NEUROBIOLOGICAL 'RISK' AND 'RESILIENCE' BIOMARKERS OF SEVERE MENTAL ILLNESS

Increased cortical surface area but not altered cortical thickness or gyrification in bipolar disorder following stabilisation from a first episode of mania

Tamsyn E Van Rheenen, Sue M Cotton, Orwa Dandash, Rebecca E Cooper, Elysha Ringin, Rothanthi Daglas-Georgiou, Kelly Allott, Yann Chye, Chao Suo, Craig Macneil, Melissa Hasty, Karen Hallam, Patrick McGorry, Alex Fornito, Murat Yucel, Christos Pantelis, Michael Berk

2023-03-02

BACKGROUND: Despite reports of altered brain morphology in established bipolar disorder (BD), there is limited understanding of wh..

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.

Constantinos Constantinides, Laura KM Han, Clara Alloza, Linda Antonella Antonucci, Celso Arango, Rosa Ayesa-Arriola, Nerisa Banaj, Alessandro Bertolino, Stefan Borgwardt, Jason Bruggemann, Juan Bustillo, Oleg Bykhovski, Vince Calhoun, Vaughan Carr, Stanley Catts, Young-Chul Chung, Benedicto Crespo-Facorro, Covadonga M Díaz-Caneja, Gary Donohoe, Stefan Du Plessis

2023-03-01

Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and prema..

Delineating gene-environment effects using virtual twins of patients treated with clozapine.

Sam Mostafa, Thomas M Polasek, Chad Bousman, Amin Rostami-Hodjegan, Leslie J Sheffield, Ian Everall, Christos Pantelis, Carl MJ Kirkpatrick

2023-02-01

Studies that focus on individual covariates, while ignoring their interactions, may not be adequate for model-informed precision d..

Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis

Helen Baldwin, Joaquim Radua, Mathilde Antoniades, Shalaila S Haas, Sophia Frangou, Ingrid Agartz, Paul Allen, Ole A Andreassen, Kimberley Atkinson, Peter Bachman, Inmaculada Baeza, Cali F Bartholomeusz, Michael WL Chee, Tiziano Colibazzi, Rebecca E Cooper, Cheryl M Corcoran, Vanessa L Cropley, Bjorn H Ebdrup, Adriana Fortea, Louise Birkedal Glenthoj

2022-07-26

Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. Howev..

Virtual Ontogeny of Cortical Growth Preceding Mental Illness

Yash Patel, Jean Shin, Christoph Abe, Ingrid Agartz, Clara Alloza, Dag Alnaes, Sonia Ambrogi, Linda A Antonucci, Celso Arango, Volker Arolt, Guillaume Auzias, Rosa Ayesa-Arriola, Nerisa Banaj, Tobias Banaschewski, Cibele Bandeira, Zeynep Basgoze, Renata Basso Cupertino, Claiton HD Bau, Jochen Bauer, Sarah Baumeister

2022-07-25

BACKGROUND: Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental orig..

Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis

Ana Catalan, Stefania Tognin, Matthew J Kempton, Daniel Stahl, Gonzalo Salazar de Pablo, Barnaby Nelson, Christos Pantelis, Anita Riecher-Rossler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart PF Rutten, Jim van Os, Lieuwe de Haan, Mark van der Gaag, Lucia R Valmaggia, Philip McGuire

2022-06-01

BACKGROUND: Psychosis is associated with a reasoning bias, which manifests as a tendency to 'jump to conclusions'. We examined thi..

Pineal morphology of the clinical high-risk state for psychosis and different psychotic disorders

Tsutomu Takahashi, Stephen J Wood, Alison R Yung, Barnaby Nelson, Ashleigh Lin, Hok Pan Yuen, Lisa J Phillips, Michio Suzuki, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis

2022-04-26

BACKGROUND: Pineal volume reductions have been reported in schizophrenia and clinical high-risk states for the development of psyc..

Pattern of predictive features of continued cannabis use in patients with recent-onset psychosis and clinical high-risk for psychosis

Nora Penzel, Rachele Sanfelici, Linda A Antonucci, Linda T Betz, Dominic Dwyer, Anne Ruef, Kang Ik K Cho, Paul Cumming, Oliver Pogarell, Oliver Howes, Peter Falkai, Rachel Upthegrove, Stefan Borgwardt, Paolo Brambilla, Rebekka Lencer, Eva Meisenzahl, Frauke Schultze-Lutter, Marlene Rosen, Theresa Lichtenstein, Lana Kambeitz-Ilankovic

2022-03-09

Continued cannabis use (CCu) is an important predictor for poor long-term outcomes in psychosis and clinically high-risk patients,..

Brain Morphological Characteristics of Cognitive Subgroups of Schizophrenia-Spectrum Disorders and Bipolar Disorder: A Systematic Review with Narrative Synthesis

James A Karantonis, Sean P Carruthers, Katherine E Burdick, Christos Pantelis, Melissa Green, Susan L Rossell, Matthew E Hughes, Vanessa Cropley, Tamsyn E Van Rheenen

2022-02-22

Despite a growing body of research, there is yet to be a cohesive synthesis of studies examining differences in brain morphology a..

Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis

Emily P Hedges, Hannah Dickson, Stefania Tognin, Gemma Modinos, Mathilde Antoniades, Mark van der Gaag, Lieuwe de Haan, Patrick McGorry, Christos Pantelis, Anita Riecher-Rossler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart P Rutten, Jim van Os, Lucia R Valmaggia, Philip McGuire

2022-02-17

Robust deficits in cognitive functioning are present in people with psychosis and are evident in the early stages of the disorder...

Cell type-specific manifestations of cortical thickness heterogeneity in schizophrenia

Maria A Di Biase, Michael P Geaghan, William R Reay, Jakob Seidlitz, Cynthia Shannon Weickert, Alice Pebay, Melissa J Green, Yann Quide, Joshua R Atkins, Michael J Coleman, Sylvain Bouix, Evdokiya E Knyazhanskaya, Amanda E Lyall, Ofer Pasternak, Marek Kubicki, Yogesh Rathi, Andrew Visco, Megan Gaunnac, Jinglei Lv, Raquelle Mesholam-Gately

2022-02-10

Brain morphology differs markedly between individuals with schizophrenia, but the cellular and genetic basis of this heterogeneity..

Frontostriatothalamic effective connectivity and dopaminergic function in the psychosis continuum

Kristina Sabaroedin, Adeel Razi, Sidhant Chopra, Nancy Tran, Andrii Pozaruk, Zhaolin Chen, Amy Finlay, Barnaby Nelson, Kelly Allott, Mario Alvarez-Jimenez, Jessica Graham, Hok P Yuen, Susy Harrigan, Vanessa Cropley, Sujit Sharma, Bharat Saluja, Rob Williams, Christos Pantelis, Stephen J Wood, Brian O'Donoghue

2022-01-30

Dysfunction of fronto-striato-thalamic (FST) circuits is thought to contribute to dopaminergic dysfunction and symptom onset in ps..

Relationships between global functioning and neuropsychological predictors in subjects at high risk of psychosis or with a recent onset of depression

Letizia Squarcina, Lana Kambeitz-Ilankovic, Carolina Bonivento, Cecilia Prunas, Lucio Oldani, Julian Wenzel, Anne Ruef, Dominic Dwyer, Adele Ferro, Stefan Borgwardt, Joseph Kambeitz, Theresa Katharina Lichtenstein, Eva Meisenzahl, Christos Pantelis, Marlene Rosen, Rachel Upthegrove, Linda A Antonucci, Alessandro Bertolino, Rebekka Lencer, Stephan Ruhrmann

2022-01-19

OBJECTIVE: Psychotic disorders are frequently associated with decline in functioning and cognitive difficulties are observed in su..

The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis.

Stefania Tognin, Anja Richter, Matthew J Kempton, Gemma Modinos, Mathilde Antoniades, Matilda Azis, Paul Allen, Matthijs G Bossong, Jesus Perez, Christos Pantelis, Barnaby Nelson, Paul Amminger, Anita Riecher-Rössler, Neus Barrantes-Vidal, Marie-Odile Krebs, Birte Glenthøj, Stephan Ruhrmann, Gabriele Sachs, Bart PF Rutten, Lieuwe de Haan

2022-01-01

OBJECTIVE: To examine the association between baseline alterations in grey matter volume (GMV) and clinical and functional outcome..

A Meta-analysis of Mental Time Travel in Individuals with Autism Spectrum Disorders

Jun-yan Ye, Xiao-jing Qin, Ji-fang Cui, Qian Ren, Lu-xia Jia, Ya Wang, Christos Pantelis, Raymond CK Chan

2021-11-25

Autism spectrum disorders (ASD) are associated with cognitive dysfunctions, including mental time travel (MTT). However, findings ..

