TARGETING COMMITMENT TO SEXUAL DIFFERENTIATION IN PLASMODIUM

Grant number: 1098992 | Funding period: 2016 - 2018

Completed

Abstract

Efforts to control malaria in endemic areas are very often thwarted by "carriers", who have transmissible parasites in their bloodstream (called gametocytes), but who suffer no symptoms. These gametocytes serve as a reservoir ready to reinitiate disease transmission when mosquito numbers increase. This project will develop urgently needed strategies to target gametocytes, and thus block malaria transmission.

Related publications (8)

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Plasmodium falciparum goes bananas for sex

Matthew WA Dixon, Leann Tilley

2021-07-01

The sexual blood stages of the human malaria parasite Plasmodium falciparum undergo a remarkable transformation from a roughly sph..

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Non-canonical metabolic pathways in the malaria parasite detected by isotope-tracing metabolomics

Simon A Cobbold, Madel Tutor, Philip Frasse, Emma McHugh, Markus Karnthaler, Darren J Creek, Audrey Odom John, Leann Tilley, Stuart A Ralph, Malcolm J McConville

2021-04-01

The malaria parasite, Plasmodium falciparum, proliferates rapidly in human erythrocytes by actively scavenging multiple carbon sou..

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Role of Plasmodium falciparum Protein GEXPO7 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking

Emma McHugh, Olivia MS Carmo, Adam Blanch, Oliver Looker, Boyin Liu, Snigdha Tiash, Dean Andrew, Steven Batinovic, Andy JY Low, Hyun-Jung Cho, Paul McMillan, Leann Tilley, Matthew WA Dixon

2020-03-01

The malaria parasite Plasmodium falciparum traffics the virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) to..

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The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum

Laure Dumont, Mark B Richardson, Phillip van der Peet, Danushka S Marapana, Tony Triglia, Matthew WA Dixon, Alan F Cowman, Spencer J Williams, Leann Tilley, Malcolm J McConville, Simon A Cobbold

2019-11-01

Members of the haloacid dehalogenase (HAD) family of metabolite phosphatases play an important role in regulating multiple pathway..

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The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly

Oliver Looker, Adam J Blanch, Boyin Liu, Juan Nunez-Iglesias, Paul J McMillan, Leann Tilley, Matthew WA Dixon

2019-05-01

Plasmodium falciparum mediates adhesion of infected red blood cells (RBCs) to blood vessel walls by assembling a multi-protein com..

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Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development

Molly Parkyn Schneider, Boyin Liu, Philipp Glock, Annika Suttie, Emma McHugh, Dean Andrew, Steven Batinovic, Nicholas Williamson, Eric Hanssen, Paul McMillan, Marion Hliscs, Leann Tilley, Matthew WA Dixon

2017-10-01

Transmission of malaria parasites relies on the formation of a specialized blood form called the gametocyte. Gametocytes of the hu..

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Structured illumination microscopy reveals actin I localization in discreet foci in Plasmodium berghei gametocytes

Chiara Curra, Paul J McMillan, Lefteris Spanos, Vanessa Mollard, Elena Deligianni, Geoffrey McFadden, Leann Tilley, Inga Siden-Kiamos

2017-10-01

Actin has important roles in Plasmodium parasites but its exact function in different life stages is not yet fully elucidated. Her..

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A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability

Fabio L da Silva, Matthew WA Dixon, Colin M Stack, Franka Teuscher, Elena Taran, Malcolm K Jones, Erica Lovas, Leann Tilley, Christopher L Brown, Katharine R Trenholme, John P Dalton, Donald L Gardiner, Tina S Skinner-Adams

2016-10-01

Infection with the apicomplexan parasite Plasmodium falciparum is a major cause of morbidity and mortality worldwide. One of the s..

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