Novel Strategies to Promote Myelin Repair in the Brain

Grant number: 1105108 | Funding period: 2016 - 2018

Completed

Abstract

Demyelinating diseases of the central nervous system such as multiple sclerosis have a lifelong impact and devastating impact on quality of life. We have identified that a growth factor, brain derived neurotrophic factor (BDNF), plays an important role in promoting myelination during development. We will investigate the potential of translating these findings into effective clinical treatment, by characterising the efficacy of BDNF in promoting CNS remyelination after a demyelinating insult.

Related publications (5)

Scholarly works icon

CSF infusion of TrkB agonist, 7,8-dihydroxyflavone, is ineffective in promoting remyelination in cuprizone and EAE models of multiple sclerosis

Jessica Fletcher, Rhiannon Wood, Alexa Prawdiuk, Ryan O’Rafferty, Ophelia Ehrlich, David Gonsalvez, Simon Murray

2021-01-01

Small molecular weight functional mimetics of brain-derived neurotrophic factor (BDNF) which act via the TrkB receptor have been d..

Scholarly works icon

TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum

HTH Nguyen, RJ Wood, AR Prawdiuk, SGB Furness, J Xiao, SS Murray, JL Fletcher

2019-08-27

The neurotrophin, brain-derived neurotrophic factor (BDNF) promotes central nervous system (CNS) myelination during development an..

Scholarly works icon

Inhibiting bone morphogenetic protein 4 type i receptor signaling promotes remyelination by potentiating oligodendrocyte differentiation

AE Govier-Cole, RJ Wood, JL Fletcher, DG Gonsalvez, D Merlo, HS Cate, SS Murray, J Xiao

2019-01-01

Blocking inhibitory factors within CNS demyelinating lesions is regarded as a promising strategy to promote remyelination. Bone mo..

Scholarly works icon

Targeting TrkB with a brain-derived neurotrophic factor mimetic promotes myelin repair in the brain

JL Fletcher, RJ Wood, J Nguyen, EML Norman, CMK Jun, AR Prawdiuk, M Biemond, HTH Nguyen, SE Northfield, RA Hughes, DG Gonsalvez, J Xiao, SS Murray

2018-08-08

Methods to promote myelin regeneration in response to central myelin loss are essential to prevent the progression of clinical dis..

Scholarly works icon

Brain-derived neurotrophic factor in central nervous system myelination: A new mechanism to promote myelin plasticity and repair

JL Fletcher, SS Murray, J Xiao

2018-01-01

Brain-derived neurotrophic factor (BDNF) plays vitally important roles in neural development and plasticity in both health and dis..

University of Melbourne Researchers