Engineering drug transportation behaviour in polymeric gel systems

Abstract

In collaboration with Seagull Technologies, this project aims to engineer, study and mathematically model ultrasound-assisted biomacromolecule transport behaviour within polymeric gel systems, which may be useful in new drug delivery methods. The intended outcome is a novel set of polymeric gel systems, which can reversibly bind a wide variety of drugs (small molecules, nucleic acid based drugs, proteins), in which drug release is triggered by an electric potential and drug transport is controlled by means of sonophoresis. The main advantage of drug delivery via sonophoresis is elimination of risks associated with injections such as infection and damage to local tissue, and elimination of pa..

Related publications (1)

Reduced administration frequency for the treatment of fungal keratitis: a sustained natamycin release from a micellar solution.

Yiyuan Guo, Fatemeh Karimi, Qiang Fu, Greg G Qiao, Hong Zhang

2020-02-03

Background: Natamycin is the only topical ophthalmic antifungal drug approved by the Food and Drug Administration (FDA) of the Uni..