IDENTIFICATION AND FUNCTION OF GENES THAT INCREASE RISK FOR ENDOMETRIOSIS

Grant number: 1105321 | Funding period: 2016 - 2019

Completed

Abstract

Endometriosis is a common disease that affects 7% of reproductive age women in Australia, resulting in pelvic pain, subfertility and painful periods. We have undertaken genetic studies that identified a number of candidate genes that show strong evidence for increasing a woman’s risk of having endometriosis. We now seek funding to investigate the functional roles that these endometriosis susceptibility genes play within the uterus, with the goal of identifying new treatments for endometriosis.

Related publications (7)

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Genetic risk factors for endometriosis near estrogen receptor 1 and coexpression of genes in this region in endometrium.

S Marla, S Mortlock, S Houshdaran, J Fung, B McKinnon, SJ Holdsworth-Carson, JE Girling, PAW Rogers, LC Giudice, GW Montgomery

2021-01-22

The etiology and pathogenesis of endometriosis are complex with both genetic and environmental factors contributing to disease ris..

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Superficial peritoneal endometriotic lesions are histologically diverse and rarely demonstrate menstrual cycle synchronicity with matched eutopic endometrium

EM Colgrave, S Bittinger, M Healey, UP Dior, PAW Rogers, JR Keast, JE Girling, SJ Holdsworth-Carson

2020-12-01

STUDY QUESTION: Do menstrual cycle-dependent changes occur in the histological appearance of superficial peritoneal endometriotic ..

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Tissue specific regulation of transcription in endometrium and association with disease

Sally Mortlock, Raden I Kendarsari, Jenny N Fung, Greg Gibson, Fei Yang, Restuadi Restuadi, Jane E Girling, Sarah J Holdsworth-Carson, Wan Tinn Teh, Samuel W Lukowski, Martin Healey, Ting Qi, Peter AW Rogers, Jian Yang, Brett McKinnon, Grant W Montgomery

2020-02-01

STUDY QUESTION: Are genetic effects on endometrial gene expression tissue specific and/or associated with reproductive traits and ..

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Generation of immortalized human endometrial stromal cell lines with different endometriosis risk genotypes

SJ Holdsworth-Carson, EM Colgrave, JF Donoghue, JN Fung, ML Churchill, S Mortlock, P Paiva, M Healey, GW Montgomery, JE Girling, PAW Rogers

2019-04-01

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Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases

Sally Mortlock, Restuadi Restuadi, Rupert Levien, Jane E Girling, Sarah J Holdsworth-Carson, Martin Healey, Zhihong Zhu, Ting Qi, Yang Wu, Samuel W Lukowski, Peter AW Rogers, Jian Yang, Allan F McRae, Jenny N Fung, Grant W Montgomery

2019-03-14

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Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome

Jenny N Fung, Sally Mortlock, Jane E Girling, Sarah J Holdsworth-Carson, Wan Tinn Teh, Zhihong Zhu, Samuel W Lukowski, Brett D McKinnon, Allan McRae, Jian Yang, Martin Healey, Joseph E Powell, Peter AW Rogers, Grant W Montgomery

2018-07-30

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The genetic regulation of transcription in human endometrial tissue

Jenny N Fung, Jane E Girling, Samuel W Lukowski, Yadav Sapkota, Leanne Wallace, Sarah J Holdsworth-Carson, Anjali K Henders, Martin Healey, Peter AW Rogers, Joseph E Powell, Grant W Montgomery

2017-04-01