NEUROBIOLOGICAL 'RISK' AND 'RESILIENCE' BIOMARKERS OF SEVERE MENTAL ILLNESS
Grant number: 1105825 | Funding period: 2016 - 2020
Mental disorders of childhood (schizotypal disorder, autism spectrum disorders) and adolescence (psychoses, schizophrenia) represent a major burden of disease. We will use sophisticated neuroimaging to examine trajectories of brain growth from childhood to adulthood and identify factors (stress, drugs, inflammation, genes) relevant to risk and resilience to developing these disorders. This will lead to novel early interventions to reduce or ameliorate these conditions.
Related publications (86)
Effective Connectivity and Dopaminergic Function of Fronto-Striato-Thalamic Circuitry in First-Episode Psychosis, Established Schizophrenia, and Healthy Controls
Kristina Sabaroedin, Adeel Razi, Sidhant Chopra, Nancy Tran, Andrii Pozaruk, Zhaolin Chen, Amy Finlay, Barnaby Nelson, Kelly Allott, Mario Alvarez-Jimenez, Jessica Graham, Lara Baldwin, Steven Tahtalian, Hok P Yuen, Susy Harrigan, Vanessa Cropley, Sujit Sharma, Bharat Saluja, Robert Williams, Christos Pantelis
<jats:title>Abstract</jats:title><jats:p>Dysfunction of fronto-striato-thalamic (FST) circuits is thought to contribute to dopamin..
Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort
Jinglei Lv, Maria Di Biase, Robin FH Cash, Luca Cocchi, Vanessa Cropley, Paul Klauser, Ye Tian, Johanna Bayer, Lianne Schmaal, Suheyla Cetin-Karayumak, Yogesh Rathi, Ofer Pasternak, Chad Bousman, Christos Pantelis, Fernando Calamante, Andrew Zalesky
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The heterogeneity of schizophrenia has defie..
Changes in negative symptoms are linked to white matter changes in superior longitudinal fasciculus in individuals at ultra-high risk for psychosis
Tina D Kristensen, Louise B Glenthoj, Jayachandra M Ragahava, Warda Syeda, Rene CW Mandl, Christina Wenneberg, Kristine Krakauer, Birgitte Fagerlund, Christos Pantelis, Birte Y Glenthoj, Merete Nordentoft, Bjorn H Ebdrup
AIM: Growing evidence suggests that subtle white matter (WM) alterations are associated with psychopathology in individuals at ult..
Disruptions in white matter microstructure associated with impaired visual associative memory in schizophrenia-spectrum illness
Cassandra MJ Wannan, Cali F Bartholomeusz, Christos Pantelis, Maria A Di Biase, Warda T Syeda, M Mallar Chakravarty, Chad A Bousman, Ian P Everall, Patrick D McGorry, Andrew Zalesky, Vanessa L Cropley
Episodic memory ability relies on hippocampal-prefrontal connectivity. However, few studies have examined relationships between me..
Prediction of Early Symptom Remission in Two Independent Samples of First-Episode Psychosis Patients Using Machine Learning.
Rigas F Soldatos, Micah Cearns, Mette Ø Nielsen, Costas Kollias, Lida-Alkisti Xenaki, Pentagiotissa Stefanatou, Irene Ralli, Stefanos Dimitrakopoulos, Alex Hatzimanolis, Ioannis Kosteletos, Ilias I Vlachos, Mirjana Selakovic, Stefania Foteli, Nikolaos Nianiakas, Leonidas Mantonakis, Theoni F Triantafyllou, Aggeliki Ntigridaki, Vanessa Ermiliou, Marina Voulgaraki, Evaggelia Psarra
BACKGROUND: Validated clinical prediction models of short-term remission in psychosis are lacking. Our aim was to develop a clinic..
Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness.
Rachele Sanfelici, Anne Ruef, Linda A Antonucci, Nora Penzel, Aristeidis Sotiras, Mark Sen Dong, Maria Urquijo-Castro, Julian Wenzel, Lana Kambeitz-Ilankovic, Meike D Hettwer, Stephan Ruhrmann, Katharine Chisholm, Anita Riecher-Rössler, Peter Falkai, Christos Pantelis, Raimo KR Salokangas, Rebekka Lencer, Alessandro Bertolino, Joseph Kambeitz, Eva Meisenzahl
Adult gyrification provides a window into coordinated early neurodevelopment when disruptions predispose individuals to psychiatri..
Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis
Ya Wang, Esmee E Braam, Cassandra MJ Wannan, Tamsyn E Van Rheenen, Raymond CK Chan, Barnaby Nelson, Patrick D McGorry, Alison R Yung, Ashleigh Lin, Warrick J Brewer, John Koutsogiannis, Stephen J Wood, Dennis Velakoulis, Christos Pantelis, Vanessa L Cropley
Increased severity of neurological soft signs (NSS) in schizophrenia have been associated with abnormal brain morphology in cerebe..
