THE TRANSMISSION OF PERINATAL MATERNAL MENTAL HEALTH TO PRESCHOOL EMOTIONAL DISORDERS: EXAMINING PATHWAYS AND INTERVENTION POINTS IN THE MPEWS STUDY
Grant number: 1106823 | Funding period: 2016 - 2021
While it is known that depression, anxiety and stress in pregnancy increase the risk for poorer child mental health, what is unknown is the key pathways and intervention points to prevent this transmission of risk. This study will examine potential mechanisms and intervention points through a selected cohort study: Mercy Pregnancy and Emotional Wellbeing Study. This study follows 500 women and their children from first trimester in pregnancy until the children are 3 years of age.
Related publications (12)
Fetal programming pathway from maternal mental health to infant cortisol functioning: The role of placental 11fl-HSD2 mRNA expression
Megan Galbally, Stuart J Watson, Martha Lappas, E Ron de Kloet, Elisabeth van Rossum, Caitlin Wyrwoll, Peter Mark, Andrew J Lewis
Placental 11β-HSD2 has been a focus of research for understanding potential fetal programming associated with maternal emotional d..
Maternal perinatal depression, circulating oxytocin levels and childhood emotional disorders at 4 years of age: The importance of psychosocial context.
Megan Galbally, Stuart J Watson, Jeff Keelan, Kelli K MacMillan, Josephine Power, Marinus van IJzendoorn, Andrew J Lewis
Oxytocin has been a hormone of interest in understanding both depression and parenting. Here, the role of oxytocin has been explor..
The mother, the infant and the mother-infant relationship: What is the impact of antidepressant medication in pregnancy.
Megan Galbally, Stuart J Watson, Philip Boyce, Thinh Nguyen, Andrew J Lewis
BACKGROUND: Both antidepressant use and depression in pregnancy have the potential to impact on outcomes for the women, their moth..
Maternal depression and the emotional availability of mothers at six months postpartum: Findings from the Mercy Pregnancy and Emotional Wellbeing Study (MPEWS) pregnancy cohort.
Kelli K MacMillan, Andrew J Lewis, Stuart J Watson, Megan Galbally
BACKGROUND: Existing research suggests maternal depression may reduce the quality of early mother-infant interaction and this migh..
Trans-generational stress regulation: Mother-infant cortisol and maternal mental health across the perinatal period.
Megan Galbally, Elisabeth FC van Rossum, Stuart J Watson, Edo Ronald de Kloet, Andrew J Lewis
Understanding maternal mental health and cortisol regulation across pregnancy and the relationship to the development of the offsp..
Depression across pregnancy and the postpartum, antidepressant use and the association with female sexual function
Megan Galbally, Stuart J Watson, Michael Permezel, Andrew J Lewis
BACKGROUND: There is an established relationship between depression and sexual functioning in women. However, there is limited res..
The role of trauma and partner support in perinatal depression and parenting stress: An Australian pregnancy cohort study.
Megan Galbally, Stuart J Watson, Philip Boyce, Andrew J Lewis
BACKGROUND: Improving our understanding of the relationship between maternal depression and parenting stress is likely to lie in t..
Breastfeeding, Antidepressants, and Depression in the Mercy Pregnancy and Emotional Well-Being Study.
Megan Galbally, Stuart J Watson, Helen Ball, Andrew James Lewis
BACKGROUND:: Depression is consistently shown to predict lower rates of breastfeeding. In a handful of studies, breastfeeding has ..
Perinatal maternal depression, antidepressant use and infant sleep outcomes: Exploring cross-lagged associations in a pregnancy cohort study.
Megan Galbally, Stuart J Watson, Doug Teti, Andrew J Lewis
BACKGROUND: Both perinatal depression and infant sleep problems are common concerns in many communities, with these problems often..
Exercise frequency and maternal mental health: Parallel process modelling across the perinatal period in an Australian pregnancy cohort.
Stuart J Watson, Andrew J Lewis, Philip Boyce, Megan Galbally
OBJECTIVE: Since the potential mental health benefits of exercise during pregnancy remain unclear, this study examined longitudina..
Maternal depression, antidepressant use and placental oxytocin receptor DNA methylation: Findings from the MPEWS study
Megan Galbally, Joanne Ryan, Marinus van IJzendoorn, Stuart J Watson, Olav Spigset, Martha Lappas, Richard Saffery, Ron de Kloet, Andrew James Lewis
The aim of this study was to investigate placental DNA methylation of the oxytocin receptor gene (OXTR) in women with depression i..
Neonatal adaptation following intrauterine antidepressant exposure: assessment, drug assay levels, and infant development outcomes
Megan Galbally, Olav Spigset, Andrew R Johnson, Rolland Kohan, Martha Lappas, Andrew J Lewis
BackgroundAlthough a meta-analysis has confirmed the association between antidepressant exposure in utero and subsequent poor neon..