Centre of Research Excellence for the Protection of Pancreatic Beta Cells

Grant number: 1078106 | Funding period: 2014 - 2019

Completed

Abstract

Type 1 diabetes (T1D) is an autoimmune disorder that results in the destruction of the pancreatic beta cells. The overall aim of the CRE is to elucidate the gene-environment interactions and modifiable environmental exposures that are driving the development of islet autoimmunity and progression to T1D. The CRE will unify and add value to new and established collaborations with multi-disciplinary input from genomics, bioinformatics and systems biology into the investigation of T1D.

Related publications (5)

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Cytotoxicity-Related Gene Expression and Chromatin Accessibility Define a Subset of CD4 T Cells That Mark Progression to Type 1 Diabetes

NG Bediaga, AL Garnham, G Naselli, E Bandala-Sanchez, NL Stone, J Cobb, JE Harbison, JM Wentworth, AG Ziegler, JJ Coupe, GK Smyth, LC Harrison

2022-03-01

Type 1 diabetes in children is heralded by a preclinical phase defined by circulating autoantibodies to pancreatic islet antigens...

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Women with type 1 diabetes exhibit a progressive increase in gut Saccharomyces cerevisiae in pregnancy associated with evidence of gut inflammation

E Bandala-Sanchez, AJ Roth-Schulze, H Oakey, MAS Penno, NG Bediaga, G Naselli, KM Ngui, AD Smith, D Huang, E Zozaya-Valdes, RL Thomson, JD Brown, PJ Vuillermin, SC Barry, ME Craig, WD Rawlinson, EA Davis, M Harris, G Soldatos, PG Colman

2022-02-01

Aims: Studies of the gut microbiome have focused on its bacterial composition. We aimed to characterize the gut fungal microbiome ..

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Type 1 diabetes in pregnancy is associated with distinct changes in the composition and function of the gut microbiome

AJ Roth-Schulze, MAS Penno, KM Ngui, H Oakey, E Bandala-Sanchez, AD Smith, TR Allnutt, RL Thomson, PJ Vuillermin, ME Craig, WD Rawlinson, EA Davis, M Harris, G Soldatos, PG Colman, JM Wentworth, A Haynes, SC Barry, RO Sinnott, G Morahan

2021-12-01

Background: The gut microbiome changes in response to a range of environmental conditions, life events and disease states. Pregnan..

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A type 1 diabetes genetic risk score predicts progression of islet autoimmunity and development of type 1 diabetes in individuals at risk

MJ Redondo, S Geyer, AK Steck, S Sharp, JM Wentworth, MN Weedon, P Antinozzi, J Sosenko, M Atkinson, A Pugliese, RA Oram

2018-09-01

OBJECTIVE: We tested the ability of a type 1 diabetes (T1D) genetic risk score (GRS) to predict progression of islet autoimmunity ..

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Interferon-gamma released from omental adipose tissue of insulin-resistant humans alters adipocyte phenotype and impairs response to insulin and adiponectin release

JM Wentworth, JG Zhang, E Bandala-Sanchez, G Naselli, R Liu, M Ritchie, GK Smyth, PE O'Brien, LC Harrison

2017-12-01

Background:Inflammatory factors derived from adipose tissue have been implicated in mediating insulin resistance in obesity. We so..

University of Melbourne Researchers