NEUROBIOLOGICAL 'RISK' AND 'RESILIENCE' BIOMARKERS OF SEVERE MENTAL ILLNESS

Effective Connectivity and Dopaminergic Function of Fronto-Striato-Thalamic Circuitry in First-Episode Psychosis, Established Schizophrenia, and Healthy Controls

Kristina Sabaroedin, Adeel Razi, Sidhant Chopra, Nancy Tran, Andrii Pozaruk, Zhaolin Chen, Amy Finlay, Barnaby Nelson, Kelly Allott, Mario Alvarez-Jimenez, Jessica Graham, Lara Baldwin, Steven Tahtalian, Hok P Yuen, Susy Harrigan, Vanessa Cropley, Sujit Sharma, Bharat Saluja, Robert Williams, Christos Pantelis

<jats:title>Abstract</jats:title><jats:p>Dysfunction of fronto-striato-thalamic (FST) circuits is thought to contribute to dopamin..

Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort

Jinglei Lv, Maria Di Biase, Robin FH Cash, Luca Cocchi, Vanessa Cropley, Paul Klauser, Ye Tian, Johanna Bayer, Lianne Schmaal, Suheyla Cetin-Karayumak, Yogesh Rathi, Ofer Pasternak, Chad Bousman, Christos Pantelis, Fernando Calamante, Andrew Zalesky

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The heterogeneity of schizophrenia has defie..

Changes in negative symptoms are linked to white matter changes in superior longitudinal fasciculus in individuals at ultra-high risk for psychosis

Tina D Kristensen, Louise B Glenthoj, Jayachandra M Ragahava, Warda Syeda, Rene CW Mandl, Christina Wenneberg, Kristine Krakauer, Birgitte Fagerlund, Christos Pantelis, Birte Y Glenthoj, Merete Nordentoft, Bjorn H Ebdrup

2021-11-01

AIM: Growing evidence suggests that subtle white matter (WM) alterations are associated with psychopathology in individuals at ult..

Disruptions in white matter microstructure associated with impaired visual associative memory in schizophrenia-spectrum illness

Cassandra MJ Wannan, Cali F Bartholomeusz, Christos Pantelis, Maria A Di Biase, Warda T Syeda, M Mallar Chakravarty, Chad A Bousman, Ian P Everall, Patrick D McGorry, Andrew Zalesky, Vanessa L Cropley

2021-09-24

Episodic memory ability relies on hippocampal-prefrontal connectivity. However, few studies have examined relationships between me..

Prediction of Early Symptom Remission in Two Independent Samples of First-Episode Psychosis Patients Using Machine Learning.

Rigas F Soldatos, Micah Cearns, Mette Ø Nielsen, Costas Kollias, Lida-Alkisti Xenaki, Pentagiotissa Stefanatou, Irene Ralli, Stefanos Dimitrakopoulos, Alex Hatzimanolis, Ioannis Kosteletos, Ilias I Vlachos, Mirjana Selakovic, Stefania Foteli, Nikolaos Nianiakas, Leonidas Mantonakis, Theoni F Triantafyllou, Aggeliki Ntigridaki, Vanessa Ermiliou, Marina Voulgaraki, Evaggelia Psarra

2021-09-18

BACKGROUND: Validated clinical prediction models of short-term remission in psychosis are lacking. Our aim was to develop a clinic..

Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness.

Rachele Sanfelici, Anne Ruef, Linda A Antonucci, Nora Penzel, Aristeidis Sotiras, Mark Sen Dong, Maria Urquijo-Castro, Julian Wenzel, Lana Kambeitz-Ilankovic, Meike D Hettwer, Stephan Ruhrmann, Katharine Chisholm, Anita Riecher-Rössler, Peter Falkai, Christos Pantelis, Raimo KR Salokangas, Rebekka Lencer, Alessandro Bertolino, Joseph Kambeitz, Eva Meisenzahl

2021-09-14

Adult gyrification provides a window into coordinated early neurodevelopment when disruptions predispose individuals to psychiatri..

Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis

Ya Wang, Esmee E Braam, Cassandra MJ Wannan, Tamsyn E Van Rheenen, Raymond CK Chan, Barnaby Nelson, Patrick D McGorry, Alison R Yung, Ashleigh Lin, Warrick J Brewer, John Koutsogiannis, Stephen J Wood, Dennis Velakoulis, Christos Pantelis, Vanessa L Cropley

2021-08-31

Increased severity of neurological soft signs (NSS) in schizophrenia have been associated with abnormal brain morphology in cerebe..

Global fractional anisotropy predicts transition to psychosis after 12 months in individuals at ultra-high risk for psychosis

Tina D Kristensen, Louise B Glenthoj, Karen Ambrosen, Warda Syeda, Jayachandra M Ragahava, Kristine Krakauer, Christina Wenneberg, Birgitte Fagerlund, Christos Pantelis, Birte Y Glenthoj, Merete Nordentoft, Bjorn H Ebdrup

2021-08-09

OBJECTIVE: Psychosis spectrum disorders are associated with cerebral changes, but the prognostic value and clinical utility of the..

A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum.

