NEUROBIOLOGICAL 'RISK' AND 'RESILIENCE' BIOMARKERS OF SEVERE MENTAL ILLNESS
Grant number: 1105825 | Funding period: 2016 - 2020
Mental disorders of childhood (schizotypal disorder, autism spectrum disorders) and adolescence (psychoses, schizophrenia) represent a major burden of disease. We will use sophisticated neuroimaging to examine trajectories of brain growth from childhood to adulthood and identify factors (stress, drugs, inflammation, genes) relevant to risk and resilience to developing these disorders. This will lead to novel early interventions to reduce or ameliorate these conditions.
Related publications (73)
Cognitive ability and metabolic physical health in first-episode psychosis.
Sarah Whitson, Brian O'Donoghue, Robert Hester, Lara Baldwin, Susy Harrigan, Shona Francey, Jessica Graham, Barnaby Nelson, Aswin Ratheesh, Mario Alvarez-Jimenez, Alex Fornito, Christos Pantelis, Hok Pan Yuen, Andrew Thompson, Melissa Kerr, Michael Berk, Stephen J Wood, Patrick McGorry, Kelly Allott
Cognitive impairments are a core feature of first-episode psychosis (FEP), arising before illness onset and antipsychotic exposure..
Brain-Predicted Age Associates With Psychopathology Dimensions in Youths
Vanessa L Cropley, Ye Tian, Kavisha Fernando, L Sina Mansour, Christos Pantelis, Luca Cocchi, Andrew Zalesky
BACKGROUND: This study aimed to investigate whether dimensional constructs of psychopathology relate to variation in patterns of b..
Associations between cognition and white matter microstructure in first-episode antipsychotic-naïve patients with schizophrenia and healthy controls: A multivariate pattern analysis.
Marie B Thomas, Jayachandra M Raghava, Christos Pantelis, Egill Rostrup, Mette Ø Nielsen, Maria H Jensen, Birte Y Glenthøj, René CW Mandl, Bjørn H Ebdrup, Birgitte Fagerlund
BACKGROUND: Cognitive functions have been associated with white matter (WM) microstructure in schizophrenia, but most studies are ..
Differentiating the effect of antipsychotic medication and illness on brain volume reductions in first-episode psychosis: A Longitudinal, Randomised, Triple-blind, Placebo-controlled MRI Study
Sidhant Chopra, Alex Fornito, Shona M Francey, Brian O'Donoghue, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Steven Tahtalian, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Kristina Sabaroedin, Christos Pantelis, Stephen J Wood, Patrick McGorry
Changes in brain volume are a common finding in Magnetic Resonance Imaging (MRI) studies of people with psychosis and numerous lon..
Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases
Parsa Ravanfar, Samantha M Loi, Warda T Syeda, Tamsyn E Van Rheenen, Ashley I Bush, Patricia Desmond, Vanessa L Cropley, Darius JR Lane, Carlos M Opazo, Bradford A Moffat, Dennis Velakoulis, Christos Pantelis
Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In the past decade, development of the new m..
Traces of Trauma: A Multivariate Pattern Analysis of Childhood Trauma, Brain Structure, and Clinical Phenotypes
David Popovic, Anne Ruef, Dominic B Dwyer, Linda A Antonucci, Julia Eder, Rachele Sanfelici, Lana Kambeitz-Ilankovic, Omer Faruk Oztuerk, Mark S Dong, Riya Paul, Marco Paolini, Dennis Hedderich, Theresa Haidl, Joseph Kambeitz, Stephan Ruhrmann, Katharine Chisholm, Frauke Schultze-Lutter, Peter Falkai, Giulio Pergola, Giuseppe Blasi
BACKGROUND: Childhood trauma (CT) is a major yet elusive psychiatric risk factor, whose multidimensional conceptualization and het..
Altered empathy-related resting-state functional connectivity in adolescents with early-onset schizophrenia and autism spectrum disorders
Li-juan Shi, Han-yu Zhou, Yi Wang, Yan-mei Shen, Yu-min Fang, Yu-qiong He, Jian-jun Ou, Hua-bing Li, Xue-rong Luo, Eric FC Cheung, Christos Pantelis, Raymond CK Chan
Empathy refers to the ability to understand other people's feelings and reacting emotionally to others. Impaired empathy has been ..
Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19
Christos Pantelis, Mahesh Jayaram, Anthony J Hannan, Robb Wesselingh, Jess Nithianantharajah, Cassandra MJ Wannan, Warda Taqdees Syeda, KH Christopher Choy, Daniela Zantomio, Arthur Christopoulos, Dennis Velakoulis, Terence J O'Brien
Although COVID-19 is predominantly a respiratory disease, it is known to affect multiple organ systems. In this article, we highli..
Validation of the Bullying Scale for Adults - Results of the PRONIA-study
Theresa Katharina Haidl, Nicole Schneider, Kim Dickmann, Stephan Ruhrmann, Nathalie Kaiser, Marlene Rosen, Mauro Seves, Thorsten Lichtenstein, Rachel Upthegrove, Raimo KR Salokangas, Christos Pantelis, Eva Meisenzahl, Stephen J Wood, Paolo Brambilla, Stefan Borgwardt, Lencer Rebekka, Joseph Kambeitz, Nikolaos Koutsouleris, Frauke Schultze-Lutter, Linda Betz
BACKGROUND: Bullying as a specific subtype of adverse life events is a major risk factor for poor mental health. Although many que..
Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort
Jinglei Lv, Maria Di Biase, Robin FH Cash, Luca Cocchi, Vanessa L Cropley, Paul Klauser, Ye Tian, Johanna Bayer, Lianne Schmaal, Suheyla Cetin-Karayumak, Yogesh Rathi, Ofer Pasternak, Chad Bousman, Christos Pantelis, Fernando Calamante, Andrew Zalesky
The heterogeneity of schizophrenia has defied efforts to derive reproducible and definitive anatomical maps of structural brain ch..
Predicting individual improvement in schizophrenia symptom severity at 1-year follow-up: Comparison of connectomic, structural, and clinical predictors
Akhil Kottaram, Leigh A Johnston, Ye Tian, Eleni P Ganella, Liliana Laskaris, Luca Cocchi, Patrick McGorry, Christos Pantelis, Ramamohanarao Kotagiri, Vanessa Cropley, Andrew Zalesky
In a machine learning setting, this study aims to compare the prognostic utility of connectomic, brain structural, and clinical/de..
A machine-learning framework for robust and reliable prediction of short- and long-term treatment response in initially antipsychotic-naive schizophrenia patients based on multimodal neuropsychiatric data
Karen S Ambrosen, Martin W Skjerbaek, Jonathan Foldager, Martin C Axelsen, Nikolaj Bak, Lars Arvastson, Soren R Christensen, Louise B Johansen, Jayachandra M Raghava, Bob Oranje, Egill Rostrup, Mette O Nielsen, Merete Osler, Birgitte Fagerlund, Christos Pantelis, Bruce J Kinon, Birte Y Glenthoj, Lars K Hansen, Bjorn H Ebdrup
The reproducibility of machine-learning analyses in computational psychiatry is a growing concern. In a multimodal neuropsychiatri..
Impact of CYP1A2, CYP2C19, and CYP2D6 genotype- and phenoconversion-predicted enzyme activity on clozapine exposure and symptom severity
Dorothea Lesche, Sam Mostafa, Ian Everall, Christos Pantelis, Chad A Bousman
Clozapine is an atypical antipsychotic metabolized by CYP1A2, CYP2D6, and CYP2C19 enzymes. Among 66 adult schizophrenia patients t..
The genetic architecture of the human cerebral cortex
Katrina L Grasby, Neda Jahanshad, Jodie N Painter, Lucia Colodro-Conde, Janita Bralten, Derrek P Hibar, Penelope A Lind, Fabrizio Pizzagalli, Christopher RK Ching, Mary Agnes B McMahon, Natalia Shatokhina, Leo CP Zsembik, Sophia I Thomopoulos, Alyssa H Zhu, Lachlan T Strike, Ingrid Agartz, Saud Alhusaini, Marcio AA Almeida, Dag Alnaes, Inge K Amlien
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influen..
Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study
Ya Wang, Ian H Harding, Renee Testa, Bruce Tonge, Harvey Jones, Marc Seal, Nola Ross, Raymond CK Chan, Florian van Beurden, Ahmad Abu-Akel, Efstratios Skafidas, Christos Pantelis
Schizotypal disorder lies in the schizophrenia spectrum and is widely studied in adult populations. Schizotypal disorder in childr..
