Systematic Screening Approach to Identify New Therapeutics for Preeclampsia

Grant number: 1101871 | Funding period: 2016 - 2019

Completed

Abstract

Preeclampsia is a pregnancy complication where factors are released from the placenta into the mum's bloodstream, causing widespread blood vessel and organ damage. Sadly, there is no treatment. Our laboratory has a set up a system to test whether drugs might be useful as a treatment for preeclampsia. We test whether the drugs decrease the release of these factors and protect blood vessels. In this grant, we propose testing three exciting drug treatments for preeclampsia.

Related publications (4)

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Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia

NK Binder, FC Brownfoot, S Beard, P Cannon, TV Nguyen, S Tong, TJ Kaitu'u-Lino, NJ Hannan

2020-10-01

Development and repurposing of therapies that show promise in the prevention or treatment of preeclampsia would be a major advance..

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Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction – implications for treating preeclampsia

TJ Kaitu'u-Lino, FC Brownfoot, S Beard, P Cannon, R Hastie, TV Nguyen, NK Binder, S Tong, NJ Hannan

2018-02-01

Introduction The discovery of new treatments that prevent or treat preeclampsia would be a major advance. Antiangiogenic factors s..

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Placental-specific sFLT-1: Role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis

KR Palmer, S Tong, TJ Kaitu'u-Lino

2017-02-06

Pre-eclampsia is a common obstetric complication globally responsible for a significant burden of maternal and perinatal morbidity..

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Metformin as a prevention and treatment for preeclampsia: Effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction

FC Brownfoot, R Hastie, NJ Hannan, P Cannon, L Tuohey, LJ Parry, S Senadheera, SE Illanes, TJ Kaitu'U-Lino, S Tong

2016-03-01

Background Preeclampsia is associated with placental ischemia/hypoxia and secretion of soluble fms-like tyrosine kinase 1 and solu..