Genomic-Based Tools To Support The Control Of Urogenital Schistosomiasis And Hepatic Opisthorchiasis
Grant number: 1109829 | Funding period: 2016 - 2019
Over 100 million people are affected by parasitic flukes that promote malignant tumours. Parasite control depends on a single drug, making resistance an imminent threat. I will deliver new genomic tools to unravel the complex interactions between parasites and humans, and explore parasite population diversity on a continental scale. I will then prioritise a panel of anti-parasitic drug targets and vaccine candidates to deliver the next generation of interventions against parasitic diseases.
Related publications (7)
yy Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain
Sarah Preston, Pasi K Korhonen, Laurent Mouchiroud, Matteo Cornaglia, Sean L McGee, Neil D Young, Rohan A Davis, Simon Crawford, Cameron Nowell, Brendan RE Ansell, Gillian M Fisher, Katherine T Andrews, Bill CH Chang, Martin AM Gijs, Paul W Sternberg, Johan Auwerx, Jonathan Baell, Andreas Hofmann, Abdul Jabbar, Robin B Gasser
Genomics of worms, with an emphasis on Opisthorchis viverrini - opportunities for fundamental discovery and biomedical outcomes.
Robin B Gasser, Patrick Tan, Bin Tean Teh, Sopit Wongkham, Neil D Young
Neglected tropical diseases cause substantial morbidity and mortality in animals and people globally. Opisthorchiasis is one such ..
Oestrous cycle-dependent equine uterine immune response to induced infectious endometritis
CD Marth, SM Firestone, LY Glenton, GF Browning, ND Young, N Krekeler
© 2016 The Author(s). Infectious endometritis is a major cause of reduced pregnancy rates in horses. The objectives of this study ..
Comparative Transcriptomic Exploration Reveals Unique Molecular Adaptations of Neuropathogenic Trichobilharzia to Invade and Parasitize Its Avian Definitive Host
Roman Leontovyc, Neil D Young, Pasi K Korhonen, Ross S Hall, Patrick Tan, Libor Mikes, Martin Kasny, Petr Horak, Robin B Gasser