Cognitive behavioral markers of neurodevelopmental trajectories in rodents

KH Christopher Choy, Jiaqi K Luo, Cassandra MJ Wannan, Liliana Laskaris, Antonia Merritt, Warda T Syeda, Patrick M Sexton, Arthur Christopoulos, Christos Pantelis, Jess Nithianantharajah

2021-10-30

Between adolescence and adulthood, the brain critically undergoes maturation and refinement of synaptic and neural circuits that s..

Detailed clinical phenotyping and generalisability in prognostic models of functioning in at-risk populations

Marlene Rosen, Linda T Betz, Natalie Kaiser, Nora Penzel, Dominic Dwyer, Theresa K Lichtenstein, Frauke Schultze-Lutter, Lana Kambeitz-Ilankovic, Alessandro Bertolino, Stefan Borgwardt, Paolo Brambilla, Rebekka Lencer, Eva Meisenzahl, Christos Pantelis, Raimo KR Salokangas, Rachel Upthegrove, Stephen Wood, Stephan Ruhrmann, Nikolaos Koutsouleris, Joseph Kambeitz

2021-10-06

Personalised prediction of functional outcomes is a promising approach for targeted early intervention in psychiatry. However, gen..

Disruptions in white matter microstructure associated with impaired visual associative memory in schizophrenia-spectrum illness

Cassandra MJ Wannan, Cali F Bartholomeusz, Christos Pantelis, Maria A Di Biase, Warda T Syeda, M Mallar Chakravarty, Chad A Bousman, Ian P Everall, Patrick D McGorry, Andrew Zalesky, Vanessa L Cropley

2021-09-24

Episodic memory ability relies on hippocampal-prefrontal connectivity. However, few studies have examined relationships between me..

Prediction of Early Symptom Remission in Two Independent Samples of First-Episode Psychosis Patients Using Machine Learning

Rigas F Soldatos, Micah Cearns, Mette O Nielsen, Costas Kollias, Lida-Alkisti Xenaki, Pentagiotissa Stefanatou, Irene Ralli, Stefanos Dimitrakopoulos, Alex Hatzimanolis, Ioannis Kosteletos, Ilias I Vlachos, Mirjana Selakovic, Stefania Foteli, Nikolaos Nianiakas, Leonidas Mantonakis, Theoni F Triantafyllou, Aggeliki Ntigridaki, Vanessa Ermiliou, Marina Voulgaraki, Evaggelia Psarra

2021-09-18

BACKGROUND: Validated clinical prediction models of short-term remission in psychosis are lacking. Our aim was to develop a clinic..

Changes in negative symptoms are linked to white matter changes in superior longitudinal fasciculus in individuals at ultra-high risk for psychosis

Tina D Kristensen, Louise B Glenthoj, Jayachandra M Ragahava, Warda Syeda, Rene CW Mandl, Christina Wenneberg, Kristine Krakauer, Birgitte Fagerlund, Christos Pantelis, Birte Y Glenthoj, Merete Nordentoft, Bjorn H Ebdrup

2021-09-17

AIM: Growing evidence suggests that subtle white matter (WM) alterations are associated with psychopathology in individuals at ult..

Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness

Rachele Sanfelici, Anne Ruef, Linda A Antonucci, Nora Penzel, Aristeidis Sotiras, Mark Sen Dong, Maria Urquijo-Castro, Julian Wenzel, Lana Kambeitz-Ilankovic, Meike D Hettwer, Stephan Ruhrmann, Katharine Chisholm, Anita Riecher-Rossler, Peter Falkai, Christos Pantelis, Raimo KR Salokangas, Rebekka Lencer, Alessandro Bertolino, Joseph Kambeitz, Eva Meisenzahl

2021-09-14

Adult gyrification provides a window into coordinated early neurodevelopment when disruptions predispose individuals to psychiatri..

Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis

Marta Rapado-Castro, Mara Villar-Arenzana, Joost Janssen, David Fraguas, Igor Bombin, Josefina Castro-Fornieles, Maria Mayoral, Ana Gonzalez-Pinto, Elena de la Serna, Mara Parellada, Dolores Moreno, Beatriz Paya, Montserrat Graell, Inmaculada Baeza, Christos Pantelis, Celso Arango

2021-09-01

Cognitive maturation during adolescence is modulated by brain maturation. However, it is unknown how these processes intertwine in..

Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis

Ya Wang, Esmee E Braam, Cassandra MJ Wannan, Tamsyn E Van Rheenen, Raymond CK Chan, Barnaby Nelson, Patrick D McGorry, Alison R Yung, Ashleigh Lin, Warrick J Brewer, John Koutsogiannis, Stephen J Wood, Dennis Velakoulis, Christos Pantelis, Vanessa L Cropley

2021-08-31

Increased severity of neurological soft signs (NSS) in schizophrenia have been associated with abnormal brain morphology in cerebe..

Global fractional anisotropy predicts transition to psychosis after 12 months in individuals at ultra-high risk for psychosis

Tina D Kristensen, Louise B Glenthoj, Karen Ambrosen, Warda Syeda, Jayachandra M Ragahava, Kristine Krakauer, Christina Wenneberg, Birgitte Fagerlund, Christos Pantelis, Birte Y Glenthoj, Merete Nordentoft, Bjorn H Ebdrup

2021-08-09

OBJECTIVE: Psychosis spectrum disorders are associated with cerebral changes, but the prognostic value and clinical utility of the..

The relative and interactive impact of multiple risk factors in schizophrenia spectrum disorders: a combined register-based and clinical twin study

C Lemvigh, R Brouwer, R Hilker, S Anhoj, L Baandrup, C Pantelis, B Glenthoj, B Fagerlund

2021-08-05

BACKGROUND: Research has yielded evidence for genetic and environmental factors influencing the risk of schizophrenia. Numerous en..

Characterization and interrelationships of theory of mind, socially competitive emotions and affective empathy in bipolar disorder

Cecilie K Lemvigh, James A Karantonis, Lisa S Furlong, Sean P Carruthers, Christos Pantelis, Susan L Rossell, Tamsyn E Van Rheenen

2021-07-07

OBJECTIVE: Evidence shows impaired theory of mind (ToM) in patients with bipolar disorder (BD), yet research examining its cogniti..

The non-specific nature of mental health and structural brain outcomes following childhood trauma

Theresa K Haidl, Dennis M Hedderich, Marlene Rosen, Nathalie Kaiser, Mauro Seves, Thorsten Lichtenstein, Nora Penzel, Julian Wenzel, Lana Kambeitz-Ilankovic, Anne Ruef, David Popovic, Frauke Schultze-Lutter, Katharine Chisholm, Rachel Upthegrove, Raimo KR Salokangas, Christos Pantelis, Eva Meisenzahl, Stephen J Wood, Paolo Brambilla, Stefan Borgwardt

2021-07-06

BACKGROUND: Childhood trauma (CT) is associated with an increased risk of mental health disorders; however, it is unknown whether ..

Differential effects of age at illness onset on verbal memory functions in antipsychotic-naive schizophrenia patients aged 12-43 years

Birgitte Fagerlund, Christos Pantelis, Jens Richardt Mollegaard Jepsen, Jayachandra Mitta Raghava, Egill Rostrup, Marie Bjerregaard Thomas, Mette Odegaard Nielsen, Kirsten Bojesen, Karsten Gjessing Jensen, Marie Stentebjerg-Decara, Dea Gowers Klauber, Ditte Ruda, Bjorn H Ebdrup, Kasper Jessen, Anne Sigvard, Karen Tangmose, Pia Jeppesen, Christoph U Correll, Anders Fink-Jensen, Anne Katrine Pagsberg

2021-07-01

BACKGROUND: The typical onset of schizophrenia coincides with the maturational peak in cognition; however, for a significant propo..

Functional Connectivity in Antipsychotic-Treated and Antipsychotic-Naive Patients With First-Episode Psychosis and Low Risk of Self-harm or Aggression A Secondary Analysis of a Randomized Clinical Trial

Sidhant Chopra, Shona M Francey, Brian O'Donoghue, Kristina Sabaroedin, Aurina Arnatkeviciute, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Steven Tahtalian, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Christos Pantelis, Stephen J Wood, Patrick McGorry, Alex Fornito

2021-06-23

IMPORTANCE: Altered functional connectivity (FC) is a common finding in resting-state functional magnetic resonance imaging (rs-fM..

A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum

James A Karantonis, Sean P Carruthers, Susan L Rossell, Christos Pantelis, Matthew Hughes, Cassandra Wannan, Vanessa Cropley, Tamsyn E Van Rheenen

2021-06-07

The nature of the relationship between cognition and brain morphology in schizophrenia-spectrum disorders (SSD) and bipolar disord..