James A Karantonis, Sean P Carruthers, Susan L Rossell, Christos Pantelis, Matthew Hughes, Cassandra Wannan, Vanessa Cropley, Tamsyn E Van Rheenen

2021-06-07

The nature of the relationship between cognition and brain morphology in schizophrenia-spectrum disorders (SSD) and bipolar disord..

Associations between cognition and white matter microstructure in first-episode antipsychotic-naive patients with schizophrenia and healthy controls: A multivariate pattern analysis

Marie B Thomas, Jayachandra M Raghava, Christos Pantelis, Egill Rostrup, Mette O Nielsen, Maria H Jensen, Birte Y Glenthoj, Rene CW Mandl, Bjorn H Ebdrup, Birgitte Fagerlund

2021-06-01

BACKGROUND: Cognitive functions have been associated with white matter (WM) microstructure in schizophrenia, but most studies are ..

Cognitive ability and metabolic physical health in first-episode psychosis

Sarah Whitson, Brian O'Donoghue, Robert Hester, Lara Baldwin, Susy Harrigan, Shona Francey, Jessica Graham, Barnaby Nelson, Aswin Ratheesh, Mario Alvarez-Jimenez, Alex Fornito, Christos Pantelis, Hok Pan Yuen, Andrew Thompson, Melissa Kerr, Michael Berk, Stephen J Wood, Patrick McGorry, Kelly Allott

2021-06-01

Cognitive impairments are a core feature of first-episode psychosis (FEP), arising before illness onset and antipsychotic exposure..

Brain-Predicted Age Associates With Psychopathology Dimensions in Youths

Vanessa L Cropley, Ye Tian, Kavisha Fernando, L Sina Mansour, Christos Pantelis, Luca Cocchi, Andrew Zalesky

2021-04-01

BACKGROUND: This study aimed to investigate whether dimensional constructs of psychopathology relate to variation in patterns of b..

Differentiating the effect of antipsychotic medication and illness on brain volume reductions in first-episode psychosis: A Longitudinal, Randomised, Triple-blind, Placebo-controlled MRI Study

Sidhant Chopra, Alex Fornito, Shona M Francey, Brian O'Donoghue, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Steven Tahtalian, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Kristina Sabaroedin, Christos Pantelis, Stephen J Wood, Patrick McGorry

2021-02-26

Changes in brain volume are a common finding in Magnetic Resonance Imaging (MRI) studies of people with psychosis and numerous lon..

Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases

Parsa Ravanfar, Samantha M Loi, Warda T Syeda, Tamsyn E Van Rheenen, Ashley I Bush, Patricia Desmond, Vanessa L Cropley, Darius JR Lane, Carlos M Opazo, Bradford A Moffat, Dennis Velakoulis, Christos Pantelis

2021-02-18

Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In the past decade, development of the new m..

White Matter Alterations Between Brain Network Hubs Underlie Processing Speed Impairment in Patients With Schizophrenia

Paul Klauser, Vanessa L Cropley, Philipp S Baumann, Jinglei Lv, Pascal Steullet, Daniella Dwir, Yasser Alemán-Gómez, Meritxell Bach Cuadra, Michel Cuenod, Kim Q Do, Philippe Conus, Christos Pantelis, Alex Fornito, Tamsyn E Van Rheenen, Andrew Zalesky

2021-01-01

<jats:title>Abstract</jats:title> <jats:p>Processing speed (PS) impairment is one of the most severe and common cog..

Neural Correlates of Audiovisual Temporal Binding Window in Individuals With Schizotypal and Autistic Traits: Evidence From Resting-State Functional Connectivity

Han-yu Zhou, Yong-ming Wang, Rui-ting Zhang, Eric FC Cheung, Christos Pantelis, Raymond CK Chan

2020-12-14

Temporal proximity is an important clue for multisensory integration. Previous evidence indicates that individuals with autism and..

Traces of Trauma: A Multivariate Pattern Analysis of Childhood Trauma, Brain Structure, and Clinical Phenotypes

David Popovic, Anne Ruef, Dominic B Dwyer, Linda A Antonucci, Julia Eder, Rachele Sanfelici, Lana Kambeitz-Ilankovic, Omer Faruk Oztuerk, Mark S Dong, Riya Paul, Marco Paolini, Dennis Hedderich, Theresa Haidl, Joseph Kambeitz, Stephan Ruhrmann, Katharine Chisholm, Frauke Schultze-Lutter, Peter Falkai, Giulio Pergola, Giuseppe Blasi

2020-12-01

BACKGROUND: Childhood trauma (CT) is a major yet elusive psychiatric risk factor, whose multidimensional conceptualization and het..

Altered empathy-related resting-state functional connectivity in adolescents with early-onset schizophrenia and autism spectrum disorders

Li-juan Shi, Han-yu Zhou, Yi Wang, Yan-mei Shen, Yu-min Fang, Yu-qiong He, Jian-jun Ou, Hua-bing Li, Xue-rong Luo, Eric FC Cheung, Christos Pantelis, Raymond CK Chan

2020-10-01

Empathy refers to the ability to understand other people's feelings and reacting emotionally to others. Impaired empathy has been ..

Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19

Christos Pantelis, Mahesh Jayaram, Anthony J Hannan, Robb Wesselingh, Jess Nithianantharajah, Cassandra MJ Wannan, Warda Taqdees Syeda, KH Christopher Choy, Daniela Zantomio, Arthur Christopoulos, Dennis Velakoulis, Terence J O'Brien

2020-10-01

Although COVID-19 is predominantly a respiratory disease, it is known to affect multiple organ systems. In this article, we highli..

Validation of the Bullying Scale for Adults - Results of the PRONIA-study

Theresa Katharina Haidl, Nicole Schneider, Kim Dickmann, Stephan Ruhrmann, Nathalie Kaiser, Marlene Rosen, Mauro Seves, Thorsten Lichtenstein, Rachel Upthegrove, Raimo KR Salokangas, Christos Pantelis, Eva Meisenzahl, Stephen J Wood, Paolo Brambilla, Stefan Borgwardt, Lencer Rebekka, Joseph Kambeitz, Nikolaos Koutsouleris, Frauke Schultze-Lutter, Linda Betz

2020-10-01

BACKGROUND: Bullying as a specific subtype of adverse life events is a major risk factor for poor mental health. Although many que..

Individual deviations from normative models of brain structure in a large cross-sectional schizophrenia cohort

Jinglei Lv, Maria Di Biase, Robin FH Cash, Luca Cocchi, Vanessa L Cropley, Paul Klauser, Ye Tian, Johanna Bayer, Lianne Schmaal, Suheyla Cetin-Karayumak, Yogesh Rathi, Ofer Pasternak, Chad Bousman, Christos Pantelis, Fernando Calamante, Andrew Zalesky

2020-09-22

The heterogeneity of schizophrenia has defied efforts to derive reproducible and definitive anatomical maps of structural brain ch..

Increased power by harmonizing structural MRI site differences with the ComBat batch method in ENIGMA

Joaquim Radua, Eduard Vieta, Russell Shinohara, Peter Kochunov, Yann Quide, Melissa J Green, Cynthia S Weickert, Thomas Weickert, Jason Bruggemann, Tilo Kircher, Igor Nenadic, Murray J Cairns, Marc Seal, Ulrich Schall, Frans Henskens, Janice M Fullerton, Bryan Mowry, Christos Pantelis, Rhoshel Lenroot, Vanessa Cropley

2020-09-01

A common limitation of neuroimaging studies is their small sample sizes. To overcome this hurdle, the Enhancing Neuro Imaging Gene..

Predicting individual improvement in schizophrenia symptom severity at 1-year follow-up: Comparison of connectomic, structural, and clinical predictors

Akhil Kottaram, Leigh A Johnston, Ye Tian, Eleni P Ganella, Liliana Laskaris, Luca Cocchi, Patrick McGorry, Christos Pantelis, Ramamohanarao Kotagiri, Vanessa Cropley, Andrew Zalesky

2020-08-15

In a machine learning setting, this study aims to compare the prognostic utility of connectomic, brain structural, and clinical/de..

A machine-learning framework for robust and reliable prediction of short- and long-term treatment response in initially antipsychotic-naive schizophrenia patients based on multimodal neuropsychiatric data

Karen S Ambrosen, Martin W Skjerbaek, Jonathan Foldager, Martin C Axelsen, Nikolaj Bak, Lars Arvastson, Soren R Christensen, Louise B Johansen, Jayachandra M Raghava, Bob Oranje, Egill Rostrup, Mette O Nielsen, Merete Osler, Birgitte Fagerlund, Christos Pantelis, Bruce J Kinon, Birte Y Glenthoj, Lars K Hansen, Bjorn H Ebdrup

2020-08-10

The reproducibility of machine-learning analyses in computational psychiatry is a growing concern. In a multimodal neuropsychiatri..

Brain-predicted age associates with psychopathology dimensions in youth

Vanessa Cropley, Ye Tian, Kavisha Fernando, L Sina Mansour, Christos Pantelis, Luca Cocchi, Andrew Zalesky

2020-06-14

<h4>Background</h4> This study aims to investigate whether dimensional constructs of psychopathology relate to advanced, attenuate..

Impact of CYP1A2, CYP2C19, and CYP2D6 genotype- and phenoconversion-predicted enzyme activity on clozapine exposure and symptom severity

Dorothea Lesche, Sam Mostafa, Ian Everall, Christos Pantelis, Chad A Bousman

2020-04-01

Clozapine is an atypical antipsychotic metabolized by CYP1A2, CYP2D6, and CYP2C19 enzymes. Among 66 adult schizophrenia patients t..

The genetic architecture of the human cerebral cortex

Katrina L Grasby, Neda Jahanshad, Jodie N Painter, Lucia Colodro-Conde, Janita Bralten, Derrek P Hibar, Penelope A Lind, Fabrizio Pizzagalli, Christopher RK Ching, Mary Agnes B McMahon, Natalia Shatokhina, Leo CP Zsembik, Sophia I Thomopoulos, Alyssa H Zhu, Lachlan T Strike, Ingrid Agartz, Saud Alhusaini, Marcio AA Almeida, Dag Alnaes, Inge K Amlien

2020-03-20

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influen..

Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study

Ya Wang, Ian H Harding, Renee Testa, Bruce Tonge, Harvey Jones, Marc Seal, Nola Ross, Raymond CK Chan, Florian van Beurden, Ahmad Abu-Akel, Efstratios Skafidas, Christos Pantelis

2020-03-18

Schizotypal disorder lies in the schizophrenia spectrum and is widely studied in adult populations. Schizotypal disorder in childr..

Heritability of Memory Functions and Related Brain Volumes: A Schizophrenia Spectrum Study of 214 Twins

Cecilie K Lemvigh, Rachel M Brouwer, Barbara J Sahakian, Trevor W Robbins, Louise B Johansen, Christian S Legind, Simon J Anhøj, Rikke Hilker, Hilleke E Hulshoff Pol, Bjørn H Ebdrup, Christos Pantelis, Birte Y Glenthøj, Birgitte Fagerlund

2020-01-01

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> ..

Schizotypal Disorder in Children—A Neglected Diagnosis

Bruce J Tonge, Renee Testa, Carmela Díaz-Arteche, Avril V Brereton, Katerina Stephanou, Christos Pantelis

2020-01-01

<jats:title>Abstract</jats:title> <jats:p>Disabling psychotic-like perceptions, thoughts, and behavior have long be..

Aripiprazole compared with placebo for auditory verbal hallucinations in youth with borderline personality disorder: Protocol for the VERBATIM randomized controlled trial

Andrew M Chanen, Jennifer Betts, Henry Jackson, Patrick McGorry, Barnaby Nelson, Sue M Cotton, Cali Bartholomeusz, Martina Jovev, Aswin Ratheesh, Christopher Davey, Christos Pantelis, Louise McCutcheon, Shona Francey, Amit Bhaduri, Danielle Lowe, Victoria Rayner, Katherine Thompson

2019-12-01

AIM: Up to half of patients with borderline personality disorder report auditory verbal hallucinations that are phenomenologically..

Common mechanisms of executive attention underlie executive function and effortful control in children

Jeggan Tiego, Mark A Bellgrove, Sarah Whittle, Christos Pantelis, Renee Testa

2019-11-26

Executive Function (EF) and Effortful Control (EC) have traditionally been viewed as distinct constructs related to cognition and ..

Wnt receptor gene FZD1 was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort

Xiaoman Liu, Siew-Kee Low, Joshua R Atkins, Jing Qin Wu, William R Reay, Heath M Cairns, Melissa J Green, Ulrich Schall, Assen Jablensky, Bryan Mowry, Patricia T Michie, Stan V Catts, Frans Henskens, Christos Pantelis, Carmel Loughland, Alan V Boddy, Paul A Tooney, Rodney J Scott, Vaughan J Carr, Murray J Cairns

2019-11-16

OBJECTIVES: Large-scale genetic analysis of common variation in schizophrenia has been a powerful approach to understanding this c..

Olfactory sulcus morphology in teenagers with first-presentation borderline personality disorder

Tsutomu Takahashi, Yumiko Nishikawa, Dennis Velakoulis, Michio Suzuki, Patrick D McGorry, Christos Pantelis, Andrew M Chanen

2019-10-30

Gray matter reduction of the orbitofrontal cortex (OFC) has been reported in borderline personality disorder (BPD), but it remains..

Diagnostic stability and long-term symptomatic and functional outcomes in first-episode antipsychotic-naive patients with schizophrenia

Lea R Klaerke, Lone Baandrup, Birgitte Fagerlund, Bjorn H Ebdrup, Christos Pantelis, Birte Y Glenthoj, Mette O Nielsen

2019-10-01

OBJECTIVE: In a prospective cohort design, we investigated: i) diagnostic stability of initially antipsychotic-naïve schizophrenia..

Hippocampal subfields and visuospatial associative memory across stages of schizophrenia-spectrum disorder

Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Tamsyn E Van Rheenen, Sam Mancuso, Chad Bousman, Ian Everall, Patrick D McGorry, Christos Pantelis, Cali F Bartholomeusz

2019-10-01

BACKGROUND: While previous studies have identified relationships between hippocampal volumes and memory performance in schizophren..

The schizophrenia genetics knowledgebase: a comprehensive update of findings from candidate gene studies

Chenxing Liu, Tetsufumi Kanazawa, Ye Tian, Suriati Mohamed Saini, Serafino Mancuso, Md Shaki Mostaid, Atsushi Takahashi, Dai Zhang, Fuquan Zhang, Hao Yu, Hyoung Doo Shin, Hyun Sub Cheong, Masashi Ikeda, Michiaki Kubo, Nakao Iwata, Sung-Il Woo, Weihua Yue, Yoichiro Kamatani, Yongyong Shi, Zhiqiang Li

2019-08-27

Over 3000 candidate gene association studies have been performed to elucidate the genetic underpinnings of schizophrenia. However,..

