NEUROBIOLOGICAL 'RISK' AND 'RESILIENCE' BIOMARKERS OF SEVERE MENTAL ILLNESS
Grant number: 1105825 | Funding period: 2016 - 2020
Mental disorders of childhood (schizotypal disorder, autism spectrum disorders) and adolescence (psychoses, schizophrenia) represent a major burden of disease. We will use sophisticated neuroimaging to examine trajectories of brain growth from childhood to adulthood and identify factors (stress, drugs, inflammation, genes) relevant to risk and resilience to developing these disorders. This will lead to novel early interventions to reduce or ameliorate these conditions.
Related publications (43)
Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19
Christos Pantelis, Mahesh Jayaram, Anthony J Hannan, Robb Wesselingh, Jess Nithianantharajah, Cassandra MJ Wannan, Warda Taqdees Syeda, KH Christopher Choy, Daniela Zantomio, Arthur Christopoulos, Dennis Velakoulis, Terence J O'Brien
Although COVID-19 is predominantly a respiratory disease, it is known to affect multiple organ systems. In this article, we highli..
Validation of the Bullying Scale for Adults - Results of the PRONIA-study
Theresa Katharina Haidl, Nicole Schneider, Kim Dickmann, Stephan Ruhrmann, Nathalie Kaiser, Marlene Rosen, Mauro Seves, Thorsten Lichtenstein, Rachel Upthegrove, Raimo KR Salokangas, Christos Pantelis, Eva Meisenzahl, Stephen J Wood, Paolo Brambilla, Stefan Borgwardt, Lencer Rebekka, Joseph Kambeitz, Nikolaos Koutsouleris, Frauke Schultze-Lutter, Linda Betz
BACKGROUND: Bullying as a specific subtype of adverse life events is a major risk factor for poor mental health. Although many que..
Predicting individual improvement in schizophrenia symptom severity at 1-year follow-up: Comparison of connectomic, structural, and clinical predictors
Akhil Kottaram, Leigh A Johnston, Ye Tian, Eleni P Ganella, Liliana Laskaris, Luca Cocchi, Patrick McGorry, Christos Pantelis, Ramamohanarao Kotagiri, Vanessa Cropley, Andrew Zalesky
In a machine learning setting, this study aims to compare the prognostic utility of connectomic, brain structural, and clinical/de..
Impact of CYP1A2, CYP2C19, and CYP2D6 genotype- and phenoconversion-predicted enzyme activity on clozapine exposure and symptom severity
Dorothea Lesche, Sam Mostafa, Ian Everall, Christos Pantelis, Chad A Bousman
Clozapine is an atypical antipsychotic metabolized by CYP1A2, CYP2D6, and CYP2C19 enzymes. Among 66 adult schizophrenia patients t..
The genetic architecture of the human cerebral cortex
Katrina L Grasby, Neda Jahanshad, Jodie N Painter, Lucia Colodro-Conde, Janita Bralten, Derrek P Hibar, Penelope A Lind, Fabrizio Pizzagalli, Christopher RK Ching, Mary Agnes B McMahon, Natalia Shatokhina, Leo CP Zsembik, Sophia I Thomopoulos, Alyssa H Zhu, Lachlan T Strike, Ingrid Agartz, Saud Alhusaini, Marcio AA Almeida, Dag Alnaes, Inge K Amlien
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influen..
Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study
Ya Wang, Ian H Harding, Renee Testa, Bruce Tonge, Harvey Jones, Marc Seal, Nola Ross, Raymond CK Chan, Florian van Beurden, Ahmad Abu-Akel, Efstratios Skafidas, Christos Pantelis
Schizotypal disorder lies in the schizophrenia spectrum and is widely studied in adult populations. Schizotypal disorder in childr..