Global fractional anisotropy predicts transition to psychosis after 12 months in individuals at ultra-high risk for psychosis
Tina D Kristensen, Louise B Glenthoj, Karen Ambrosen, Warda Syeda, Jayachandra M Ragahava, Kristine Krakauer, Christina Wenneberg, Birgitte Fagerlund, Christos Pantelis, Birte Y Glenthoj, Merete Nordentoft, Bjorn H Ebdrup
OBJECTIVE: Psychosis spectrum disorders are associated with cerebral changes, but the prognostic value and clinical utility of the..
A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum.
James A Karantonis, Sean P Carruthers, Susan L Rossell, Christos Pantelis, Matthew Hughes, Cassandra Wannan, Vanessa Cropley, Tamsyn E Van Rheenen
The nature of the relationship between cognition and brain morphology in schizophrenia-spectrum disorders (SSD) and bipolar disord..
Associations between cognition and white matter microstructure in first-episode antipsychotic-naive patients with schizophrenia and healthy controls: A multivariate pattern analysis
Marie B Thomas, Jayachandra M Raghava, Christos Pantelis, Egill Rostrup, Mette O Nielsen, Maria H Jensen, Birte Y Glenthoj, Rene CW Mandl, Bjorn H Ebdrup, Birgitte Fagerlund
BACKGROUND: Cognitive functions have been associated with white matter (WM) microstructure in schizophrenia, but most studies are ..
Cognitive ability and metabolic physical health in first-episode psychosis
Sarah Whitson, Brian O'Donoghue, Robert Hester, Lara Baldwin, Susy Harrigan, Shona Francey, Jessica Graham, Barnaby Nelson, Aswin Ratheesh, Mario Alvarez-Jimenez, Alex Fornito, Christos Pantelis, Hok Pan Yuen, Andrew Thompson, Melissa Kerr, Michael Berk, Stephen J Wood, Patrick McGorry, Kelly Allott
Cognitive impairments are a core feature of first-episode psychosis (FEP), arising before illness onset and antipsychotic exposure..
Brain-Predicted Age Associates With Psychopathology Dimensions in Youths
Vanessa L Cropley, Ye Tian, Kavisha Fernando, L Sina Mansour, Christos Pantelis, Luca Cocchi, Andrew Zalesky
BACKGROUND: This study aimed to investigate whether dimensional constructs of psychopathology relate to variation in patterns of b..
Differentiating the effect of antipsychotic medication and illness on brain volume reductions in first-episode psychosis: A Longitudinal, Randomised, Triple-blind, Placebo-controlled MRI Study
Sidhant Chopra, Alex Fornito, Shona M Francey, Brian O'Donoghue, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Steven Tahtalian, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Kristina Sabaroedin, Christos Pantelis, Stephen J Wood, Patrick McGorry
Changes in brain volume are a common finding in Magnetic Resonance Imaging (MRI) studies of people with psychosis and numerous lon..
Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases
Parsa Ravanfar, Samantha M Loi, Warda T Syeda, Tamsyn E Van Rheenen, Ashley I Bush, Patricia Desmond, Vanessa L Cropley, Darius JR Lane, Carlos M Opazo, Bradford A Moffat, Dennis Velakoulis, Christos Pantelis
Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In the past decade, development of the new m..
White Matter Alterations Between Brain Network Hubs Underlie Processing Speed Impairment in Patients With Schizophrenia
Paul Klauser, Vanessa L Cropley, Philipp S Baumann, Jinglei Lv, Pascal Steullet, Daniella Dwir, Yasser Alemán-Gómez, Meritxell Bach Cuadra, Michel Cuenod, Kim Q Do, Philippe Conus, Christos Pantelis, Alex Fornito, Tamsyn E Van Rheenen, Andrew Zalesky
<jats:title>Abstract</jats:title> <jats:p>Processing speed (PS) impairment is one of the most severe and common cog..
Neural Correlates of Audiovisual Temporal Binding Window in Individuals With Schizotypal and Autistic Traits: Evidence From Resting-State Functional Connectivity
Han-yu Zhou, Yong-ming Wang, Rui-ting Zhang, Eric FC Cheung, Christos Pantelis, Raymond CK Chan
Temporal proximity is an important clue for multisensory integration. Previous evidence indicates that individuals with autism and..
