund, Chika Honda, Sari Aaltonen, Yoshie Yokoyama, Adam D Tarnoki, David L Tarnoki, Feng Ning, Fuling Ji, Zengchang Pang, Juan R Ordonana, Juan F Sanchez-Romera, Lucia Colodro-Conde, S Alexandra Burt, Kelly L Klump, Sarah E Medland, Grant W Montgomery, Christian Kandler, Tom A McAdams

2015-08-01

For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body ..

Why Accurate Knowledge of Zygosity is Important to Twins

Tessa L Cutler, Kate Murphy, John L Hopper, Louise A Keogh, Yun Dai, Jeffrey M Craig

2015-06-01

All same-sex dizygotic (DZ) twins and approximately one-third of monozygotic (MZ) twin pairs have separate placentas, making it im..