INTEGRATION OF BIOSTATISTICS AND MATHEMATICAL MODELLING TO IMPROVE THE CONTROL OF INFECTIOUS DISEASES
Grant number: 1104975 | Funding period: 2016 - 2020
Improving the control of infectious diseases requires the evaluation of interventions that prevent disease at the population level and successfully treat infections at the individual level. This proposal brings together advanced biostatistical research with mathematical modelling to discover novel methods for evaluating antimalarial treatments and malaria vaccine candidates, leading to new insights in infectious disease control and building capacity in this emerging cross-disciplinary field.
Related publications (79)
Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis
Prabin Dahal, Julie Anne Simpson, Salim Abdulla, Jane Achan, Ishag Adam, Aarti Agarwal, Richard Allan, Anupkumar R Anvikar, Elizabeth A Ashley, Quique Bassat, Steffen Borrmann, Teun Bousema, Hasifa Bukirwa, Verena Carrara, Marco Corsi, Umberto D'Alessandro, Timothy ME Davis, Philippe Deloron, Meghna Desai, Pedro Rafael Dimbu
BACKGROUND: The duration of trial follow-up affects the ability to detect recrudescent infections following anti-malarial treatmen..
HPV self-sampling and follow-up over two rounds of cervical screening in Australia - the iPap trial
Farhana Sultana, Dorota M Gertig, Dallas R English, Julie A Simpson, Kelly T Drennan, C David Wrede, Robyn M Mullins, Stella Heley, Marion Saville, Julia ML Brotherton
OBJECTIVES: Previously, based on 6 months of follow-up, we showed that HPV self-sampling improved participation in cervical screen..
Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data
Rashid Mansoor, Robert J Commons, Nicholas M Douglas, Benjamin Abuaku, Jane Achan, Ishag Adam, George O Adjei, Martin Adjuik, Bereket H Alemayehu, Richard Allan, Elizabeth N Allen, Anupkumar R Anvikar, Emmanuel Arinaitwe, Elizabeth A Ashley, Hazel Ashurst, Puji BS Asih, Nathan Bakyaita, Hubert Barennes, Karen Barnes, Leonardo Basco
BACKGROUND: Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug fa..
Supervised versus unsupervised primaquine radical cure for the treatment of falciparum and vivax malaria in Papua, Indonesia: a cluster-randomised, controlled, open-label superiority trial
Jeanne Rini Poespoprodjo, Faustina Helena Burdam, Freis Candrawati, Benedikt Ley, Niamh Meagher, Enny Kenangalem, Ratni Indrawanti, Leily Trianty, Kamala Thriemer, David J Price, Julie A Simpson, Ric N Price
BACKGROUND: There is a high risk of Plasmodium vivax recurrence in patients treated for Plasmodium falciparum malaria in co-endemi..
Child linear growth trajectories during the first three years of life in relation to infant iron status: a prospective cohort study in rural Vietnam
Sarah Hanieh, Sabine Braat, Thach D Tran, Tran T Ha, Julie A Simpson, Tran Tuan, Jane Fisher, Beverley-Ann Biggs
BACKGROUND: Early childhood growth patterns have long-term consequences for health and disease. Little is known about the interpla..
Adiposity and breast, endometrial, and colorectal cancer risk in postmenopausal women: Quantification of the mediating effects of leptin, C-reactive protein, fasting insulin, and estradiol
S Ghazaleh Dashti, Julie A Simpson, Vivian Viallon, Amalia Karahalios, Margarita Moreno-Betancur, Theodore Brasky, Kathy Pan, Thomas E Rohan, Aladdin H Shadyab, Cynthia A Thomson, Robert A Wild, Sylvia Wassertheil-Smoller, Gloria YF Ho, Howard D Strickler, Dallas R English, Marc J Gunter
BACKGROUND: Mechanisms underlying the adiposity-cancer relationship are incompletely understood. We quantified the mediating roles..
Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malaria
Elizabeth H Aitken, Timon Damelang, Amaya Ortega-Pajares, Agersew Alemu, Wina Hasang, Saber Dini, Holger W Unger, Maria Ome-Kaius, Morten A Nielsen, Ali Salanti, Joe Smith, Stephen Kent, P Mark Hogarth, Bruce D Wines, Julie A Simpson, Amy Chung, Stephen J Rogerson
BACKGROUND: Plasmodium falciparum causes placental malaria, which results in adverse outcomes for mother and child. P. falciparum-..
