NEW ANTBIOTICS FROM OLD MICROBES
Grant number: 1105522 | Funding period: 2016 - 2019
Once treatable infections are becoming deadly because bacteria are developing broad antibiotic resistance. New medicines are urgently needed. Microbes themselves are the richest known source of new antibiotics but finding the 'good bugs' is like finding a needle in a microbial haystack. This project will use state-of-the art science to screen a previously overlooked source of rich microbial biodiversity and find new antibiotics.
Related publications (10)
Mining Symbionts of a Spider-Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones
Sarah P Niehs, Benjamin Dose, Sophie Richter, Sacha J Pidot, Hans-Martin Dahse, Timothy P Stinear, Christian Hertweck
A spider-transmitted fungus (Rhizopus microsporus) that was isolated from necrotic human tissue was found to harbor endofungal bac..
Genomics-Driven Discovery of NO-Donating Diazeniumdiolate Siderophores in Diverse Plant-Associated Bacteria
Ron Hermenau, Jule L Mehl, Keishi Ishida, Benjamin Dose, Sacha Pidot, Timothy P Stinear, Christian Hertweck
Siderophores are key players in bacteria-host interactions, with the main function to provide soluble iron for their producers. Gr..
Genome Mining Reveals Endopyrroles from a Nonribosomal Peptide Assembly Line Triggered in Fungal-Bacterial Symbiosis
Sarah P Niehs, Benjamin Dose, Kirstin Scherlach, Sacha J Pidot, Timothy P Stinear, Christian Hertweck
The bacterial endosymbiont (Burkholderia rhizoxinica) of the rice seedling blight fungus (Rhizopus microsporus) harbors a large nu..
Biosynthesis of Diverse Antimicrobial and Antiproliferative Acyloins in Anaerobic Bacteria.
Sebastian Schieferdecker, Gulimila Shabuer, Anne-Catrin Letzel, Barbara Urbansky, Mie Ishida-Ito, Keishi Ishida, Michael Cyrulies, Hans-Martin Dahse, Sacha Pidot, Christian Hertweck
Metabolic profiling and genome mining revealed that anaerobic bacteria have the potential to produce acyloin natural products. In ..
Biosynthesis and Ether‐Bridge Formation in Nargenicin Macrolides
Sacha J Pidot, Marion Herisse, Liam Sharkey, Liselle Atkin, Jessica L Porter, Torsten Seemann, Benjamin P Howden, Mark A Rizzacasa, Timothy P Stinear
Abstract: The nargenicin family of antibiotics are macrolides containing a rare ether‐bridged cis‐decalin motif. Several of these ..
Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus
Nicholas J Tobias, Hendrik Wolff, Bardya Djahanschiri, Florian Grundmann, Max Kronenwerth, Yi-Ming Shi, Svenja Simonyi, Peter Gruen, David Shapiro-Ilan, Sacha J Pidot, Timothy P Stinear, Ingo Ebersberger, Helge B Bode
Structure and Biosynthesis of Isatropolones, Bioactive Amine-Scavenging Fluorescent Natural Products from Streptomyces Go66
Xiaofeng Cai, Yi-Ming Shi, Nicole Poehlmann, Ole Revermann, Isabel Bahner, Sacha J Pidot, Frank Wesche, Helmut Lackner, Claudia Buechel, Marcel Kaiser, Christian Richter, Harald Schwalbe, Timothy P Stinear, Axel Zeeck, Helge B Bode