Prevention Of Multi-Drug Resistant Tuberculosis In A High Prevalence Setting: ‘Connecting The Dots’ In Vietnam
Grant number: 1081443 | Funding period: 2015 - 2019
The close contacts of people with multi-drug resistant tuberculosis (MDR-TB) have a high risk of developing the disease. The V-QUIN MDR-TB Trial will evaluate the effectiveness of an oral antibiotic (levofloxacin) in preventing drug resistant TB among infected household contacts of TB patients. Household contacts from 10 Provinces in Vietnam will be randomly allocated to receive six-months of either levofloxacin or a placebo, and then followed for two years to see if they develop tuberculosis.
Related publications (1)
Levofloxacin versus placebo for the treatment of latent tuberculosis among contacts of patients with multidrug-resistant tuberculosis (the VQUIN MDR trial): a protocol for a randomised controlled trial.
Greg J Fox, Cam Binh Nguyen, Thu Anh Nguyen, Phuong Thuy Tran, Ben J Marais, Steve M Graham, Binh Hoa Nguyen, Kavi Velen, David W Dowdy, Paul Mason, Warwick J Britton, Marcel A Behr, Andrea Benedetti, Dick Menzies, Viet Nhung Nguyen, Guy B Marks
INTRODUCTION: Treatment of latent tuberculosis infection (LTBI) plays a substantial role in the prevention of drug-susceptible tub..