Bactericidal activities and post-antibiotic effects of ofloxacin and ceftriaxone against drug-resistant Salmonella enterica serovar Typhi
John Wain, Julie A Simpson, Thi Diem Nga Luong, Song Diep To, Thanh Duy Pham, Stephen Baker, Nicholas PJ Day, Nicholas J White, Christopher M Parry
BACKGROUND: The clinical response to ceftriaxone in patients with typhoid fever is significantly slower than with ofloxacin, despi..
Development and Validation of an In Silico Decision Tool To Guide Optimization of Intravenous Artesunate Dosing Regimens for Severe Falciparum Malaria Patients
Sophie G Zaloumis, Jason M Whyte, Joel Tarning, Sanjeev Krishna, James M McCaw, Pengxing Cao, Michael T White, Saber Dini, Freya J Fowkes, Richard J Maude, Peter Kremsner, Arjen Dondorp, Ric N Price, Nicholas J White, Julie A Simpson
Most deaths from severe falciparum malaria occur within 24 h of presentation to a hospital. Intravenous (i.v.) artesunate is the f..
Global economic costs due to vivax malaria and the potential impact of its radical cure: A modelling study
Angela Devine, Katherine E Battle, Niamh Meagher, Rosalind E Howes, Saber Dini, Peter W Gething, Julie A Simpson, Ric N Price, Yoel Lubell
BACKGROUND: In 2017, an estimated 14 million cases of Plasmodium vivax malaria were reported from Asia, Central and South America,..
Community-based molecular and serological surveillance of subclinical malaria in Myanmar
Katherine O'Flaherty, Win Han Oo, Sophie G Zaloumis, Julia C Cutts, Kyaw Zayar Aung, Myat Mon Thein, Damien R Drew, Zahra Razook, Alyssa E Barry, Naanki Parischa, Nyi Nyi Zaw, Htin Kyaw Thu, Aung Thi, Wai Yan Min Htay, Aung Paing Soe, Julie A Simpson, James G Beeson, Paul A Agius, Freya JI Fowkes
BACKGROUND: In the Greater Mekong Subregion (GMS), current malaria surveillance strategies rely on a network of village health vol..
Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance
Lydia Burgert, Sophie Zaloumis, Saber Dini, Louise Marquart, Pengxing Cao, Mohammed Cherkaoui, Nathalie Gobeau, James McCarthy, Julie A Simpson, Jorg J Mohrle, Melissa A Penny
Ensuring continued success against malaria depends on a pipeline of new antimalarials. Antimalarial drug development utilizes prec..
A scoping review of studies using observational data to optimise dynamic treatment regimens
Robert K Mahar, Myra B McGuinness, Bibhas Chakraborty, John B Carlin, Maarten J IJzerman, Julie A Simpson
BACKGROUND: Dynamic treatment regimens (DTRs) formalise the multi-stage and dynamic decision problems that clinicians often face w..
Multiple imputation methods for handling missing values in longitudinal studies with sampling weights: Comparison of methods implemented in Stata
Anurika P De Silva, Alysha M De Livera, Katherine J Lee, Margarita Moreno-Betancur, Julie A Simpson
Many analyses of longitudinal cohorts require incorporating sampling weights to account for unequal sampling probabilities of part..
Adiposity and Endometrial Cancer Risk in Postmenopausal Women: A Sequential Causal Mediation Analysis
S Ghazaleh Dashti, Dallas R English, Julie A Simpson, Amalia Karahalios, Margarita Moreno-Betancur, Carine Biessy, Sabina Rinaldi, Pietro Ferrari, Anne Tjonneland, Jytte Halkjaer, Christina C Dahm, Helene Tilma Vistisen, Florence Menegaux, Vittorio Perduca, Gianluca Severi, Krasimira Aleksandrova, Matthias B Schulze, Giovanna Masala, Sabina Sieri, Rosario Tumino
BACKGROUND: Adiposity increases endometrial cancer risk, possibly through inflammation, hyperinsulinemia, and increasing estrogens..
The risk of adverse clinical outcomes following treatment of Plasmodium vivax malaria with and without primaquine in Papua, Indonesia
Kamala Thriemer, Jeanne-Rini Poespoprodjo, Enny Kenangalem, Nicholas M Douglas, Paulus Sugiarto, Nicholas M Anstey, Julie Anne Simpson, Ric N Price
The widespread use of primaquine (PQ) radical cure for P. vivax, is constrained by concerns over its safety. We used routinely col..