Aripiprazole compared with placebo for auditory verbal hallucinations in youth with borderline personality disorder: Protocol for the VERBATIM randomized controlled trial
Andrew M Chanen, Jennifer Betts, Henry Jackson, Patrick McGorry, Barnaby Nelson, Sue M Cotton, Cali Bartholomeusz, Martina Jovev, Aswin Ratheesh, Christopher Davey, Christos Pantelis, Louise McCutcheon, Shona Francey, Amit Bhaduri, Danielle Lowe, Victoria Rayner, Katherine Thompson
AIM: Up to half of patients with borderline personality disorder report auditory verbal hallucinations that are phenomenologically..
Hippocampal subfields and visuospatial associative memory across stages of schizophrenia-spectrum disorder
Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Tamsyn E Van Rheenen, Sam Mancuso, Chad Bousman, Ian Everall, Patrick D McGorry, Christos Pantelis, Cali F Bartholomeusz
BACKGROUND: While previous studies have identified relationships between hippocampal volumes and memory performance in schizophren..
Patterns of Cortical Structures and Cognition in Antipsychotic-Naive Patients With First-Episode Schizophrenia: A Partial Least Squares Correlation Analysis
Kasper Jessen, Rene CW Mandl, Birgitte Fagerlund, Kirsten B Bojesen, Jayachandra M Raghava, Hayder G Obaid, Marie B Jensen, Louise B Johansen, Mette O Nielsen, Christos Pantelis, Egill Rostrup, Birte Y Glenthoj, Bjorn H Ebdrup
BACKGROUND: Schizophrenia is associated with alterations in cortical structures and cognitive impairments, but antipsychotic medic..
Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia
CA Bousman, V Cropley, P Klauser, JL Hess, A Pereira, R Idrizi, J Bruggemann, MS Mostaid, R Lenroot, TW Weickert, SJ Glatt, IP Everall, S Sundram, A Zalesky, CS Weickert, C Pantelis
Differential effect of disease-associated ST8S/A2 haplotype on cerebral white matter diffusion properties in schizophrenia and healthy controls
Janice M Fullerton, Paul Klauser, Rhoshel K Lenroot, Alex D Shaw, Bronwyn Overs, Anna Heath, Murray J Cairns, Joshua Atkins, Rodney Scott, Peter R Schofield, Cyndi Shannon Weickert, Christos Pantelis, Alex Fornito, Thomas J Whitford, Thomas W Weickert, Andrew Zalesky
Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution
Koji Kamagata, Andrew Zalesky, Taku Hatano, Maria Angelique Di Biase, Omar El Samad, Shinji Saiki, Keigo Shimoji, Kanako K Kumamaru, Kouhei Kamiya, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki, Christos Pantelis
PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia
MA Di Biase, A Zalesky, G O'keefe, L Laskaris, BT Baune, CS Weickert, J Olver, PD McGorry, GP Amminger, B Nelson, AM Scott, I Hickie, R Banati, F Turkheimer, M Yaqub, IP Everall, C Pantelis, V Cropley
Quetiapine v. lithium in the maintenance phase following a first episode of mania: randomised controlled trial
Michael Berk, Rothanthi Daglas, Orwa Dandash, Murat Yucel, Lisa Henry, Karen Hallam, Craig Macneil, Melissa Hasty, Christos Pantelis, Brendan P Murphy, Linda Kader, Saji Damodaran, Michael TH Wong, Philippe Conus, Aswin Ratheesh, Patrick D McGorry, Sue M Cotton
A prospective cohort study of depression course, functional disability, and NEET status in help-seeking young adults
Bridianne O'Dea, Rico SC Lee, Patrick D McGorry, Ian B Hickie, Jan Scott, Daniel F Hermens, Arnstein Mykeltun, Rosemary Purcell, Eoin Killackey, Christos Pantelis, G Paul Amminger, Nicholas Glozier
White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids
Nandita Vijayakumar, Cali Bartholomeusz, Thomas Whitford, Daniel F Hermens, Barnaby Nelson, Simon Rice, Sarah Whittle, Christos Pantelis, Patrick McGorry, Miriam R Schafer, G Paul Amminger