CAN MALARIA PARASTIE RESISTANCE TO AN IMPORTANT DRUG SPREAD?
Grant number: 1106213 | Funding period: 2016 - 2019
Malaria is a major global health issue. Drugs are a key weapon against the disease, but resistance eventually emerges and spreads, rendering a succession of drugs useless. We have preliminary evidence that resistance to a safe and cheap drug is unable to spread. We believe drug resistant parasites die when attempting to transmit from person to person via the mosquito vector. Inability to spread resistance would make this drug extremely valuable in the fight against malaria.
Related publications (5)
A single point mutation in the Plasmodium falciparum FtsH1 metalloprotease confers actinonin resistance
Christopher D Goodman, Taher Uddin, Natalie J Spillman, Geoffrey McFadden
The antibiotic actinonin kills malaria parasites (Plasmodium falciparum) by interfering with apicoplast function. Early evidence s..
A genetic screen in rodent malaria parasites identifies five new apicoplast putative membrane transporters, one of which is essential in human malaria parasites
Claire P Sayers, Vanessa Mollard, Hayley D Buchanan, Geoffrey I McFadden, Christopher D Goodman
The malaria-causing parasite, Plasmodium, contains a unique non-photosynthetic plastid known as the apicoplast. The apicoplast is ..
Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites
Taher Uddin, Geoffrey Ian McFadden, Christopher Dean Goodman
Malaria parasites contain a relict plastid, the apicoplast, which is considered an excellent drug target due to its bacterial-like..
A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasite
Upeksha L Rathnapala, Christopher D Goodman, Geoffrey I McFadden
The combination of drug resistance, lack of an effective vaccine, and ongoing conflict and poverty means that malaria remains a ma..