TRANSLATING SCIENCE INTO BETTER POSTTRAUMATIC MENTAL HEALTH
Grant number: 1073041 | Funding period: 2015 - 2020
Trauma is responsible for a significant amount of mental health problems worldwide. Increasing disasters, violence, and war lead to much trauma in the communities. Unfortunately, most affected people do not receive much-needed care. This Program builds on discoveries from basic science to develop and evaluate clinical and population-based programs to address the range of posttraumatic mental health needs in both Australia and globally.
Related publications (94)
Subcortical contributions to salience network functioning during negative emotional processing.
Sevil Ince, Trevor Steward, Ben J Harrison, Alec J Jamieson, Christopher G Davey, James A Agathos, Bradford A Moffat, Rebecca K Glarin, Kim L Felmingham
Core regions of the salience network (SN), including the anterior insula (aINS) and dorsal anterior cingulate cortex (dACC), coord..
Changes in neural responses during affective and non-affective tasks and improvement of posttraumatic stress disorder symptoms following trauma-focused psychotherapy.
Mayuresh S Korgaonkar, Kim L Felmingham, Gin S Malhi, Thomas H Williamson, Leanne M Williams, Richard A Bryant
At least one-third posttraumatic stress disorder (PTSD) patients do not respond to trauma-focused psychotherapy (TF-psychotherapy)..
Association of Neural Connectome With Early Experiences of Abuse in Adults.
Mayuresh S Korgaonkar, Isabella A Breukelaar, Kim Felmingham, Leanne M Williams, Richard A Bryant
IMPORTANCE: More than 10% of children experience sexual, physical, or emotional abuse, and abuse experienced during sensitive neur..
Potential peripheral biomarkers associated with the emergence and presence of posttraumatic stress disorder symptomatology: A systematic review
Alyssa M Sbisa, Kelsey Madden, Catherine Toben, Alexander C McFarlane, Lisa Dell, Ellie Lawrence-Wood
BACKGROUND: Evidence suggests posttraumatic stress disorder (PTSD) involves an interplay between psychological manifestations and ..
A comparison of methods to harmonize cortical thickness measurements across scanners and sites.
Delin Sun, Gopalkumar Rakesh, Courtney C Haswell, Mark Logue, C Lexi Baird, Erin N O'Leary, Andrew S Cotton, Hong Xie, Marijo Tamburrino, Tian Chen, Emily L Dennis, Neda Jahanshad, Lauren E Salminen, Sophia I Thomopoulos, Faisal Rashid, Christopher RK Ching, Saskia BJ Koch, Jessie L Frijling, Laura Nawijn, Mirjam van Zuiden
Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific profiles in participants' demograph..
Sex differences in the effect of subjective sleep on fear conditioning, extinction learning, and extinction recall in individuals with a range of PTSD symptom severity
Maya T Schenker, Sevil Ince, Luke J Ney, Chia-Ming K Hsu, Daniel V Zuj, Amy S Jordan, Christian L Nicholas, Kim L Felmingham
Sleep has been found to play a key role in fear conditioning, extinction learning and extinction recall, and sleep disturbances ar..
A comparison of the functional connectome in mild traumatic brain injury and post-traumatic stress disorder
Aleksandra Klimova, Isabella A Breukelaar, Richard A Bryant, Mayuresh S Korgaonkar
Post-traumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) often co-occur in the context of threat to one's life..
Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium.
Delin Sun, Gopalkumar Rakesh, Emily K Clarke-Rubright, Courtney C Haswell, Mark W Logue, Erin N O'Leary, Andrew S Cotton, Hong Xie, Emily L Dennis, Neda Jahanshad, Lauren E Salminen, Sophia I Thomopoulos, Faisal M Rashid, Christopher RK Ching, Saskia BJ Koch, Jessie L Frijling, Laura Nawijn, Mirjam van Zuiden, Xi Zhu, Benjamin Suarez-Jimenez
BACKGROUND: Posttraumatic stress disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in ..
Characterisation of Deficits and Sex Differences in Verbal and Visual Memory/Learning in Bipolar Disorder
Andrea Gogos, Jinwon Son, Susan L Rossell, James Karantonis, Lisa S Furlong, Kim Felmingham, Tamsyn E Van Rheenen
OBJECTIVE: Cognitive impairment is consistently reported in bipolar disorder (BD), but few studies have characterised which memory..
Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume.
Yuanchao Zheng, Melanie E Garrett, Delin Sun, Emily K Clarke-Rubright, Courtney C Haswell, Adam X Maihofer, Jeremy A Elman, Carol E Franz, Michael J Lyons, William S Kremen, Matthew Peverill, Kelly Sambrook, Katie A McLaughlin, Nicholas D Davenport, Seth Disner, Scott R Sponheim, Elpiniki Andrew, Mayuresh Korgaonkar, Richard Bryant, Tim Varkevisser
The volume of subcortical structures represents a reliable, quantitative, and objective phenotype that captures genetic effects, e..
Residual posttraumatic stress disorder symptoms after provision of brief behavioral intervention in low- and middle-income countries: An individual-patient data meta-analysis
Aemal Akhtar, Phiona Koyiet, Atif Rahman, Alison Schafer, Syed Usman Hamdani, Pim Cuijpers, Marit Sijbrandij, Richard A Bryant
BACKGROUND: To address shortages of mental health specialists in low- and middle-income countries, task-shifting approaches have b..
Reappraisal-related neural predictors of treatment response to cognitive behavior therapy for post-traumatic stress disorder
Richard A Bryant, May Erlinger, Kim Felmingham, Aleksandra Klimova, Leanne M Williams, Gin Malhi, David Forbes, Mayuresh S Korgaonkar
BACKGROUND: Although trauma-focused cognitive behavior therapy (TF-CBT) is the frontline treatment for post-traumatic stress disor..
Two-year follow-up of trauma-focused cognitive behavior therapy for posttraumatic stress disorder in emergency service personnel: A randomized clinical trial
Richard A Bryant, Lucy Kenny, Natasha Rawson, Catherine Cahill, Amy Joscelyne, Benjamin Garber, Julia Tockar, Jenny Tran, Katie Dawson
BACKGROUND: Emergency service personnel experience elevated rates of posttraumatic stress disorder (PTSD). There are few controlle..
Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.
Emily L Dennis, Seth G Disner, Negar Fani, Lauren E Salminen, Mark Logue, Emily K Clarke, Courtney C Haswell, Christopher L Averill, Lee A Baugh, Jessica Bomyea, Steven E Bruce, Jiook Cha, Kyle Choi, Nicholas D Davenport, Maria Densmore, Stefan du Plessis, Gina L Forster, Jessie L Frijling, Atilla Gonenc, Staci Gruber
A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (P..
BDNF genotype Val66Met interacts with acute plasma BDNF levels to predict fear extinction and recall
Luke John Ney, Allison Matthews, Emma Nicholson, Daniel Zuj, Chia Ming Ken Hsu, Trevor Steward, Bronwyn Graham, Ben Harrison, David Nichols, Kim Felmingham
Brain-derived neurotropic factor (BDNF) is a potent regulator of memory processes and is believed to influence the consolidation o..
Cannabinoid polymorphisms interact with plasma endocannabinoid levels to predict fear extinction learning
Luke J Ney, Allison Matthews, Chia-Ming Ken Hsu, Daniel Zuj, Emma Nicholson, Trevor Steward, David Nichols, Bronwyn Graham, Ben Harrison, Raimondo Bruno, Kim Felmingham
BACKGROUND: The endocannabinoid system is gaining increasing attention as a favorable target for improving posttraumatic stress di..
Lower estradiol predicts increased reinstatement of fear in women
Kim L Felmingham, Julia M Caruana, Lisa N Miller, Luke J Ney, Daniel Zuj, Chia Ming K Hsu, Emma Nicholson, Annie To, Richard A Bryant
Low levels of estradiol in women have been associated with impaired fear extinction recall, with suggestions this may promote the ..
Investigating neural circuits of emotion regulation to distinguish euthymic patients with bipolar disorder and major depressive disorder.
Sabina Rai, Kristi Griffiths, Isabella A Breukelaar, Ana R Barreiros, Wenting Chen, Philip Boyce, Philip Hazell, Sheryl Foster, Gin S Malhi, Richard A Bryant, Anthony WF Harris, Mayuresh S Korgaonkar
BACKGROUND: Up to 40% of patients with bipolar disorder (BD) are initially diagnosed as having major depressive disorder (MDD), an..
Neural activity during response inhibition in mild traumatic brain injury and posttraumatic stress disorder.