Estimating the Proportion of Plasmodium vivax Recurrences Caused by Relapse: A Systematic Review and Meta-Analysis
Robert J Commons, Julie A Simpson, James Watson, Nicholas J White, Ric N Price
Plasmodium vivax and Plasmodium ovale form dormant liver hypnozoites that can reactivate weeks to months following initial infecti..
Evaluation of the effectiveness of topical repellent distributed by village health volunteer networks against Plasmodium spp. infection in Myanmar: A stepped-wedge cluster randomised trial
Paul A Agius, Julia C Cutts, Win Han Oo, Aung Thi, Katherine O'Flaherty, Kyaw Zayar Aung, Htin Kyaw Thu, Poe Poe Aung, Myat Mon Thein, Nyi Nyi Zaw, Wai Yan Min Htay, Aung Paing Soe, Zahra Razook, Alyssa E Barry, Win Htike, Angela Devine, Julie A Simpson, Brendan S Crabb, James G Beeson, Naanki Pasricha
BACKGROUND: The World Health Organization has yet to endorse deployment of topical repellents for malaria prevention as part of pu..
Identifying and combating the impacts of COVID-19 on malaria
Stephen J Rogerson, James G Beeson, Moses Laman, Jeanne Rini Poespoprodjo, Timothy William, Julie A Simpson, Ric N Price
BACKGROUND: The COVID-19 pandemic has resulted in millions of infections, hundreds of thousands of deaths and major societal disru..
Population Pharmacokinetics and Pharmacodynamics of Chloroquine in aPlasmodium vivaxVolunteer Infection Study
Azrin N Abd-Rahman, Louise Marquart, Nathalie Gobeau, Anne Kummel, Julie A Simpson, Stephan Chalon, Jorg J Mohrle, James S McCarthy
Chloroquine has been used for the treatment of malaria for > 70 years; however, chloroquine pharmacokinetic (PK) and pharmacodynam..
Explaining the link between adiposity and colorectal cancer risk in men and postmenopausal women in the UK Biobank: A sequential causal mediation analysis
S Ghazaleh Dashti, Vivian Viallon, Julie A Simpson, Amalia Karahalios, Margarita Moreno-Betancur, Dallas R English, Marc J Gunter, Neil Murphy
Mechanisms underlying adiposity-colorectal cancer (CRC) association are incompletely understood. Using UK Biobank data, we investi..
Adiposity and estrogen receptor-positive, postmenopausal breast cancer risk: Quantification of the mediating effects of fasting insulin and free estradiol
S Ghazaleh Dashti, Julie A Simpson, Amalia Karahalios, Vivian Viallon, Margarita Moreno-Betancur, Lyle C Gurrin, Robert J MacInnis, Brigid M Lynch, Laura Baglietto, Howard A Morris, Marc J Gunter, Pietro Ferrari, Roger L Milne, Graham G Giles, Dallas R English
Adiposity increases estrogen receptor (ER)-positive postmenopausal breast cancer risk. While mechanisms underlying this relationsh..
The cumulative effect of living with disability on mental health in working-age adults: an analysis using marginal structural models
Amalia Karahalios, Frank Pega, Zoe Aitken, Allison Milner, Julie A Simpson, Anne M Kavanagh
PURPOSE: Previous studies have shown that acquiring a disability is associated with a reduction in mental health, but they have no..
The risk of morbidity and mortality following recurrent malaria in Papua, Indonesia: a retrospective cohort study
Saber Dini, Nicholas M Douglas, Jeanne Rini Poespoprodjo, Enny Kenangalem, Paulus Sugiarto, Ian D Plumb, Ric N Price, Julie A Simpson
BACKGROUND: An acute episode of malaria can be followed by multiple recurrent episodes either due to re-infection, recrudescence o..
Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review
Julia C Cutts, Paul A Agius, Lin Zaw, Rosanna Powell, Kerryn Moore, Bridget Draper, Julie A Simpson, Freya JI Fowkes
BACKGROUND: In endemic areas, pregnant women are highly susceptible to Plasmodium falciparum malaria characterized by the accumula..
