Optimising haemodynamics in complex stented arteries

Grant number: LP150100233 | Funding period: 2016 - 2021

Completed

Abstract

This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as restenosis and thrombosis, ultimately resulting in negative outcomes. In this project, advanced research methods from fluid dynamics and optimisation and control will be used to potentially minimise these highly undesirable effects.

Related publications (6)

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A direct comparison of pulsatile and non-pulsatile rough-wall turbulent pipe flow

TO Jelly, RC Chin, SJ Illingworth, JP Monty, I Marusic, A Ooi

2020-07-25

Pulsatile rough-wall turbulent pipe flow is compared against its non-pulsatile counterpart using data obtained from direct numeric..

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Numerical Study of Incomplete Stent Apposition Caused by Deploying Undersized Stent in Arteries With Elliptical Cross Sections

Bo Jiang, Vikas Thondapu, Eric KW Poon, Peter Barlis, Andrew SH Ooi

2019-05-01

Incomplete stent apposition (ISA) is one of the causes leading to poststent complications, which can be found when an undersized o..

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Elevated Blood Viscosity and Microrecirculation Resulting From Coronary Stent Malapposition

Eric KW Poon, Vikas Thondapu, Umair Hayat, Peter Barlis, Chooi Yin Yap, Po-Hung Kuo, Qisen Wang, Jiawei Ma, Shuang J Zhu, Stephen Moore, Andrew SH Ooi

2018-05-01

One particular complexity of coronary artery is the natural tapering of the vessel with proximal segments having larger caliber an..

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Can difference in pulsatile waveform change patient’s outcomes?

EKW Poon, V Thondapu, P Barlis, ASH Ooi

2018-01-01

© 2018 Australasian Fluid Mechanics Society. All rights reserved. In this study, we aim to identify the importance in employing an..

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Quadruple decomposition of current-dominated pulsatile rough-wall turbulent pipe flow

TO Jelly, RC Chin, SJ Illingworth, JP Monty, I Marusic, ASH Ooi

2018-01-01

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Five-year follow-up of underexpanded and overexpanded bioresorbable scaffolds: self-correction and impact on shear stress

Ryo Torii, Erhan Tenekecioglu, Christos Bourantas, Eric Poon, Vikas Thondapu, Frank Gijsen, Yohei Sotomi, Yoshinobu Onuma, Peter Barlis, Andrew SH Ooi, Patrick W Serruys

2017-04-01