Heritability of Memory Functions and Related Brain Volumes: A Schizophrenia Spectrum Study of 214 Twins
Cecilie K Lemvigh, Rachel M Brouwer, Barbara J Sahakian, Trevor W Robbins, Louise B Johansen, Christian S Legind, Simon J Anhøj, Rikke Hilker, Hilleke E Hulshoff Pol, Bjørn H Ebdrup, Christos Pantelis, Birte Y Glenthøj, Birgitte Fagerlund
<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> ..
Aripiprazole compared with placebo for auditory verbal hallucinations in youth with borderline personality disorder: Protocol for the VERBATIM randomized controlled trial
Andrew M Chanen, Jennifer Betts, Henry Jackson, Patrick McGorry, Barnaby Nelson, Sue M Cotton, Cali Bartholomeusz, Martina Jovev, Aswin Ratheesh, Christopher Davey, Christos Pantelis, Louise McCutcheon, Shona Francey, Amit Bhaduri, Danielle Lowe, Victoria Rayner, Katherine Thompson
AIM: Up to half of patients with borderline personality disorder report auditory verbal hallucinations that are phenomenologically..
Common mechanisms of executive attention underlie executive function and effortful control in children
Jeggan Tiego, Mark A Bellgrove, Sarah Whittle, Christos Pantelis, Renee Testa
Executive Function (EF) and Effortful Control (EC) have traditionally been viewed as distinct constructs related to cognition and ..
Wnt receptor gene FZD1 was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort
Xiaoman Liu, Siew-Kee Low, Joshua R Atkins, Jing Qin Wu, William R Reay, Heath M Cairns, Melissa J Green, Ulrich Schall, Assen Jablensky, Bryan Mowry, Patricia T Michie, Stan V Catts, Frans Henskens, Christos Pantelis, Carmel Loughland, Alan V Boddy, Paul A Tooney, Rodney J Scott, Vaughan J Carr, Murray J Cairns
OBJECTIVES: Large-scale genetic analysis of common variation in schizophrenia has been a powerful approach to understanding this c..
Diagnostic stability and long-term symptomatic and functional outcomes in first-episode antipsychotic-naive patients with schizophrenia
Lea R Klaerke, Lone Baandrup, Birgitte Fagerlund, Bjorn H Ebdrup, Christos Pantelis, Birte Y Glenthoj, Mette O Nielsen
OBJECTIVE: In a prospective cohort design, we investigated: i) diagnostic stability of initially antipsychotic-naïve schizophrenia..
Hippocampal subfields and visuospatial associative memory across stages of schizophrenia-spectrum disorder
Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Tamsyn E Van Rheenen, Sam Mancuso, Chad Bousman, Ian Everall, Patrick D McGorry, Christos Pantelis, Cali F Bartholomeusz
BACKGROUND: While previous studies have identified relationships between hippocampal volumes and memory performance in schizophren..
The schizophrenia genetics knowledgebase: a comprehensive update of findings from candidate gene studies
Chenxing Liu, Tetsufumi Kanazawa, Ye Tian, Suriati Mohamed Saini, Serafino Mancuso, Md Shaki Mostaid, Atsushi Takahashi, Dai Zhang, Fuquan Zhang, Hao Yu, Hyoung Doo Shin, Hyun Sub Cheong, Masashi Ikeda, Michiaki Kubo, Nakao Iwata, Sung-Il Woo, Weihua Yue, Yoichiro Kamatani, Yongyong Shi, Zhiqiang Li
Exploring Heterogeneity on the Wisconsin Card Sorting Test in Schizophrenia Spectrum Disorders: A Cluster Analytical Investigation
Sean P Carruthers, Caroline T Gurvich, Denny Meyer, Chad Bousman, Ian P Everall, Erica Neill, Christos Pantelis, Philip J Sumner, Eric J Tan, Elizabeth HX Thomas, Tamsyn E Van Rheenen, Susan L Rossell
OBJECTIVES: The Wisconsin Card Sorting Test (WCST) is a complex measure of executive function that is frequently employed to inves..