Multiple imputation methods for handling incomplete longitudinal and clustered data where the target analysis is a linear mixed effects model
Md Hamidul Huque, Margarita Moreno-Betancur, Matteo Quartagno, Julie A Simpson, John B Carlin, Katherine J Lee
Multiple imputation (MI) is increasingly popular for handling multivariate missing data. Two general approaches are available in s..
The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network
Mohammad S Hossain, Robert J Commons, Nicholas M Douglas, Kamala Thriemer, Bereket H Alemayehu, Chanaki Amaratunga, Anupkumar R Anvikar, Elizabeth A Ashley, Puji BS Asih, Verena I Carrara, Chanthap Lon, Umberto D'Alessandro, Timothy ME Davis, Arjen M Dondorp, Michael D Edstein, Rick M Fairhurst, Marcelo U Ferreira, Jimee Hwang, Bart Janssens, Harin Karunajeewa
BACKGROUND: There is a high risk of Plasmodium vivax parasitaemia following treatment of falciparum malaria. Our study aimed to qu..
Sustained adherence to a Mediterranean diet and physical activity on all-cause mortality in the Melbourne Collaborative Cohort Study: application of the g-formula
Elizabeth J Williamson, Julia Polak, Julie A Simpson, Graham G Giles, Dallas R English, Allison Hodge, Lyle Gurrin, Andrew B Forbes
BACKGROUND: Adherence to a traditional Mediterranean diet has been associated with lower mortality and cardiovascular disease risk..
A comparison of methods to estimate the survivor average causal effect in the presence of missing data: a simulation study
Myra B McGuinness, Jessica Kasza, Amalia Karahalios, Robyn H Guymer, Robert P Finger, Julie A Simpson
BACKGROUND: Attrition due to death and non-attendance are common sources of bias in studies of age-related diseases. A simulation ..
Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting
Prabin Dahal, Kasia Stepniewska, Philippe J Guerin, Umberto D'Alessandro, Ric N Price, Julie A Simpson
BACKGROUND: Antimalarial clinical efficacy studies for uncomplicated Plasmodium falciparum malaria frequently encounter situations..
The Stunting Tool for Early Prevention: development and external validation of a novel tool to predict risk of stunting in children at 3 years of age
Sarah Hanieh, Sabine Braat, Julie A Simpson, Thi Thu Ha Tran, Thach D Tran, Tuan Tran, Jane Fisher, Beverley-Ann Biggs
INTRODUCTION: Globally, an estimated 151 million children under 5 years of age still suffer from the adverse effects of stunting. ..
Early and late mortality after malaria in young children in Papua, Indonesia
Dewi Patriani, Eggi Arguni, Enny Kenangalem, Saber Dini, Paulus Sugiarto, Afdhal Hasanuddin, Daniel Adrian Lampah, Nicholas M Douglas, Nicholas M Anstey, Julie Anne Simpson, Ric N Price, Jeanne Rini Poespoprodjo
BACKGROUND: In southern Papua, Indonesia, malaria is highly prevalent in young children and is a significant cause of morbidity an..
Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection
Pengxing Cao, Katharine A Collins, Sophie Zaloumis, Thanaporn Wattanakul, Joel Tarning, Julie A Simpson, James McCarthy, James M McCaw
Renewed efforts to eliminate malaria have highlighted the potential to interrupt human-to-mosquito transmission - a process mediat..
Does the effect of disability acquisition on mental health differ by employment characteristics? A longitudinal fixed-effects analysis
Zoe Aitken, Julie Anne Simpson, Rebecca Bentley, Allison Milner, Anthony Daniel LaMontagne, Anne Marie Kavanagh
PURPOSE: Longitudinal studies have suggested a causal relationship between disability acquisition and mental health, but there is ..
Contribution of Functional Antimalarial Immunity to Measures of Parasite Clearance in Therapeutic Efficacy Studies of Artemisinin Derivatives
Katherine O'Flaherty, Ricardo Ataide, Sophie G Zaloumis, Elizabeth A Ashley, Rosanna Powell, Gaoqian Feng, Linda Reiling, Arjen M Dondorp, Nicholas P Day, Mehul Dhorda, Rick M Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tinh Hien Tran, Ye Htut, Mayfong Mayxay, M Abul Faiz, James G Beeson, Francois Nosten
BACKGROUND: Antibodies to the blood stages of malaria parasites enhance parasite clearance and antimalarial efficacy. The antibody..
