REGULATION OF MESENCHYMAL TO EPITHELIAL TRANSITIONS BY NETRIN RECEPTORS

Grant number: 1107123 | Funding period: 2016 - 2020

Completed

Abstract

The formation of 2D cellular sheets is important during development, tissue repair, and tumor growth. The mechanisms involved, however, remain largely unknown. Recent findings in the fly and in human cells suggest Frazzled/Neogenin receptors drive this process, by establishing polarised scaffolds in the cell. We will test this hypothesis using fly genetics and analysis of 3-dimensional culture of mammalian cells. Our results will help guide future therapies for human disease.

Researchers