Brain morphology is differentially impacted by peripheral cytokines in schizophrenia-spectrum disorder

Liliana Laskaris, Sam Mancuso, Cynthia Shannon Weickert, Andrew Zalesky, Gursharan Chana, Cassandra Wannan, Chad Bousman, Bernhard T Baune, Patrick McGorry, Christos Pantelis, Vanessa L Cropley

2021-06-04

Deficits in brain morphology are one of the most widely replicated neuropathological features in schizophrenia-spectrum disorder (..

Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis An ENIGMA Working Group Mega-analysis

Maria Jalbrzikowski, Rebecca A Hayes, Stephen J Wood, Dorte Nordholm, Juan H Zhou, Paolo Fusar-Poli, Peter J Uhlhaas, Tsutomu Takahashi, Gisela Sugranyes, Yoo Bin Kwak, Daniel H Mathalon, Naoyuki Katagiri, Christine I Hooker, Lukasz Smigielski, Tiziano Colibazzi, Esther Via, Jinsong Tang, Shinsuke Koike, Paul E Rasser, Chantal Michel

2021-05-05

IMPORTANCE: The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled neuroimaging sample of individuals at..

Associations between cognition and white matter microstructure in first-episode antipsychotic-naive patients with schizophrenia and healthy controls: A multivariate pattern analysis

Marie B Thomas, Jayachandra M Raghava, Christos Pantelis, Egill Rostrup, Mette O Nielsen, Maria H Jensen, Birte Y Glenthoj, Rene CW Mandl, Bjorn H Ebdrup, Birgitte Fagerlund

2021-04-29

BACKGROUND: Cognitive functions have been associated with white matter (WM) microstructure in schizophrenia, but most studies are ..

Brain-Predicted Age Associates With Psychopathology Dimensions in Youths

Vanessa L Cropley, Ye Tian, Kavisha Fernando, L Sina Mansour, Christos Pantelis, Luca Cocchi, Andrew Zalesky

2021-04-05

BACKGROUND: This study aimed to investigate whether dimensional constructs of psychopathology relate to variation in patterns of b..

Increased peripheral inflammation in schizophrenia is associated with worse cognitive performance and related cortical thickness reductions

Hayley F North, Jason Bruggemann, Vanessa Cropley, Vaidy Swaminathan, Suresh Sundram, Rhoshel Lenroot, Avril M Pereira, Andrew Zalesky, Chad Bousman, Christos Pantelis, Thomas W Weickert, Cynthia Shannon Weickert

2021-03-24

While the biological substrates of brain and behavioural changes in persons with schizophrenia remain unclear, increasing evidence..

Effective Connectivity and Dopaminergic Function of Fronto-Striato-Thalamic Circuitry in First-Episode Psychosis, Established Schizophrenia, and Healthy Controls

Kristina Sabaroedin, Adeel Razi, Sidhant Chopra, Nancy Tran, Andrii Pozaruk, Zhaolin Chen, Amy Finlay, Barnaby Nelson, Kelly Allott, Mario Alvarez-Jimenez, Jessica Graham, Lara Baldwin, Steven Tahtalian, Hok Yuen, Susy Harrigan, Vanessa Cropley, Sujit Sharma, Bharat Saluja, Robert Williams, Christos Pantelis

2021-03-15

Dysfunction of fronto-striato-thalamic (FST) circuits is thought to contribute to dopaminergic dysfunction and symptom onset in ps..

Network Analysis of Symptom Comorbidity in Schizophrenia: Relationship to Illness Course and Brain White Matter Microstructure

Hua Ye, Andrew Zalesky, Jinglei Lv, Samantha M Loi, Suheyla Cetin-Karayumak, Yogesh Rathi, Ye Tian, Christos Pantelis, Maria A Di Biase

2021-03-08

INTRODUCTION: Recent network-based analyses suggest that schizophrenia symptoms are intricately connected and interdependent, such..

Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis

Nora Penzel, Linda A Antonucci, Linda T Betz, Rachele Sanfelici, Johanna Weiske, Oliver Pogarell, Paul Cumming, Boris B Quednow, Oliver Howes, Peter Falkai, Rachel Upthegrove, Alessandro Bertolino, Stefan Borgwardt, Paolo Brambilla, Rebekka Lencer, Eva Meisenzahl, Marlene Rosen, Theresa Haidl, Lana Kambeitz-Ilankovic, Stephan Ruhrmann

2021-03-03

Cannabis use during adolescence is associated with an increased risk of developing psychosis. According to a current hypothesis, t..

Large-Scale Evidence for an Association Between Peripheral Inflammation and White Matter Free Water in Schizophrenia and Healthy Individuals

Maria A Di Biase, Andrew Zalesky, Suheyla Cetin-Karayumak, Yogesh Rathi, Jinglei Lv, Danny Boerrigter, Hayley North, Paul Tooney, Christos Pantelis, Ofer Pasternak, Cynthia Shannon Weickert, Vanessa L Cropley

2021-03-01

INTRODUCTION: Clarifying the role of neuroinflammation in schizophrenia is subject to its detection in the living brain. Free-wate..

Differentiating the effect of antipsychotic medication and illness on brain volume reductions in first-episode psychosis: A Longitudinal, Randomised, Triple-blind, Placebo-controlled MRI Study

Sidhant Chopra, Alex Fornito, Shona M Francey, Brian O'Donoghue, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Steven Tahtalian, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Kristina Sabaroedin, Christos Pantelis, Stephen J Wood, Patrick McGorry

2021-02-26

Changes in brain volume are a common finding in Magnetic Resonance Imaging (MRI) studies of people with psychosis and numerous lon..

Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases

Parsa Ravanfar, Samantha M Loi, Warda T Syeda, Tamsyn E Van Rheenen, Ashley I Bush, Patricia Desmond, Vanessa L Cropley, Darius JR Lane, Carlos M Opazo, Bradford A Moffat, Dennis Velakoulis, Christos Pantelis

2021-02-18

Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In the past decade, development of the new m..

Cognitive ability and metabolic physical health in first-episode psychosis

Sarah Whitson, Brian O'Donoghue, Robert Hester, Lara Baldwin, Susy Harrigan, Shona Francey, Jessica Graham, Barnaby Nelson, Aswin Ratheesh, Mario Alvarez-Jimenez, Alex Fornito, Christos Pantelis, Hok Pan Yuen, Andrew Thompson, Melissa Kerr, Michael Berk, Stephen J Wood, Patrick McGorry, Kelly Allott

2021-02-13

Cognitive impairments are a core feature of first-episode psychosis (FEP), arising before illness onset and antipsychotic exposure..

Brain morphology does not clearly map to cognition in individuals on the bipolar-schizophrenia-spectrum: a cross-diagnostic study of cognitive subgroups

James A Karantonis, Susan L Rossell, Sean P Carruthers, Philip Sumner, Matthew Hughes, Melissa J Green, Christos Pantelis, Katherine E Burdick, Vanessa Cropley, Tamsyn E Van Rheenen

2021-01-20

BACKGROUND: Characterisation of brain morphological features common to cognitively similar individuals with bipolar disorder (BD) ..

The impact of smoking status on cognition and brain morphology in schizophrenia spectrum disorders

Elysha Ringin, Vanessa Cropley, Andrew Zalesky, Jason Bruggemann, Suresh Sundram, Cynthia Shannon Weickert, Thomas W Weickert, Chad A Bousman, Christos Pantelis, Tamsyn E Van Rheenen

2021-01-14

BACKGROUND: Cigarette smoking is associated with worse cognition and decreased cortical volume and thickness in healthy cohorts. C..

Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings

Eva Velthorst, Josephine Mollon, Robin M Murray, Lieuwe de Haan, Inez Myin Germeys, David C Glahn, Celso Arango, Els van der Ven, Marta Di Forti, Miguel Bernardo, Sinan Guloksuz, Philippe Delespaul, Gisela Mezquida, Silvia Amoretti, Julio Bobes, Pilar A Saiz, Maria Paz Garcia-Portilla, Jose Luis Santos, Estela Jimenez-Lopez, Julio Sanjuan

2021-01-07

Important questions remain about the profile of cognitive impairment in psychotic disorders across adulthood and illness stages. T..

White Matter Alterations Between Brain Network Hubs Underlie Processing Speed Impairment in Patients With Schizophrenia.

Paul Klauser, Vanessa L Cropley, Philipp S Baumann, Jinglei Lv, Pascal Steullet, Daniella Dwir, Yasser Alemán-Gómez, Meritxell Bach Cuadra, Michel Cuenod, Kim Q Do, Philippe Conus, Christos Pantelis, Alex Fornito, Tamsyn E Van Rheenen, Andrew Zalesky

2021-01-01

Processing speed (PS) impairment is one of the most severe and common cognitive deficits in schizophrenia. Previous studies have r..

