PB1-F2 IS CRITICAL TO INFLUENZA A VIRUS PATHOGENICITY THROUGH ACTIVATION OF THE INFLAMMASOME
Grant number: 1079924 | Funding period: 2015 - 2018
Fatal Influenza A virus infections are excessive inflammation. We identified the IAV protein PB1-F2 as critical in driving excessive inflammation via activating the host inflammasome complex. Our study evaluates PB1-F2-mediated inflammation contribution to inflammatory responses. Identifying PB1-F2 in emerging IAV strains is invaluable in aiding health policy makers to quickly assess fatal IAV pandemics. Our research will potentially identify treatment targets towards reducing this inflammation
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