Understanding Self-Organizing Tissues

Grant number: DP130102939 | Funding period: 2015 - 2016

Completed

Abstract

This project will discover how an organ can form from a mixture of component cells by 'self-organisation'. Understanding of how this can occur, could potentially be applied to the bioengineering of organs from component cells.

Related publications (4)

Self-organisation after embryonic kidney dissociation is driven via selective adhesion of ureteric epithelial cells

JG Lefevre, HS Chiu, AN Combes, JM Vanslambrouck, A Ju, NA Hamilton, MH Little

2017-03-15

Human pluripotent stem cells, after directed differentiation in vitro, can spontaneously generate complex tissues via self-organis..

Understanding kidney morphogenesis to guide renal tissue regeneration

MH Little, AN Combes, M Takasato

2016-10-01

The treatment of renal failure has seen little change in the past 70 years. Patients with end-stage renal disease (ESRD) are treat..

Cell-cell interactions driving kidney morphogenesis

AN Combes, JA Davies, MH Little

2015-01-01

The mammalian kidney forms via cell-cell interactions between an epithelial outgrowth of the nephric duct and the surrounding neph..

The origin of the mammalian kidney: Implications for recreating the kidney in vitro

M Takasato, MH Little

2015-01-01

The mammalian kidney, the metanephros, is a mesodermal organ classically regarded as arising from the intermediate mesoderm (IM). ..

University of Melbourne Researchers

Little, MH