Neural Correlates of Audiovisual Temporal Binding Window in Individuals With Schizotypal and Autistic Traits: Evidence From Resting-State Functional Connectivity

Han-yu Zhou, Yong-ming Wang, Rui-ting Zhang, Eric FC Cheung, Christos Pantelis, Raymond CK Chan

2020-12-14

Temporal proximity is an important clue for multisensory integration. Previous evidence indicates that individuals with autism and..

Traces of Trauma: A Multivariate Pattern Analysis of Childhood Trauma, Brain Structure, and Clinical Phenotypes

David Popovic, Anne Ruef, Dominic B Dwyer, Linda A Antonucci, Julia Eder, Rachele Sanfelici, Lana Kambeitz-Ilankovic, Omer Faruk Oztuerk, Mark S Dong, Riya Paul, Marco Paolini, Dennis Hedderich, Theresa Haidl, Joseph Kambeitz, Stephan Ruhrmann, Katharine Chisholm, Frauke Schultze-Lutter, Peter Falkai, Giulio Pergola, Giuseppe Blasi

2020-12-01

BACKGROUND: Childhood trauma (CT) is a major yet elusive psychiatric risk factor, whose multidimensional conceptualization and het..

Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study

Helene Walger, Linda A Antonucci, Alessandro Pigoni, Rachel Upthegrove, Raimo KR Salokangas, Rebekka Lencer, Katharine Chisholm, Anita Riecher-Rossler, Theresa Haidl, Eva Meisenzahl, Marlene Rosen, Stephan Ruhrmann, Joseph Kambeitz, Lana Kambeitz-Ilankovic, Peter Falkai, Anne Ruef, Jarmo Hietala, Christos Pantelis, Stephen J Wood, Paolo Brambilla

2020-11-17

In community studies, both attenuated psychotic symptoms (APS) and basic symptoms (BS) were more frequent but less clinically rele..

Altered empathy-related resting-state functional connectivity in adolescents with early-onset schizophrenia and autism spectrum disorders

Li-juan Shi, Han-yu Zhou, Yi Wang, Yan-mei Shen, Yu-min Fang, Yu-qiong He, Jian-jun Ou, Hua-bing Li, Xue-rong Luo, Eric FC Cheung, Christos Pantelis, Raymond CK Chan

2020-10-01

Empathy refers to the ability to understand other people's feelings and reacting emotionally to others. Impaired empathy has been ..

Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19

Christos Pantelis, Mahesh Jayaram, Anthony J Hannan, Robb Wesselingh, Jess Nithianantharajah, Cassandra MJ Wannan, Warda Taqdees Syeda, KH Christopher Choy, Daniela Zantomio, Arthur Christopoulos, Dennis Velakoulis, Terence J O'Brien

2020-10-01

Although COVID-19 is predominantly a respiratory disease, it is known to affect multiple organ systems. In this article, we highli..

Validation of the Bullying Scale for Adults - Results of the PRONIA-study

Theresa Katharina Haidl, Nicole Schneider, Kim Dickmann, Stephan Ruhrmann, Nathalie Kaiser, Marlene Rosen, Mauro Seves, Thorsten Lichtenstein, Rachel Upthegrove, Raimo KR Salokangas, Christos Pantelis, Eva Meisenzahl, Stephen J Wood, Paolo Brambilla, Stefan Borgwardt, Lencer Rebekka, Joseph Kambeitz, Nikolaos Koutsouleris, Frauke Schultze-Lutter, Linda Betz

2020-10-01

BACKGROUND: Bullying as a specific subtype of adverse life events is a major risk factor for poor mental health. Although many que..

Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort

Jinglei Lv, Maria Di Biase, Robin FH Cash, Luca Cocchi, Vanessa L Cropley, Paul Klauser, Ye Tian, Johanna Bayer, Lianne Schmaal, Suheyla Cetin-Karayumak, Yogesh Rathi, Ofer Pasternak, Chad Bousman, Christos Pantelis, Fernando Calamante, Andrew Zalesky

2020-09-22

The heterogeneity of schizophrenia has defied efforts to derive reproducible and definitive anatomical maps of structural brain ch..

Increased power by harmonizing structural MRI site differences with the ComBat batch method in ENIGMA

Joaquim Radua, Eduard Vieta, Russell Shinohara, Peter Kochunov, Yann Quide, Melissa J Green, Cynthia S Weickert, Thomas Weickert, Jason Bruggemann, Tilo Kircher, Igor Nenadic, Murray J Cairns, Marc Seal, Ulrich Schall, Frans Henskens, Janice M Fullerton, Bryan Mowry, Christos Pantelis, Rhoshel Lenroot, Vanessa Cropley

2020-09-01

A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Gene..

No Effects of Cognitive Remediation on Cerebral White Matter in Individuals at Ultra-High Risk for Psychosis-A Randomized Clinical Trial

Tina D Kristensen, Bjorn H Ebdrup, Carsten Hjorthoj, Rene CW Mandl, Jayachandra M Raghava, Jens Richardt M Jepsen, Birgitte Fagerlund, Louise B Glenthoj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Birte Y Glenthoj, Merete Nordentoft

2020-08-28

BACKGROUND: Individuals at ultra-high risk for psychosis (UHR) present with subtle alterations in cerebral white matter (WM), whic..

Predicting individual improvement in schizophrenia symptom severity at 1-year follow-up: Comparison of connectomic, structural, and clinical predictors

Akhil Kottaram, Leigh A Johnston, Ye Tian, Eleni P Ganella, Liliana Laskaris, Luca Cocchi, Patrick McGorry, Christos Pantelis, Ramamohanarao Kotagiri, Vanessa Cropley, Andrew Zalesky

2020-08-15

In a machine learning setting, this study aims to compare the prognostic utility of connectomic, brain structural, and clinical/de..

A machine-learning framework for robust and reliable prediction of short- and long-term treatment response in initially antipsychotic-naive schizophrenia patients based on multimodal neuropsychiatric data

Karen S Ambrosen, Martin W Skjerbaek, Jonathan Foldager, Martin C Axelsen, Nikolaj Bak, Lars Arvastson, Soren R Christensen, Louise B Johansen, Jayachandra M Raghava, Bob Oranje, Egill Rostrup, Mette O Nielsen, Merete Osler, Birgitte Fagerlund, Christos Pantelis, Bruce J Kinon, Birte Y Glenthoj, Lars K Hansen, Bjorn H Ebdrup

2020-08-10

The reproducibility of machine-learning analyses in computational psychiatry is a growing concern. In a multimodal neuropsychiatri..

Cognitive reserve attenuates age-related cognitive decline in the context of putatively accelerated brain ageing in schizophrenia-spectrum disorders

Tamsyn E Van Rheenen, Vanessa Cropley, Birgitte Fagerlund, Cassandra Wannan, Jason Bruggemann, Rhoshel K Lenroot, Suresh Sundram, Cynthia Shannon Weickert, Thomas W Weickert, Andrew Zalesky, Chad A Bousman, Christos Pantelis

2020-07-01

BACKGROUND: In schizophrenia, relative stability in the magnitude of cognitive deficits across age and illness duration is inconsi..

Impaired olfactory ability associated with larger left hippocampus and rectus volumes at earliest stages of schizophrenia: A sign of neuroinflammation?

Yuri Masaoka, Dennis Velakoulis, Warrick J Brewer, Vanessa L Cropley, Cali F Bartholomeusz, Alison R Yung, Barnaby Nelson, Dominic Dwyer, Cassandra MJ Wannan, Masahiko Izumizaki, Patrick D McGorry, Stephen J Wood, Christos Pantelis

2020-07-01

Impaired olfactory identification has been reported as a first sign of schizophrenia during the earliest stages of illness, includ..

Cognitive validation of cross-diagnostic cognitive subgroups on the schizophrenia-bipolar spectrum

James A Karantonis, Susan L Rossell, Sean P Carruthers, Philip Sumner, Matthew Hughes, Melissa J Green, Christos Pantelis, Katherine E Burdick, Vanessa Cropley, Tamsyn E Van Rheenen

2020-04-01

BACKGROUND: Cognitive heterogeneity in schizophrenia spectrum disorders (SSD) and bipolar disorder (BD) has been explored using cl..

Impact of CYP1A2, CYP2C19, and CYP2D6 genotype- and phenoconversion-predicted enzyme activity on clozapine exposure and symptom severity

Dorothea Lesche, Sam Mostafa, Ian Everall, Christos Pantelis, Chad A Bousman

2020-04-01

Clozapine is an atypical antipsychotic metabolized by CYP1A2, CYP2D6, and CYP2C19 enzymes. Among 66 adult schizophrenia patients t..

