A SINGLE MOLECULE REAL-TIME DNA SEQUENCING FACILITY

Grant number: LE150100035 | Funding period: 2015 - 2015

Completed

Abstract

A PacBio SMRT sequencing facility will be established and used to accelerate ten specific research programs across a breadth of biological disciplines at two institutions. A specialised high throughput DNA sequencing technology called Single Molecule Real-Time (SMRT) sequencing developed by Pacific Biosciences (PacBio) is revolutionising biological research. SMRT sequencing allows researchers to discover important information in DNA and RNA molecules that are missed by other modern DNA sequencing approaches. It is expected that this facility will also be a key infrastructure resource for the wider scientific community, helping to address fundamental questions in biology.

Related publications (9)

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Mitochondrial Phylogenomics yields Strongly Supported Hypotheses for Ascaridomorph Nematodes

Guo-Hua Liu, Steven A Nadler, Shan-Shan Liu, Magdalena Podolska, Stefano D'Amelio, Renfu Shao, Robin B Gasser, Xing-Quan Zhu

2016-12-16

Ascaridomorph nematodes threaten the health of humans and other animals worldwide. Despite their medical, veterinary and economic ..

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Population structure of Haemonchus contortus from seven geographical regions in China, determined on the basis of microsatellite markers

Fangyuan Yin, Robin B Gasser, Facai Li, Min Bao, Weiyi Huang, Fengcai Zou, Guanghui Zhao, Chunren Wang, Xin Yang, Yanqin Zhou, Junlong Zhao, Rui Fang, Min Hu

2016-11-15

BACKGROUND: Studying genetic variation within and among Haemonchus contortus populations can inform some aspects of this parasite'..

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More parasiticmyositis cases in humans in Australia, and the definition of genetic markers for the causative agents as a basis for molecular diagnosis

Anson V Koehler, David M Spratt, Robert Norton, Sanchia Warren, Belinda McEwan, Ravindra Urkude, Suresh Murthy, Thomas Robertson, Naomi McCallum, Fiona Parsonson, Richard S Bradbury, Robin B Gasser

2016-10-01

Since 1998, there have been six reported human cases of myositis in Australia, attributable to infection with the nematode Haycock..

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A blow to the fly - Lucilia cuprina draft genome and transcriptome to support advances in biology and biotechnology

Clare A Anstead, Philip Batterham, Pasi K Korhonen, Neil D Young, Ross S Hall, Vernon M Bowles, Stephen Richards, Maxwell J Scott, Robin B Gasser

2016-09-01

The blow fly, Lucilia cuprina (Wiedemann, 1830) is a parasitic insect of major global economic importance. Maggots of this fly par..

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MicroRNAs of Toxocara canis and their predicted functional roles

Guangxu Ma, Yongfang Luo, Honghong Zhu, Yongli Luo, Pasi K Korhonen, Neil D Young, Robin B Gasser, Rongqiong Zhou

2016-04-23

BACKGROUND: Toxocara canis is the causative agent of toxocariasis of humans and other animals. This parasitic nematode (roundworm)..

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Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention

Samantha N McNulty, Christina Struebe, Bruce A Rosa, John C Martin, Rahul Tyagi, Young-Jun Choi, Qi Wang, Kymberlie Hallsworth Pepin, Xu Zhang, Philip Ozersky, Richard K Wilson, Paul W Sternberg, Robin B Gasser, Makedonka Mitreva

2016-02-09

The bovine lungworm, Dictyocaulus viviparus (order Strongylida), is an important parasite of livestock that causes substantial eco..

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Molecular characterization of the Haemonchus contortus phosphoinositide-dependent protein kinase-1 gene (Hc-pdk-1)

Fa-Cai Li, Robin B Gasser, James B Lok, Pasi K Korhonen, Li He, Wen-Da Di, Fang-Yuan Yin, Rui Zhou, Yan-Qin Zhou, Jun-Long Zhao, Min Hu

2016-02-03

BACKGROUND: Phosphoinositide-dependent protein kinase-1 (PDK-1), which functions downstream of phosphoinositide 3-kinase (AGE-1) a..

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Practical and low cost whole-organism motility assay: A step-by-step protocol

Sarah Preston, Abdul Jabbar, Cameron Nowell, Anja Joachim, Baerbel Ruttkowski, Tony Cardno, Andreas Hofmann, Robin B Gasser

2016-02-01

Here, we provide a step-by-step protocol for a practical and low cost whole-organism assay for the screening of chemical compounds..

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Harnessing the Toxocara Genome to Underpin Toxocariasis Research and New Interventions

Robin B Gasser, Pasi K Korhonen, Xing-Quan Zhux, Neil D Young

2016-01-01

Parasitic worms, such as flatworms (platyhelminths) and roundworms (nematodes), cause substantial morbidity and mortality in anima..