LOCAL CARDIAC SEX STEROIDS - NEW THERAPEUTIC TARGETS

Grant number: 1099352 | Funding period: 2016 - 2019

Completed

Abstract

The sex hormones, estrogen and testosterone, are implicated in susceptibility to heart diseases - the timing and type of disease development is different for women and men. The mechanisms for this are unknown. In this project we investigate the synthesis and breakdown of these hormones in the heart and determine how local hormone levels may affect heart muscle cell survival and function. The aim is to find ways of adjusting hormone balance to optimize protection when the heart is under stress.

Related publications (4)

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Cardiomyocyte functional screening: interrogating comparative electrophysiology of high-throughput model cell systems

Simon P Wells, Helen M Waddell, Choon Boon Sim, Shiang Y Lim, Gabriel B Bernasochi, Davor Pavlovic, Paulus Kirchhof, Enzo R Porrello, Lea MD Delbridge, James R Bell

2019-12-01

Cardiac arrhythmias of both atrial and ventricular origin are an important feature of cardiovascular disease. Novel antiarrhythmic..

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Myocardial Energy Stress, Autophagy Induction, and Cardiomyocyte Functional Responses

Lorna J Daniels, Upasna Varma, Marco Annandale, Eleia Chan, Kimberley M Mellor, Lea MD Delbridge

2019-08-20

Significance: Energy stress in the myocardium occurs in a variety of acute and chronic pathophysiological contexts, including isch..

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Impact of Estrogens on the Regulation of White, Beige, and Brown Adipose Tissue Depots

Gabriel B Bernasochi, James R Bell, Evan R Simpson, Lea MD Delbridge, Wah Chin Boon

2019-04-01

As adipose tissue depots are active endocrine organs, they secrete a variety of hormones (including estrogens from white adipose) ..

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Pericardial adipose and aromatase: A new translational target for aging, obesity and arrhythmogenesis?

Gabriel B Bernasochi, Wah Chin Boon, Claire L Curl, Upasna Varma, Salvatore Pepe, Marianne Tare, Laura J Parry, Evdokia Dimitriadis, Stephen B Harrap, Chrishan J Nalliah, Jonathan M Kalman, Lea MD Delbridge, James R Bell

2017-10-01

A correlation exists between the extent of pericardial adipose and atrial fibrillation (AF) risk, though the underlying mechanisms..