Exploring Heterogeneity on the Wisconsin Card Sorting Test in Schizophrenia Spectrum Disorders: A Cluster Analytical Investigation

Sean P Carruthers, Caroline T Gurvich, Denny Meyer, Chad Bousman, Ian P Everall, Erica Neill, Christos Pantelis, Philip J Sumner, Eric J Tan, Elizabeth HX Thomas, Tamsyn E Van Rheenen, Susan L Rossell

2019-08-01

OBJECTIVES: The Wisconsin Card Sorting Test (WCST) is a complex measure of executive function that is frequently employed to inves..

Evidence for Network-Based Cortical Thickness Reductions in Schizophrenia

Cassandra MJ Wannan, Vanessa L Cropley, M Mallar Chakravarty, Chad Bousman, Eleni P Ganella, Jason M Bruggemann, Thomas W Weickert, Cynthia Shannon Weickert, Ian Everall, Patrick McGorry, Dennis Velakoulis, Stephen J Wood, Cali F Bartholomeusz, Christos Pantelis, Andrew Zalesky

2019-07-01

OBJECTIVE: Cortical thickness reductions in schizophrenia are irregularly distributed across multiple loci. The authors hypothesiz..

Brain network dynamics in schizophrenia: Reduced dynamism of the default mode network

Akhil Kottaram, Leigh A Johnston, Luca Cocchi, Eleni P Ganella, Ian Everall, Christos Pantelis, Ramamohanarao Kotagiri, Andrew Zalesky

2019-05-01

Complex human behavior emerges from dynamic patterns of neural activity that transiently synchronize between distributed brain net..

Patterns of Cortical Structures and Cognition in Antipsychotic-Naive Patients With First-Episode Schizophrenia: A Partial Least Squares Correlation Analysis

Kasper Jessen, Rene CW Mandl, Birgitte Fagerlund, Kirsten B Bojesen, Jayachandra M Raghava, Hayder G Obaid, Marie B Jensen, Louise B Johansen, Mette O Nielsen, Christos Pantelis, Egill Rostrup, Birte Y Glenthoj, Bjorn H Ebdrup

2019-05-01

BACKGROUND: Schizophrenia is associated with alterations in cortical structures and cognitive impairments, but antipsychotic medic..

Insula Functional Connectivity in Schizophrenia: Subregions, Gradients, and Symptoms

Ye Tian, Andrew Zalesky, Chad Bousman, Ian Everall, Christos Pantelis

2019-04-01

BACKGROUND: The insular cortex is connected to a diverse network of cortical and subcortical areas. This study aimed to investigat..

Longitudinal changes in striatum and sub-threshold positive symptoms in individuals with an 'at risk mental state' (ARMS)

Naoyuki Katagiri, Christos Pantelis, Takahiro Nemoto, Naohisa Tsujino, Junichi Saito, Masaaki Hori, Taiju Yamaguchi, Tomoyuki Funatogawa, Masafumi Mizuno

2019-03-30

Recent studies have revealed that several psychotic symptom changes observed in the 'at risk mental state' (ARMS) are associated w..

The impact of schizophrenia and intelligence on the relationship between age and brain volume

Maria H Jensen, Nikolaj Bak, Egill Rostrup, Mette O Nielsen, Christos Pantelis, Birte Y Glenthoj, Bjorn H Ebdrup, Birgitte Fagerlund

2019-03-01

Age has been shown to have an impact on both grey (GM) and white matter (WM) volume, with a steeper slope of age-related decline i..

Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia

Chad A Bousman, Sandra Luza, Serafino G Mancuso, Dali Kang, Carlos M Opazo, Md Shaki Mostaid, Vanessa Cropley, Patrick McGorry, Cynthia Shannon Weickert, Christos Pantelis, Ashley I Bush, Ian P Everall

2019-02-19

Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation ..

An Interleukin-1 beta (IL1B) haplotype linked with psychosis transition is associated with IL1B gene expression and brain structure

Md Shaki Mostaid, Stefanos Dimitrakopoulos, Cassandra Wannan, Vanessa Cropley, Cynthia Shannon Weickert, Jan P Everall, Christos Pantelis, Chad A Bousman

2019-02-01

We investigated IL1B genetic variation previously associated with risk for transition to psychosis for its association with gene e..

Investigation of peripheral complement factors across stages of psychosis

Liliana Laskaris, Andrew Zalesky, Cynthia Shannon Weickert, Maria A Di Biase, Gursharan Chana, Bernhard T Baune, Chad Bousman, Barnaby Nelson, Patrick McGorry, Ian Everall, Christos Pantelis, Vanessa Cropley

2019-02-01

The complement cascade has been proposed to contribute to the pathogenesis of schizophrenia. However, it remains unclear whether p..

Decreased peripheral TNF alpha (TNF-alpha) mRNA expression in patients with treatment-resistant schizophrenia

Md Shaki Mostaid, Christos Pantelis, Ian P Everall, Chad A Bousman

2018-12-01

An fMRI study of theory of mind in individuals with first episode psychosis

Cali F Bartholomeusz, Eleni P Ganella, Sarah Whittle, Kelly Allott, Andrew Thompson, Ahmad Abu-Akerl, Henrik Walter, Patrick McGorry, Eoin Killackey, Christos Pantelis, Stephen J Wood

2018-11-30

Theory of mind (ToM), the ability to infer one's own and others' mental states, is the social cognitive process shown to have the ..