Mayuresh S Korgaonkar, Thomas Williamson, Richard A Bryant
Mild traumatic brain injury (mTBI) is often characterized by deficits in response inhibition, which can contribute to marked socia..
The distinctive neural circuitry of complex posttraumatic stress disorder during threat processing
Richard A Bryant, Kim L Felmingham, Gin Malhi, Elpiniki Andrew, Mayuresh S Korgaonkar
BACKGROUND: There is controversy over the extent to which the new International Classification of Diseases (ICD-11) diagnosis of c..
Neural activity during response inhibition associated with improvement of dysphoric symptoms of PTSD after trauma-focused psychotherapy-an EEG-fMRI study
Richard A Bryant, Thomas Williamson, May Erlinger, Kim L Felmingham, Gin Malhi, Mark Hinton, Leanne Williams, Mayuresh S Korgaonkar
Although trauma-focused cognitive behavioural therapy (TF-CBT) is the frontline treatment for posttraumatic stress disorder (PTSD)..
Dopamine, endocannabinoids and their interaction in fear extinction and negative affect in PTSD
Luke J Ney, Jane Akhurst, Raimondo Bruno, Patrick AF Laing, Allison Matthews, Kim L Felmingham
There currently exist few frameworks for common neurobiology between reexperiencing and negative cognitions and mood symptoms of P..
The Effect of Self-Reported REM Behavior Disorder Symptomology on Intrusive Memories in Post-Traumatic Stress Disorder
Luke J Ney, Chia Ming K Hsu, Emma Nicholson, Daniel V Zuj, L Clark, Birgit Kleim, Kim L Felmingham
Background: PTSD is characterised by severe sleep disturbances, which is increasingly recognised to in many cases consist of simil..
The impact of posttraumatic stress disorder on event-related potentials in affective and non-affective paradigms: A systematic review with meta-analysis
Lisa N Miller, Julian G Simmons, Sarah Whittle, David Forbes, Kim Felmingham
Post-traumatic stress disorder (PTSD) is associated with neural processing deficits affecting early automatic and later conscious ..
Endocannabinoid reactivity to acute stress: Investigation of the relationship between salivary and plasma levels
Luke Ney, Caleb Stone, David Nichols, Kim Felmingham, Raimondo Bruno, Allison Matthews
The endogenous cannabinoid (eCB) system has been shown in animal models to regulate the initiation and termination of central nerv..
A Pilot Study of the Efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Treating Posttraumatic Psychopathology: A Randomized Controlled Trial
Meaghan L O'Donnell, Winnie Lau, Katherine Chisholm, James Agathos, Jonathon Little, Sonia Terhaag, Rachel Brand, Andrea Putica, Alexander CN Holmes, Lynda Katona, Kim L Felmingham, Kim Murray, Fardous Hosseiny, Matthew W Gallagher
The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) is an intervention that targets common mechanisms t..
White matter anisotropy and response to cognitive behavior therapy for posttraumatic stress disorder
Mayuresh S Korgaonkar, Kim L Felmingham, Aleksandra Klimova, May Erlinger, Leanne M Williams, Richard A Bryant
Trauma-focused cognitive behavior therapy (TF-CBT) is the gold standard treatment for posttraumatic stress disorder (PTSD), up to ..
Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis
Xin Wang, Hong Xie, Tian Chen, Andrew S Cotton, Lauren E Salminen, Mark W Logue, Emily K Clarke-Rubright, John Wall, Emily L Dennis, Brian M O'Leary, Chadi G Abdallah, Elpiniki Andrew, Lee A Baugh, Jessica Bomyea, Steven E Bruce, Richard Bryant, Kyle Choi, Judith K Daniels, Nicholas D Davenport, Richard J Davidson
Studies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple regions of the cerebral cortex. However, f..
Reproducibility of saliva progesterone measured by immunoassay compared to liquid chromatography mass spectrometry
Luke J Ney, Kim L Felmingham, David Nichols
Immunoassay overestimates progesterone in blood, but no studies have tested whether this occurs in saliva. We measured progesteron..
Brain-derived neurotropic factor and cortisol levels negatively predict working memory performance in healthy males
Luke Ney, Kim Felmingham, David S Nichols, Allison Matthews
There is now significant literature suggesting that increasing brain-derived neurotropic factor (BDNF) signalling may improve memo..