The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: A systematic review and individual patient data meta-analysis
Robert J Commons, Julie A Simpson, Kamala Thriemer, Tesfay Abreha, Ishag Adam, Nicholas M Anstey, Ashenafi Assefa, Ghulam R Awab, J Kevin Baird, Bridget E Barber, Cindy S Chu, Prabin Dahal, Andre Daher, Timothy ME Davis, Arjen M Dondorp, Matthew J Grigg, Georgina S Humphreys, Jimee Hwang, Harin Karunajeewa, Moses Laman
BACKGROUND: Artemisinin-based combination therapy (ACT) is recommended for uncomplicated Plasmodium vivax malaria in areas of emer..
The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
Robert J Commons, Julie A Simpson, Kamala Thriemer, Cindy S Chu, Nicholas M Douglas, Tesfay Abreha, Sisay G Alemu, Arletta Anez, Nicholas M Anstey, Abraham Aseffa, Ashenafi Assefa, Ghulam R Awab, J Kevin Baird, Bridget E Barber, Isabelle Borghini-Fuhrer, Umberto D'Alessandro, Prabin Dahal, Andre Daher, Peter J de Vries, Annette Erhart
BACKGROUND: Malaria causes a reduction in haemoglobin that is compounded by primaquine, particularly in patients with glucose-6-ph..
Competing risk events in antimalarial drug trials in uncomplicated Plasmodium falciparum malaria: a WorldWide Antimalarial Resistance Network individual participant data meta-analysis
Prabin Dahal, Julie Anne Simpson, Salim Abdulla, Jane Achan, Ishag Adam, Aarti Agarwal, Richard Allan, Anupkumar R Anvikar, Emmanuel Arinaitwe, Elizabeth A Ashley, Ghulam Rahim Awab, Quique Bassat, Anders Bjorkman, Francois Bompart, Steffen Borrmann, Teun Bousema, Ingrid Broek, Hasifa Bukirwa, Verena I Carrara, Marco Corsi
BACKGROUND: Therapeutic efficacy studies in uncomplicated Plasmodium falciparum malaria are confounded by new infections, which co..
Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria
Carlo Giannangelo, Freya JI Fowkes, Julie A Simpson, Susan A Charman, Darren J Creek
The ozonides are one of the most advanced drug classes in the antimalarial development pipeline and were designed to improve on li..
Evaluating antimalarial efficacy in single-armed and comparative drug trials using competing risk survival analysis: a simulation study
Prabin Dahal, Philippe J Guerin, Ric N Price, Julie A Simpson, Kasia Stepniewska
BACKGROUND: Antimalarial efficacy studies in patients with uncomplicated Plasmodium falciparum are confounded by a new infection (..
Safety of primaquine in infants with Plasmodium vivax malaria in Papua, Indonesia
Agus Setyadi, Eggi Arguni, Enny Kenangalem, Afdhal Hasanuddin, Daniel A Lampah, Kamala Thriemer, Nicholas M Anstey, Paulus Sugiarto, Julie A Simpson, Ric N Price, Nicholas M Douglas, Jeanne R Poespoprodjo
BACKGROUND: Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogena..
The use of mathematical modeling studies for evidence synthesis and guideline development: A glossary
Teegwende Porgo, Susan L Norris, Georgia Salanti, Leigh F Johnson, Julie A Simpsons, Nicola Low, Matthias Egger, Christian L Althaus
Mathematical modeling studies are increasingly recognised as an important tool for evidence synthesis and to inform clinical and p..
The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial
Lorenz von Seidlein, Thomas J Peto, Jordi Landier, Nguyen Thuy-Nhien, Rupam Tripura, Koukeo Phommasone, Tiengkham Pongvongsa, Khin Maung Lwin, Lilly Keereecharoen, Ladda Kajeechiwa, May Myo Thwin, Daniel M Parker, Jacher Wiladphaingern, Suphak Nosten, Stephane Proux, Vincent Corbel, Tuong-Vy Nguyen, Le Phuc-Nhi Truong, Hung Son Do, Nguyen Huong-Thu Pham
BACKGROUND: The emergence and spread of multidrug-resistant Plasmodium falciparum in the Greater Mekong Subregion (GMS) threatens ..
