UNRAVELING THE NEURAL CIRCUITRY OF CONTEXT-INDUCED RELAPSE TO ALCOHOL SEEKING AFTER PUNISHMENT-IMPOSED ABSTINENCE

Grant number: 1105741 | Funding period: 2016 - 2019

Completed

Abstract

Alcohol use disorder (alcoholism) causes significant social and economic costs to Australian society. Alcoholism is a brain disease, and relapse during abstinence is the main problem in successful treatment. In this project, we use an animal model of relapse to alcohol seeking after abstinence imposed by a negative consequence (punishment). This project will identify brain regions which can be targeted in future clinical studies in human alcoholics.

Related publications (8)

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Orexin-1 receptor signaling within the lateral hypothalamus, but not bed nucleus of the stria terminalis, mediates context-induced relapse to alcohol seeking

Erin J Campbell, Mitchell KR Hill, Xavier J Maddern, Shubo Jin, Terence Y Pang, Andrew J Lawrence

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BACKGROUND: The lateral hypothalamic orexin (hypocretin) system has a well-established role in the motivation for reward. This has..

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A sleeping giant: Suvorexant for the treatment of alcohol use disorder?

Erin J Campbell, Nathan J Marchant, Andrew J Lawrence

2020-03-15

There are currently 3 FDA approved treatments for alcohol use disorder (AUD) in the USA, opioid receptor antagonists such as naltr..

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Environmental enrichment reduces the propensity to relapse following punishment-imposed abstinence of alcohol seeking

Erin J Campbell, Shubo Jin, Andrew J Lawrence

2019-10-15

Environmental enrichment during periods of abstinence can reduce the risk of relapse to drug-seeking behavior. We trained rats to ..

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Anterior Insular Cortex is Critical for the Propensity to Relapse Following Punishment-Imposed Abstinence of Alcohol Seeking

Erin J Campbell, Jeremy PM Flanagan, Leigh C Walker, Mitchell KR Hill, Nathan J Marchant, Andrew J Lawrence

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Humans with alcohol use disorder typically abstain because of the negative consequences associated with excessive drinking, and ex..

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Novel approaches to alcohol rehabilitation: Modification of stress-responsive brain regions through environmental enrichment

Terence Y Pang, Anthony J Hannan, Andrew J Lawrence

2019-02-01

Relapse remains the most prominent hurdle to successful rehabilitation from alcoholism. The neural mechanisms underlying relapse a..

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New steps for treating alcohol use disorder

Erin J Campbell, Andrew J Lawrence, Christina J Perry

2018-06-01

Alcohol use disorder is a complex syndrome with multiple treatment points including drug-induced pathology, withdrawal management,..

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Distinct Accumbens Shell Output Pathways Promote versus Prevent Relapse to Alcohol Seeking

Gabrielle D Gibson, Asheeta A Prasad, Philip Jean-Richard-dit-Bressel, Joanna OY Yau, E Zayra Millan, Yu Liu, Erin J Campbell, Jun Lim, Nathan J Marchant, John M Power, Simon Killcross, Andrew J Lawrence, Gavan P McNally

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Contexts exert bi-directional control over relapse to drug seeking. Contexts associated with drug self-administration promote rela..

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Reduced alcohol-seeking in male offspring of sires exposed to alcohol self-administration followed by punishment-imposed abstinence

Erin J Campbell, Jeremy PM Flanagan, Nathan J Marchant, Andrew J Lawrence

2018-04-01

Emerging evidence has demonstrated that paternal alcohol use can modify the behavior of offspring, particularly male offspring. Ho..