Traces of Trauma: A Multivariate Pattern Analysis of Childhood Trauma, Brain Structure, and Clinical Phenotypes
David Popovic, Anne Ruef, Dominic B Dwyer, Linda A Antonucci, Julia Eder, Rachele Sanfelici, Lana Kambeitz-Ilankovic, Omer Faruk Oztuerk, Mark S Dong, Riya Paul, Marco Paolini, Dennis Hedderich, Theresa Haidl, Joseph Kambeitz, Stephan Ruhrmann, Katharine Chisholm, Frauke Schultze-Lutter, Peter Falkai, Giulio Pergola, Giuseppe Blasi
BACKGROUND: Childhood trauma (CT) is a major yet elusive psychiatric risk factor, whose multidimensional conceptualization and het..
Altered empathy-related resting-state functional connectivity in adolescents with early-onset schizophrenia and autism spectrum disorders
Li-juan Shi, Han-yu Zhou, Yi Wang, Yan-mei Shen, Yu-min Fang, Yu-qiong He, Jian-jun Ou, Hua-bing Li, Xue-rong Luo, Eric FC Cheung, Christos Pantelis, Raymond CK Chan
Empathy refers to the ability to understand other people's feelings and reacting emotionally to others. Impaired empathy has been ..
Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19
Christos Pantelis, Mahesh Jayaram, Anthony J Hannan, Robb Wesselingh, Jess Nithianantharajah, Cassandra MJ Wannan, Warda Taqdees Syeda, KH Christopher Choy, Daniela Zantomio, Arthur Christopoulos, Dennis Velakoulis, Terence J O'Brien
Although COVID-19 is predominantly a respiratory disease, it is known to affect multiple organ systems. In this article, we highli..
Validation of the Bullying Scale for Adults - Results of the PRONIA-study
Theresa Katharina Haidl, Nicole Schneider, Kim Dickmann, Stephan Ruhrmann, Nathalie Kaiser, Marlene Rosen, Mauro Seves, Thorsten Lichtenstein, Rachel Upthegrove, Raimo KR Salokangas, Christos Pantelis, Eva Meisenzahl, Stephen J Wood, Paolo Brambilla, Stefan Borgwardt, Lencer Rebekka, Joseph Kambeitz, Nikolaos Koutsouleris, Frauke Schultze-Lutter, Linda Betz
BACKGROUND: Bullying as a specific subtype of adverse life events is a major risk factor for poor mental health. Although many que..
Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort
Jinglei Lv, Maria Di Biase, Robin FH Cash, Luca Cocchi, Vanessa L Cropley, Paul Klauser, Ye Tian, Johanna Bayer, Lianne Schmaal, Suheyla Cetin-Karayumak, Yogesh Rathi, Ofer Pasternak, Chad Bousman, Christos Pantelis, Fernando Calamante, Andrew Zalesky
The heterogeneity of schizophrenia has defied efforts to derive reproducible and definitive anatomical maps of structural brain ch..
Increased power by harmonizing structural MRI site differences with the ComBat batch method in ENIGMA
Joaquim Radua, Eduard Vieta, Russell Shinohara, Peter Kochunov, Yann Quide, Melissa J Green, Cynthia S Weickert, Thomas Weickert, Jason Bruggemann, Tilo Kircher, Igor Nenadic, Murray J Cairns, Marc Seal, Ulrich Schall, Frans Henskens, Janice M Fullerton, Bryan Mowry, Christos Pantelis, Rhoshel Lenroot, Vanessa Cropley
A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Gene..
Predicting individual improvement in schizophrenia symptom severity at 1-year follow-up: Comparison of connectomic, structural, and clinical predictors
Akhil Kottaram, Leigh A Johnston, Ye Tian, Eleni P Ganella, Liliana Laskaris, Luca Cocchi, Patrick McGorry, Christos Pantelis, Ramamohanarao Kotagiri, Vanessa Cropley, Andrew Zalesky
In a machine learning setting, this study aims to compare the prognostic utility of connectomic, brain structural, and clinical/de..
A machine-learning framework for robust and reliable prediction of short- and long-term treatment response in initially antipsychotic-naive schizophrenia patients based on multimodal neuropsychiatric data
Karen S Ambrosen, Martin W Skjerbaek, Jonathan Foldager, Martin C Axelsen, Nikolaj Bak, Lars Arvastson, Soren R Christensen, Louise B Johansen, Jayachandra M Raghava, Bob Oranje, Egill Rostrup, Mette O Nielsen, Merete Osler, Birgitte Fagerlund, Christos Pantelis, Bruce J Kinon, Birte Y Glenthoj, Lars K Hansen, Bjorn H Ebdrup
The reproducibility of machine-learning analyses in computational psychiatry is a growing concern. In a multimodal neuropsychiatri..
