TARGETING COMMITMENT TO SEXUAL DIFFERENTIATION IN PLASMODIUM
Grant number: 1098992 | Funding period: 2016 - 2018
Efforts to control malaria in endemic areas are very often thwarted by 'carriers', who have transmissible parasites in their bloodstream (called gametocytes), but who suffer no symptoms. These gametocytes serve as a reservoir ready to reinitiate disease transmission when mosquito numbers increase. This project will develop urgently needed strategies to target gametocytes, and thus block malaria transmission.
Related publications (12)
Repurposing the mitotic machinery to drive cellular elongation and chromatin reorganisation in Plasmodium falciparum gametocytes
Jiahong Li, Gerald J Shami, Ellie Cho, Boyin Liu, Eric Hanssen, Matthew WA Dixon, Leann Tilley
The sexual stage gametocytes of the malaria parasite, Plasmodium falciparum, adopt a falciform (crescent) shape driven by the asse..
Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer's clefts vesiculation, host cell remodeling defects, and loss of surface presentation of EMP1
Olivia MSW Carmo, Gerald Shami, Dezerae W Cox, Boyin Liu, Adam W Blanch, Snigdha Tiash, Leann W Tilley, Matthew WA Dixon
Presentation of the variant antigen, Plasmodium falciparum erythrocyte membrane protein 1 (EMP1), at knob-like protrusions on the ..
Multimodal imaging reveals membrane skeleton reorganisation during reticulocyte maturation and differences in dimple and rim regions of mature erythrocytes
Adam J Blanch, Juan Nunez-Iglesias, Arman Namvar, Sebastien Menant, Oliver Looker, Vijay Rajagopal, Wai-Hong Tham, Leann Tilley, Matthew WA Dixon
The red blood cell (RBC) is remarkable in its ability to deform as it passages through the vasculature. Its deformability derives ..
Non-canonical metabolic pathways in the malaria parasite detected by isotope-tracing metabolomics
Simon A Cobbold, Madel Tutor, Philip Frasse, Emma McHugh, Markus Karnthaler, Darren J Creek, Audrey Odom John, Leann Tilley, Stuart A Ralph, Malcolm J McConville
The malaria parasite, Plasmodium falciparum, proliferates rapidly in human erythrocytes by actively scavenging multiple carbon sou..
Role of Plasmodium falciparum Protein GEXPO7 in Maurer's Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking
Emma McHugh, Olivia MS Carmo, Adam Blanch, Oliver Looker, Boyin Liu, Snigdha Tiash, Dean Andrew, Steven Batinovic, Andy JY Low, Hyun-Jung Cho, Paul McMillan, Leann Tilley, Matthew WA Dixon
The malaria parasite Plasmodium falciparum traffics the virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) to..
The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum
Laure Dumont, Mark B Richardson, Phillip van der Peet, Danushka S Marapana, Tony Triglia, Matthew WA Dixon, Alan F Cowman, Spencer J Williams, Leann Tilley, Malcolm J McConville, Simon A Cobbold
Members of the haloacid dehalogenase (HAD) family of metabolite phosphatases play an important role in regulating multiple pathway..
The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly
Oliver Looker, Adam J Blanch, Boyin Liu, Juan Nunez-Iglesias, Paul J McMillan, Leann Tilley, Matthew WA Dixon
Plasmodium falciparum mediates adhesion of infected red blood cells (RBCs) to blood vessel walls by assembling a multi-protein com..
Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development
Molly Parkyn Schneider, Boyin Liu, Philipp Glock, Annika Suttie, Emma McHugh, Dean Andrew, Steven Batinovic, Nicholas Williamson, Eric Hanssen, Paul McMillan, Marion Hliscs, Leann Tilley, Matthew WA Dixon
Transmission of malaria parasites relies on the formation of a specialized blood form called the gametocyte. Gametocytes of the hu..
Structured illumination microscopy reveals actin I localization in discreet foci in Plasmodium berghei gametocytes
Chiara Curra, Paul J McMillan, Lefteris Spanos, Vanessa Mollard, Elena Deligianni, Geoffrey McFadden, Leann Tilley, Inga Siden-Kiamos
Actin has important roles in Plasmodium parasites but its exact function in different life stages is not yet fully elucidated. Her..
A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability
Fabio L da Silva, Matthew WA Dixon, Colin M Stack, Franka Teuscher, Elena Taran, Malcolm K Jones, Erica Lovas, Leann Tilley, Christopher L Brown, Katharine R Trenholme, John P Dalton, Donald L Gardiner, Tina S Skinner-Adams
Infection with the apicomplexan parasite Plasmodium falciparum is a major cause of morbidity and mortality worldwide. One of the s..