MECHANISMS UNDERLYING THE CONTRIBUTION OF UREMIC TOXINS TO CARDIORENAL SYNDROME

Grant number: 1087355 | Funding period: 2015 - 2017

Completed

Abstract

Cardiorenal syndrome (CRS) is an umbrella term that defines disorders of the heart and kidneys whereby “acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other”. We have demonstrated a significant association between heart and kidney fibrosis (scarring) and levels of a uremic toxin called indoxyl sulphate (IS), in relevant animal models and that blockade of production of this toxin reduces cardiac fibrosis. This project aims to explore this association.

Researchers