MECHANISMS UNDERLYING THE CONTRIBUTION OF UREMIC TOXINS TO CARDIORENAL SYNDROME

Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition

Feby Savira, Ruth Magaye, Carmen Scullino, Bernard L Flynn, Stuart M Pitson, Dovile Anderson, Darren J Creek, Yue Hua, Xin Xiong, Li Huang, Danny Liew, Christopher Reid, David Kaye, Andrew R Kompa, Bing Hui Wang

2021-07-24

Non-dialysable protein-bound uremic toxins (PBUTs) contribute to the development of cardiovascular disease (CVD) in chronic kidney..

Dihydrosphingosine driven enrichment of sphingolipids attenuates TGF beta induced collagen synthesis in cardiac fibroblasts

Ruth R Magaye, Feby Savira, Xin Xiong, Kevin Huynh, Peter J Meikle, Christopher Reid, Bernard L Flynn, David Kaye, Danny Liew, Bing H Wang

2021-07-06

The sphingolipid de novo synthesis pathway, encompassing the sphingolipids, the enzymes and the cell membrane receptors, are being..

Apoptosis signal-regulating kinase 1 inhibition reverses deleterious indoxyl sulfate-mediated endothelial effects

Feby Savira, Andrew R Kompa, Ruth Magaye, Xin Xiong, Li Huang, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang

2021-02-24

AIMS: Indoxyl sulfate (IS), a protein-bound uremic toxin, is implicated in endothelial dysfunction, which contributes to adverse c..

RE: Blockade of apoptosis signal-regulating kinase 1 ameliorates cardiac dysfunction in cardiorenal syndrome via enhancing angiogenesis

Feby Savira, Andrew R Kompa, Amanda J Edgley, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang

2021-02-08

RE: Inhibition of apoptosis signal-regulating kinase 1 might be a novel therapeutic target in the treatment of cardiorenal syndrome

Feby Savira, Amanda J Edgley, Beat M Jucker, Robert N Willette, Henry Krum, Darren J Kelly, Andrew R Kompa, Bing H Wang

2021-01-15

RE: ASK1, a new target in treating cardiorenal syndrome (CRS)

Feby Savira, Andrew R Kompa, Amanda J Edgley, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang

2020-10-01

Exogenous dihydrosphingosine 1 phosphate mediates collagen synthesis in cardiac fibroblasts through JAK/STAT signalling and regulation of TIMP1.

Ruth R Magaye, Feby Savira, Yue Hua, Xin Xiong, Li Huang, Christopher Reid, Bernard Flynn, David Kaye, Danny Liew, Bing H Wang

2020-08-01

Cardiac fibrosis and myocyte hypertrophy are hallmarks of the cardiac remodelling process in cardiomyopathies such as heart failur..

Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome

Feby Savira, Bing H Wang, Amanda J Edgley, Beat M Jucker, Robert N Willette, Henry Krum, Darren J Kelly, Andrew R Kompa

2020-07-01

BACKGROUND: Cardiorenal syndrome (CRS) is a major health burden worldwide in need of novel therapies, as current treatments remain..

Cardiorenal syndrome: Multi-organ dysfunction involving the heart, kidney and vasculature

Feby Savira, Ruth Magaye, Danny Liew, Christopher Reid, Darren J Kelly, Andrew R Kompa, S Jeson Sangaralingham, John C Burnett, David Kaye, Bing H Wang

2020-05-13

Cardiorenal syndrome (CRS) is a multi-organ disease, encompassing heart, kidney and vascular system dysfunction. CRS is a worldwid..

Molecular mechanisms of protein-bound uremic toxin-mediated cardiac, renal and vascular effects: underpinning intracellular targets for cardiorenal syndrome therapy

Feby Savira, Ruth Magaye, Yue Hua, Danny Liew, David Kaye, Tom Marwick, Bing Hui Wang

2019-06-15

Cardiorenal syndrome (CRS) remains a global health burden with a lack of definitive and effective treatment. Protein-bound uremic ..

Inhibition of Apoptosis Signal-Regulating Kinase 1 Attenuates Myocyte Hypertrophy and Fibroblast Collagen Synthesis

Wendi Yang, Bing Hui Wang, Ian Wang, Li Huang, Feby Savira, Andrew Kompa, Beat M Jucker, Robert N Willette, Darren Kelly, Henry Krum, Zhiliang Li, Qian Fu

2019-03-01

BACKGROUND: Cardiac remodelling is a dynamic process whereby structural and functional changes occur within the heart in response ..

The role of dihydrosphingolipids in disease

Ruth R Magaye, Feby Savira, Yue Hua, Darren J Kelly, Christopher Reid, Bernard Flynn, Danny Liew, Bing H Wang

2019-03-01

Dihydrosphingolipids refer to sphingolipids early in the biosynthetic pathway that do not contain a C4-trans-double bond in the sp..

The Challenges of Stem Cell Therapy in Myocardial Infarction and Heart Failure and the Potential Strategies to Improve the Outcomes

Bing Hui Wang, Danny Liew, Kevin W Huang, Li Huang, Wenjie Tang, Darren J Kelly, Christopher Reid, Zhongmin Liu

2018-12-01

<jats:p> Cardiovascular disease remains the single highest global cause of death and a significant financial burden on the healthc..

Cardiac fibrosis in the ageing heart: Contributors and mechanisms

Lu Lu, Jingbin Guo, Yue Hua, Kevin Huang, Ruth Magaye, Jake Cornell, Darren J Kelly, Christopher Reid, Danny Liew, Yingchun Zhou, Aihua Chen, Wei Xiao, Qiang Fu, Bing Hui Wang

2017-12-01

Cardiac fibrosis refers to an excessive deposition of extracellular matrix (ECM) in cardiac tissue. Fibrotic tissue is stiffer and..