Non-Alzheimer’s Disease Degenerative Dementias: Identifying Prodromal Genetic/Familial Phenotypes Modifying Factors and Protein Variations Involved in Progression

Susceptibility to visual hallucinations in the amyotrophic lateral sclerosis-frontotemporal dementia spectrum: The role of dysfunctional attentional networks

NY Tse, IF Orlando, C O'Callaghan, NL Taylor, JM Shine, A Zalesky, S Tu, RM Ahmed, GM Halliday, O Piguet, JR Hodges, MC Kiernan, SJG Lewis, EM Devenney

2025-11-01

Psychotic symptoms are well established across the amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) spectrum and co..

MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study

RR Valentino, WJ Scotton, SF Roemer, T Lashley, MG Heckman, M Shoai, A Martinez-Carrasco, N Tamvaka, RL Walton, MC Baker, HL Macpherson, R Real, AI Soto-Beasley, K Mok, T Revesz, EA Christopher, M DeTure, WW Seeley, EB Lee, MP Frosch

2024-05-01

Background: Pick's disease is a rare and predominantly sporadic form of frontotemporal dementia that is classified as a primary ta..

Short tandem repeat expansions in sporadic amyotrophic lateral sclerosis and frontotemporal dementia

L Henden, LG Fearnley, N Grima, EP McCann, C Dobson-Stone, L Fitzpatrick, K Friend, L Hobson, SC Moi Fat, DB Rowe, S D Silva, JB Kwok, GM Halliday, MC Kiernan, S Mazumder, HC Timmins, M Zoing, R Pamphlett, L Adams, M Bahlo

2023-05-03

Pathogenic short tandem repeat (STR) expansions cause over 20 neurodegenerative diseases. To determine the contribution of STRs in..

The acute phase protein lactoferrin is a key feature of Alzheimer’s disease and predictor of Aβ burden through induction of APP amyloidogenic processing

A Tsatsanis, AN McCorkindale, BX Wong, E Patrick, TM Ryan, RW Evans, AI Bush, GT Sutherland, A Sivaprasadarao, B Guennewig, JA Duce

2021-10-01

Amyloidogenic processing of the amyloid precursor protein (APP) forms the amyloid-β peptide (Aβ) component of pathognomonic extrac..

Dementia in long-term Parkinson’s disease patients: a multicentre retrospective study

JYY Szeto, CC Walton, A Rizos, P Martinez-Martin, GM Halliday, SL Naismith, KR Chaudhuri, SJG Lewis

2020-12-01

While several studies have investigated the clinical progression of cognitive decline in Parkinson’s disease (PD) patients, there ..

CYLD is a causative gene for frontotemporal dementia - Amyotrophic lateral sclerosis

C Dobson-Stone, M Hallupp, H Shahheydari, AMG Ragagnin, Z Chatterton, F Carew-Jones, CE Shepherd, H Stefen, E Paric, T Fath, EM Thompson, P Blumbergs, CL Short, CD Field, PK Panegyres, J Hecker, G Nicholson, AD Shaw, JM Fullerton, AA Luty

2020-03-01

Frontotemporal dementia and amyotrophic lateral sclerosis are clinically and pathologically overlapping disorders with shared gene..

Evidence for subtypes of freezing of gait in Parkinson's disease

KA Ehgoetz Martens, JM Shine, CC Walton, MJ Georgiades, M Gilat, JM Hall, AJ Muller, JYY Szeto, SJG Lewis

2018-07-01

Background: The purpose of this study is to identify and characterize subtypes of freezing of gait by using a novel questionnaire ..

Alterations in white matter network topology contribute to freezing of gait in Parkinson’s disease

JM Hall, JM Shine, KA Ehgoetz Martens, M Gilat, KM Broadhouse, JYY Szeto, CC Walton, AA Moustafa, SJG Lewis

2018-06-01

Freezing of gait (FOG) is a common symptom in advanced Parkinson’s disease (PD). Despite current advances, the neural mechanisms u..

Predicting the onset of freezing of gait: A longitudinal study

KA Ehgoetz Martens, EL Lukasik, MJ Georgiades, M Gilat, JM Hall, CC Walton, SJG Lewis

2018-01-01

Background: Freezing of gait is a disabling symptom of Parkinson's disease that ultimately affects approximately 80% of patients, ..