Brain-predicted age associates with psychopathology dimensions in youth
Vanessa Cropley, Ye Tian, Kavisha Fernando, L Sina Mansour, Christos Pantelis, Luca Cocchi, Andrew Zalesky
<h4>Background</h4> This study aims to investigate whether dimensional constructs of psychopathology relate to advanced, attenuate..
Impact of CYP1A2, CYP2C19, and CYP2D6 genotype- and phenoconversion-predicted enzyme activity on clozapine exposure and symptom severity
Dorothea Lesche, Sam Mostafa, Ian Everall, Christos Pantelis, Chad A Bousman
Clozapine is an atypical antipsychotic metabolized by CYP1A2, CYP2D6, and CYP2C19 enzymes. Among 66 adult schizophrenia patients t..
The genetic architecture of the human cerebral cortex
Katrina L Grasby, Neda Jahanshad, Jodie N Painter, Lucia Colodro-Conde, Janita Bralten, Derrek P Hibar, Penelope A Lind, Fabrizio Pizzagalli, Christopher RK Ching, Mary Agnes B McMahon, Natalia Shatokhina, Leo CP Zsembik, Sophia I Thomopoulos, Alyssa H Zhu, Lachlan T Strike, Ingrid Agartz, Saud Alhusaini, Marcio AA Almeida, Dag Alnaes, Inge K Amlien
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influen..
Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study
Ya Wang, Ian H Harding, Renee Testa, Bruce Tonge, Harvey Jones, Marc Seal, Nola Ross, Raymond CK Chan, Florian van Beurden, Ahmad Abu-Akel, Efstratios Skafidas, Christos Pantelis
Schizotypal disorder lies in the schizophrenia spectrum and is widely studied in adult populations. Schizotypal disorder in childr..
Heritability of Memory Functions and Related Brain Volumes: A Schizophrenia Spectrum Study of 214 Twins
Cecilie K Lemvigh, Rachel M Brouwer, Barbara J Sahakian, Trevor W Robbins, Louise B Johansen, Christian S Legind, Simon J Anhøj, Rikke Hilker, Hilleke E Hulshoff Pol, Bjørn H Ebdrup, Christos Pantelis, Birte Y Glenthøj, Birgitte Fagerlund
<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> ..
Aripiprazole compared with placebo for auditory verbal hallucinations in youth with borderline personality disorder: Protocol for the VERBATIM randomized controlled trial
Andrew M Chanen, Jennifer Betts, Henry Jackson, Patrick McGorry, Barnaby Nelson, Sue M Cotton, Cali Bartholomeusz, Martina Jovev, Aswin Ratheesh, Christopher Davey, Christos Pantelis, Louise McCutcheon, Shona Francey, Amit Bhaduri, Danielle Lowe, Victoria Rayner, Katherine Thompson
AIM: Up to half of patients with borderline personality disorder report auditory verbal hallucinations that are phenomenologically..
Common mechanisms of executive attention underlie executive function and effortful control in children
Jeggan Tiego, Mark A Bellgrove, Sarah Whittle, Christos Pantelis, Renee Testa
Executive Function (EF) and Effortful Control (EC) have traditionally been viewed as distinct constructs related to cognition and ..
Wnt receptor gene FZD1 was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort
Xiaoman Liu, Siew-Kee Low, Joshua R Atkins, Jing Qin Wu, William R Reay, Heath M Cairns, Melissa J Green, Ulrich Schall, Assen Jablensky, Bryan Mowry, Patricia T Michie, Stan V Catts, Frans Henskens, Christos Pantelis, Carmel Loughland, Alan V Boddy, Paul A Tooney, Rodney J Scott, Vaughan J Carr, Murray J Cairns
OBJECTIVES: Large-scale genetic analysis of common variation in schizophrenia has been a powerful approach to understanding this c..
Olfactory sulcus morphology in teenagers with first-presentation borderline personality disorder
Tsutomu Takahashi, Yumiko Nishikawa, Dennis Velakoulis, Michio Suzuki, Patrick D McGorry, Christos Pantelis, Andrew M Chanen
Gray matter reduction of the orbitofrontal cortex (OFC) has been reported in borderline personality disorder (BPD), but it remains..
Diagnostic stability and long-term symptomatic and functional outcomes in first-episode antipsychotic-naive patients with schizophrenia
Lea R Klaerke, Lone Baandrup, Birgitte Fagerlund, Bjorn H Ebdrup, Christos Pantelis, Birte Y Glenthoj, Mette O Nielsen
OBJECTIVE: In a prospective cohort design, we investigated: i) diagnostic stability of initially antipsychotic-naïve schizophrenia..
