UNRAVELING THE NEURAL CIRCUITRY OF CONTEXT-INDUCED RELAPSE TO ALCOHOL SEEKING AFTER PUNISHMENT-IMPOSED ABSTINENCE
Grant number: 1105741 | Funding period: 2016 - 2019
Alcohol use disorder (alcoholism) causes significant social and economic costs to Australian society. Alcoholism is a brain disease, and relapse during abstinence is the main problem in successful treatment. In this project, we use an animal model of relapse to alcohol seeking after abstinence imposed by a negative consequence (punishment). This project will identify brain regions which can be targeted in future clinical studies in human alcoholics.
Related publications (8)
Orexin-1 receptor signaling within the lateral hypothalamus, but not bed nucleus of the stria terminalis, mediates context-induced relapse to alcohol seeking
Erin J Campbell, Mitchell KR Hill, Xavier J Maddern, Shubo Jin, Terence Y Pang, Andrew J Lawrence
BACKGROUND: The lateral hypothalamic orexin (hypocretin) system has a well-established role in the motivation for reward. This has..
Environmental enrichment reduces the propensity to relapse following punishment-imposed abstinence of alcohol seeking
Erin J Campbell, Shubo Jin, Andrew J Lawrence
Environmental enrichment during periods of abstinence can reduce the risk of relapse to drug-seeking behavior. We trained rats to ..
Anterior Insular Cortex is Critical for the Propensity to Relapse Following Punishment-Imposed Abstinence of Alcohol Seeking
Erin J Campbell, Jeremy PM Flanagan, Leigh C Walker, Mitchell KR Hill, Nathan J Marchant, Andrew J Lawrence
Humans with alcohol use disorder typically abstain because of the negative consequences associated with excessive drinking, and ex..
Novel approaches to alcohol rehabilitation: Modification of stress-responsive brain regions through environmental enrichment
Terence Y Pang, Anthony J Hannan, Andrew J Lawrence
Relapse remains the most prominent hurdle to successful rehabilitation from alcoholism. The neural mechanisms underlying relapse a..
Distinct Accumbens Shell Output Pathways Promote versus Prevent Relapse to Alcohol Seeking
Gabrielle D Gibson, Asheeta A Prasad, Philip Jean-Richard-dit-Bressel, Joanna OY Yau, E Zayra Millan, Yu Liu, Erin J Campbell, Jun Lim, Nathan J Marchant, John M Power, Simon Killcross, Andrew J Lawrence, Gavan P McNally
Contexts exert bi-directional control over relapse to drug seeking. Contexts associated with drug self-administration promote rela..
Reduced alcohol-seeking in male offspring of sires exposed to alcohol self-administration followed by punishment-imposed abstinence
Erin J Campbell, Jeremy PM Flanagan, Nathan J Marchant, Andrew J Lawrence
Emerging evidence has demonstrated that paternal alcohol use can modify the behavior of offspring, particularly male offspring. Ho..