Collider bias and the apparent protective effect of glucose-6-phosphate dehydrogenase deficiency on cerebral malaria
James A Watson, Stije J Leopold, Julie A Simpson, Nicholas PJ Day, Arjen M Dondorp, Nicholas J White
Case fatality rates in severe falciparum malaria depend on the pattern and degree of vital organ dysfunction. Recent large-scale c..
Multiple imputation methods for handling missing values in a longitudinal categorical variable with restrictions on transitions over time: a simulation study
Anurika Priyanjali De Silva, Margarita Moreno-Betancur, Alysha Madhu De Livera, Katherine Jane Lee, Julie Anne Simpson
BACKGROUND: Longitudinal categorical variables are sometimes restricted in terms of how individuals transition between categories ..
Evaluation of a treatment protocol for anaemia in pregnancy nested in routine antenatal care in a limited-resource setting
Mary Ellen Gilder, Julie A Simpson, Germana Bancone, Laura McFarlane, Neha Shah, Rob van Aalsburg, Moo Koh Paw, Mupawjay Pimanpanarak, Jacher Wiladphaingern, Aung Myat Min, Claudia Turner, Marcus J Rijken, Machteld Boel, Gabie Hoogenboom, Nay Win Tun, Prakaykaew Charunwatthana, Verena I Carrara, Francois Nosten, Rose McGready
Background: Anaemia in pregnancy is typically due to iron deficiency (IDA) but remains a complex and pervasive problem, particular..
Risk of Plasmodium vivax parasitaemia after Plasmodium falciparum infection: a systematic review and meta-analysis
Robert J Commons, Julie A Simpson, Kamala Thriemer, Mohammad S Hossain, Nicholas M Douglas, Georgina S Humphreys, Carol H Sibley, Philippe J Guerin, Ric N Price
BACKGROUND: A 14-day course of primaquine is used for radical cure of Plasmodium vivax and Plasmodium ovale malaria only. We quant..
Sequential infection experiments for quantifying innate and adaptive immunity during influenza infection
Ada WC Yan, Sophie G Zaloumis, Julie A Simpson, James M McCaw
Laboratory models are often used to understand the interaction of related pathogens via host immunity. For example, recent experim..
Canonical Causal Diagrams to Guide the Treatment of Missing Data in Epidemiologic Studies
Margarita Moreno-Betancur, Katherine J Lee, Finbarr P Leacy, Ian R White, Julie A Simpson, John B Carlin
With incomplete data, the "missing at random" (MAR) assumption is widely understood to enable unbiased estimation with appropriate..
In Silico Investigation of the Decline in Clinical Efficacy of Artemisinin Combination Therapies Due to Increasing Artemisinin and Partner Drug Resistance
Sophie G Zaloumis, Pengxing Cao, Saber Dini, Miles P Davenport, Deborah Cromer, David S Khoury, Freya JI Fowkes, James M McCaw, Julie A Simpson
Antimalarial treatment currently relies on an artemisinin derivative and a longer-acting partner drug. With the emergence of resis..
Investigating the Efficacy of Triple Artemisinin-Based Combination Therapies for Treating Plasmodium falciparum Malaria Patients Using Mathematical Modeling
Saber Dini, Sophie Zaloumis, Pengxing Cao, Ric N Price, Freya J Fowkes, E Rob W van der Pluijm, James M McCaw, Julie A Simpson
The first line treatment for uncomplicated falciparum malaria is artemisinin-based combination therapy (ACT), which consists of an..
The impact of social housing on mental health: longitudinal analyses using marginal structural models and machine learning-generated weights
Rebecca Bentley, Emma Baker, Koen Simons, Julie A Simpson, Tony Blakely
BACKGROUND: Social housing may provide an affordable and secure residential environment, but has also been associated with stigma,..
Iron deficiency during pregnancy is associated with a reduced risk of adverse birth outcomes in a malaria-endemic area in a longitudinal cohort study
Freya JI Fowkes, Kerryn A Moore, D Herbert Opi, Julie A Simpson, Freya Langham, Danielle I Stanisic, Alice Ura, Christopher L King, Peter M Siba, Ivo Mueller, Stephen J Rogerson, James G Beeson
BACKGROUND: Low birth weight (LBW) and preterm birth (PTB) are major contributors to infant mortality and chronic childhood morbid..
