BIOLOGICAL ACTIONS OF ESTRADIOL IN MEN

Grant number: 1099173 | Funding period: 2016 - 2022

Completed

Abstract

In men, oestrogen may be important for strong bones and maintaining a healthy weight. Men with prostate cancer are given medical castration treatment to decrease testosterone, because testosterone is required for prostate cancer growth. Because oestrogen is derived from testosterone, they also have very low oestrogen levels. We want to conduct a trial in these men to find out whether giving back oestrogen will prevent bone loss and weight gain, among other health benefits.

Related publications (7)

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Consensus guidelines for sarcopenia prevention, diagnosis and management in Australia and New Zealand

Jesse Zanker, Marc Sim, Kate Anderson, Saliu Balogun, Sharon L Brennan-Olsen, Elsa Dent, Gustavo Duque, Christian M Girgis, Mathis Grossmann, Alan Hayes, Tim Henwood, Vasant Hirani, Charles Inderjeeth, Sandra Iuliano, Justin Keogh, Josh Lewis, Gordon S Lynch, Julie A Pasco, Steven Phu, Esmee M Reijnierse

2022-11-09

BACKGROUND: Sarcopenia is an age-associated skeletal muscle condition characterized by low muscle mass, strength, and physical per..

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Effects of oestradiol treatment on hot flushes in men undergoing androgen deprivation therapy for prostate cancer: a randomised placebo-controlled trial

Nicholas Russell, Rudolf Hoermann, Ada S Cheung, Jeffrey D Zajac, Mathis Grossmann

2022-11-01

OBJECTIVE: Most men undergoing androgen deprivation therapy (ADT) for prostate cancer experience hot flushes. Current treatments h..

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Effects of estradiol on bone in men undergoing androgen deprivation therapy: a randomized placebo-controlled trial

Nicholas Russell, Ali Ghasem-Zadeh, Rudolf Hoermann, Ada S Cheung, Jeffrey D Zajac, Cat Shore-Lorenti, Peter R Ebeling, David J Handelsman, Mathis Grossmann

2022-08-01

OBJECTIVE: In men, many effects of testosterone (T) on the skeleton are thought to be mediated by estradiol (E2), but trial eviden..

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Effect of estradiol on cognition in men undergoing androgen deprivation therapy: A randomized placebo-controlled trial

Nicholas Russell, James Allebone, Orwa Dandash, Rudolf Hoermann, Ada S Cheung, Jeffrey D Zajac, David J Handelsman, Richard A Kanaan, Mathis Grossmann

2022-02-21

OBJECTIVE: Roles for estradiol in modulating cognition in men remain uncertain. We assessed the isolated effects of estradiol on c..

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MECHANISMS IN ENDOCRINOLOGY Estradiol as a male hormone

Nicholas Russell, Mathis Grossmann

2019-07-01

Evidence has been accumulating that, in men, some of the biological actions traditionally attributed to testosterone acting via th..

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Reproductive Endocrinology of Nonalcoholic Fatty Liver Disease

Mathis Grossmann, Margaret E Wierman, Peter Angus, David J Handelsman

2019-04-01

The liver and the reproductive system interact in a multifaceted bidirectional fashion. Sex steroid signaling influences hepatic e..

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Testosterone treatment in older men: clinical implications and unresolved questions from the Testosterone Trials

Bu B Yeap, Stephanie T Page, Mathis Grossmann

2018-08-01

A decrease in the concentration of circulating testosterone in many older men is a biomarker and possibly a rectifiable contributi..