TARGETING THE CANONICAL WNT SIGNALLING PATHWAY TO PROMOTE CENTRAL NERVOUS SYSTEM REMYELINATION IN VIVO

Grant number: 1111041 | Funding period: 2016 - 2019

Completed

Abstract

Multiple Sclerosis (MS) occurs when immune cells attack the sheaths, called myelin, that cover and protect nerve connections. If myelin is damaged nerve cells cannot function properly, leading to severe disability. The brain has a group of cells that could potentially replace damaged myelin, but as MS worsens these cells are blocked in a state where they cannot help in repair. I will remove a signal specifically from these cells and determine if this unblocks them resulting myelin repair.

University of Melbourne Researchers