GENOME-BASED TOOLS TO SUPPORT UROGENITAL SCHISTOSOMIASIS CONTROL
Grant number: 1102322 | Funding period: 2016 - 2019
More than 100 million sub-Saharan Africans have urogenital schistosomiasis, a disease that promotes malignant cancer and HIV/AIDS. Control depends on a single drug, making resistance an imminent threat. We will deliver new molecular tools to assess parasite genetic diversity and to prioritise a panel of anti-parasitic drug targets and vaccine candidates. These outcomes will deliver the next generation of interventions against urogenital schistosomiasis.
Related publications (13)
Synthesis and structure-activity relationship study of pyrrolidine-oxadiazoles as anthelmintics against Haemonchus contortus
Banfeng Ruan, Yuezhou Zhang, Solomon Tadesse, Sarah Preston, Aya C Taki, Abdul Jabbar, Andreas Hofmann, Yaqing Jiao, Jose Garcia-Bustos, Jitendra Harjani, Thuy Giang Le, Swapna Varghese, Silvia Teguh, Yiyue Xie, Jephthah Odiba, Min Hu, Robin B Gasser, Jonathan Baell
Parasitic roundworms (nematodes) are significant pathogens of humans and animals and cause substantive socioeconomic losses due to..
Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium
Harald Oey, Martha Zakrzewski, Kerstin Gravermann, Neil D Young, Pasi K Korhonen, Geoffrey N Gobert, Sujeevi Nawaratna, Shihab Hasan, David M Martinez, Hong You, Martin Lavin, Malcolm K Jones, Mark A Ragan, Jens Stoye, Ana Oleaga, Aidan M Emery, Bonnie Webster, David Rollinson, Robin B Gasser, Donald P McManus
Mesenteric infection by the parasitic blood fluke Schistosoma bovis is a common veterinary problem in Africa and the Middle East a..
Genomics of worms, with an emphasis on Opisthorchis viverrini - opportunities for fundamental discovery and biomedical outcomes.
Robin B Gasser, Patrick Tan, Bin Tean Teh, Sopit Wongkham, Neil D Young
Neglected tropical diseases cause substantial morbidity and mortality in animals and people globally. Opisthorchiasis is one such ..
Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites
Kristian E Swearingen, Scott E Lindner, Erika L Flannery, Ashley M Vaughan, Robert D Morrison, Rapatbhorn Patrapuvich, Cristian Koepfli, Ivo Muller, Aaron Jex, Robert L Moritz, Stefan HI Kappe, Jetsumon Sattabongkot, Sebastian A Mikolajczak
Plasmodium falciparum and Plasmodium vivax cause the majority of human malaria cases. Research efforts predominantly focus on P. f..
Mitochondrial Phylogenomics yields Strongly Supported Hypotheses for Ascaridomorph Nematodes
Guo-Hua Liu, Steven A Nadler, Shan-Shan Liu, Magdalena Podolska, Stefano D'Amelio, Renfu Shao, Robin B Gasser, Xing-Quan Zhu
Ascaridomorph nematodes threaten the health of humans and other animals worldwide. Despite their medical, veterinary and economic ..
Population structure of Haemonchus contortus from seven geographical regions in China, determined on the basis of microsatellite markers
Fangyuan Yin, Robin B Gasser, Facai Li, Min Bao, Weiyi Huang, Fengcai Zou, Guanghui Zhao, Chunren Wang, Xin Yang, Yanqin Zhou, Junlong Zhao, Rui Fang, Min Hu
BACKGROUND: Studying genetic variation within and among Haemonchus contortus populations can inform some aspects of this parasite'..
Genomic resources for a unique, low-virulence Babesia taxon from China
Guiquan Guan, Pasi K Korhonen, Neil D Young, Anson V Koehler, Tao Wang, Youquan Li, Zhijie Liu, Jianxun Luo, Hong Yin, Robin B Gasser
BACKGROUND: Babesiosis is a socioeconomically important tick-borne disease of animals (including humans) caused by haemoprotozoan ..
More parasiticmyositis cases in humans in Australia, and the definition of genetic markers for the causative agents as a basis for molecular diagnosis
Anson V Koehler, David M Spratt, Robert Norton, Sanchia Warren, Belinda McEwan, Ravindra Urkude, Suresh Murthy, Thomas Robertson, Naomi McCallum, Fiona Parsonson, Richard S Bradbury, Robin B Gasser
Since 1998, there have been six reported human cases of myositis in Australia, attributable to infection with the nematode Haycock..
MicroRNAs of Toxocara canis and their predicted functional roles
Guangxu Ma, Yongfang Luo, Honghong Zhu, Yongli Luo, Pasi K Korhonen, Neil D Young, Robin B Gasser, Rongqiong Zhou
BACKGROUND: Toxocara canis is the causative agent of toxocariasis of humans and other animals. This parasitic nematode (roundworm)..
Dictyocaulus viviparus genome, variome and transcriptome elucidate lungworm biology and support future intervention
Samantha N McNulty, Christina Struebe, Bruce A Rosa, John C Martin, Rahul Tyagi, Young-Jun Choi, Qi Wang, Kymberlie Hallsworth Pepin, Xu Zhang, Philip Ozersky, Richard K Wilson, Paul W Sternberg, Robin B Gasser, Makedonka Mitreva
The bovine lungworm, Dictyocaulus viviparus (order Strongylida), is an important parasite of livestock that causes substantial eco..
Reconstruction of the insulin-like signalling pathway of Haemonchus contortus
Namitha Mohandas, Min Hu, Andreas J Stroehlein, Neil D Young, Paul W Sternberg, James B Lok, Robin B Gasser
BACKGROUND: In the present study, we reconstructed the insulin/insulin-like growth factor 1 signalling (IIS) pathway for Haemonchu..
Molecular analysis of Cryptosporidium from cattle from five states of Peninsular Malaysia
Nan Jiun Yap, Anson V Koehler, Janine Ebner, Tiong Kai Tan, Yvonne AL Lim, Robin B Gasser
Despite the importance of the cattle industry in Malaysia, there are very few studies of the diversity and public health significa..