Genomic-Based Tools To Support The Control Of Urogenital Schistosomiasis And Hepatic Opisthorchiasis

Grant number: 1109829 | Funding period: 2016 - 2019

Completed

Abstract

Over 100 million people are affected by parasitic flukes that promote malignant tumours. Parasite control depends on a single drug, making resistance an imminent threat. I will deliver new genomic tools to unravel the complex interactions between parasites and humans, and explore parasite population diversity on a continental scale. I will then prioritise a panel of anti-parasitic drug targets and vaccine candidates to deliver the next generation of interventions against parasitic diseases.

Related publications (7)

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yy Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

Sarah Preston, Pasi K Korhonen, Laurent Mouchiroud, Matteo Cornaglia, Sean L McGee, Neil D Young, Rohan A Davis, Simon Crawford, Cameron Nowell, Brendan RE Ansell, Gillian M Fisher, Katherine T Andrews, Bill CH Chang, Martin AM Gijs, Paul W Sternberg, Johan Auwerx, Jonathan Baell, Andreas Hofmann, Abdul Jabbar, Robin B Gasser

2017-10-01

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Genomics of worms, with an emphasis on Opisthorchis viverrini - opportunities for fundamental discovery and biomedical outcomes.

Robin B Gasser, Patrick Tan, Bin Tean Teh, Sopit Wongkham, Neil D Young

2017-08-01

Neglected tropical diseases cause substantial morbidity and mortality in animals and people globally. Opisthorchiasis is one such ..

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Oestrous cycle-dependent equine uterine immune response to induced infectious endometritis

CD Marth, SM Firestone, LY Glenton, GF Browning, ND Young, N Krekeler

2016-11-08

© 2016 The Author(s). Infectious endometritis is a major cause of reduced pregnancy rates in horses. The objectives of this study ..

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Making sense of genomes of parasitic worms: Tackling bioinformatic challenges

Pasi K Korhonen, Neil D Young, Robin B Gasser

2016-09-01

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Pipeline for the identification and classification of ion channels in parasitic flatworms

Bahiyah Nor, Neil D Young, Pasi K Korhonen, Ross S Hall, Patrick Tan, Andrew Lonie, Robin B Gasser

2016-03-16

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Comparative Transcriptomic Exploration Reveals Unique Molecular Adaptations of Neuropathogenic Trichobilharzia to Invade and Parasitize Its Avian Definitive Host

Roman Leontovyc, Neil D Young, Pasi K Korhonen, Ross S Hall, Patrick Tan, Libor Mikes, Martin Kasny, Petr Horak, Robin B Gasser

2016-02-01

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Whole transcriptome profiling of adult and infective stages of the trematode Opisthorchis felineus

Mikhail Yu Pomaznoy, Maria D Logacheva, Neil D Young, Aleksey A Penin, Nikita I Ershov, Alexey V Katokhin, Viatcheslav A Mordvinov

2016-02-01

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