Resting-state functional brain networks in first-episode psychosis: A 12-month follow-up study

Eleni P Ganella, Caio Seguin, Christos Pantelis, Sarah Whittle, Bernhard T Baune, James Olver, G Paul Amminger, Patrick D McGorry, Vanessa Cropley, Andrew Zalesky, Cali F Bartholomeusz

2018-09-01

INTRODUCTION: Schizophrenia is increasingly conceived as a disorder of brain network connectivity and organization. However, repor..

Spatio-temporal dynamics of resting-state brain networks improve single-subject prediction of schizophrenia diagnosis

Akhil Kottaram, Leigh Johnston, Eleni Ganella, Christos Pantelis, Ramamohanarao Kotagiri, Andrew Zalesky

2018-09-01

Correlation in functional MRI activity between spatially separated brain regions can fluctuate dynamically when an individual is a..

A Hierarchical Model of Inhibitory Control

Jeggan Tiego, Renee Testa, Mark A Bellgrove, Christos Pantelis, Sarah Whittle

2018-08-02

Inhibitory control describes the suppression of goal-irrelevant stimuli and behavioral responses. Current developmental taxonomies..

Fragility and volatility of structural hubs in the human connectome

Leonardo L Gollo, James A Roberts, Vanessa L Cropley, Maria A Di Biase, Christos Pantelis, Andrew Zalesky, Michael Breakspear

2018-08-01

Brain structure reflects the influence of evolutionary processes that pit the costs of its anatomical wiring against the computati..

Downregulation of plasma SELENBP1 protein in patients with recent-onset schizophrenia

Edith J Chau, Md Shaki Mostaid, Vanessa Cropley, Patrick McGorry, Christos Pantelis, Chad A Bousman, Ian P Everall

2018-07-13

Upregulation of selenium binding protein 1 (SELENBP1) mRNA expression has been reported in schizophrenia, primarily in the dorsola..

Duration of untreated psychosis and neurocognitive functioning in first-episode psychosis: a systematic review and meta-analysis

K Allott, D Fraguas, CF Bartholomeusz, CM Diaz-Caneja, C Wannan, EM Parrish, GP Amminger, C Pantelis, C Arango, PD McGorry, M Rapado-Castro

2018-07-01

BACKGROUND: Previous reviews suggest there is minimal evidence for an association between duration of untreated psychosis (DUP) an..

Genetic variation in cytokine genes and risk for transition to psychosis among individuals at ultra-high risk

Chad A Bousman, Tae Young Lee, Minah Kim, Junhee Lee, Md Shaki Mostaid, Minji Bang, Suk Kyoon An, Ian P Everall, Christos Pantelis, Jun Soo Kwon

2018-05-01

Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia

CA Bousman, V Cropley, P Klauser, JL Hess, A Pereira, R Idrizi, J Bruggemann, MS Mostaid, R Lenroot, TW Weickert, SJ Glatt, IP Everall, S Sundram, A Zalesky, CS Weickert, C Pantelis

2018-04-01

BACKGROUND: Two single-nucleotide polymorphisms (SNPs) (rs4281084 and rs12155594) within the neuregulin-1 (NRG1) gene have been as..

Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania

Orwa Dandash, Murat Yucel, Rothanthi Daglas, Christos Pantelis, Patrick McGorry, Michael Berk, Alex Fornito

2018-03-06

Mood disturbances seen in first-episode mania (FEM) are linked to disturbed functional connectivity of the striatum. Lithium and q..

Predictors and consequences of health anxiety symptoms: a novel twin modeling study

C Lopez-Sola, M Bui, JL Hopper, LF Fontenelle, CG Davey, C Pantelis, P Alonso, OA van den Heuvel, BJ Harrison

2018-03-01

OBJECTIVE: The question of how to best conceptualize health anxiety (HA) from a diagnostic and etiological perspective remains deb..

Risk and resilience brain networks in treatment-resistant schizophrenia

Eleni P Ganella, Caio Seguin, Cali F Bartholomeusz, Sarah Whittle, Chad Bousman, Cassandra MJ Wannan, Maria A Di Biase, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky

2018-03-01

BACKGROUND: Genes, molecules and neural circuits that are associated with, or confer risk to developing schizophrenia have been st..

Differential effect of disease-associated ST8S/A2 haplotype on cerebral white matter diffusion properties in schizophrenia and healthy controls

Janice M Fullerton, Paul Klauser, Rhoshel K Lenroot, Alex D Shaw, Bronwyn Overs, Anna Heath, Murray J Cairns, Joshua Atkins, Rodney Scott, Peter R Schofield, Cyndi Shannon Weickert, Christos Pantelis, Alex Fornito, Thomas J Whitford, Thomas W Weickert, Andrew Zalesky

2018-01-22

Brain white matter abnormalities are evident in individuals with schizophrenia, and also their first-degree relatives, suggesting ..

