THE COMBINATION OF CDK4 AND MAPK/ERK PATHWAY INHIBITOR THERAPY IN MELANOMA: DEFINING MELANOMA CELL INTRINSIC AND IMMUNE MEDIATED RESPONSES

Grant number: 1100189 | Funding period: 2016 - 2019

Completed

Abstract

Early-stage melanomas can often be cured with surgery, but more advanced melanomas are harder to treat because standard melanoma treatments do not induce long term disease control. Thus newer types of treatment are required to treat more advanced melanomas. Our proposal will use a drug that stops melanoma cells from growing and in combination with other drugs causes the cells to release factors that activate the immune system to eliminate the tumour.