The genetic architecture of the human cerebral cortex

Katrina L Grasby, Neda Jahanshad, Jodie N Painter, Lucia Colodro-Conde, Janita Bralten, Derrek P Hibar, Penelope A Lind, Fabrizio Pizzagalli, Christopher RK Ching, Mary Agnes B McMahon, Natalia Shatokhina, Leo CP Zsembik, Sophia I Thomopoulos, Alyssa H Zhu, Lachlan T Strike, Ingrid Agartz, Saud Alhusaini, Marcio AA Almeida, Dag Alnaes, Inge K Amlien

2020-03-20

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influen..

Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study

Ya Wang, Ian H Harding, Renee Testa, Bruce Tonge, Harvey Jones, Marc Seal, Nola Ross, Raymond CK Chan, Florian van Beurden, Ahmad Abu-Akel, Efstratios Skafidas, Christos Pantelis

2020-03-18

Schizotypal disorder lies in the schizophrenia spectrum and is widely studied in adult populations. Schizotypal disorder in childr..

Association of Adverse Outcomes With Emotion Processing and Its Neural Substrate in Individuals at Clinical High Risk for Psychosis

Gemma Modinos, Matthew J Kempton, Stefania Tognin, Maria Calem, Lilla Porffy, Mathilde Antoniades, Ava Mason, Matilda Azis, Paul Allen, Barnaby Nelson, Patrick McGorry, Christos Pantelis, Anita Riecher-Rossler, Stefan Borgwardt, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Merete Nordentoft, Birte Glenthoj, Stephan Ruhrmann

2020-02-01

IMPORTANCE: The development of adverse clinical outcomes in patients with psychosis has been associated with behavioral and neuroa..

Parenting x Brain Development interactions as predictors of adolescent depressive symptoms and well-being: Differential susceptibility or diathesis-stress?

Camille Deane, Nandita Vijayakumar, Nicholas B Allen, Orli Schwartz, Julian G Simmons, Chad A Bousman, Christos Pantelis, Sarah Whittle

2020-02-01

It is unclear how individual differences in parenting and brain development interact to influence adolescent mental health outcome..

Heritability of Memory Functions and Related Brain Volumes: A Schizophrenia Spectrum Study of 214 Twins

CK Lemvigh, RM Brouwer, BJ Sahakian, TW Robbins, LB Johansen, CS Legind, SJ Anhøj, R Hilker, HE Hulshoff Pol, BH Ebdrup, C Pantelis, BY Glenthøj, B Fagerlund

2020-01-01

Background: Memory performance is heritable and shares partial genetic etiology with schizophrenia. How the genetic overlap betwee..

Schizotypal Disorder in Children—A Neglected Diagnosis

Bruce J Tonge, Renee Testa, Carmela Díaz-Arteche, Avril V Brereton, Katerina Stephanou, Christos Pantelis

2020-01-01

<jats:title>Abstract</jats:title> <jats:p>Disabling psychotic-like perceptions, thoughts, and behavior have long be..

Protocol for Clozapine Rechallenge in a Case of Clozapine-Induced Myocarditis

G Shivakumar, N Thomas, M Sollychin, A Takacs, S Kolamunna, P Melgar, F Connally, C Neil, C Bousman, M Jayaram, C Pantelis

2019-12-09

OBJECTIVE: Protocol for clozapine rechallenge in patients with a history of clozapine-induced myocarditis. METHOD: Clozapine-relat..

Aripiprazole compared with placebo for auditory verbal hallucinations in youth with borderline personality disorder: Protocol for the VERBATIM randomized controlled trial

Andrew M Chanen, Jennifer Betts, Henry Jackson, Patrick McGorry, Barnaby Nelson, Sue M Cotton, Cali Bartholomeusz, Martina Jovev, Aswin Ratheesh, Christopher Davey, Christos Pantelis, Louise McCutcheon, Shona Francey, Amit Bhaduri, Danielle Lowe, Victoria Rayner, Katherine Thompson

2019-12-01

AIM: Up to half of patients with borderline personality disorder report auditory verbal hallucinations that are phenomenologically..

Common mechanisms of executive attention underlie executive function and effortful control in children

Jeggan Tiego, Mark A Bellgrove, Sarah Whittle, Christos Pantelis, Renee Testa

2019-11-26

Executive Function (EF) and Effortful Control (EC) have traditionally been viewed as distinct constructs related to cognition and ..

Wnt receptor gene FZD1 was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort

Xiaoman Liu, Siew-Kee Low, Joshua R Atkins, Jing Qin Wu, William R Reay, Heath M Cairns, Melissa J Green, Ulrich Schall, Assen Jablensky, Bryan Mowry, Patricia T Michie, Stan V Catts, Frans Henskens, Christos Pantelis, Carmel Loughland, Alan V Boddy, Paul A Tooney, Rodney J Scott, Vaughan J Carr, Murray J Cairns

2019-11-16

OBJECTIVES: Large-scale genetic analysis of common variation in schizophrenia has been a powerful approach to understanding this c..

Olfactory sulcus morphology in teenagers with first-presentation borderline personality disorder

Tsutomu Takahashi, Yumiko Nishikawa, Dennis Velakoulis, Michio Suzuki, Patrick D McGorry, Christos Pantelis, Andrew M Chanen

2019-10-30

Gray matter reduction of the orbitofrontal cortex (OFC) has been reported in borderline personality disorder (BPD), but it remains..

Diagnostic stability and long-term symptomatic and functional outcomes in first-episode antipsychotic-naive patients with schizophrenia

Lea R Klaerke, Lone Baandrup, Birgitte Fagerlund, Bjorn H Ebdrup, Christos Pantelis, Birte Y Glenthoj, Mette O Nielsen

2019-10-01

OBJECTIVE: In a prospective cohort design, we investigated: i) diagnostic stability of initially antipsychotic-naïve schizophrenia..

Hippocampal subfields and visuospatial associative memory across stages of schizophrenia-spectrum disorder

Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Tamsyn E Van Rheenen, Sam Mancuso, Chad Bousman, Ian Everall, Patrick D McGorry, Christos Pantelis, Cali F Bartholomeusz

2019-10-01

BACKGROUND: While previous studies have identified relationships between hippocampal volumes and memory performance in schizophren..

The schizophrenia genetics knowledgebase: a comprehensive update of findings from candidate gene studies

Chenxing Liu, Tetsufumi Kanazawa, Ye Tian, Suriati Mohamed Saini, Serafino Mancuso, Md Shaki Mostaid, Atsushi Takahashi, Dai Zhang, Fuquan Zhang, Hao Yu, Hyoung Doo Shin, Hyun Sub Cheong, Masashi Ikeda, Michiaki Kubo, Nakao Iwata, Sung-Il Woo, Weihua Yue, Yoichiro Kamatani, Yongyong Shi, Zhiqiang Li

2019-08-27

Over 3000 candidate gene association studies have been performed to elucidate the genetic underpinnings of schizophrenia. However,..

Exploring Heterogeneity on the Wisconsin Card Sorting Test in Schizophrenia Spectrum Disorders: A Cluster Analytical Investigation

Sean P Carruthers, Caroline T Gurvich, Denny Meyer, Chad Bousman, Ian P Everall, Erica Neill, Christos Pantelis, Philip J Sumner, Eric J Tan, Elizabeth HX Thomas, Tamsyn E Van Rheenen, Susan L Rossell

2019-08-01

OBJECTIVES: The Wisconsin Card Sorting Test (WCST) is a complex measure of executive function that is frequently employed to inves..

Free-Water Imaging in White and Gray Matter in Parkinson's Disease

Christina Andica, Koji Kamagata, Taku Hatano, Asami Saito, Wataru Uchida, Takashi Ogawa, Haruka Takeshige-Amano, Andrew Zalesky, Akihiko Wada, Michimasa Suzuki, Akifumi Hagiwara, Ryusuke Irie, Masaaki Hori, Kanako K Kumamaru, Genko Oyama, Yashushi Shimo, Atsushi Umemura, Christos Pantelis, Nobutaka Hattori, Shigeki Aoki

2019-08-01

This study aimed to discriminate between neuroinflammation and neuronal degeneration in the white matter (WM) and gray matter (GM)..

Neuroanatomical alterations in people with high and low cannabis dependence

Valentina Lorenzetti, Yann Chye, Chao Suo, Mark Walterfang, Dan Lubman, Michael Takagi, Sarah Whittle, Antonio Verdejo-Garcia, Janna Cousijn, Christos Pantelis, Marc Seal, Alex Fornito, Murat Yucel, Nadia Solowij

2019-07-12

OBJECTIVES: We aimed to investigate whether severity of cannabis dependence is associated with the neuroanatomy of key brain regio..

