PB1-F2 IS CRITICAL TO INFLUENZA A VIRUS PATHOGENICITY THROUGH ACTIVATION OF THE INFLAMMASOME

Grant number: 1079924 | Funding period: 2015 - 2018

Completed

Abstract

Fatal Influenza A virus infections are excessive inflammation. We identified the IAV protein PB1-F2 as critical in driving excessive inflammation via activating the host inflammasome complex. Our study evaluates PB1-F2-mediated inflammation contribution to inflammatory responses. Identifying PB1-F2 in emerging IAV strains is invaluable in aiding health policy makers to quickly assess fatal IAV pandemics. Our research will potentially identify treatment targets towards reducing this inflammation

University of Melbourne Researchers