BIOLOGICAL ACTIONS OF ESTRADIOL IN MEN
Grant number: 1099173 | Funding period: 2016 - 2022
In men, oestrogen may be important for strong bones and maintaining a healthy weight. Men with prostate cancer are given medical castration treatment to decrease testosterone, because testosterone is required for prostate cancer growth. Because oestrogen is derived from testosterone, they also have very low oestrogen levels. We want to conduct a trial in these men to find out whether giving back oestrogen will prevent bone loss and weight gain, among other health benefits.
Related publications (2)
Testosterone treatment in older men: clinical implications and unresolved questions from the Testosterone Trials
Bu B Yeap, Stephanie T Page, Mathis Grossmann
A decrease in the concentration of circulating testosterone in many older men is a biomarker and possibly a rectifiable contributi..