Hippocampal subfields and visuospatial associative memory across stages of schizophrenia-spectrum disorder
Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Tamsyn E Van Rheenen, Sam Mancuso, Chad Bousman, Ian Everall, Patrick D McGorry, Christos Pantelis, Cali F Bartholomeusz
BACKGROUND: While previous studies have identified relationships between hippocampal volumes and memory performance in schizophren..
The schizophrenia genetics knowledgebase: a comprehensive update of findings from candidate gene studies
Chenxing Liu, Tetsufumi Kanazawa, Ye Tian, Suriati Mohamed Saini, Serafino Mancuso, Md Shaki Mostaid, Atsushi Takahashi, Dai Zhang, Fuquan Zhang, Hao Yu, Hyoung Doo Shin, Hyun Sub Cheong, Masashi Ikeda, Michiaki Kubo, Nakao Iwata, Sung-Il Woo, Weihua Yue, Yoichiro Kamatani, Yongyong Shi, Zhiqiang Li
Over 3000 candidate gene association studies have been performed to elucidate the genetic underpinnings of schizophrenia. However,..
Exploring Heterogeneity on the Wisconsin Card Sorting Test in Schizophrenia Spectrum Disorders: A Cluster Analytical Investigation
Sean P Carruthers, Caroline T Gurvich, Denny Meyer, Chad Bousman, Ian P Everall, Erica Neill, Christos Pantelis, Philip J Sumner, Eric J Tan, Elizabeth HX Thomas, Tamsyn E Van Rheenen, Susan L Rossell
OBJECTIVES: The Wisconsin Card Sorting Test (WCST) is a complex measure of executive function that is frequently employed to inves..
Evidence for Network-Based Cortical Thickness Reductions in Schizophrenia
Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Chad Bousman, Eleni P Ganella, Jason M Bruggemann, Thomas W Weickert, Cynthia Shannon Weickert, Ian Everall, Patrick McGorry, Dennis Velakoulis, Stephen J Wood, Cali F Bartholomeusz, Christos Pantelis, Andrew Zalesky
OBJECTIVE: Cortical thickness reductions in schizophrenia are irregularly distributed across multiple loci. The authors hypothesiz..
Brain network dynamics in schizophrenia: Reduced dynamism of the default mode network
Akhil Kottaram, Leigh A Johnston, Luca Cocchi, Eleni P Ganella, Ian Everall, Christos Pantelis, Ramamohanarao Kotagiri, Andrew Zalesky
Complex human behavior emerges from dynamic patterns of neural activity that transiently synchronize between distributed brain net..
Patterns of Cortical Structures and Cognition in Antipsychotic-Naive Patients With First-Episode Schizophrenia: A Partial Least Squares Correlation Analysis
Kasper Jessen, Rene CW Mandl, Birgitte Fagerlund, Kirsten B Bojesen, Jayachandra M Raghava, Hayder G Obaid, Marie B Jensen, Louise B Johansen, Mette O Nielsen, Christos Pantelis, Egill Rostrup, Birte Y Glenthoj, Bjorn H Ebdrup
BACKGROUND: Schizophrenia is associated with alterations in cortical structures and cognitive impairments, but antipsychotic medic..
Longitudinal changes in striatum and sub-threshold positive symptoms in individuals with an 'at risk mental state' (ARMS)
Naoyuki Katagiri, Christos Pantelis, Takahiro Nemoto, Naohisa Tsujino, Junichi Saito, Masaaki Hori, Taiju Yamaguchi, Tomoyuki Funatogawa, Masafumi Mizuno
Recent studies have revealed that several psychotic symptom changes observed in the 'at risk mental state' (ARMS) are associated w..
The impact of schizophrenia and intelligence on the relationship between age and brain volume
Maria H Jensen, Nikolaj Bak, Egill Rostrup, Mette O Nielsen, Christos Pantelis, Birte Y Glenthoj, Bjorn H Ebdrup, Birgitte Fagerlund
Age has been shown to have an impact on both grey (GM) and white matter (WM) volume, with a steeper slope of age-related decline i..
Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia
Chad A Bousman, Sandra Luza, Serafino G Mancuso, Dali Kang, Carlos M Opazo, Md Shaki Mostaid, Vanessa Cropley, Patrick McGorry, Cynthia Shannon Weickert, Christos Pantelis, Ashley I Bush, Ian P Everall
Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation ..
An Interleukin-1 beta (IL1B) haplotype linked with psychosis transition is associated with IL1B gene expression and brain structure
Md Shaki Mostaid, Stefanos Dimitrakopoulos, Cassandra Wannan, Vanessa Cropley, Cynthia Shannon Weickert, Jan P Everall, Christos Pantelis, Chad A Bousman
We investigated IL1B genetic variation previously associated with risk for transition to psychosis for its association with gene e..
