PATHOGENIC AND ADAPTIVE MOLECULAR INTERACTIONS WITH MUTANT HUNTINGTIN EXON 1

Grant number: 1102059 | Funding period: 2016 - 2019

Completed

Abstract

This project aims to determine how the gene mutation that causes Huntington’s disease (HD) damages cells in the brain. The diseased gene creates a protein that is abnormally sticky, which causes it to form clumps. Our goal is to determine the components of the cell that are disrupted and damaged as clumping happens. Understanding this link will enable therapeutics to be logically designed in efforts to prevent harm to the brain, potentially before symptoms are evident.

Related publications (7)

University of Melbourne Researchers