NOVEL STRATEGIES TO PROMOTE MYELIN REPAIR IN THE BRAIN
Grant number: 1105108 | Funding period: 2016 - 2018
Demyelinating diseases of the central nervous system such as multiple sclerosis have a lifelong impact and devastating impact on quality of life. We have identified that a growth factor, brain derived neurotrophic factor (BDNF), plays an important role in promoting myelination during development. We will investigate the potential of translating these findings into effective clinical treatment, by characterising the efficacy of BDNF in promoting CNS remyelination after a demyelinating insult.
Related publications (2)
Brain-Derived Neurotrophic Factor in Central Nervous System Myelination: A New Mechanism to Promote Myelin Plasticity and Repair
Jessica L Fletcher, Simon S Murray, Junhua Xiao
Brain-derived neurotrophic factor (BDNF) plays vitally important roles in neural development and plasticity in both health and dis..
Targeting TrkB with a brain-derived neurotrophic factor mimetic promotes myelin repair in the brain
Jessica Fletcher, Rhiannon Wood, Jacqueline Nguyen, Eleanor ML Norman, Christine MK Jun, Alexa Prawdiuk, Melissa Biemond, Huynh TH Nguyen, Susan Northfield, Richard Hughes, David Gonsalvez, Junhua Xiao, Simon Murray
<h4>Methods: </h4> to promote myelin regeneration in response to central myelin loss are essential to prevent the progression of c..