IMMUNOLOGICAL CONTROL OF CYSTICERCOSIS AND HYDATID DISEASE
Grant number: 1105448 | Funding period: 2016 - 2020
In this project the world’s most effective vaccines against diseases caused by parasites will be translated from the laboratory to the clinic. The vaccines prevent transmission of parasites from livestock animals to humans. During the next 5 years the vaccines will be produced on a large scale and evaluated in field trials. The products of this research program will make a major contribution to reducing the number of people suffering from parasitic cysts.
Related publications (15)
Control trial of porcine cysticercosis in Uganda using a combination of the TSOL18 vaccination and oxfendazole
Zachary Nsadha, Chris Rutebarika, Chrisostom Ayebazibwe, Bukenya Aloys, M Mwanja, E Jane Poole, Elizabeth Chesang, Angela Colston, Meritxell Donadeu, Marshall W Lightowlers
BACKGROUND: Neurocysticercosis caused by Taenia solium when the parasite lodges in the central nervous system, is an important cau..
Control of cystic echinococcosis in the Middle Atlas, Morocco: Field evaluation of the EG95 vaccine in sheep and cesticide treatment in dogs
Fatimaezzahra Amarir, Abdelkbir Rhalem, Abderrahim Sadak, Marianne Raes, Mohamed Oukessou, Aouatif Saadi, Mohammed Bouslikhane, Charles G Gauci, Marshall W Lightowlers, Nathalie Kirschvink, Tanguy Marcotty
BACKGROUND: Cystic echinococcosis (CE) is an important cause of human morbidity and mortality worldwide, particularly in Morocco a..
Performance of Ag-ELISA in the diagnosis of Taenia solium cysticercosis in naturally infected pigs in Tanzania
Mwemezi L Kabululu, Maria V Johansen, James ED Mlangwa, Ernatus M Mkupasi, Uffe C Braae, Chiara Trevisan, Angela Colston, Claudia Cordel, Marshall W Lightowlers, Helena A Ngowi
BACKGROUND: Taenia solium is a zoonotic parasite responsible for neurocysticercosis-a major cause of late-onset acquired epilepsy ..
Immunological responses and potency of the EG95NC(-) recombinant sheep vaccine against cystic echinococcosis
M Jazouli, MW Lightowlers, Z Bamouh, CG Gauci, K Tadlaoui, MM Ennaji, M Elharrak
Cystic echinococcosis (CE) is a zoonotic disease caused by the cestode parasite Echinococcus granulosus. The disease has an import..
Kozen Yoshino's experimental infections with Taenia solium tapeworms: An experiment never to be repeated
Akira Ito, Mika Saito, Meritxell Donadeu, Marshall W Lightowlers
In the 1930's Kozen Yoshino published 6 papers on Taenia solium. One of these papers is particularly important because it describe..
A hyperendemic focus of porcine cystic echinococcosis in the Banke District of Nepal
Meritxell Donadeu, Charles G Gauci, Ishab Poudel, Keshav Sah, Dinesh Kumar Singh, Abdul Jabbar, Marshall W Lightowlers
Detailed post mortem analyses of 68 free-ranging, slaughter-age pigs from two sites in the Banke District of Nepal identified 36% ..
Accurate diagnosis of lesions suspected of being caused by Taenia solium in body organs of pigs with naturally acquired porcine cysticercosis
Charles G Gauci, Chrisostom Ayebazibwe, Zachary Nsadha, Chris Rutebarika, Ishab Poudel, Keshav Sah, Dinesh Kumar Singh, Andrew Stent, Angela Colston, Meritxell Donadeu, Marshall W Lightowlers
The definitive method for diagnosis of porcine cysticercosis is the detection of cysticerci at necropsy. Cysts are typically locat..
Long-read sequencing reveals a 4.4kb tandem repeat region in the mitogenome of Echinococcus granulosus (sensu stricto) genotype G1
Liina Kinkar, Pasi K Korhonen, Huimin Cai, Charles G Gauci, Marshall W Lightowlers, Urmas Saarma, David J Jenkins, Jiandong Li, Junhua Li, Neil D Young, Robin B Gasser
Implementation of a practical and effective pilot intervention against transmission of Taenia solium by pigs in the Banke district of Nepal
Ishab Poudel, Keshav Sah, Suyog Subedi, Dinesh Kumar Singh, Peetambar Kushwaha, Angela Colston, Charles G Gauci, Meritxell Donadeu, Marshall W Lightowlers
Taenia solium is a zoonotic cestode parasite which causes human neurocysticercosis. Pigs transmit the parasite by acting as the in..