Prolonged grief in refugees, parenting behaviour and children's mental health
Richard A Bryant, Ben Edwards, Mark Creamer, Meaghan O'Donnell, David Forbes, Kim L Felmingham, Derrick Silove, Zachary Steel, Alexander C McFarlane, Miranda Van Hooff, Angela Nickerson, Dusan Hadzi-Pavlovic
BACKGROUND: Many refugees experience bereavement, and as a result they suffer elevated rates of prolonged grief disorder. Evidence..
Simultaneous quantification of endocannabinoids, oleoylethanolamide and steroid hormones in human plasma and saliva
Luke J Ney, Kim L Felmingham, Raimondo Bruno, Allison Matthews, David S Nichols
Endogenous cannabinoids are an increasingly intriguing target for biological research, given the changing legal status of medicina..
Intrinsic connectomes underlying response to trauma-focused psychotherapy in post-traumatic stress disorder
Mayuresh S Korgaonkar, Cassandra Chakouch, Isabella A Breukelaar, May Erlinger, Kim L Felmingham, David Forbes, Leanne M Williams, Richard A Bryant
Although trauma-focused cognitive behavior therapy (TF-CBT) is the frontline treatment for post-traumatic stress disorder (PTSD), ..
Inconsistent analytic strategies reduce robustness in fear extinction via skin conductance response
Luke John Ney, Patrick AF Laing, Trevor Steward, Daniel Zuj, Simon Dymond, Kim L Felmingham
Robustness of fear conditioning and extinction paradigms has become increasingly important for many researchers interested in impr..
Role of self-focussed reappraisal of negative emotion in emergence of emotional symptoms in adolescent girls
Gin S Malhi, Pritha Das, Tim Outhred, Richard A Bryant, Vince Calhoun
BACKGROUND: Adolescent subthreshold emotional symptoms arise from impaired self-referential information-processing and approach-av..
An Open Label Pilot Study of a Brief Psychosocial Intervention for Disaster and Trauma Survivors
Meaghan Louise O'Donnell, Winnie Lau, Julia Fredrickson, Kari Gibson, Richard Allan Bryant, Jonathan Bisson, Susie Burke, Walter Busuttil, Andrew Coghlan, Mark Creamer, Debbie Gray, Neil Greenberg, Brett McDermott, Alexander C McFarlane, Candice M Monson, Andrea Phelps, Josef I Ruzek, Paula P Schnurr, Janette Ugsang, Patricia Watson
BACKGROUND: In the aftermath of disaster, a large proportion of people will develop psychosocial difficulties that impair recovery..
Differential neural predictors of treatment response for fear and dysphoric features of posttraumatic stress disorder
Richard A Bryant, May Erlinger, Kim Felmingham, Gin S Malhi, Meaghan L O'Donnell, Leanne M Williams, Mayuresh S Korgaonkar
BACKGROUND: Although trauma-focused cognitive behavioral therapy (TF-CBT) is the frontline treatment for posttraumatic stress diso..
Interactions of OXTR rs53576 and emotional trauma on hippocampal volumes and perceived social support in adolescent girls.
Gin S Malhi, Pritha Das, Tim Outhred, Carol Dobson-Stone, Erica Bell, Danielle Gessler, Richard Bryant, Zola Mannie
Oxytocin (OXT) is a neuropeptide involved in social behaviour and is sensitive to environmental influences to alter individual vul..
Probability of major depression diagnostic classification based on the SCID, CIDI and MINI diagnostic interviews controlling for Hospital Anxiety and Depression Scale - Depression subscale scores: An individual participant data meta-analysis of 73 primary studies
Yin Wu, Brooke Levis, Ying Sun, Ankur Krishnan, Chen He, Kira E Riehm, Danielle B Rice, Marleine Azar, Xin Wei Yan, Dipika Neupane, Parash Mani Bhandari, Mahrukh Imran, Matthew J Chiovitti, Nazanin Saadat, Jill T Boruff, Pim Cuijpers, Simon Gilbody, Dean McMillan, John PA Ioannidis, Lorie A Kloda
OBJECTIVE: Two previous individual participant data meta-analyses (IPDMAs) found that different diagnostic interviews classify dif..
An alternative theory for hormone effects on sex differences in PTSD: The role of heightened sex hormones during trauma
Luke John Ney, Andrea Gogos, Chia-Ming Ken Hsu, Kim Louise Felmingham
Women are at least twice as susceptible to developing post-traumatic stress disorder (PTSD) compared to men. Although most researc..
