REGULATION OF MESENCHYMAL TO EPITHELIAL TRANSITIONS BY NETRIN RECEPTORS
Grant number: 1107123 | Funding period: 2016 - 2020
The formation of 2D cellular sheets is important during development, tissue repair, and tumor growth. The mechanisms involved, however, remain largely unknown. Recent findings in the fly and in human cells suggest Frazzled/Neogenin receptors drive this process, by establishing polarised scaffolds in the cell. We will test this hypothesis using fly genetics and analysis of 3-dimensional culture of mammalian cells. Our results will help guide future therapies for human disease.
Related publications (3)
Maintenance of Cell Fate by the Polycomb Group Gene Sex Combs Extra Enables a Partial Epithelial Mesenchymal Transition in Drosophila
Grace Jefferies, Jason Somers, Isabelle Lohrey, Vishal Chaturvedi, Jacob Calabria, Owen J Marshall, Tony D Southall, Robert Saint, Michael J Murray
Epigenetic silencing by Polycomb group (PcG) complexes can promote epithelial-mesenchymal transition (EMT) and stemness and is ass..
Loss of Neogenin1 in human colorectal carcinoma cells causes a partial EMT and wound-healing response
Vishal Chaturvedi, Alexandre Fournier-Level, Helen M Cooper, Michael J Murray
Neogenin1 (NEO1) is a receptor of the Deleted in Colorectal Carcinoma (DCC)/Frazzled/UNC-40 family, which regulates axon guidance ..
Frazzled can act through distinct molecular pathways in epithelial cells to regulate motility, apical constriction, and localisation of E-Cadherin
Sofia Golenkina, Vishal Chaturvedi, Robert Saint, Michael J Murray
Netrin receptors of the DCC/NEO/UNC-40/Frazzled family have well established roles in cell migration and axon guidance but can als..