TARGETING CARBOHYDRATE METABOLISM IN LEISHMANIA

Analysis of the Physiological and Metabolic State of Leishmania Using Heavy Water Labeling

Joachim Kloehn, Malcolm J McConville

2020-01-01

This protocol describes the use of heavy water (2H2O) labeling to determine the growth rate and metabolic state of Leishmania para..

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites

M Fleur Sernee, Julie E Ralton, Tracy L Nero, Lukasz F Sobala, Joachim Kloehn, Marcel A Vieira-Lara, Simon A Cobbold, Lauren Stanton, Douglas EV Pires, Eric Hanssen, Alexandra Males, Tom Ward, Laurence M Bastidas, Phillip L van der Peet, Michael W Parker, David B Ascher, Spencer J Williams, Gideon J Davies, Malcolm J McConville

2019-09-11

Parasitic protists belonging to the genus Leishmania synthesize the non-canonical carbohydrate reserve, mannogen, which is compose..

DExSI: a new tool for the rapid quantitation of C-13-labelled metabolites detected by GC-MS

Michael J Dagley, Malcolm J McConville

2018-06-01

Summary: Stable isotope directed metabolomics is increasingly being used to measure metabolic fluxes in microbial, plant and anima..