IDENTIFICATION AND FUNCTION OF GENES THAT INCREASE RISK FOR ENDOMETRIOSIS

Grant number: 1105321 | Funding period: 2016 - 2019

Completed

Abstract

Endometriosis is a common disease that affects 7% of reproductive age women in Australia, resulting in pelvic pain, subfertility and painful periods. We have undertaken genetic studies that identified a number of candidate genes that show strong evidence for increasing a woman’s risk of having endometriosis. We now seek funding to investigate the functional roles that these endometriosis susceptibility genes play within the uterus, with the goal of identifying new treatments for endometriosis.

Related publications (10)

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Associations between body mass index and the surgical phenotype and location of endometriotic lesions

Katherine A Enright, Sandra Louise, Uri P Dior, Martin Healey, Sarah J Holdsworth-Carson

2021-11-01

RESEARCH QUESTION: Is there a relationship between body mass index (BMI) and endometriotic lesions, specifically surgical phenotyp..

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Comparing endometriotic lesions with eutopic endometrium: time to shift focus?

Eliza M Colgrave, Janet R Keast, Sophie Bittinger, Martin Healey, Peter AW Rogers, Sarah J Holdsworth-Carson, Jane E Girling

2021-10-18

Endometriosis is a heterogeneous disease in terms of patient symptoms, treatment responsiveness and the presentation of endometrio..

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Elucidating the role of long intergenic non-coding RNA 339 in human endometrium and endometriosis

Sarah J Holdsworth-Carson, Molly Churchill, Jacqueline F Donoghue, Sally Mortlock, Jenny N Fung, Clare Sloggett, Jessica Chung, Leonie Cann, Wan Tinn Teh, Katie-Rose Campbell, Rodney Luwor, Martin Healey, Grant Montgomery, Jane E Girling, Peter AW Rogers

2021-03-01

Endometriosis is a complex disease, influenced by genetic factors. Genetic markers associated with endometriosis exist at chromoso..

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Genetic risk factors for endometriosis near estrogen receptor 1 and coexpression of genes in this region in endometrium

S Marla, S Mortlock, S Houshdaran, J Fung, B McKinnon, SJ Holdsworth-Carson, JE Girling, PAW Rogers, LC Giudice, GW Montgomery

2021-01-01

The etiology and pathogenesis of endometriosis are complex with both genetic and environmental factors contributing to disease ris..

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Superficial peritoneal endometriotic lesions are histologically diverse and rarely demonstrate menstrual cycle synchronicity with matched eutopic endometrium

EM Colgrave, S Bittinger, M Healey, UP Dior, PAW Rogers, JR Keast, JE Girling, SJ Holdsworth-Carson

2020-12-01

STUDY QUESTION: Do menstrual cycle-dependent changes occur in the histological appearance of superficial peritoneal endometriotic ..

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Tissue specific regulation of transcription in endometrium and association with disease

Sally Mortlock, Raden I Kendarsari, Jenny N Fung, Greg Gibson, Fei Yang, Restuadi Restuadi, Jane E Girling, Sarah J Holdsworth-Carson, Wan Tinn Teh, Samuel W Lukowski, Martin Healey, Ting Qi, Peter AW Rogers, Jian Yang, Brett McKinnon, Grant W Montgomery

2020-02-01

STUDY QUESTION: Are genetic effects on endometrial gene expression tissue specific and/or associated with reproductive traits and ..

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Generation of immortalized human endometrial stromal cell lines with different endometriosis risk genotypes

SJ Holdsworth-Carson, EM Colgrave, JF Donoghue, JN Fung, ML Churchill, S Mortlock, P Paiva, M Healey, GW Montgomery, JE Girling, PAW Rogers

2019-04-01

Endometriotic lesions are composed in part of endometrial-like stromal cells, however, there is a shortage of immortalized human e..

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Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases

Sally Mortlock, Restuadi Restuadi, Rupert Levien, Jane E Girling, Sarah J Holdsworth-Carson, Martin Healey, Zhihong Zhu, Ting Qi, Yang Wu, Samuel W Lukowski, Peter AW Rogers, Jian Yang, Allan F McRae, Jenny N Fung, Grant W Montgomery

2019-03-14

BACKGROUND: Major challenges in understanding the functional consequences of genetic risk factors for human disease are which tiss..

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Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome

Jenny N Fung, Sally Mortlock, Jane E Girling, Sarah J Holdsworth-Carson, Wan Tinn Teh, Zhihong Zhu, Samuel W Lukowski, Brett D McKinnon, Allan McRae, Jian Yang, Martin Healey, Joseph E Powell, Peter AW Rogers, Grant W Montgomery

2018-07-30

Gene expression varies markedly across the menstrual cycle and expression levels for many genes are under genetic control. We anal..

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The genetic regulation of transcription in human endometrial tissue

Jenny N Fung, Jane E Girling, Samuel W Lukowski, Yadav Sapkota, Leanne Wallace, Sarah J Holdsworth-Carson, Anjali K Henders, Martin Healey, Peter AW Rogers, Joseph E Powell, Grant W Montgomery

2017-04-01

Study question: Do genetic effects regulate gene expression in human endometrium? Summary answer: This study demonstrated strong g..

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