Combination Immune Checkpoint Blocker Inhibition to Eliminate HIV Latency

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4 T cells from ART-suppressed individuals

R Fromentin, S DaFonseca, CT Costiniuk, M El-Far, FA Procopio, FM Hecht, R Hoh, SG Deeks, DJ Hazuda, SR Lewin, JP Routy, RP Sékaly, N Chomont

2019-12-01

HIV persists in latently infected CD4⁺ T cells during antiretroviral therapy (ART). Immune checkpoint molecules, includ..

A gathering storm: HIV infection and nonalcoholic fatty liver disease in low and middle-income countries

N Kapoor, J Audsley, P Rupali, J Sasadeusz, TV Paul, N Thomas, SR Lewin

2019-06-01

Despite the decreasing total incidence of liver-related deaths, liver disease remains one of the major non-AIDS causes of morbidit..

HIV integration sites and implications for maintenance of the reservoir

J Symons, PU Cameron, SR Lewin

2018-03-01

Purpose of review To provide an overview of recent research of how HIV integration relates to productive and latent infection and ..

HIV cure research: print and online media reporting in Australia

Jennifer Power, Bianca Fileborn, Gary W Dowsett, Jayne Lucke, Graham Brown, Jeanne Ellard, Sharon R Lewin, Joseph D Tucker, Sean Slavin, Jeremy Sugarman, Sophie Hill

2017-10-01

OBJECTIVES: While still in its early stages, recent scientific research towards a cure for HIV has generated widespread media inte..

Impact of Allogeneic Hematopoietic Stem Cell Transplantation on the HIV Reservoir and Immune Response in 3 HIV-Infected Individuals

KK Koelsch, TA Rasmussen, WJ Hey-Nguyen, C Pearson, Y Xu, M Bailey, KH Marks, SC Sasson, MS Taylor, R Tantau, S Obeid, B Milner, O Morrissey, AN Pinto, K Suzuki, MP Busch, SM Keating, P Kaiser, S Yukl, JK Wong

2017-07-01

Background: Allogeneic hematopoietic stem cell transplantation (HSCT) can lead to significant changes to the HIV reservoir and HIV..

A randomized controlled trial of lisinopril to decrease lymphoid fibrosis in antiretroviral-treated, HIV-infected individuals

LR Cockerham, SA Yukl, K Harvill, M Somsouk, SK Joshi, E Sinclair, T Liegler, R Hoh, S Lyons, PW Hunt, A Rupert, I Sereti, DR Morcock, A Rhodes, C Emson, MK Hellerstein, JD Estes, S Lewin, SG Deeks, H Hatano

2017-01-01

Background: In HIV infection, lymphoid tissue is disrupted by fibrosis. Angiotensin converting enzyme inhibitors have anti-fibroti..

Cancer therapies in HIV cure research

TA Rasmussen, JL Anderson, F Wightman, SR Lewin

2017-01-01

Purpose of review: This article provides an overview of anticancer therapies in various stages of clinical development as potentia..