Attentional set-shifting and social abilities in children with schizotypal and comorbid autism spectrum disorders

Ahmad Abu-Akel, Renee R Testa, Harvey P Jones, Nola Ross, Efstratios Skafidas, Bruce Tonge, Christos Pantelis

2018-01-01

OBJECTIVE: While diagnostically independent, autism and schizotypal disorders can co-occur. Their concurrent impact on outcomes an..

Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution

Koji Kamagata, Andrew Zalesky, Taku Hatano, Maria Angelique Di Biase, Omar El Samad, Shinji Saiki, Keigo Shimoji, Kanako K Kumamaru, Kouhei Kamiya, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki, Christos Pantelis

2018-01-01

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects extensive regions of the central nervous system...

Deterioration of visuospatial associative memory following a first psychotic episode: a long-term follow-up study

CMJ Wannan, CF Bartholomeusz, VL Cropley, TE Van Rheenen, A Panayiotou, WJ Brewer, TM Proffitt, L Henry, MG Harris, D Velakoulis, P McGorry, C Pantelis, SJ Wood

2018-01-01

BACKGROUND: Cognitive deficits are a core feature of schizophrenia, and impairments in most domains are thought to be stable over ..

Elevated peripheral expression of neuregulin-1 (NRG1) mRNA isoforms in clozapine-treated schizophrenia patients

Md Shaki Mostaid, Ting Ting Lee, Gursharan Chana, Suresh Sundram, Cynthia Shannon Weickert, Christos Pantelis, Ian Everall, Chad Bousman

2017-12-11

Differential expression of neuregulin-1 (NRG1) mRNA isoforms and proteins has been reported in schizophrenia, primarily in post-mo..

No preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism

Ting Ting Lee, Efstratios Skafidas, Mirella Dottori, Daniela Zantomio, Christos Pantelis, Ian Everall, Gursharan Chana

2017-12-08

Background: While evidence for white matter and astrocytic abnormalities exist in autism, a detailed investigation of astrocytes h..

White matter connectivity disruptions in early and chronic schizophrenia

MA Di Biase, VL Cropley, BT Baune, J Olver, GP Amminger, C Phassouliotis, C Bousman, PD McGorry, I Everall, C Pantelis, A Zalesky

2017-12-01

BACKGROUND: White matter disruptions in schizophrenia have been widely reported, but it remains unclear whether these abnormalitie..

PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia

MA Di Biase, A Zalesky, G O'keefe, L Laskaris, BT Baune, CS Weickert, J Olver, PD McGorry, GP Amminger, B Nelson, AM Scott, I Hickie, R Banati, F Turkheimer, M Yaqub, IP Everall, C Pantelis, V Cropley

2017-08-29

We examined putative microglial activation as a function of illness course in schizophrenia. Microglial activity was quantified us..

Meta-analysis supports GWAS-implicated link between GRM3 and schizophrenia risk

SM Saini, SG Mancuso, Md S Mostaid, C Liu, C Pantelis, IP Everall, CA Bousman

2017-08-08

Genome-wide association study (GWAS) evidence has identified the metabotropic glutamate receptor 3 (GRM3) gene as a potential harb..

Role of Positive Parenting in the Association Between Neighborhood Social Disadvantage and Brain Development Across Adolescence

Sarah Whittle, Nandita Vijayakumar, Julian G Simmons, Meg Dennison, Orli Schwartz, Christos Pantelis, Lisa Sheeber, Michelle L Byrne, Nicholas B Allen

2017-08-01

Importance: The negative effects of socioeconomic disadvantage on lifelong functioning are pronounced, with some evidence suggesti..

Functional brain networks in treatment-resistant schizophrenia

Eleni P Ganella, Cali F Bartholomeusz, Caio Seguin, Sarah Whittle, Chad Bousman, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky

2017-06-01

INTRODUCTION: Up to 20% of individuals with schizophrenia show minimal or no response to medication and are considered to have 'tr..

Quetiapine v. lithium in the maintenance phase following a first episode of mania: randomised controlled trial

Michael Berk, Rothanthi Daglas, Orwa Dandash, Murat Yucel, Lisa Henry, Karen Hallam, Craig Macneil, Melissa Hasty, Christos Pantelis, Brendan P Murphy, Linda Kader, Saji Damodaran, Michael TH Wong, Philippe Conus, Aswin Ratheesh, Patrick D McGorry, Sue M Cotton

2017-06-01

BackgroundLithium and quetiapine are considered standard maintenance agents for bipolar disorder yet it is unclear how their effic..

Challenges facing the identification of distinctive cognitive and neurobiological features of schizophrenia and bipolar disorder and the need for a data-driven approach: Response to Dr. Martino

Emre Bora, Christos Pantelis

2017-05-01

A cluster analysis exploration of autism spectrum disorder subgroups in children without intellectual disability

Felicity Klopper, Renee Testa, Christos Pantelis, Efstratios Skafidas

2017-04-01

Background The heterogeneity in autism spectrum disorder (ASD) remains poorly understood, particularly in individuals without inte..