Investigation of peripheral complement factors across stages of psychosis
Liliana Laskaris, Andrew Zalesky, Cynthia Shannon Weickert, Maria A Di Biase, Gursharan Chana, Bernhard T Baune, Chad Bousman, Barnaby Nelson, Patrick McGorry, Ian Everall, Christos Pantelis, Vanessa Cropley
The complement cascade has been proposed to contribute to the pathogenesis of schizophrenia. However, it remains unclear whether p..
An fMRI study of theory of mind in individuals with first episode psychosis
Cali F Bartholomeusz, Eleni P Ganella, Sarah Whittle, Kelly Allott, Andrew Thompson, Ahmad Abu-Akerl, Henrik Walter, Patrick McGorry, Eoin Killackey, Christos Pantelis, Stephen J Wood
Theory of mind (ToM), the ability to infer one's own and others' mental states, is the social cognitive process shown to have the ..
Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study
Eleni P Ganella, Caio Seguin, Christos Pantelis, Sarah Whittle, Bernhard T Baune, James Olver, G Paul Amminger, Patrick D McGorry, Vanessa Cropley, Andrew Zalesky, Cali F Bartholomeusz
INTRODUCTION: Schizophrenia is increasingly conceived as a disorder of brain network connectivity and organization. However, repor..
Spatio-temporal dynamics of resting-state brain networks improve single-subject prediction of schizophrenia diagnosis
Akhil Kottaram, Leigh Johnston, Eleni Ganella, Christos Pantelis, Ramamohanarao Kotagiri, Andrew Zalesky
Correlation in functional MRI activity between spatially separated brain regions can fluctuate dynamically when an individual is a..
Fragility and volatility of structural hubs in the human connectome
Leonardo L Gollo, James A Roberts, Vanessa L Cropley, Maria A Di Biase, Christos Pantelis, Andrew Zalesky, Michael Breakspear
Brain structure reflects the influence of evolutionary processes that pit the costs of its anatomical wiring against the computati..
Downregulation of plasma SELENBP1 protein in patients with recent-onset schizophrenia
Edith J Chau, Md Shaki Mostaid, Vanessa Cropley, Patrick McGorry, Christos Pantelis, Chad A Bousman, Ian P Everall
Upregulation of selenium binding protein 1 (SELENBP1) mRNA expression has been reported in schizophrenia, primarily in the dorsola..
Duration of untreated psychosis and neurocognitive functioning in first-episode psychosis: a systematic review and meta-analysis
K Allott, D Fraguas, CF Bartholomeusz, CM Diaz-Caneja, C Wannan, EM Parrish, GP Amminger, C Pantelis, C Arango, PD McGorry, M Rapado-Castro
BACKGROUND: Previous reviews suggest there is minimal evidence for an association between duration of untreated psychosis (DUP) an..
Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia
CA Bousman, V Cropley, P Klauser, JL Hess, A Pereira, R Idrizi, J Bruggemann, MS Mostaid, R Lenroot, TW Weickert, SJ Glatt, IP Everall, S Sundram, A Zalesky, CS Weickert, C Pantelis
BACKGROUND: Two single-nucleotide polymorphisms (SNPs) (rs4281084 and rs12155594) within the neuregulin-1 (NRG1) gene have been as..
Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania
Orwa Dandash, Murat Yucel, Rothanthi Daglas, Christos Pantelis, Patrick McGorry, Michael Berk, Alex Fornito
Mood disturbances seen in first-episode mania (FEM) are linked to disturbed functional connectivity of the striatum. Lithium and q..
Predictors and consequences of health anxiety symptoms: a novel twin modeling study
C Lopez-Sola, M Bui, JL Hopper, LF Fontenelle, CG Davey, C Pantelis, P Alonso, OA van den Heuvel, BJ Harrison
OBJECTIVE: The question of how to best conceptualize health anxiety (HA) from a diagnostic and etiological perspective remains deb..
Risk and resilience brain networks in treatment-resistant schizophrenia
Eleni P Ganella, Caio Seguin, Cali F Bartholomeusz, Sarah Whittle, Chad Bousman, Cassandra MJ Wannan, Maria A Di Biase, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky
BACKGROUND: Genes, molecules and neural circuits that are associated with, or confer risk to developing schizophrenia have been st..
Differential effect of disease-associated ST8S/A2 haplotype on cerebral white matter diffusion properties in schizophrenia and healthy controls
Janice M Fullerton, Paul Klauser, Rhoshel K Lenroot, Alex D Shaw, Bronwyn Overs, Anna Heath, Murray J Cairns, Joshua Atkins, Rodney Scott, Peter R Schofield, Cyndi Shannon Weickert, Christos Pantelis, Alex Fornito, Thomas J Whitford, Thomas W Weickert, Andrew Zalesky
Brain white matter abnormalities are evident in individuals with schizophrenia, and also their first-degree relatives, suggesting ..