The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis
Robert J Commons, Julie A Simpson, Kamala Thriemer, Georgina S Humphreys, Tesfay Abreha, Sisay G Alemu, Arletta Anez, Nicholas M Anstey, Ghulam R Awab, J Kevin Baird, Bridget E Barber, Isabelle Borghini-Fuhrer, Cindy S Chu, Umberto D'Alessandro, Prabin Dahal, Andre Daher, Peter J de Vries, Annette Erhart, Margarete SM Gomes, Lilia Gonzalez-Ceron
BACKGROUND: Chloroquine remains the mainstay of treatment for Plasmodium vivax malaria despite increasing reports of treatment fai..
Within-host modeling of blood-stage malaria
David S Khoury, Rosemary Aogo, Georges Randriafanomezantsoa-Radohery, James M McCaw, Julie A Simpson, James S McCarthy, Ashraful Haque, Deborah Cromer, Miles P Davenport
Malaria infection continues to be a major health problem worldwide and drug resistance in the major human parasite species, Plasmo..
Implications of population-level immunity for the emergence of artemisinin-resistant malaria: a mathematical model
Nick Scott, Ricardo Ataide, David P Wilson, Margaret Hellard, Ric N Price, Julie A Simpson, Freya J Fowkes
BACKGROUND: Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong Subregion, an area of relatively low tra..
Scabies and risk of skin sores in remote Australian Aboriginal communities: A self-controlled case series study
Thu Zar Aung Phyo, Will Cuningham, Kerry Hwang, Ross M Andrews, Jonathan Carapetis, Therese Kearns, Danielle Clucas, Jodie McVernon, Julie Ann Simpson, Steven Tong, Patricia Therese Campbell
BACKGROUND: Skin sores caused by Group A streptococcus (GAS) infection are a major public health problem in remote Aboriginal comm..
Sensitivity analysis within multiple imputation framework using delta-adjustment: Application to Longitudinal Study of Australian Children
Panteha Hayati Rezvan, Katherine J Lee, Julie A Simpson
Multiple imputation (MI) is a powerful statistical method for handling missing data. Standard implementations of MI are valid unde..
Do material, psychosocial and behavioural factors mediate the relationship between disability acquisition and mental health? A sequential causal mediation analysis
Zoe Aitken, Julie Anne Simpson, Lyle Gurrin, Rebecca Bentley, Anne Marie Kavanagh
BACKGROUND: There is evidence of a causal relationship between disability acquisition and poor mental health; however, the mechani..
NormalizeMets: assessing, selecting and implementing statistical methods for normalizing metabolomics data
Alysha M De Livera, Gavriel Olshansky, Julie A Simpson, Darren J Creek
INTRODUCTION: In metabolomics studies, unwanted variation inevitably arises from various sources. Normalization, that is the remov..
A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum
Pengxing Cao, Nectarios Klonis, Sophie Zaloumis, Con Dogovski, Stanley C Xie, Sompob Saralamba, Lisa J White, Freya JI Fowkes, Leann Tilley, Julie A Simpson, James M McCaw
Artemisinin resistance constitutes a major threat to the continued success of control programs for malaria, particularly in light ..
Quantification of the association between malaria in pregnancy and stillbirth: a systematic review and meta-analysis
Kerryn A Moore, Julie A Simpson, Michelle JL Scoullar, Rose McGready, Freya JI Fowkes
BACKGROUND: 2·6 million stillbirths occur annually worldwide. The association between malaria in pregnancy and stillbirth has yet ..
Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges
Prabin Dahal, Julie A Simpson, Grant Dorsey, Philippe J Guerin, Ric N Price, Kasia Stepniewska
The Kaplan-Meier (K-M) method is currently the preferred approach to derive an efficacy estimate from anti-malarial trial data. In..
A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection
Pengxing Cao, Nectarios Klonis, Sophie Zaloumis, David S Khoury, Deborah Cromer, Miles P Davenport, Leann Tilley, Julie A Simpson, James M McCaw
Falciparum malaria is a major parasitic disease causing widespread morbidity and mortality globally. Artemisinin derivatives-the m..
Declining Transmission and Immunity to Malaria and Emerging Artemisinin Resistance in Thailand: A Longitudinal Study
Ricardo Ataide, Rosanna Powell, Kerryn Moore, Alistair McLean, Aung Pyae Phyo, Shalini Nair, Marina White, Tim J Anderson, James G Beeson, Julie A Simpson, Francois Nosten, Freya JI Fowkes
BACKGROUND: Reductions in malaria transmission decrease naturally acquired immunity, which may influence the emergence of Plasmodi..