Lithium suppression of tau induces brain iron accumulation and neurodegeneration

P Lei, S Ayton, AT Appukuttan, S Moon, JA Duce, I Volitakis, R Cherny, SJ Wood, M Greenough, G Berger, C Pantelis, P McGorry, A Yung, DI Finkelstein, AI Bush

2017-03-01

Lithium is a first-line therapy for bipolar affective disorder. However, various adverse effects, including a Parkinson-like hand ..

Neuroanatomical Predictors of Functional Outcome in Individuals at Ultra-High Risk for Psychosis

Renate LEP Reniers, Ashleigh Lin, Alison R Yung, Nikolaos Koutsouleris, Barnaby Nelson, Vanessa L Cropley, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis, Stephen J Wood

2017-03-01

Most individuals at ultra-high risk (UHR) for psychosis do not transition to frank illness. Nevertheless, many have poor clinical ..

White Matter Disruptions in Schizophrenia Are Spatially Widespread and Topologically Converge on Brain Network Hubs

Paul Klauser, Simon T Baker, Vanessa L Cropley, Chad Bousman, Alex Fornito, Luca Cocchi, Janice M Fullerton, Paul Rasser, Ulrich Schall, Frans Henskens, Patricia T Michie, Carmel Loughland, Stanley V Catts, Bryan Mowry, Thomas W Weickert, Cynthia Shannon Weickert, Vaughan Carr, Rhoshel Lenroot, Christos Pantelis, Andrew Zalesky

2017-03-01

White matter abnormalities associated with schizophrenia have been widely reported, although the consistency of findings across st..

Pathway-wide association study identifies five shared pathways associated with schizophrenia in three ancestral distinct populations

C Liu, CA Bousman, C Pantelis, E Skafidas, D Zhang, W Yue, IP Everall

2017-02-21

Genome-wide association studies have confirmed the polygenic nature of schizophrenia and suggest that there are hundreds or thousa..

Dopamine, fronto-striato-thalamic circuits and risk for psychosis

Orwa Dandash, Christos Pantelis, Alex Fornito

2017-02-01

A series of parallel, integrated circuits link distinct regions of prefrontal cortex with specific nuclei of the striatum and thal..

Effects of cigarette smoking on cortical thickness in major depressive disorder

Nabi Zorlu, Vanessa Louise Cropley, Pelin Kurtgoz Zorlu, Dursun Hakan Delibas, Zehra Hilal Adibelli, Emel Pasa Baskin, Ozgur Sipahi Esen, Emre Bora, Christos Pantelis

2017-01-01

Findings of surface-based morphometry studies in major depressive disorder (MDD) are still inconsistent. Given that cigarette smok..

Abnormal white matter integrity in synthetic cannabinoid users

Nabi Zorlu, Maria Angelique Di Biase, Cigdem Colak Kalayci, Andrew Zalesky, Basak Bagci, Nihan Oguz, Fazil Gelal, Lutfullah Besiroglu, Seref Gulseren, Aybala Saricicek, Emre Bora, Christos Pantelis

2016-11-01

Synthetic cannabinoids have become increasingly popular in the last few years especially among adolescents and young adults. Howev..

A prospective cohort study of depression course, functional disability, and NEET status in help-seeking young adults

Bridianne O'Dea, Rico SC Lee, Patrick D McGorry, Ian B Hickie, Jan Scott, Daniel F Hermens, Arnstein Mykeltun, Rosemary Purcell, Eoin Killackey, Christos Pantelis, G Paul Amminger, Nicholas Glozier

2016-10-01

PURPOSE: To examine the associations between depression course, functional disability, and Not in Education or Training (NEET) sta..

Olfactory sulcus morphology in patients with current and past major depression

Tsutomu Takahashi, Yumiko Nishikawa, Murat Yucel, Sarah Whittle, Valentina Lorenzetti, Mark Walterfang, Daiki Sasabayashi, Michio Suzuki, Christos Pantelis, Nicholas B Allen

2016-09-30

Olfactory deficits have been reported in major depressive disorder (MDD). However, it remains largely unknown whether MDD is assoc..

White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids

Nandita Vijayakumar, Cali Bartholomeusz, Thomas Whitford, Daniel F Hermens, Barnaby Nelson, Simon Rice, Sarah Whittle, Christos Pantelis, Patrick McGorry, Miriam R Schafer, G Paul Amminger

2016-08-11

BACKGROUND: Schizophrenia is thought to be a neurodevelopmental disorder with pathophysiological processes beginning in the brain ..

Early origins of mental disorder - risk factors in the perinatal and infant period

Louise Newman, Fiona Judd, Craig A Olsson, David Castle, Chad Bousman, Penelope Sheehan, Christos Pantelis, Jeffrey M Craig, Angela Komiti, Ian Everall

2016-07-29

BACKGROUND: There is increasing understanding of the significance of early neurodevelopment in establishing risk for the range of ..

Brain change trajectories that differentiate the major psychoses

Benny Liberg, Christoffer Rahm, Anita Panayiotou, Christos Pantelis

2016-07-01

BACKGROUND: Bipolar disorder and schizophrenia are highly heritable, often chronic and debilitating psychotic disorders that can b..