Attentional set-shifting and social abilities in children with schizotypal and comorbid autism spectrum disorders
Ahmad Abu-Akel, Renee R Testa, Harvey P Jones, Nola Ross, Efstratios Skafidas, Bruce Tonge, Christos Pantelis
OBJECTIVE: While diagnostically independent, autism and schizotypal disorders can co-occur. Their concurrent impact on outcomes an..
Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution
Koji Kamagata, Andrew Zalesky, Taku Hatano, Maria Angelique Di Biase, Omar El Samad, Shinji Saiki, Keigo Shimoji, Kanako K Kumamaru, Kouhei Kamiya, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki, Christos Pantelis
Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects extensive regions of the central nervous system...
Deterioration of visuospatial associative memory following a first psychotic episode: a long-term follow-up study
CMJ Wannan, CF Bartholomeusz, VL Cropley, TE Van Rheenen, A Panayiotou, WJ Brewer, TM Proffitt, L Henry, MG Harris, D Velakoulis, P McGorry, C Pantelis, SJ Wood
BACKGROUND: Cognitive deficits are a core feature of schizophrenia, and impairments in most domains are thought to be stable over ..
Elevated peripheral expression of neuregulin-1 (NRG1) mRNA isoforms in clozapine-treated schizophrenia patients
Md Shaki Mostaid, Ting Ting Lee, Gursharan Chana, Suresh Sundram, Cynthia Shannon Weickert, Christos Pantelis, Ian Everall, Chad Bousman
Differential expression of neuregulin-1 (NRG1) mRNA isoforms and proteins has been reported in schizophrenia, primarily in post-mo..
No preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism
Ting Ting Lee, Efstratios Skafidas, Mirella Dottori, Daniela Zantomio, Christos Pantelis, Ian Everall, Gursharan Chana
Background: While evidence for white matter and astrocytic abnormalities exist in autism, a detailed investigation of astrocytes h..
White matter connectivity disruptions in early and chronic schizophrenia
MA Di Biase, VL Cropley, BT Baune, J Olver, GP Amminger, C Phassouliotis, C Bousman, PD McGorry, I Everall, C Pantelis, A Zalesky
BACKGROUND: White matter disruptions in schizophrenia have been widely reported, but it remains unclear whether these abnormalitie..
PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia
MA Di Biase, A Zalesky, G O'keefe, L Laskaris, BT Baune, CS Weickert, J Olver, PD McGorry, GP Amminger, B Nelson, AM Scott, I Hickie, R Banati, F Turkheimer, M Yaqub, IP Everall, C Pantelis, V Cropley
We examined putative microglial activation as a function of illness course in schizophrenia. Microglial activity was quantified us..
Meta-analysis supports GWAS-implicated link between GRM3 and schizophrenia risk
SM Saini, SG Mancuso, Md S Mostaid, C Liu, C Pantelis, IP Everall, CA Bousman
Genome-wide association study (GWAS) evidence has identified the metabotropic glutamate receptor 3 (GRM3) gene as a potential harb..
Role of Positive Parenting in the Association Between Neighborhood Social Disadvantage and Brain Development Across Adolescence
Sarah Whittle, Nandita Vijayakumar, Julian G Simmons, Meg Dennison, Orli Schwartz, Christos Pantelis, Lisa Sheeber, Michelle L Byrne, Nicholas B Allen
Importance: The negative effects of socioeconomic disadvantage on lifelong functioning are pronounced, with some evidence suggesti..
Functional brain networks in treatment-resistant schizophrenia
Eleni P Ganella, Cali F Bartholomeusz, Caio Seguin, Sarah Whittle, Chad Bousman, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky
INTRODUCTION: Up to 20% of individuals with schizophrenia show minimal or no response to medication and are considered to have 'tr..
Quetiapine v. lithium in the maintenance phase following a first episode of mania: randomised controlled trial
Michael Berk, Rothanthi Daglas, Orwa Dandash, Murat Yucel, Lisa Henry, Karen Hallam, Craig Macneil, Melissa Hasty, Christos Pantelis, Brendan P Murphy, Linda Kader, Saji Damodaran, Michael TH Wong, Philippe Conus, Aswin Ratheesh, Patrick D McGorry, Sue M Cotton
BackgroundLithium and quetiapine are considered standard maintenance agents for bipolar disorder yet it is unclear how their effic..