Sex differences in schizophrenia, bipolar disorder, and post-traumatic stress disorder: Are gonadal hormones the link?
Andrea Gogos, Luke J Ney, Natasha Seymour, Tamsyn E Van Rheenen, Kim L Felmingham
In this review, we describe the sex differences in prevalence, onset, symptom profiles, and disease outcome that are evident in sc..
Identifying distinctive psychological symptom profiles among a nationally representative sample of refugees resettled in Australia
Angela Nickerson, Dusan Hadzi-Pavlovic, Ben Edwards, Meaghan O'Donnell, Mark Creamer, Kim L Felmingham, David Forbes, Alexander C McFarlane, Derrick Silove, Zachary Steel, Miranda van Hoof, Richard A Bryant
OBJECTIVE: The number of refugees worldwide is unprecedented in recent history. Little is known, however, about profiles of psycho..
Resting-state neural network disturbances that underpin the emergence of emotional symptoms in adolescent girls: resting-state fMRI study
Gin S Malhi, Pritha Das, Tim Outhred, Richard A Bryant, Vince Calhoun
BACKGROUND: Subsyndromal emotional symptoms in adolescence may represent precursors for full-blown emotional disorders in early ad..
Efficacy of exposure-based cognitive behaviour therapy for post-traumatic stress disorder in emergency service personnel: a randomised clinical trial
Richard A Bryant, Lucy Kenny, Natasha Rawson, Catherine Cahill, Amy Joscelyne, Benjamin Garber, Julia Tockar, Katie Dawson, Angela Nickerson
BACKGROUND: Although emergency service personnel experience markedly elevated the rates of post-traumatic stress disorder (PTSD), ..
Cognitive and emotional impairments underpinning suicidal activity in patients with mood disorders: an fMRI study
GS Malhi, P Das, T Outhred, D Gessler, J John Mann, R Bryant
OBJECTIVE: Mood disorders are strongly associated with suicide, the prevention of which is predicated on timely detection of suici..
The effects of childhood trauma on adolescent hippocampal subfields
Gin S Malhi, Pritha Das, Tim Outhred, Lauren Irwin, Danielle Gessler, Zina Bwabi, Richard Bryant, Zola Mannie
OBJECTIVE: Mood disorders are more common among girls and typically emerge during adolescence. The precise reasons for this are un..
Effect of stress gene-by-environment interactions on hippocampal volumes and cortisol secretion in adolescent girls
Gin S Malhi, Pritha Das, Tim Outhred, Carol Dobson-Stone, Lauren Irwin, Danielle Gessler, Richard Bryant, Zola Mannie
OBJECTIVE: Adolescence is a time of increased susceptibility to environmental stress and mood disorders, and girls are particularl..
Diffusion Tensor Imaging Analysis of Mild Traumatic Brain Injury and Posttraumatic Stress Disorder.
Aleksandra Klimova, Mayuresh S Korgaonkar, Thomas Whitford, Richard A Bryant
BACKGROUND: Debate exists over the extent to which dysfunctions arising from mild traumatic brain injury (mTBI) are distinct from ..
Sex differences in intrusive memories following trauma
Chia-Ming K Hsu, Birgit Kleim, Emma L Nicholson, Daniel Zuj, Pippa J Cushing, Kate E Gray, Latifa Clark, Kim L Felmingham
BACKGROUND: A key mechanism thought to underlie Posttraumatic Stress Disorder (PTSD) is enhanced emotional memory consolidation. R..
Revising Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria for the bipolar disorders: Phase I of the AREDOC project
Gordon Parker, Gabriela Tavella, Glenda Macqueen, Michael Berk, Heinz Grunze, Thilo Deckersbach, David L Dunner, Martha Sajatovic, Jay D Amsterdam, Terence A Ketter, Lakshmi N Yatham, Lars Vedel Kessing, Darryl Bassett, Mark Zimmerman, Kostas N Fountoulakis, Anne Duffy, Martin Alda, Cynthia Calkin, Verinder Sharma, Amit Anand
OBJECTIVE: To derive new criteria sets for defining manic and hypomanic episodes (and thus for defining the bipolar I and II disor..
