SLOWING THE SPREAD OF MALARIA DRUG RESISTANCE BY EXTENDING THE LIFESPAN OF THE ARTEMISININ DERIVATIVES
Grant number: 1100394 | Funding period: 2016 - 2019
Approximately 200 million clinical cases of malaria are treated globally each year. Alarmingly, resistance to the most highly effective antimalarial drugs, has emerged in Southeast Asia, jeopardizing malaria control. This project will develop novel mathematical models that predict the action of the antimalarial drug within an infected individual to inform the malaria community of optimal treatment strategies in areas where resistance has emerged.
Related publications (9)
The risk of morbidity and mortality following recurrent malaria in Papua, Indonesia: a retrospective cohort study
Saber Dini, Nicholas M Douglas, Jeanne Rini Poespoprodjo, Enny Kenangalem, Paulus Sugiarto, Ian D Plumb, Ric N Price, Julie A Simpson
BACKGROUND: An acute episode of malaria can be followed by multiple recurrent episodes either due to re-infection, recrudescence o..
In Silico Investigation of the Decline in Clinical Efficacy of Artemisinin Combination Therapies Due to Increasing Artemisinin and Partner Drug Resistance
Sophie G Zaloumis, Pengxing Cao, Saber Dini, Miles P Davenport, Deborah Cromer, David S Khoury, Freya JI Fowkes, James M McCaw, Julie A Simpson
Antimalarial treatment currently relies on an artemisinin derivative and a longer-acting partner drug. With the emergence of resis..
Investigating the Efficacy of Triple Artemisinin-Based Combination Therapies for Treating Plasmodium falciparum Malaria Patients Using Mathematical Modeling
Saber Dini, Sophie Zaloumis, Pengxing Cao, Ric N Price, Freya J Fowkes, E Rob W van der Pluijm, James M McCaw, Julie A Simpson
The first line treatment for uncomplicated falciparum malaria is artemisinin-based combination therapy (ACT), which consists of an..
Within-host modeling of blood-stage malaria
David S Khoury, Rosemary Aogo, Georges Randriafanomezantsoa-Radohery, James M McCaw, Julie A Simpson, James S McCarthy, Ashraful Haque, Deborah Cromer, Miles P Davenport
Malaria infection continues to be a major health problem worldwide and drug resistance in the major human parasite species, Plasmo..
Implications of population-level immunity for the emergence of artemisinin-resistant malaria: a mathematical model
Nick Scott, Ricardo Ataide, David P Wilson, Margaret Hellard, Ric N Price, Julie A Simpson, Freya J Fowkes
BACKGROUND: Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong Subregion, an area of relatively low tra..
A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum
Pengxing Cao, Nectarios Klonis, Sophie Zaloumis, Con Dogovski, Stanley C Xie, Sompob Saralamba, Lisa J White, Freya JI Fowkes, Leann Tilley, Julie A Simpson, James M McCaw
Artemisinin resistance constitutes a major threat to the continued success of control programs for malaria, particularly in light ..
A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection
Pengxing Cao, Nectarios Klonis, Sophie Zaloumis, David S Khoury, Deborah Cromer, Miles P Davenport, Leann Tilley, Julie A Simpson, James M McCaw
Falciparum malaria is a major parasitic disease causing widespread morbidity and mortality globally. Artemisinin derivatives-the m..