Evidence for Network-Based Cortical Thickness Reductions in Schizophrenia

Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Chad Bousman, Eleni P Ganella, Jason M Bruggemann, Thomas W Weickert, Cynthia Shannon Weickert, Ian Everall, Patrick McGorry, Dennis Velakoulis, Stephen J Wood, Cali F Bartholomeusz, Christos Pantelis, Andrew Zalesky

2019-07-01

OBJECTIVE: Cortical thickness reductions in schizophrenia are irregularly distributed across multiple loci. The authors hypothesiz..

Blood and brain protein levels of ubiquitin-conjugating enzyme E2K (UBE2K) are elevated in individuals with schizophrenia

Hannah Meiklejohn, Md Shaki Mostaid, Sandra Luza, Serafino G Mancuso, Dali Kang, Sonny Atherton, Debora A Rothmond, Cynthia Shannon Weickert, Carlos M Opazo, Christos Pantelis, Ashley I Bush, Ian P Everall, Chad A Bousman

2019-06-01

A number of recent studies have suggested the ubiquitin proteasome system (UPS) in schizophrenia is dysfunctional. The purpose of ..

Brain network dynamics in schizophrenia: Reduced dynamism of the default mode network

Akhil Kottaram, Leigh A Johnston, Luca Cocchi, Eleni P Ganella, Ian Everall, Christos Pantelis, Ramamohanarao Kotagiri, Andrew Zalesky

2019-05-01

Complex human behavior emerges from dynamic patterns of neural activity that transiently synchronize between distributed brain net..

Patterns of Cortical Structures and Cognition in Antipsychotic-Naive Patients With First-Episode Schizophrenia: A Partial Least Squares Correlation Analysis

Kasper Jessen, Rene CW Mandl, Birgitte Fagerlund, Kirsten B Bojesen, Jayachandra M Raghava, Hayder G Obaid, Marie B Jensen, Louise B Johansen, Mette O Nielsen, Christos Pantelis, Egill Rostrup, Birte Y Glenthoj, Bjorn H Ebdrup

2019-05-01

BACKGROUND: Schizophrenia is associated with alterations in cortical structures and cognitive impairments, but antipsychotic medic..

Interrogating the Evolutionary Paradox of Schizophrenia: A Novel Framework and Evidence Supporting Recent Negative Selection of Schizophrenia Risk Alleles

Chenxing Liu, Ian Everall, Christos Pantelis, Chad Bousman

2019-04-30

Schizophrenia is a psychiatric disorder with a worldwide prevalence of ∼1%. The high heritability and reduced fertility among schi..

Insula Functional Connectivity in Schizophrenia: Subregions, Gradients, and Symptoms

Ye Tian, Andrew Zalesky, Chad Bousman, Ian Everall, Christos Pantelis

2019-04-01

BACKGROUND: The insular cortex is connected to a diverse network of cortical and subcortical areas. This study aimed to investigat..

Longitudinal changes in striatum and sub-threshold positive symptoms in individuals with an 'at risk mental state' (ARMS)

Naoyuki Katagiri, Christos Pantelis, Takahiro Nemoto, Naohisa Tsujino, Junichi Saito, Masaaki Hori, Taiju Yamaguchi, Tomoyuki Funatogawa, Masafumi Mizuno

2019-03-30

Recent studies have revealed that several psychotic symptom changes observed in the 'at risk mental state' (ARMS) are associated w..

The impact of schizophrenia and intelligence on the relationship between age and brain volume

Maria H Jensen, Nikolaj Bak, Egill Rostrup, Mette O Nielsen, Christos Pantelis, Birte Y Glenthoj, Bjorn H Ebdrup, Birgitte Fagerlund

2019-03-01

Age has been shown to have an impact on both grey (GM) and white matter (WM) volume, with a steeper slope of age-related decline i..

Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia

Chad A Bousman, Sandra Luza, Serafino G Mancuso, Dali Kang, Carlos M Opazo, Md Shaki Mostaid, Vanessa Cropley, Patrick McGorry, Cynthia Shannon Weickert, Christos Pantelis, Ashley I Bush, Ian P Everall

2019-02-19

Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation ..

An Interleukin-1 beta (IL1B) haplotype linked with psychosis transition is associated with IL1B gene expression and brain structure

Md Shaki Mostaid, Stefanos Dimitrakopoulos, Cassandra Wannan, Vanessa Cropley, Cynthia Shannon Weickert, Jan P Everall, Christos Pantelis, Chad A Bousman

2019-02-01

We investigated IL1B genetic variation previously associated with risk for transition to psychosis for its association with gene e..

Investigation of peripheral complement factors across stages of psychosis

Liliana Laskaris, Andrew Zalesky, Cynthia Shannon Weickert, Maria A Di Biase, Gursharan Chana, Bernhard T Baune, Chad Bousman, Barnaby Nelson, Patrick McGorry, Ian Everall, Christos Pantelis, Vanessa Cropley

2019-02-01

The complement cascade has been proposed to contribute to the pathogenesis of schizophrenia. However, it remains unclear whether p..

Systematic review and critical appraisal of child abuse measurement instruments

Suriati Mohamed Saini, Cassandra R Hoffmann, Christos Pantelis, Ian P Everall, Chad A Bousman

2019-02-01

Child abuse is a major public health concern and a strong predictor of adult psychopathology. However, a consensus on how best to ..

Neuroimaging and Staging Do Disparate Mental Illnesses Have Distinct Neurobiological Trajectories?

Cali F Bartholomeusz, Christos Pantelis

2019-01-01

Integration of brain structural information into prognostic and treatment formulation is key for achieving an all-encompassing bio..

Decreased peripheral TNF alpha (TNF-alpha) mRNA expression in patients with treatment-resistant schizophrenia

Md Shaki Mostaid, Christos Pantelis, Ian P Everall, Chad A Bousman

2018-12-01

An fMRI study of theory of mind in individuals with first episode psychosis

Cali F Bartholomeusz, Eleni P Ganella, Sarah Whittle, Kelly Allott, Andrew Thompson, Ahmad Abu-Akerl, Henrik Walter, Patrick McGorry, Eoin Killackey, Christos Pantelis, Stephen J Wood

2018-11-30

Theory of mind (ToM), the ability to infer one's own and others' mental states, is the social cognitive process shown to have the ..

Exploring the moderating effects of dopaminergic polymorphisms and childhood adversity on brain morphology in schizophrenia-spectrum disorders

Cassandra Hoffmann, Tamsyn E Van Rheenen, Serafino G Mancuso, Andrew Zalesky, Jason Bruggemann, Rhoshel K Lenroot, Suresh Sundram, Cynthia Shannon Weickert, Thomas W Weickert, Christos Pantelis, Vanessa Cropley, Chad A Bousman

2018-11-30

Genetic and environmental etiologies may contribute to schizophrenia and its associated neurobiological profile. We examined the i..

Prediction Models of Functional Outcomes for Individuals in the Clinical High-Risk State for Psychosis or With Recent-Onset Depression A Multimodal, Multisite Machine Learning Analysis

Nikolaos Koutsouleris, Lana Kambeitz-Ilankovic, Stephan Ruhrmann, Marlene Rosen, Anne Ruef, Dominic B Dwyer, Marco Paolini, Katharine Chisholm, Joseph Kambeitz, Theresa Haidl, Andre Schmidt, John Gillam, Frauke Schultze-Lutter, Peter Falkai, Maximilian Reiser, Anita Riecher-Rossler, Rachel Upthegrove, Jarmo Hietala, Raimo KR Salokangas, Christos Pantelis

2018-11-01

IMPORTANCE: Social and occupational impairments contribute to the burden of psychosis and depression. There is a need for risk str..

Brain Subtyping Enhances The Neuroanatomical Discrimination of Schizophrenia

Dominic B Dwyer, Carlos Cabral, Lana Kambeitz-Ilankovic, Rachele Sanfelici, Joseph Kambeitz, Vince Calhoun, Peter Falkai, Christos Pantelis, Eva Meisenzahl, Nikolaos Koutsouleris

2018-09-01

Identifying distinctive subtypes of schizophrenia could ultimately enhance diagnostic and prognostic accuracy. We aimed to uncover..

Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study

Eleni P Ganella, Caio Seguin, Christos Pantelis, Sarah Whittle, Bernhard T Baune, James Olver, G Paul Amminger, Patrick D McGorry, Vanessa Cropley, Andrew Zalesky, Cali F Bartholomeusz

2018-09-01

INTRODUCTION: Schizophrenia is increasingly conceived as a disorder of brain network connectivity and organization. However, repor..