Greater sleep disturbance and longer sleep onset latency facilitate SCR specific fear reinstatement in PTSD
Daniel V Zuj, Matthew A Palmer, Gin S Malhi, Richard A Bryant, Kim L Felmingham
Fear reinstatement is one of several paradigms designed to measure fear return following extinction, as a laboratory model for the..
Modulation of the endocannabinoid system by sex hormones: Implications for posttraumatic stress disorder
Luke John Ney, Allison Matthews, Raimondo Bruno, Kim Louise Felmingham
The endocannabinoid system is an increasingly recognised pharmacological target for treating stress and anxiety disorders, includi..
The role of site and severity of injury as predictors of mental health outcomes following traumatic injury
Katharine Baecher, Maria Kangas, Alan Taylor, Meaghan L O'Donnell, Richard A Bryant, Derrick Silove, Alexander C McFarlane, Darryl Wade
The aim of this study was to investigate the influence of injury site and severity as predictors of mental health outcomes in the ..
Adjustment of refugee children and adolescents in Australia: outcomes from wave three of the Building a New Life in Australia study
Winnie Lau, Derrick Silove, Ben Edwards, David Forbes, Richard Bryant, Alexander McFarlane, Dusan Hadzi-Pavlovic, Zachary Steel, Angela Nickerson, Miranda Van Hooff, Kim Felmingham, Sean Cowlishaw, Nathan Alkemade, Dzenana Kartal, Meaghan O'Donnell
BACKGROUND: High-income countries like Australia play a vital role in resettling refugees from around the world, half of whom are ..
The BDNF Val66Met polymorphism moderates the relationship between Posttraumatic Stress Disorder and fear extinction learning
Kim L Felmingham, Daniel V Zuj, Ken Chia Ming Hsu, Emma Nicholson, Matthew A Palmer, Kimberley Stuart, James C Vickers, Gin S Malhi, Richard A Bryant
The low expression Met allele of the BDNF Val66Met polymorphism is associated with impaired fear extinction in healthy controls, a..
The effect of post-traumatic stress disorder on refugees' parenting and their children's mental health: a cohort study
Richard A Bryant, Ben Edwards, Mark Creamer, Meaghan O'Donnell, David Forbes, Kim L Felmingham, Derrick Silove, Zachary Steel, Angela Nickerson, Alexander C McFarlane, Miranda Van Hooff, Dusan Hadzi-Pavlovic
BACKGROUND: Children and adolescents, who account for most of the world's refugees, have an increased prevalence of psychological ..
Development of prediction models of stress and long-term disability among claimants to injury compensation systems: a cohort study
Matthew J Spittal, Genevieve Grant, Meaghan O'Donnell, Alexander C McFarlane, David M Studdert
OBJECTIVES: We sought to develop prognostic risk scores for compensation-related stress and long-term disability using markers col..
Endogenous salivary alpha-amylase does not interact with skin conductance response during fear extinction in posttraumatic stress disorder
Daniel V Zuj, Matthew A Palmer, Gin S Malhi, Richard A Bryant, Kim L Felmingham
Posttraumatic Stress Disorder (PTSD) is associated with elevated noradrenergic signaling, which has an impact on emotional learnin..
An investigation of potential neural correlates of intrusive retrieval of distressing memories
Eva Battaglini, Belinda J Liddell, Pritha Das, Gin S Malhi, Kim Felmingham, Richard A Bryant
BACKGROUND AND OBJECTIVES: Despite the prevalence of intrusive memories across psychological disorders, little is known about the ..
Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia
Mark W Logue, Sanne JH van Rooij, Emily L Dennis, Sarah L Davis, Jasmeet P Hayes, Jennifer S Stevens, Maria Densmore, Courtney C Haswell, Jonathan Ipser, Saskia BJ Koch, Mayuresh Korgaonkar, Lauren AM Lebois, Matthew Peverill, Justin T Baker, Premika SW Boedhoe, Jessie L Frijling, Staci A Gruber, Ilan Harpaz-Rotem, Neda Jahanshad, Sheri Koopowitz
BACKGROUND: Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings hav..
Neural activity and emotional processing following military deployment: Effects of mild traumatic brain injury and posttraumatic stress disorder
Daniel V Zuj, Kim L Felmingham, Matthew A Palmer, Ellie Lawrence-Wood, Miranda Van Hooff, Andrew J Lawrence, Richard A Bryant, Alexander C McFarlane
Posttraumatic Stress Disorder (PTSD) and mild traumatic brain injury (mTBI) are common comorbidities during military deployment th..
