UNRAVELING THE NEURAL CIRCUITRY OF CONTEXT-INDUCED RELAPSE TO ALCOHOL SEEKING AFTER PUNISHMENT-IMPOSED ABSTINENCE
Grant number: 1105741 | Funding period: 2016 - 2019
Alcohol use disorder (alcoholism) causes significant social and economic costs to Australian society. Alcoholism is a brain disease, and relapse during abstinence is the main problem in successful treatment. In this project, we use an animal model of relapse to alcohol seeking after abstinence imposed by a negative consequence (punishment). This project will identify brain regions which can be targeted in future clinical studies in human alcoholics.
Related publications (7)
Orexin-1 receptor signaling within the lateral hypothalamus, but not bed nucleus of the stria terminalis, mediates context-induced relapse to alcohol seeking
Erin J Campbell, Mitchell KR Hill, Xavier J Maddern, Shubo Jin, Terence Y Pang, Andrew J Lawrence
BACKGROUND: The lateral hypothalamic orexin (hypocretin) system has a well-established role in the motivation for reward. This has..
Environmental enrichment reduces the propensity to relapse following punishment-imposed abstinence of alcohol seeking
Erin J Campbell, Shubo Jin, Andrew J Lawrence
Environmental enrichment during periods of abstinence can reduce the risk of relapse to drug-seeking behavior. We trained rats to ..
Distinct Accumbens Shell Output Pathways Promote versus Prevent Relapse to Alcohol Seeking
Gabrielle D Gibson, Asheeta A Prasad, Philip Jean-Richard-dit-Bressel, Joanna OY Yau, E Zayra Millan, Yu Liu, Erin J Campbell, Jun Lim, Nathan J Marchant, John M Power, Simon Killcross, Andrew J Lawrence, Gavan P McNally