Spatio-temporal dynamics of resting-state brain networks improve single-subject prediction of schizophrenia diagnosis

Akhil Kottaram, Leigh Johnston, Eleni Ganella, Christos Pantelis, Ramamohanarao Kotagiri, Andrew Zalesky

2018-09-01

Correlation in functional MRI activity between spatially separated brain regions can fluctuate dynamically when an individual is a..

A Hierarchical Model of Inhibitory Control

Jeggan Tiego, Renee Testa, Mark A Bellgrove, Christos Pantelis, Sarah Whittle

2018-08-02

Inhibitory control describes the suppression of goal-irrelevant stimuli and behavioral responses. Current developmental taxonomies..

Fragility and volatility of structural hubs in the human connectome

Leonardo L Gollo, James A Roberts, Vanessa L Cropley, Maria A Di Biase, Christos Pantelis, Andrew Zalesky, Michael Breakspear

2018-08-01

Brain structure reflects the influence of evolutionary processes that pit the costs of its anatomical wiring against the computati..

Downregulation of plasma SELENBP1 protein in patients with recent-onset schizophrenia

Edith J Chau, Md Shaki Mostaid, Vanessa Cropley, Patrick McGorry, Christos Pantelis, Chad A Bousman, Ian P Everall

2018-07-13

Upregulation of selenium binding protein 1 (SELENBP1) mRNA expression has been reported in schizophrenia, primarily in the dorsola..

Duration of untreated psychosis and neurocognitive functioning in first-episode psychosis: a systematic review and meta-analysis

K Allott, D Fraguas, CF Bartholomeusz, CM Diaz-Caneja, C Wannan, EM Parrish, GP Amminger, C Pantelis, C Arango, PD McGorry, M Rapado-Castro

2018-07-01

BACKGROUND: Previous reviews suggest there is minimal evidence for an association between duration of untreated psychosis (DUP) an..

Genetic variation in cytokine genes and risk for transition to psychosis among individuals at ultra-high risk

Chad A Bousman, Tae Young Lee, Minah Kim, Junhee Lee, Md Shaki Mostaid, Minji Bang, Suk Kyoon An, Ian P Everall, Christos Pantelis, Jun Soo Kwon

2018-05-01

Widespread Volumetric Reductions in Schizophrenia and Schizoaffective Patients Displaying Compromised Cognitive Abilities

Tamsyn E Van Rheenen, Vanessa Cropley, Andrew Zalesky, Chad Bousman, Ruth Wells, Jason Bruggemann, Suresh Sundram, Danielle Weinberg, Roshel K Lenroot, Avril Pereira, Cynthia Shannon Weickert, Thomas W Weickert, Christos Pantelis

2018-05-01

OBJECTIVE: Progress toward understanding brain mechanisms in psychosis is hampered by failures to account for within-group heterog..

Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia

CA Bousman, V Cropley, P Klauser, JL Hess, A Pereira, R Idrizi, J Bruggemann, MS Mostaid, R Lenroot, TW Weickert, SJ Glatt, IP Everall, S Sundram, A Zalesky, CS Weickert, C Pantelis

2018-04-01

BACKGROUND: Two single-nucleotide polymorphisms (SNPs) (rs4281084 and rs12155594) within the neuregulin-1 (NRG1) gene have been as..

Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania

Orwa Dandash, Murat Yucel, Rothanthi Daglas, Christos Pantelis, Patrick McGorry, Michael Berk, Alex Fornito

2018-03-06

Mood disturbances seen in first-episode mania (FEM) are linked to disturbed functional connectivity of the striatum. Lithium and q..

Predictors and consequences of health anxiety symptoms: a novel twin modeling study

C Lopez-Sola, M Bui, JL Hopper, LF Fontenelle, CG Davey, C Pantelis, P Alonso, OA van den Heuvel, BJ Harrison

2018-03-01

OBJECTIVE: The question of how to best conceptualize health anxiety (HA) from a diagnostic and etiological perspective remains deb..

Risk and resilience brain networks in treatment-resistant schizophrenia

Eleni P Ganella, Caio Seguin, Cali F Bartholomeusz, Sarah Whittle, Chad Bousman, Cassandra MJ Wannan, Maria A Di Biase, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky

2018-03-01

BACKGROUND: Genes, molecules and neural circuits that are associated with, or confer risk to developing schizophrenia have been st..

Differential effect of disease-associated ST8S/A2 haplotype on cerebral white matter diffusion properties in schizophrenia and healthy controls

Janice M Fullerton, Paul Klauser, Rhoshel K Lenroot, Alex D Shaw, Bronwyn Overs, Anna Heath, Murray J Cairns, Joshua Atkins, Rodney Scott, Peter R Schofield, Cyndi Shannon Weickert, Christos Pantelis, Alex Fornito, Thomas J Whitford, Thomas W Weickert, Andrew Zalesky

2018-01-22

Brain white matter abnormalities are evident in individuals with schizophrenia, and also their first-degree relatives, suggesting ..

Attentional set-shifting and social abilities in children with schizotypal and comorbid autism spectrum disorders

Ahmad Abu-Akel, Renee R Testa, Harvey P Jones, Nola Ross, Efstratios Skafidas, Bruce Tonge, Christos Pantelis

2018-01-01

OBJECTIVE: While diagnostically independent, autism and schizotypal disorders can co-occur. Their concurrent impact on outcomes an..

Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution

Koji Kamagata, Andrew Zalesky, Taku Hatano, Maria Angelique Di Biase, Omar El Samad, Shinji Saiki, Keigo Shimoji, Kanako K Kumamaru, Kouhei Kamiya, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki, Christos Pantelis

2018-01-01

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects extensive regions of the central nervous system...

Deterioration of visuospatial associative memory following a first psychotic episode: a long-term follow-up study

CMJ Wannan, CF Bartholomeusz, VL Cropley, TE Van Rheenen, A Panayiotou, WJ Brewer, TM Proffitt, L Henry, MG Harris, D Velakoulis, P McGorry, C Pantelis, SJ Wood

2018-01-01

BACKGROUND: Cognitive deficits are a core feature of schizophrenia, and impairments in most domains are thought to be stable over ..

Elevated peripheral expression of neuregulin-1 (NRG1) mRNA isoforms in clozapine-treated schizophrenia patients

Md Shaki Mostaid, Ting Ting Lee, Gursharan Chana, Suresh Sundram, Cynthia Shannon Weickert, Christos Pantelis, Ian Everall, Chad Bousman

2017-12-11

Differential expression of neuregulin-1 (NRG1) mRNA isoforms and proteins has been reported in schizophrenia, primarily in post-mo..

No preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism

Ting Ting Lee, Efstratios Skafidas, Mirella Dottori, Daniela Zantomio, Christos Pantelis, Ian Everall, Gursharan Chana

2017-12-08

BACKGROUND: While evidence for white matter and astrocytic abnormalities exist in autism, a detailed investigation of astrocytes h..

White matter connectivity disruptions in early and chronic schizophrenia

MA Di Biase, VL Cropley, BT Baune, J Olver, GP Amminger, C Phassouliotis, C Bousman, PD McGorry, I Everall, C Pantelis, A Zalesky

2017-12-01

BACKGROUND: White matter disruptions in schizophrenia have been widely reported, but it remains unclear whether these abnormalitie..

Peripheral Transcription of NRG-ErbB Pathway Genes Are Upregulated in Treatment-Resistant Schizophrenia

Md Shaki Mostaid, Ting Ting Lee, Gursharan Chana, Suresh Sundram, Cynthia Shannon Weickert, Christos Pantelis, Ian Everall, Chad Bousman

2017-11-06

Investigation of peripheral gene expression patterns of transcripts within the NRG-ErbB signaling pathway, other than neuregulin-1..

Systematic evaluation of commercial pharmacogenetic testing in psychiatry: a focus on CYP2D6 and CYP2C19 allele coverage and results reporting

Chad A Bousman, Philip Jaksa, Christos Pantelis

2017-11-01

OBJECTIVE: The aim of this study was to systematically assess commercial pharmacogenetic tests relevant to prescribing in psychiat..

PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia

MA Di Biase, A Zalesky, G O'keefe, L Laskaris, BT Baune, CS Weickert, J Olver, PD McGorry, GP Amminger, B Nelson, AM Scott, I Hickie, R Banati, F Turkheimer, M Yaqub, IP Everall, C Pantelis, V Cropley

2017-08-29

We examined putative microglial activation as a function of illness course in schizophrenia. Microglial activity was quantified us..

Meta-analysis supports GWAS-implicated link between GRM3 and schizophrenia risk

SM Saini, SG Mancuso, Md S Mostaid, C Liu, C Pantelis, IP Everall, CA Bousman

2017-08-08

Genome-wide association study (GWAS) evidence has identified the metabotropic glutamate receptor 3 (GRM3) gene as a potential harb..

