CAN MALARIA PARASTIE RESISTANCE TO AN IMPORTANT DRUG SPREAD?

Grant number: 1106213 | Funding period: 2016 - 2019

Completed

Abstract

Malaria is a major global health issue. Drugs are a key weapon against the disease, but resistance eventually emerges and spreads, rendering a succession of drugs useless. We have preliminary evidence that resistance to a safe and cheap drug is unable to spread. We believe drug resistant parasites die when attempting to transmit from person to person via the mosquito vector. Inability to spread resistance would make this drug extremely valuable in the fight against malaria.

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Christopher D Goodman, Hayley D Buchanan, Geoffrey I McFadden

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Rapid emergence of resistance to atovaquone, which targets electron transport in the malaria parasite mitochondrion, relegated its..

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