GENOMIC-BASED TOOLS TO SUPPORT THE CONTROL OF UROGENITAL SCHISTOSOMIASIS AND HEPATIC OPISTHORCHIASIS
Grant number: 1109829 | Funding period: 2016 - 2019
Over 100 million people are affected by parasitic flukes that promote malignant tumours. Parasite control depends on a single drug, making resistance an imminent threat. I will deliver new genomic tools to unravel the complex interactions between parasites and humans, and explore parasite population diversity on a continental scale. I will then prioritise a panel of anti-parasitic drug targets and vaccine candidates to deliver the next generation of interventions against parasitic diseases.
Related publications (9)
Comparative genome analysis indicates high evolutionary potential of pathogenicity genes in Colletotrichum tanaceti
Ruvini Lelwala, Pasi K Korhonen, Neil D Young, Jason B Scott, Peter K Ades, Robin B Gasser, Paul WJ Taylor
Colletotrichum tanaceti is an emerging foliar fungal pathogen of commercially grown pyrethrum (Tanacetum cinerariifolium). Despite..
Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity
Patpicha Arunsan, Wannaporn Ittiprasert, Michael J Smout, Christina J Cochran, Victoria H Mann, Sujittra Chaiyadet, Shannon E Karinshak, Banchob Sripa, Neil David Young, Javier Sotillo, Alex Loukas, Paul J Brindley, Thewarach Laha
Infection with the food-borne liver fluke Opisthorchis viverrini is the principal risk factor (IARC Working Group on the Evaluatio..
yy Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain
Sarah Preston, Pasi K Korhonen, Laurent Mouchiroud, Matteo Cornaglia, Sean L McGee, Neil D Young, Rohan A Davis, Simon Crawford, Cameron Nowell, Brendan RE Ansell, Gillian M Fisher, Katherine T Andrews, Bill CH Chang, Martin AM Gijs, Paul W Sternberg, Johan Auwerx, Jonathan Baell, Andreas Hofmann, Abdul Jabbar, Robin B Gasser
As a result of limited classes of anthelmintics and an over-reliance on chemical control, there is a great need to discover new co..
Genomics of worms, with an emphasis on Opisthorchis viverrini - opportunities for fundamental discovery and biomedical outcomes.
Robin B Gasser, Patrick Tan, Bin Tean Teh, Sopit Wongkham, Neil D Young
Neglected tropical diseases cause substantial morbidity and mortality in animals and people globally. Opisthorchiasis is one such ..
Oestrous cycle-dependent equine uterine immune response to induced infectious endometritis
CD Marth, SM Firestone, LY Glenton, GF Browning, ND Young, N Krekeler
© 2016 The Author(s). Infectious endometritis is a major cause of reduced pregnancy rates in horses. The objectives of this study ..
Pipeline for the identification and classification of ion channels in parasitic flatworms
Bahiyah Nor, Neil D Young, Pasi K Korhonen, Ross S Hall, Patrick Tan, Andrew Lonie, Robin B Gasser
BACKGROUND: Ion channels are well characterised in model organisms, principally because of the availability of functional genomic ..
Comparative Transcriptomic Exploration Reveals Unique Molecular Adaptations of Neuropathogenic Trichobilharzia to Invade and Parasitize Its Avian Definitive Host
Roman Leontovyc, Neil D Young, Pasi K Korhonen, Ross S Hall, Patrick Tan, Libor Mikes, Martin Kasny, Petr Horak, Robin B Gasser
To date, most molecular investigations of schistosomatids have focused principally on blood flukes (schistosomes) of humans. Despi..
Whole transcriptome profiling of adult and infective stages of the trematode Opisthorchis felineus
Mikhail Yu Pomaznoy, Maria D Logacheva, Neil D Young, Aleksey A Penin, Nikita I Ershov, Alexey V Katokhin, Viatcheslav A Mordvinov
Opisthorchis felineus, the trematode belonging to the family Opisthorchiidae, is a causative agent of the infection called opistho..