Evidence for Network-Based Cortical Thickness Reductions in Schizophrenia
Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Chad Bousman, Eleni P Ganella, Jason M Bruggemann, Thomas W Weickert, Cynthia Shannon Weickert, Ian Everall, Patrick McGorry, Dennis Velakoulis, Stephen J Wood, Cali F Bartholomeusz, Christos Pantelis, Andrew Zalesky
Patterns of Cortical Structures and Cognition in Antipsychotic-Naive Patients With First-Episode Schizophrenia: A Partial Least Squares Correlation Analysis
Kasper Jessen, Rene CW Mandl, Birgitte Fagerlund, Kirsten B Bojesen, Jayachandra M Raghava, Hayder G Obaid, Marie B Jensen, Louise B Johansen, Mette O Nielsen, Christos Pantelis, Egill Rostrup, Birte Y Glenthoj, Bjorn H Ebdrup
BACKGROUND: Schizophrenia is associated with alterations in cortical structures and cognitive impairments, but antipsychotic medic..
The impact of schizophrenia and intelligence on the relationship between age and brain volume.
Maria H Jensen, Nikolaj Bak, Egill Rostrup, Mette Ø Nielsen, Christos Pantelis, Birte Y Glenthøj, Bjørn H Ebdrup, Birgitte Fagerlund
Age has been shown to have an impact on both grey (GM) and white matter (WM) volume, with a steeper slope of age-related decline i..
Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia
CA Bousman, V Cropley, P Klauser, JL Hess, A Pereira, R Idrizi, J Bruggemann, MS Mostaid, R Lenroot, TW Weickert, SJ Glatt, IP Everall, S Sundram, A Zalesky, CS Weickert, C Pantelis
Differential effect of disease-associated ST8S/A2 haplotype on cerebral white matter diffusion properties in schizophrenia and healthy controls
Janice M Fullerton, Paul Klauser, Rhoshel K Lenroot, Alex D Shaw, Bronwyn Overs, Anna Heath, Murray J Cairns, Joshua Atkins, Rodney Scott, Peter R Schofield, Cyndi Shannon Weickert, Christos Pantelis, Alex Fornito, Thomas J Whitford, Thomas W Weickert, Andrew Zalesky
Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution
Koji Kamagata, Andrew Zalesky, Taku Hatano, Maria Angelique Di Biase, Omar El Samad, Shinji Saiki, Keigo Shimoji, Kanako K Kumamaru, Kouhei Kamiya, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki, Christos Pantelis
PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia
MA Di Biase, A Zalesky, G O'keefe, L Laskaris, BT Baune, CS Weickert, J Olver, PD McGorry, GP Amminger, B Nelson, AM Scott, I Hickie, R Banati, F Turkheimer, M Yaqub, IP Everall, C Pantelis, V Cropley
Quetiapine v. lithium in the maintenance phase following a first episode of mania: randomised controlled trial
Michael Berk, Rothanthi Daglas, Orwa Dandash, Murat Yucel, Lisa Henry, Karen Hallam, Craig Macneil, Melissa Hasty, Christos Pantelis, Brendan P Murphy, Linda Kader, Saji Damodaran, Michael TH Wong, Philippe Conus, Aswin Ratheesh, Patrick D McGorry, Sue M Cotton
White Matter Disruptions in Schizophrenia Are Spatially Widespread and Topologically Converge on Brain Network Hubs
Paul Klauser, Simon T Baker, Vanessa L Cropley, Chad Bousman, Alex Fornito, Luca Cocchi, Janice M Fullerton, Paul Rasser, Ulrich Schall, Frans Henskens, Patricia T Michie, Carmel Loughland, Stanley V Catts, Bryan Mowry, Thomas W Weickert, Cynthia Shannon Weickert, Vaughan Carr, Rhoshel Lenroot, Christos Pantelis, Andrew Zalesky
A prospective cohort study of depression course, functional disability, and NEET status in help-seeking young adults
Bridianne O'Dea, Rico SC Lee, Patrick D McGorry, Ian B Hickie, Jan Scott, Daniel F Hermens, Arnstein Mykeltun, Rosemary Purcell, Eoin Killackey, Christos Pantelis, G Paul Amminger, Nicholas Glozier
White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids
Nandita Vijayakumar, Cali Bartholomeusz, Thomas Whitford, Daniel F Hermens, Barnaby Nelson, Simon Rice, Sarah Whittle, Christos Pantelis, Patrick McGorry, Miriam R Schafer, G Paul Amminger