Continuing Medical Education: Age-related macular degeneration and mortality: the Melbourne Collaborative Cohort Study
MB McGuinness, RP Finger, A Karahalios, RH Guymer, DR English, EW Chong, AM Hodge, LD Robman, GG Giles, JA Simpson
AimsTo assess associations between features of age-related macular degeneration (AMD) and mortality.MethodsA total of 21 129 parti..
Survival Bias When Assessing Risk Factors for Age-Related Macular Degeneration: A Tutorial with Application to the Exposure of Smoking
Myra B McGuinness, Amalia Karahalios, Jessica Kasza, Robyn H Guymer, Robert P Finger, Julie A Simpson
PURPOSE: We illustrate the effect of survival bias when investigating risk factors for eye disease in elderly populations for whom..
Unsupervised primaquine for the treatment of Plasmodium vivax malaria relapses in southern Papua: A hospital-based cohort study
Nicholas M Douglas, Jeanne Rini Poespoprodjo, Dewi Patriani, Michael J Malloy, Enny Kenangalem, Paulus Sugiarto, Julie A Simpson, Yati Soenarto, Nicholas M Anstey, Ric N Price
BACKGROUND: Primaquine is the only licensed drug for eradicating Plasmodium vivax hypnozoites and, therefore, preventing relapses ..
A comparison of multiple imputation methods for handling missing values in longitudinal data in the presence of a time-varying covariate with a non-linear association with time: a simulation study
Anurika Priyanjali De Silva, Margarita Moreno-Betancur, Alysha Madhu De Livera, Katherine Jane Lee, Julie Anne Simpson
BACKGROUND: Missing data is a common problem in epidemiological studies, and is particularly prominent in longitudinal data, which..
Influence of the number and timing of malaria episodes during pregnancy on prematurity and small-for-gestational-age in an area of low transmission
Kerryn A Moore, Julie A Simpson, Jacher Wiladphaingern, Aung Myat Min, Mupawjay Pimanpanarak, Moo Kho Paw, Jathee Raksuansak, Sasithon Pukrittayakamee, Freya JI Fowkes, Nicholas J White, Francois Nosten, Rose McGready
BACKGROUND: Most evidence on the association between malaria in pregnancy and adverse pregnancy outcomes focuses on falciparum mal..
Mediation of the effect of malaria in pregnancy on stillbirth and neonatal death in an area of low transmission: observational data analysis
Kerryn A Moore, Freya JI Fowkes, Jacher Wiladphaingern, Nan San Wai, Moo Kho Paw, Mupawjay Pimanpanarak, Verena I Carrara, Jathee Raksuansak, Julie A Simpson, Nicholas J White, Francois Nosten, Rose McGready
BACKGROUND: Malaria in pregnancy is preventable and contributes significantly to the estimated 5.5 million stillbirths and neonata..
Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort
Ricardo Ataide, Elizabeth A Ashley, Rosanna Powell, Jo-Anne Chan, Michael J Malloy, Katherine O'Flaherty, Eizo Takashima, Christine Langer, Takafumi Tsuboi, Arjen M Dondorp, Nicholas P Day, Mehul Dhorda, Rick M Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tinh Hien Tran, Ye Htut, Mayfong Mayxay, M Abul Faiz
Artemisinin-resistant falciparum malaria, defined by a slow-clearance phenotype and the presence of kelch13 mutants, has emerged i..
Effect of low-dose versus higher-dose antenatal iron supplementation on child health outcomes at 36 months of age in Viet Nam: longitudinal follow-up of a cluster randomised controlled trial.
Sarah Hanieh, Tran T Ha, Julie A Simpson, Sabine Braat, Tran T Thuy, Thach D Tran, Janet King, Tran Tuan, Jane Fisher, Beverley-Ann Biggs
INTRODUCTION: Intermittent iron-folic acid supplementation (IFA) is currently recommended for pregnant women in populations where ..
Change in weight and waist circumference and risk of colorectal cancer: results from the Melbourne Collaborative Cohort Study
A Karahalios, J Simpson, L Baglietto, RJ MacInnis, AM Hodge, GG Giles, DR English
BACKGROUND: Studies reporting the association between change in weight or body mass index during midlife and risk of colorectal ca..