BREAST CANCER RISK AFTER DIAGNOSTIC GENE SEQUENCING (BRIDGES)

Grant number: 1101400 | Funding period: 2015 - 2021

Active

Abstract

In BRIDGES, we aim to build a knowledge base to better define individual breast cancer risk. We bring together, in a multidisciplinary team, data and expertise from clinical genetics, epidemiology, bioinformatics, statistics, and gene biology. Specifically, we will use state-of-the art DNA screening to evaluate all suspected breast cancer genes in a large sample of breast cancer cases and controls. We will then use in silico and in vitro functional analyses to evaluate the likely pathogenicity o