A cluster analysis exploration of autism spectrum disorder subgroups in children without intellectual disability
Felicity Klopper, Renee Testa, Christos Pantelis, Efstratios Skafidas
Background The heterogeneity in autism spectrum disorder (ASD) remains poorly understood, particularly in individuals without inte..
Lithium suppression of tau induces brain iron accumulation and neurodegeneration
P Lei, S Ayton, AT Appukuttan, S Moon, JA Duce, I Volitakis, R Cherny, SJ Wood, M Greenough, G Berger, C Pantelis, P McGorry, A Yung, DI Finkelstein, AI Bush
Lithium is a first-line therapy for bipolar affective disorder. However, various adverse effects, including a Parkinson-like hand ..
Neuroanatomical Predictors of Functional Outcome in Individuals at Ultra-High Risk for Psychosis
Renate LEP Reniers, Ashleigh Lin, Alison R Yung, Nikolaos Koutsouleris, Barnaby Nelson, Vanessa L Cropley, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis, Stephen J Wood
Most individuals at ultra-high risk (UHR) for psychosis do not transition to frank illness. Nevertheless, many have poor clinical ..
White Matter Disruptions in Schizophrenia Are Spatially Widespread and Topologically Converge on Brain Network Hubs
Paul Klauser, Simon T Baker, Vanessa L Cropley, Chad Bousman, Alex Fornito, Luca Cocchi, Janice M Fullerton, Paul Rasser, Ulrich Schall, Frans Henskens, Patricia T Michie, Carmel Loughland, Stanley V Catts, Bryan Mowry, Thomas W Weickert, Cynthia Shannon Weickert, Vaughan Carr, Rhoshel Lenroot, Christos Pantelis, Andrew Zalesky
White matter abnormalities associated with schizophrenia have been widely reported, although the consistency of findings across st..
Pathway-wide association study identifies five shared pathways associated with schizophrenia in three ancestral distinct populations
C Liu, CA Bousman, C Pantelis, E Skafidas, D Zhang, W Yue, IP Everall
Genome-wide association studies have confirmed the polygenic nature of schizophrenia and suggest that there are hundreds or thousa..
Effects of cigarette smoking on cortical thickness in major depressive disorder
Nabi Zorlu, Vanessa Louise Cropley, Pelin Kurtgoz Zorlu, Dursun Hakan Delibas, Zehra Hilal Adibelli, Emel Pasa Baskin, Ozgur Sipahi Esen, Emre Bora, Christos Pantelis
Findings of surface-based morphometry studies in major depressive disorder (MDD) are still inconsistent. Given that cigarette smok..
Abnormal white matter integrity in synthetic cannabinoid users
Nabi Zorlu, Maria Angelique Di Biase, Cigdem Colak Kalayci, Andrew Zalesky, Basak Bagci, Nihan Oguz, Fazil Gelal, Lutfullah Besiroglu, Seref Gulseren, Aybala Saricicek, Emre Bora, Christos Pantelis
Synthetic cannabinoids have become increasingly popular in the last few years especially among adolescents and young adults. Howev..
A prospective cohort study of depression course, functional disability, and NEET status in help-seeking young adults
Bridianne O'Dea, Rico SC Lee, Patrick D McGorry, Ian B Hickie, Jan Scott, Daniel F Hermens, Arnstein Mykeltun, Rosemary Purcell, Eoin Killackey, Christos Pantelis, G Paul Amminger, Nicholas Glozier
PURPOSE: To examine the associations between depression course, functional disability, and Not in Education or Training (NEET) sta..
Olfactory sulcus morphology in patients with current and past major depression
Tsutomu Takahashi, Yumiko Nishikawa, Murat Yucel, Sarah Whittle, Valentina Lorenzetti, Mark Walterfang, Daiki Sasabayashi, Michio Suzuki, Christos Pantelis, Nicholas B Allen
Olfactory deficits have been reported in major depressive disorder (MDD). However, it remains largely unknown whether MDD is assoc..
White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids
Nandita Vijayakumar, Cali Bartholomeusz, Thomas Whitford, Daniel F Hermens, Barnaby Nelson, Simon Rice, Sarah Whittle, Christos Pantelis, Patrick McGorry, Miriam R Schafer, G Paul Amminger
BACKGROUND: Schizophrenia is thought to be a neurodevelopmental disorder with pathophysiological processes beginning in the brain ..
Early origins of mental disorder - risk factors in the perinatal and infant period
Louise Newman, Fiona Judd, Craig A Olsson, David Castle, Chad Bousman, Penelope Sheehan, Christos Pantelis, Jeffrey M Craig, Angela Komiti, Ian Everall
BACKGROUND: There is increasing understanding of the significance of early neurodevelopment in establishing risk for the range of ..