Neural migration: Which cells advance and which stay behind?

Grant number: DP150103709 | Funding period: 2015 - 2017

Completed

Abstract

This project aims to examine the neural crest cells that colonise the developing gut and to identify why some cells advance while others stay behind to populate a region. Directed cell migration is essential for normal development, including for the nervous system. In most of the migratory cell populations that have been analysed to date, all of the cells migrate as a collective from one location to another. However, there are also migratory cell populations that must populate the areas through which they migrate, and thus some cells get left behind while others advance. The planned data are likely to be relevant to other cell populations that also populate the areas through which they migra..

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Related publications (6)

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Role of JNK, MEK and adenylyl cyclase signalling in speed and directionality of enteric neural crest-derived cells

Marlene M Hao, Annette J Bergner, TH Nguyen Huynh, Paige Dissanayake, Laura E Burnett, C Danielle Hopkins, Kevin Zeng, Heather M Young, Lincon A Stamp

2019-11-15

BACKGROUND: Cells derived from the neural crest colonize the developing gut and give rise to the enteric nervous system. The rate ..

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Technologies for Live Imaging of Enteric Neural Crest-Derived Cells.

Marlene M Hao, Annette J Bergner, Donald F Newgreen, Hideki Enomoto, Heather M Young

2019-01-01

Time-lapse imaging of gut explants from embryonic mice in which neural crest-derived cells express fluorescent proteins allows the..

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Kif1bp loss in mice leads to defects in the peripheral and central nervous system and perinatal death

Caroline S Hirst, Lincon A Stamp, Annette J Bergner, Marlene M Hao, Mai X Tran, Jan M Morgan, Matthias Dutschmann, Andrew M Allen, George Paxinos, Teri M Furlong, Sonja J McKeown, Heather M Young

2017-11-30

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Spontaneous calcium waves in the developing enteric nervous system

Marlene M Hao, Annette J Bergner, Caroline S Hirst, Lincon A Stamp, Franca Casagranda, Joel C Bornstein, Werend Boesmans, Pieter Vanden Berghe, Heather M Young

2017-08-01

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Exposure to GDNF Enhances the Ability of Enteric Neural Progenitors to Generate an Enteric Nervous System

Sonja J McKeown, Mitra Mohsenipour, Annette J Bergner, Heather M Young, Lincon A Stamp

2017-02-14

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Development of the Autonomic Nervous System

WH Chan, LA Stamp, CS Hirst, SJ McKeown, CR Anderson, H YOUNG

2016-01-01

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