Cardiac Resynchronisation Therapy and Av Node Ablation for Atrial Fibrillation in Heart Failure

Abstract

Heart failure (HF) and Atrial Fibrillation (AF) are both significant health issues that often coexist. Cardiac resynchronisation therapy (CRT) is a proven therapy for HF with ventricular dyssynchrony (uncoordinated contraction of the left ventricle). While CRT reduces symptoms and improves survival in normal rhythm, there are mixed reports in patients with AF. This prospective randomised multicentre study, will assess the role of AV node ablation to improve outcomes in CRT in AF.

Related publications (1)

Cardiac resynchronization therapy and AV node ablation in heart failure with reduced ejection fraction and atrial fibrillation: Rationale and design of the CAAN-AF trial

P Sanders, JP Ariyaratnam, A Puvrez, ME Middeldorp, SJ Nicholls, G Thomas, A Ganesan, V Paul, SP Thomas, WP Abhayaratna, MK Stiles, JM Kalman

2025-11-01

Background Cardiac resynchronization therapy (CRT) is an important treatment modality for patients with symptomatic heart failure ..