Negative appraisals and fear extinction are independently related to PTSD symptoms
Daniel V Zuj, Matthew A Palmer, Kate E Gray, Chia-Ming K Hsu, Emma L Nicholson, Gin S Malhi, Richard A Bryant, Kim L Felmingham
BACKGROUND: Considerable research has revealed impaired fear extinction to be a significant predictor of PTSD. Fear extinction is ..
Separation from parents during childhood trauma predicts adult attachment security and post-traumatic stress disorder
RA Bryant, M Creamer, M O'Donnell, D Forbes, KL Felmingham, D Silove, G Malhi, M van Hoof, AC McFarlane, A Nickerson
BACKGROUND: Prolonged separation from parental support is a risk factor for psychopathology. This study assessed the impact of bri..
Women in the midluteal phase of the menstrual cycle have difficulty suppressing the processing of negative emotional stimuli: An event-related potential study
Bethany R Lusk, Andrea R Carr, Valerie A Ranson, Kim L Felmingham
Emotion regulation deficits have been implicated in anxiety and depressive disorders, and these internalising disorders are more p..
Endogenous cortisol reactivity moderates the relationship between fear inhibition to safety signals and posttraumatic stress disorder symptoms
Daniel V Zuj, Matthew A Palmer, Gin S Malhi, Richard A Bryant, Kim L Felmingham
OBJECTIVE: Posttraumatic stress symptoms (PTSS) are commonly associated with impairments in extinguishing fear to signals previous..
The contribution of gender-based violence and network trauma to gender differences in Post-Traumatic Stress Disorder
Derrick Silove, Jess R Baker, Mohammed Mohsin, Maree Teesson, Mark Creamer, Meaghan O'Donnell, David Forbes, Natacha Carragher, Tim Slade, Katherine Mills, Richard Bryant, Alexander McFarlane, Zachary Steel, Kim Felmingham, Susan Rees
BACKGROUND: Posttraumatic stress disorder (PTSD) occurs twice as commonly amongst women as men. Two common domains of trauma, netw..
Acute and Chronic Posttraumatic Stress Symptoms in the Emergendce of Posttraumatic Stress Disorder A Network Analysis
Richard A Bryant, Mark Creamer, Meaghan O'Donnell, David Forbes, Alexander C McFarlane, Derrick Silove, Dusan Hadzi-Pavlovic
IMPORTANCE: Little is understood about how the symptoms of posttraumatic stress develop over time into the syndrome of posttraumat..
Predictors of treatment response for cognitive behaviour therapy for prolonged grief disorder.
Richard A Bryant, Lucy Kenny, Amy Joscelyne, Natasha Rawson, Fiona Maccallum, Catherine Cahill, Sally Hopwood
Background: Prolonged grief disorder (PGD) causes significant impairment in approximately 7% of bereaved people. Although cognitiv..
A Longitudinal Study of Adjustment Disorder After Trauma Exposure
Meaghan L O'Donnell, Nathan Alkemade, Mark Creamer, Alexander C McFarlane, Derrick Sibve, Richard A Bryant, Kim Felmingham, Zachery Steel, David Forbes
OBJECTIVE: Adjustment disorder has been recategorized as a trauma- and stressor-related disorder in DSM-5. The aim of this study w..
IMPAIRED FEAR EXTINCTION ASSOCIATED WITH PTSD INCREASES WITH HOURS-SINCE-WAKING.
Daniel V Zuj, Matthew A Palmer, Chia-Ming K Hsu, Emma L Nicholson, Pippa J Cushing, Kate E Gray, Kim L Felmingham
BACKGROUND: Prior research has demonstrated that time-of-day may play an important role in the extinction of conditioned fear, wit..
Gender differences in salivary alpha-amylase and attentional bias towards negative facial expressions following acute stress induction.
Andrea Rose Carr, Alana Scully, Miriam Webb, Kim Louise Felmingham
This study investigated gender differences in two key processes involved in anxiety, arousal and attentional bias towards threat. ..
Early visual processing is enhanced in the midluteal phase of the menstrual cycle
Bethany R Lusk, Andrea R Carr, Valerie A Ranson, Richard A Bryant, Kim L Felmingham
Event-related potential (ERP) studies have revealed an early attentional bias in processing unpleasant emotional images in women. ..