CLOSED-LOOP DEEP BRAIN STIMULATION: OPTIMISING TREATMENT OF PARKINSON’S DISEASE USING ADAPTIVE STIMULATION

Grant number: 1103238 | Funding period: 2016 - 2019

Completed

Abstract

Deep brain stimulation is an established therapy for Parkinson's disease when patients’ symptoms cannot be controlled adequately using medication. Although deep brain stimulation usually improves quality of life significantly, existing devices have shortcomings that often result in poor symptom alleviation and/or undesirable side-effects. This project is aimed at developing an innovative system that automatically adjusts stimulation according to the continually fluctuating needs of each patient.

Related publications (5)

Scholarly works icon

Deep brain stimulation for Parkinson's disease modulates high-frequency evoked and spontaneous neural activity

Nicholas C Sinclair, Hugh J McDermott, James B Fallon, Thushara Perera, Peter Brown, Kristian J Bulluss, Wesley Thevathasan

2019-10-01

Deep brain stimulation is an established therapy for Parkinson's disease; however, its effectiveness is hindered by limited unders..

Scholarly works icon

On the neural basis of deep brain stimulation evoked resonant activity

Nicholas C Sinclair, James B Fallon, Kristian J Bulluss, Wesley Thevathasan, Hugh J McDermott

2019-08-01

Objective: Deep brain stimulation can be a remarkably effective treatment for Parkinson's disease and other conditions; however, a..

Scholarly works icon

A palm-worn device to quantify rigidity in Parkinson's disease

Thushara Perera, Wee-Lih Lee, Mary Jones, Joy L Tan, Elizabeth L Proud, Angus Begg, Nicholas C Sinclair, Richard Peppard, Hugh J McDermott

2019-04-01

BACKGROUND: Parkinsonian rigidity is identified on clinical examination as resistance to passive movement. Measurement of rigidity..

Scholarly works icon

Objective evaluation of bradykinesia in Parkinson's disease using an inexpensive marker-less motion tracking system

Wee Lih Lee, Nicholas C Sinclair, Mary Jones, Joy L Tan, Elizabeth L Proud, Richard Peppard, Hugh J McDermott, Thushara Perera

2019-01-01

OBJECTIVE: Quantification of bradykinesia (slowness of movement) is crucial for the treatment and monitoring of Parkinson's diseas..

Scholarly works icon

Subthalamic nucleus deep brain stimulation evokes resonant neural activity

Nicholas C Sinclair, Hugh J McDermott, Kristian J Bulluss, James B Fallon, Thushara Perera, San San Xu, Peter Brown, Wesley Thevathasan

2018-05-01

Deep brain stimulation (DBS) is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target-speci..

University of Melbourne Researchers