UNDERSTANDING THE ROLE OF SEX HORMONES IN MENTAL ILLNESS
Grant number: 1108098 | Funding period: 2016 - 2016
Evidence suggests that the female hormone, estrogen, protects against schizophrenia, although the exact mechanism of action underlying this effect is unclear. We believe that by measuring estrogen-induced changes in the levels of genes in the brain, we will identify the way that estrogens protect against the symptoms of schizophrenia and improve antipsychotic treatment response.
Related publications (10)
Long-term effects of young-adult methamphetamine on dorsal raphe serotonin systems in mice: Role of brain-derived neurotrophic factor
Mauricio Sepulveda, Elizabeth E Manning, Andrea Gogos, Matthew Hale, Maarten van den Buuse
To assess the long-term effects of chronic adolescent methamphetamine (METH) treatment on the serotonin system in the brain, we us..
The impact of ovariectomy and chronic estrogen treatment on gene expression in the rat cortex: Implications for psychiatric disorders
Brian Dean, Andrea Gogos
Estrogens, via estrogen-mediated changes in CNS function, have been suggested to be beneficial in the treatment of several psychia..
Cortical expression of the RAPGEF1 gene in schizophrenia: investigating regional differences and suicide
Andrea Gogos, Jeehae Sun, Madhara Udawela, Andrew Gibbons, Maarten van den Buuse, Elizabeth Scarr, Brian Dean
Rap guanine nucleotide exchange factor 1 (RAPGEF1) is involved in cell adhesion and neuronal migration. Previously we found lower ..
Impact of hypoxia-ischemia and dopamine treatment on dopamine receptor binding density in the preterm fetal sheep brain
FY Wong, A Gogos, N Hale, SA Ingelse, N Brew, KL Shepherd, M van den Buuse, DW Walker
Dopamine is often used to treat hypotension in preterm infants who are at risk of hypoxic-ischemic (HI) brain injury due to cerebr..
The effect of 17 beta-estradiol on maternal immune activation-induced changes in prepulse inhibition and dopamine receptor and transporter binding in female rats
Alyssa Sbisa, Snezana Kusljic, Damon Zethoven, Maarten van den Buuse, Andrea Gogos
Maternal immune activation (MIA) during pregnancy is associated with an increased risk of development of schizophrenia in later li..
Sex differences in schizophrenia, bipolar disorder, and post-traumatic stress disorder: Are gonadal hormones the link?
Andrea Gogos, Luke J Ney, Natasha Seymour, Tamsyn E Van Rheenen, Kim L Felmingham
In this review, we describe the sex differences in prevalence, onset, symptom profiles, and disease outcome that are evident in sc..
Differential effects of chronic 17 beta-oestradiol treatment on rat behaviours relevant to depression
Andrea Gogos, Madeleine McCarthy, Adam J Walker, Madhara Udawela, Andrew Gibbons, Brian Dean, Snezana Kusljic
Sex differences are a prominent feature of the pathophysiology of psychiatric disorders, such as major depressive disorder, which ..
Progesterone: The neglected hormone in schizophrenia? A focus on progesterone-dopamine interactions
Jeehae Sun, Adam J Walker, Brian Dean, Maarten van den Buuse, Andrea Gogos
Sex differences appear to be an important factor in schizophrenia. Women with schizophrenia tend to exhibit less disease impairmen..