Role of Positive Parenting in the Association Between Neighborhood Social Disadvantage and Brain Development Across Adolescence

Sarah Whittle, Nandita Vijayakumar, Julian G Simmons, Meg Dennison, Orli Schwartz, Christos Pantelis, Lisa Sheeber, Michelle L Byrne, Nicholas B Allen

2017-08-01

IMPORTANCE: The negative effects of socioeconomic disadvantage on lifelong functioning are pronounced, with some evidence suggesti..

Gray Matter Abnormalities in Idiopathic Parkinson's Disease: Evaluation by Diffusional Kurtosis Imaging and Neurite Orientation Dispersion and Density Imaging

Koji Kamagata, Andrew Zalesky, Taku Hatano, Ryo Ueda, Maria Angelique Di Biase, Ayami Okuzumi, Keigo Shimoji, Masaaki Hori, Karen Caeyenberghs, Christos Pantelis, Nobutaka Hattori, Shigeki Aoki

2017-07-01

Mapping gray matter (GM) pathology in Parkinson's disease (PD) with conventional MRI is challenging, and the need for more sensiti..

Functional brain networks in treatment-resistant schizophrenia

Eleni P Ganella, Cali F Bartholomeusz, Caio Seguin, Sarah Whittle, Chad Bousman, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky

2017-06-01

INTRODUCTION: Up to 20% of individuals with schizophrenia show minimal or no response to medication and are considered to have 'tr..

Quetiapine v. lithium in the maintenance phase following a first episode of mania: randomised controlled trial

Michael Berk, Rothanthi Daglas, Orwa Dandash, Murat Yucel, Lisa Henry, Karen Hallam, Craig Macneil, Melissa Hasty, Christos Pantelis, Brendan P Murphy, Linda Kader, Saji Damodaran, Michael TH Wong, Philippe Conus, Aswin Ratheesh, Patrick D McGorry, Sue M Cotton

2017-06-01

BackgroundLithium and quetiapine are considered standard maintenance agents for bipolar disorder yet it is unclear how their effic..

Challenges facing the identification of distinctive cognitive and neurobiological features of schizophrenia and bipolar disorder and the need for a data-driven approach: Response to Dr. Martino

Emre Bora, Christos Pantelis

2017-05-01

Structural neuroimaging across early-stage psychosis: Aberrations in neurobiological trajectories and implications for the staging model

Cali F Bartholomeusz, Vanessa L Cropley, Cassandra Wannan, Maria Di Biase, Patrick D McGorry, Christos Pantelis

2017-05-01

OBJECTIVE: This review critically examines the structural neuroimaging evidence in psychotic illness, with a focus on longitudinal..

A cluster analysis exploration of autism spectrum disorder subgroups in children without intellectual disability

Felicity Klopper, Renee Testa, Christos Pantelis, Efstratios Skafidas

2017-04-01

Background The heterogeneity in autism spectrum disorder (ASD) remains poorly understood, particularly in individuals without inte..

Accelerated Gray and White Matter Deterioration With Age in Schizophrenia

Vanessa L Cropley, Paul Klauser, Rhoshel K Lenroot, Jason Bruggemann, Suresh Sundram, Chad Bousman, Avril Pereira, Maria A Di Biase, Thomas W Weickert, Cynthia Shannon Weickert, Christos Pantelis, Andrew Zalesky

2017-03-01

OBJECTIVE: Although brain changes in schizophrenia have been proposed to mirror those found with advancing age, the trajectory of ..

Lithium suppression of tau induces brain iron accumulation and neurodegeneration

P Lei, S Ayton, AT Appukuttan, S Moon, JA Duce, I Volitakis, R Cherny, SJ Wood, M Greenough, G Berger, C Pantelis, P McGorry, A Yung, DI Finkelstein, AI Bush

2017-03-01

Lithium is a first-line therapy for bipolar affective disorder. However, various adverse effects, including a Parkinson-like hand ..

Neuroanatomical Predictors of Functional Outcome in Individuals at Ultra-High Risk for Psychosis

Renate LEP Reniers, Ashleigh Lin, Alison R Yung, Nikolaos Koutsouleris, Barnaby Nelson, Vanessa L Cropley, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis, Stephen J Wood

2017-03-01

Most individuals at ultra-high risk (UHR) for psychosis do not transition to frank illness. Nevertheless, many have poor clinical ..

White Matter Disruptions in Schizophrenia Are Spatially Widespread and Topologically Converge on Brain Network Hubs

Paul Klauser, Simon T Baker, Vanessa L Cropley, Chad Bousman, Alex Fornito, Luca Cocchi, Janice M Fullerton, Paul Rasser, Ulrich Schall, Frans Henskens, Patricia T Michie, Carmel Loughland, Stanley V Catts, Bryan Mowry, Thomas W Weickert, Cynthia Shannon Weickert, Vaughan Carr, Rhoshel Lenroot, Christos Pantelis, Andrew Zalesky

2017-03-01

White matter abnormalities associated with schizophrenia have been widely reported, although the consistency of findings across st..

Pathway-wide association study identifies five shared pathways associated with schizophrenia in three ancestral distinct populations

C Liu, CA Bousman, C Pantelis, E Skafidas, D Zhang, W Yue, IP Everall

2017-02-21

Genome-wide association studies have confirmed the polygenic nature of schizophrenia and suggest that there are hundreds or thousa..

Dopamine, fronto-striato-thalamic circuits and risk for psychosis

Orwa Dandash, Christos Pantelis, Alex Fornito

2017-02-01

A series of parallel, integrated circuits link distinct regions of prefrontal cortex with specific nuclei of the striatum and thal..

Effects of cigarette smoking on cortical thickness in major depressive disorder

Nabi Zorlu, Vanessa Louise Cropley, Pelin Kurtgoz Zorlu, Dursun Hakan Delibas, Zehra Hilal Adibelli, Emel Pasa Baskin, Ozgur Sipahi Esen, Emre Bora, Christos Pantelis

2017-01-01

Findings of surface-based morphometry studies in major depressive disorder (MDD) are still inconsistent. Given that cigarette smok..

Abnormal white matter integrity in synthetic cannabinoid users

Nabi Zorlu, Maria Angelique Di Biase, Cigdem Colak Kalayci, Andrew Zalesky, Basak Bagci, Nihan Oguz, Fazil Gelal, Lutfullah Besiroglu, Seref Gulseren, Aybala Saricicek, Emre Bora, Christos Pantelis

2016-11-01

Synthetic cannabinoids have become increasingly popular in the last few years especially among adolescents and young adults. Howev..

A prospective cohort study of depression course, functional disability, and NEET status in help-seeking young adults

Bridianne O'Dea, Rico SC Lee, Patrick D McGorry, Ian B Hickie, Jan Scott, Daniel F Hermens, Arnstein Mykeltun, Rosemary Purcell, Eoin Killackey, Christos Pantelis, G Paul Amminger, Nicholas Glozier

2016-10-01

PURPOSE: To examine the associations between depression course, functional disability, and Not in Education or Training (NEET) sta..

Olfactory sulcus morphology in patients with current and past major depression

Tsutomu Takahashi, Yumiko Nishikawa, Murat Yucel, Sarah Whittle, Valentina Lorenzetti, Mark Walterfang, Daiki Sasabayashi, Michio Suzuki, Christos Pantelis, Nicholas B Allen

2016-09-30

Olfactory deficits have been reported in major depressive disorder (MDD). However, it remains largely unknown whether MDD is assoc..

White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids

Nandita Vijayakumar, Cali Bartholomeusz, Thomas Whitford, Daniel F Hermens, Barnaby Nelson, Simon Rice, Sarah Whittle, Christos Pantelis, Patrick McGorry, Miriam R Schafer, G Paul Amminger

2016-08-11

BACKGROUND: Schizophrenia is thought to be a neurodevelopmental disorder with pathophysiological processes beginning in the brain ..

Early origins of mental disorder - risk factors in the perinatal and infant period

Louise Newman, Fiona Judd, Craig A Olsson, David Castle, Chad Bousman, Penelope Sheehan, Christos Pantelis, Jeffrey M Craig, Angela Komiti, Ian Everall

2016-07-29

BACKGROUND: There is increasing understanding of the significance of early neurodevelopment in establishing risk for the range of ..

Brain change trajectories that differentiate the major psychoses

Benny Liberg, Christoffer Rahm, Anita Panayiotou, Christos Pantelis

2016-07-01

BACKGROUND: Bipolar disorder and schizophrenia are highly heritable, often chronic and debilitating psychotic disorders that can b..